MERS coronavirus induces apoptosis in kidney and lung by upregulating Smad7 and FGF2
Identifieur interne : 000B13 ( Pmc/Checkpoint ); précédent : 000B12; suivant : 000B14MERS coronavirus induces apoptosis in kidney and lung by upregulating Smad7 and FGF2
Auteurs : Man-Lung Yeung ; Yanfeng Yao ; Lilong Jia ; Jasper F. W. Chan ; Kwok-Hung Chan ; Kwok-Fan Cheung ; Honglin Chen ; Vincent K. M. Poon ; Alan K. L. Tsang ; Kelvin K. W. To ; Ming-Kwong Yiu ; Jade L. L. Teng ; Hin Chu ; Jie Zhou ; Qing Zhang ; Wei Deng ; Susanna K. P. Lau ; Johnson Y. N. Lau ; Patrick C. Y. Woo ; Tak-Mao Chan ; Susan Yung ; Bo-Jian Zheng ; Dong-Yan Jin ; Peter W. Mathieson ; Chuan Qin ; Kwok-Yung YuenSource :
- Nature Microbiology [ 2058-5276 ] ; 2016.
Abstract
Middle East respiratory syndrome coronavirus (MERS-CoV) causes sporadic zoonotic disease and healthcare-associated outbreaks in human. MERS is often complicated by acute respiratory distress syndrome (ARDS) and multi-organ failure
The online version of this article (doi:10.1038/nmicrobiol.2016.4) contains supplementary material, which is available to authorized users.
Url:
DOI: 10.1038/nmicrobiol.2016.4
PubMed: 27572168
PubMed Central: 7097571
Affiliations:
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PMC:7097571Le document en format XML
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<author><name sortKey="Qin, Chuan" sort="Qin, Chuan" uniqKey="Qin C" first="Chuan" last="Qin">Chuan Qin</name>
<affiliation><nlm:aff id="Aff5"><institution-wrap><institution-id institution-id-type="GRID">grid.482592.0</institution-id>
<institution>Institute of Laboratory Animal Sciences, Chinese Academy of Medical Sciences,</institution>
</institution-wrap>
Chaoyang District, 100021 Beijing China</nlm:aff>
<wicri:noCountry code="subfield">100021 Beijing China</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Yuen, Kwok Yung" sort="Yuen, Kwok Yung" uniqKey="Yuen K" first="Kwok-Yung" last="Yuen">Kwok-Yung Yuen</name>
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China</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="GRID">grid.194645.b</institution-id>
<institution-id institution-id-type="ISNI">0000000121742757</institution-id>
<institution>Department of Microbiology,</institution>
<institution>The University of Hong Kong, Hong Kong Special Administrative Region, Hong Kong,</institution>
</institution-wrap>
China</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="GRID">grid.194645.b</institution-id>
<institution-id institution-id-type="ISNI">0000000121742757</institution-id>
<institution>Research Centre of Infection and Immunology, The University of Hong Kong, Hong Kong Special Administrative Region, Hong Kong,</institution>
</institution-wrap>
China</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="Aff4"><institution-wrap><institution-id institution-id-type="GRID">grid.194645.b</institution-id>
<institution-id institution-id-type="ISNI">0000000121742757</institution-id>
<institution>Carol Yu Centre for Infection, The University of Hong Kong, Hong Kong Special Administrative Region, Hong Kong,</institution>
</institution-wrap>
China</nlm:aff>
</affiliation>
</author>
</titleStmt>
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<idno type="pmid">27572168</idno>
<idno type="pmc">7097571</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7097571</idno>
<idno type="RBID">PMC:7097571</idno>
<idno type="doi">10.1038/nmicrobiol.2016.4</idno>
<date when="2016">2016</date>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">MERS coronavirus induces apoptosis in kidney and lung by upregulating Smad7 and FGF2</title>
<author><name sortKey="Yeung, Man Lung" sort="Yeung, Man Lung" uniqKey="Yeung M" first="Man-Lung" last="Yeung">Man-Lung Yeung</name>
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<institution>State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Hong Kong Special Administrative Region, Hong Kong,</institution>
</institution-wrap>
China</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="GRID">grid.194645.b</institution-id>
<institution-id institution-id-type="ISNI">0000000121742757</institution-id>
<institution>Department of Microbiology,</institution>
<institution>The University of Hong Kong, Hong Kong Special Administrative Region, Hong Kong,</institution>
</institution-wrap>
China</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="GRID">grid.194645.b</institution-id>
<institution-id institution-id-type="ISNI">0000000121742757</institution-id>
<institution>Research Centre of Infection and Immunology, The University of Hong Kong, Hong Kong Special Administrative Region, Hong Kong,</institution>
</institution-wrap>
China</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="Aff4"><institution-wrap><institution-id institution-id-type="GRID">grid.194645.b</institution-id>
<institution-id institution-id-type="ISNI">0000000121742757</institution-id>
<institution>Carol Yu Centre for Infection, The University of Hong Kong, Hong Kong Special Administrative Region, Hong Kong,</institution>
</institution-wrap>
China</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Yao, Yanfeng" sort="Yao, Yanfeng" uniqKey="Yao Y" first="Yanfeng" last="Yao">Yanfeng Yao</name>
<affiliation><nlm:aff id="Aff5"><institution-wrap><institution-id institution-id-type="GRID">grid.482592.0</institution-id>
<institution>Institute of Laboratory Animal Sciences, Chinese Academy of Medical Sciences,</institution>
</institution-wrap>
Chaoyang District, 100021 Beijing China</nlm:aff>
<wicri:noCountry code="subfield">100021 Beijing China</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Jia, Lilong" sort="Jia, Lilong" uniqKey="Jia L" first="Lilong" last="Jia">Lilong Jia</name>
<affiliation><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="GRID">grid.194645.b</institution-id>
<institution-id institution-id-type="ISNI">0000000121742757</institution-id>
<institution>Department of Microbiology,</institution>
<institution>The University of Hong Kong, Hong Kong Special Administrative Region, Hong Kong,</institution>
</institution-wrap>
China</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Chan, Jasper F W" sort="Chan, Jasper F W" uniqKey="Chan J" first="Jasper F. W." last="Chan">Jasper F. W. Chan</name>
<affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.194645.b</institution-id>
<institution-id institution-id-type="ISNI">0000000121742757</institution-id>
<institution>State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Hong Kong Special Administrative Region, Hong Kong,</institution>
</institution-wrap>
China</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="GRID">grid.194645.b</institution-id>
<institution-id institution-id-type="ISNI">0000000121742757</institution-id>
<institution>Department of Microbiology,</institution>
<institution>The University of Hong Kong, Hong Kong Special Administrative Region, Hong Kong,</institution>
</institution-wrap>
China</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="GRID">grid.194645.b</institution-id>
<institution-id institution-id-type="ISNI">0000000121742757</institution-id>
<institution>Research Centre of Infection and Immunology, The University of Hong Kong, Hong Kong Special Administrative Region, Hong Kong,</institution>
</institution-wrap>
China</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="Aff4"><institution-wrap><institution-id institution-id-type="GRID">grid.194645.b</institution-id>
<institution-id institution-id-type="ISNI">0000000121742757</institution-id>
<institution>Carol Yu Centre for Infection, The University of Hong Kong, Hong Kong Special Administrative Region, Hong Kong,</institution>
</institution-wrap>
China</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Chan, Kwok Hung" sort="Chan, Kwok Hung" uniqKey="Chan K" first="Kwok-Hung" last="Chan">Kwok-Hung Chan</name>
<affiliation><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="GRID">grid.194645.b</institution-id>
<institution-id institution-id-type="ISNI">0000000121742757</institution-id>
<institution>Department of Microbiology,</institution>
<institution>The University of Hong Kong, Hong Kong Special Administrative Region, Hong Kong,</institution>
</institution-wrap>
China</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Cheung, Kwok Fan" sort="Cheung, Kwok Fan" uniqKey="Cheung K" first="Kwok-Fan" last="Cheung">Kwok-Fan Cheung</name>
<affiliation><nlm:aff id="Aff6"><institution-wrap><institution-id institution-id-type="GRID">grid.194645.b</institution-id>
<institution-id institution-id-type="ISNI">0000000121742757</institution-id>
<institution>Department of Medicine,</institution>
<institution>The University of Hong Kong, Hong Kong Special Administrative Region, Hong Kong,</institution>
</institution-wrap>
China</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Chen, Honglin" sort="Chen, Honglin" uniqKey="Chen H" first="Honglin" last="Chen">Honglin Chen</name>
<affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.194645.b</institution-id>
<institution-id institution-id-type="ISNI">0000000121742757</institution-id>
<institution>State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Hong Kong Special Administrative Region, Hong Kong,</institution>
</institution-wrap>
China</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="GRID">grid.194645.b</institution-id>
<institution-id institution-id-type="ISNI">0000000121742757</institution-id>
<institution>Department of Microbiology,</institution>
<institution>The University of Hong Kong, Hong Kong Special Administrative Region, Hong Kong,</institution>
</institution-wrap>
China</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="GRID">grid.194645.b</institution-id>
<institution-id institution-id-type="ISNI">0000000121742757</institution-id>
<institution>Research Centre of Infection and Immunology, The University of Hong Kong, Hong Kong Special Administrative Region, Hong Kong,</institution>
</institution-wrap>
China</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="Aff4"><institution-wrap><institution-id institution-id-type="GRID">grid.194645.b</institution-id>
<institution-id institution-id-type="ISNI">0000000121742757</institution-id>
<institution>Carol Yu Centre for Infection, The University of Hong Kong, Hong Kong Special Administrative Region, Hong Kong,</institution>
</institution-wrap>
China</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Poon, Vincent K M" sort="Poon, Vincent K M" uniqKey="Poon V" first="Vincent K. M." last="Poon">Vincent K. M. Poon</name>
<affiliation><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="GRID">grid.194645.b</institution-id>
<institution-id institution-id-type="ISNI">0000000121742757</institution-id>
<institution>Department of Microbiology,</institution>
<institution>The University of Hong Kong, Hong Kong Special Administrative Region, Hong Kong,</institution>
</institution-wrap>
China</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Tsang, Alan K L" sort="Tsang, Alan K L" uniqKey="Tsang A" first="Alan K. L." last="Tsang">Alan K. L. Tsang</name>
<affiliation><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="GRID">grid.194645.b</institution-id>
<institution-id institution-id-type="ISNI">0000000121742757</institution-id>
<institution>Department of Microbiology,</institution>
<institution>The University of Hong Kong, Hong Kong Special Administrative Region, Hong Kong,</institution>
</institution-wrap>
China</nlm:aff>
</affiliation>
</author>
<author><name sortKey="To, Kelvin K W" sort="To, Kelvin K W" uniqKey="To K" first="Kelvin K. W." last="To">Kelvin K. W. To</name>
<affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.194645.b</institution-id>
<institution-id institution-id-type="ISNI">0000000121742757</institution-id>
<institution>State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Hong Kong Special Administrative Region, Hong Kong,</institution>
</institution-wrap>
China</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="GRID">grid.194645.b</institution-id>
<institution-id institution-id-type="ISNI">0000000121742757</institution-id>
<institution>Department of Microbiology,</institution>
<institution>The University of Hong Kong, Hong Kong Special Administrative Region, Hong Kong,</institution>
</institution-wrap>
China</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="GRID">grid.194645.b</institution-id>
<institution-id institution-id-type="ISNI">0000000121742757</institution-id>
<institution>Research Centre of Infection and Immunology, The University of Hong Kong, Hong Kong Special Administrative Region, Hong Kong,</institution>
</institution-wrap>
China</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="Aff4"><institution-wrap><institution-id institution-id-type="GRID">grid.194645.b</institution-id>
<institution-id institution-id-type="ISNI">0000000121742757</institution-id>
<institution>Carol Yu Centre for Infection, The University of Hong Kong, Hong Kong Special Administrative Region, Hong Kong,</institution>
</institution-wrap>
China</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Yiu, Ming Kwong" sort="Yiu, Ming Kwong" uniqKey="Yiu M" first="Ming-Kwong" last="Yiu">Ming-Kwong Yiu</name>
<affiliation><nlm:aff id="Aff7"><institution-wrap><institution-id institution-id-type="GRID">grid.194645.b</institution-id>
<institution-id institution-id-type="ISNI">0000000121742757</institution-id>
<institution>Department of Surgery,</institution>
<institution>The University of Hong Kong, Hong Kong Special Administrative Region, Hong Kong,</institution>
</institution-wrap>
China</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Teng, Jade L L" sort="Teng, Jade L L" uniqKey="Teng J" first="Jade L. L." last="Teng">Jade L. L. Teng</name>
<affiliation><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="GRID">grid.194645.b</institution-id>
<institution-id institution-id-type="ISNI">0000000121742757</institution-id>
<institution>Department of Microbiology,</institution>
<institution>The University of Hong Kong, Hong Kong Special Administrative Region, Hong Kong,</institution>
</institution-wrap>
China</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Chu, Hin" sort="Chu, Hin" uniqKey="Chu H" first="Hin" last="Chu">Hin Chu</name>
<affiliation><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="GRID">grid.194645.b</institution-id>
<institution-id institution-id-type="ISNI">0000000121742757</institution-id>
<institution>Department of Microbiology,</institution>
<institution>The University of Hong Kong, Hong Kong Special Administrative Region, Hong Kong,</institution>
</institution-wrap>
China</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Zhou, Jie" sort="Zhou, Jie" uniqKey="Zhou J" first="Jie" last="Zhou">Jie Zhou</name>
<affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.194645.b</institution-id>
<institution-id institution-id-type="ISNI">0000000121742757</institution-id>
<institution>State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Hong Kong Special Administrative Region, Hong Kong,</institution>
</institution-wrap>
China</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="GRID">grid.194645.b</institution-id>
<institution-id institution-id-type="ISNI">0000000121742757</institution-id>
<institution>Department of Microbiology,</institution>
<institution>The University of Hong Kong, Hong Kong Special Administrative Region, Hong Kong,</institution>
</institution-wrap>
China</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="GRID">grid.194645.b</institution-id>
<institution-id institution-id-type="ISNI">0000000121742757</institution-id>
<institution>Research Centre of Infection and Immunology, The University of Hong Kong, Hong Kong Special Administrative Region, Hong Kong,</institution>
</institution-wrap>
China</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="Aff4"><institution-wrap><institution-id institution-id-type="GRID">grid.194645.b</institution-id>
<institution-id institution-id-type="ISNI">0000000121742757</institution-id>
<institution>Carol Yu Centre for Infection, The University of Hong Kong, Hong Kong Special Administrative Region, Hong Kong,</institution>
</institution-wrap>
China</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Zhang, Qing" sort="Zhang, Qing" uniqKey="Zhang Q" first="Qing" last="Zhang">Qing Zhang</name>
<affiliation><nlm:aff id="Aff6"><institution-wrap><institution-id institution-id-type="GRID">grid.194645.b</institution-id>
<institution-id institution-id-type="ISNI">0000000121742757</institution-id>
<institution>Department of Medicine,</institution>
<institution>The University of Hong Kong, Hong Kong Special Administrative Region, Hong Kong,</institution>
</institution-wrap>
China</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Deng, Wei" sort="Deng, Wei" uniqKey="Deng W" first="Wei" last="Deng">Wei Deng</name>
<affiliation><nlm:aff id="Aff5"><institution-wrap><institution-id institution-id-type="GRID">grid.482592.0</institution-id>
<institution>Institute of Laboratory Animal Sciences, Chinese Academy of Medical Sciences,</institution>
</institution-wrap>
Chaoyang District, 100021 Beijing China</nlm:aff>
<wicri:noCountry code="subfield">100021 Beijing China</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Lau, Susanna K P" sort="Lau, Susanna K P" uniqKey="Lau S" first="Susanna K. P." last="Lau">Susanna K. P. Lau</name>
<affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.194645.b</institution-id>
<institution-id institution-id-type="ISNI">0000000121742757</institution-id>
<institution>State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Hong Kong Special Administrative Region, Hong Kong,</institution>
</institution-wrap>
China</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="GRID">grid.194645.b</institution-id>
<institution-id institution-id-type="ISNI">0000000121742757</institution-id>
<institution>Department of Microbiology,</institution>
<institution>The University of Hong Kong, Hong Kong Special Administrative Region, Hong Kong,</institution>
</institution-wrap>
China</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="GRID">grid.194645.b</institution-id>
<institution-id institution-id-type="ISNI">0000000121742757</institution-id>
<institution>Research Centre of Infection and Immunology, The University of Hong Kong, Hong Kong Special Administrative Region, Hong Kong,</institution>
</institution-wrap>
China</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="Aff4"><institution-wrap><institution-id institution-id-type="GRID">grid.194645.b</institution-id>
<institution-id institution-id-type="ISNI">0000000121742757</institution-id>
<institution>Carol Yu Centre for Infection, The University of Hong Kong, Hong Kong Special Administrative Region, Hong Kong,</institution>
</institution-wrap>
China</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Lau, Johnson Y N" sort="Lau, Johnson Y N" uniqKey="Lau J" first="Johnson Y. N." last="Lau">Johnson Y. N. Lau</name>
<affiliation><nlm:aff id="Aff4"><institution-wrap><institution-id institution-id-type="GRID">grid.194645.b</institution-id>
<institution-id institution-id-type="ISNI">0000000121742757</institution-id>
<institution>Carol Yu Centre for Infection, The University of Hong Kong, Hong Kong Special Administrative Region, Hong Kong,</institution>
</institution-wrap>
China</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Woo, Patrick C Y" sort="Woo, Patrick C Y" uniqKey="Woo P" first="Patrick C. Y." last="Woo">Patrick C. Y. Woo</name>
<affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.194645.b</institution-id>
<institution-id institution-id-type="ISNI">0000000121742757</institution-id>
<institution>State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Hong Kong Special Administrative Region, Hong Kong,</institution>
</institution-wrap>
China</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="GRID">grid.194645.b</institution-id>
<institution-id institution-id-type="ISNI">0000000121742757</institution-id>
<institution>Department of Microbiology,</institution>
<institution>The University of Hong Kong, Hong Kong Special Administrative Region, Hong Kong,</institution>
</institution-wrap>
China</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="GRID">grid.194645.b</institution-id>
<institution-id institution-id-type="ISNI">0000000121742757</institution-id>
<institution>Research Centre of Infection and Immunology, The University of Hong Kong, Hong Kong Special Administrative Region, Hong Kong,</institution>
</institution-wrap>
China</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="Aff4"><institution-wrap><institution-id institution-id-type="GRID">grid.194645.b</institution-id>
<institution-id institution-id-type="ISNI">0000000121742757</institution-id>
<institution>Carol Yu Centre for Infection, The University of Hong Kong, Hong Kong Special Administrative Region, Hong Kong,</institution>
</institution-wrap>
China</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Chan, Tak Mao" sort="Chan, Tak Mao" uniqKey="Chan T" first="Tak-Mao" last="Chan">Tak-Mao Chan</name>
<affiliation><nlm:aff id="Aff6"><institution-wrap><institution-id institution-id-type="GRID">grid.194645.b</institution-id>
<institution-id institution-id-type="ISNI">0000000121742757</institution-id>
<institution>Department of Medicine,</institution>
<institution>The University of Hong Kong, Hong Kong Special Administrative Region, Hong Kong,</institution>
</institution-wrap>
China</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Yung, Susan" sort="Yung, Susan" uniqKey="Yung S" first="Susan" last="Yung">Susan Yung</name>
<affiliation><nlm:aff id="Aff6"><institution-wrap><institution-id institution-id-type="GRID">grid.194645.b</institution-id>
<institution-id institution-id-type="ISNI">0000000121742757</institution-id>
<institution>Department of Medicine,</institution>
<institution>The University of Hong Kong, Hong Kong Special Administrative Region, Hong Kong,</institution>
</institution-wrap>
China</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Zheng, Bo Jian" sort="Zheng, Bo Jian" uniqKey="Zheng B" first="Bo-Jian" last="Zheng">Bo-Jian Zheng</name>
<affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.194645.b</institution-id>
<institution-id institution-id-type="ISNI">0000000121742757</institution-id>
<institution>State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Hong Kong Special Administrative Region, Hong Kong,</institution>
</institution-wrap>
China</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="GRID">grid.194645.b</institution-id>
<institution-id institution-id-type="ISNI">0000000121742757</institution-id>
<institution>Department of Microbiology,</institution>
<institution>The University of Hong Kong, Hong Kong Special Administrative Region, Hong Kong,</institution>
</institution-wrap>
China</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="GRID">grid.194645.b</institution-id>
<institution-id institution-id-type="ISNI">0000000121742757</institution-id>
<institution>Research Centre of Infection and Immunology, The University of Hong Kong, Hong Kong Special Administrative Region, Hong Kong,</institution>
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China</nlm:aff>
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<affiliation><nlm:aff id="Aff4"><institution-wrap><institution-id institution-id-type="GRID">grid.194645.b</institution-id>
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<institution>Carol Yu Centre for Infection, The University of Hong Kong, Hong Kong Special Administrative Region, Hong Kong,</institution>
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China</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Jin, Dong Yan" sort="Jin, Dong Yan" uniqKey="Jin D" first="Dong-Yan" last="Jin">Dong-Yan Jin</name>
<affiliation><nlm:aff id="Aff8"><institution-wrap><institution-id institution-id-type="GRID">grid.194645.b</institution-id>
<institution-id institution-id-type="ISNI">0000000121742757</institution-id>
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<institution>The University of Hong Kong, Hong Kong Special Administrative Region, Hong Kong,</institution>
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China</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Mathieson, Peter W" sort="Mathieson, Peter W" uniqKey="Mathieson P" first="Peter W." last="Mathieson">Peter W. Mathieson</name>
<affiliation><nlm:aff id="Aff6"><institution-wrap><institution-id institution-id-type="GRID">grid.194645.b</institution-id>
<institution-id institution-id-type="ISNI">0000000121742757</institution-id>
<institution>Department of Medicine,</institution>
<institution>The University of Hong Kong, Hong Kong Special Administrative Region, Hong Kong,</institution>
</institution-wrap>
China</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="Aff9"><institution-wrap><institution-id institution-id-type="GRID">grid.194645.b</institution-id>
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<institution>President's Office, The University of Hong Kong, Hong Kong Special Administrative Region, Hong Kong,</institution>
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China</nlm:aff>
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</author>
<author><name sortKey="Qin, Chuan" sort="Qin, Chuan" uniqKey="Qin C" first="Chuan" last="Qin">Chuan Qin</name>
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<institution>Institute of Laboratory Animal Sciences, Chinese Academy of Medical Sciences,</institution>
</institution-wrap>
Chaoyang District, 100021 Beijing China</nlm:aff>
<wicri:noCountry code="subfield">100021 Beijing China</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Yuen, Kwok Yung" sort="Yuen, Kwok Yung" uniqKey="Yuen K" first="Kwok-Yung" last="Yuen">Kwok-Yung Yuen</name>
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<institution>State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Hong Kong Special Administrative Region, Hong Kong,</institution>
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China</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="GRID">grid.194645.b</institution-id>
<institution-id institution-id-type="ISNI">0000000121742757</institution-id>
<institution>Department of Microbiology,</institution>
<institution>The University of Hong Kong, Hong Kong Special Administrative Region, Hong Kong,</institution>
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China</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="GRID">grid.194645.b</institution-id>
<institution-id institution-id-type="ISNI">0000000121742757</institution-id>
<institution>Research Centre of Infection and Immunology, The University of Hong Kong, Hong Kong Special Administrative Region, Hong Kong,</institution>
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China</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="Aff4"><institution-wrap><institution-id institution-id-type="GRID">grid.194645.b</institution-id>
<institution-id institution-id-type="ISNI">0000000121742757</institution-id>
<institution>Carol Yu Centre for Infection, The University of Hong Kong, Hong Kong Special Administrative Region, Hong Kong,</institution>
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China</nlm:aff>
</affiliation>
</author>
</analytic>
<series><title level="j">Nature Microbiology</title>
<idno type="eISSN">2058-5276</idno>
<imprint><date when="2016">2016</date>
</imprint>
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<front><div type="abstract" xml:lang="en"><p id="Par1">Middle East respiratory syndrome coronavirus (MERS-CoV) causes sporadic zoonotic disease and healthcare-associated outbreaks in human. MERS is often complicated by acute respiratory distress syndrome (ARDS) and multi-organ failure<sup><xref ref-type="bibr" rid="CR1">1</xref>
,<xref ref-type="bibr" rid="CR2">2</xref>
</sup>
. The high incidence of renal failure in MERS is a unique clinical feature not often found in other human coronavirus infections<sup><xref ref-type="bibr" rid="CR3">3</xref>
,<xref ref-type="bibr" rid="CR4">4</xref>
</sup>
. Whether MERS-CoV infects the kidney and how it triggers renal failure are not understood<sup><xref ref-type="bibr" rid="CR5">5</xref>
,<xref ref-type="bibr" rid="CR6">6</xref>
</sup>
. Here, we demonstrated renal infection and apoptotic induction by MERS-CoV in human <italic>ex vivo</italic>
organ culture and a nonhuman primate model. High-throughput analysis revealed that the cellular genes most significantly perturbed by MERS-CoV have previously been implicated in renal diseases. Furthermore, MERS-CoV induced apoptosis through upregulation of Smad7 and fibroblast growth factor 2 (FGF2) expression in both kidney and lung cells. Conversely, knockdown of Smad7 effectively inhibited MERS-CoV replication and protected cells from virus-induced cytopathic effects. We further demonstrated that hyperexpression of Smad7 or FGF2 induced a strong apoptotic response in kidney cells. Common marmosets infected by MERS-CoV developed ARDS and disseminated infection in kidneys and other organs. Smad7 and FGF2 expression were elevated in the lungs and kidneys of the infected animals. Our results provide insights into the pathogenesis of MERS-CoV and host targets for treatment.</p>
<sec><title>Supplementary information</title>
<p>The online version of this article (doi:10.1038/nmicrobiol.2016.4) contains supplementary material, which is available to authorized users.</p>
</sec>
</div>
</front>
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<pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Nat Microbiol</journal-id>
<journal-id journal-id-type="iso-abbrev">Nat Microbiol</journal-id>
<journal-title-group><journal-title>Nature Microbiology</journal-title>
</journal-title-group>
<issn pub-type="epub">2058-5276</issn>
<publisher><publisher-name>Nature Publishing Group UK</publisher-name>
<publisher-loc>London</publisher-loc>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">27572168</article-id>
<article-id pub-id-type="pmc">7097571</article-id>
<article-id pub-id-type="publisher-id">BFnmicrobiol20164</article-id>
<article-id pub-id-type="doi">10.1038/nmicrobiol.2016.4</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Article</subject>
</subj-group>
</article-categories>
<title-group><article-title>MERS coronavirus induces apoptosis in kidney and lung by upregulating Smad7 and FGF2</article-title>
</title-group>
<contrib-group><contrib contrib-type="author" equal-contrib="yes"><name><surname>Yeung</surname>
<given-names>Man-Lung</given-names>
</name>
<xref ref-type="aff" rid="Aff1">1</xref>
<xref ref-type="aff" rid="Aff2">2</xref>
<xref ref-type="aff" rid="Aff3">3</xref>
<xref ref-type="aff" rid="Aff4">4</xref>
</contrib>
<contrib contrib-type="author" equal-contrib="yes"><name><surname>Yao</surname>
<given-names>Yanfeng</given-names>
</name>
<xref ref-type="aff" rid="Aff5">5</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Jia</surname>
<given-names>Lilong</given-names>
</name>
<xref ref-type="aff" rid="Aff2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Chan</surname>
<given-names>Jasper F. W.</given-names>
</name>
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<xref ref-type="aff" rid="Aff2">2</xref>
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<xref ref-type="aff" rid="Aff4">4</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Chan</surname>
<given-names>Kwok-Hung</given-names>
</name>
<xref ref-type="aff" rid="Aff2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Cheung</surname>
<given-names>Kwok-Fan</given-names>
</name>
<xref ref-type="aff" rid="Aff6">6</xref>
</contrib>
<contrib contrib-type="author"><contrib-id contrib-id-type="orcid">http://orcid.org/0000-0001-5108-8338</contrib-id>
<name><surname>Chen</surname>
<given-names>Honglin</given-names>
</name>
<xref ref-type="aff" rid="Aff1">1</xref>
<xref ref-type="aff" rid="Aff2">2</xref>
<xref ref-type="aff" rid="Aff3">3</xref>
<xref ref-type="aff" rid="Aff4">4</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Poon</surname>
<given-names>Vincent K. M.</given-names>
</name>
<xref ref-type="aff" rid="Aff2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Tsang</surname>
<given-names>Alan K. L.</given-names>
</name>
<xref ref-type="aff" rid="Aff2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>To</surname>
<given-names>Kelvin K.W.</given-names>
</name>
<xref ref-type="aff" rid="Aff1">1</xref>
<xref ref-type="aff" rid="Aff2">2</xref>
<xref ref-type="aff" rid="Aff3">3</xref>
<xref ref-type="aff" rid="Aff4">4</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Yiu</surname>
<given-names>Ming-Kwong</given-names>
</name>
<xref ref-type="aff" rid="Aff7">7</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Teng</surname>
<given-names>Jade L. L.</given-names>
</name>
<xref ref-type="aff" rid="Aff2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Chu</surname>
<given-names>Hin</given-names>
</name>
<xref ref-type="aff" rid="Aff2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Zhou</surname>
<given-names>Jie</given-names>
</name>
<xref ref-type="aff" rid="Aff1">1</xref>
<xref ref-type="aff" rid="Aff2">2</xref>
<xref ref-type="aff" rid="Aff3">3</xref>
<xref ref-type="aff" rid="Aff4">4</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Zhang</surname>
<given-names>Qing</given-names>
</name>
<xref ref-type="aff" rid="Aff6">6</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Deng</surname>
<given-names>Wei</given-names>
</name>
<xref ref-type="aff" rid="Aff5">5</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Lau</surname>
<given-names>Susanna K. P.</given-names>
</name>
<xref ref-type="aff" rid="Aff1">1</xref>
<xref ref-type="aff" rid="Aff2">2</xref>
<xref ref-type="aff" rid="Aff3">3</xref>
<xref ref-type="aff" rid="Aff4">4</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Lau</surname>
<given-names>Johnson Y. N.</given-names>
</name>
<xref ref-type="aff" rid="Aff4">4</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Woo</surname>
<given-names>Patrick C. Y.</given-names>
</name>
<xref ref-type="aff" rid="Aff1">1</xref>
<xref ref-type="aff" rid="Aff2">2</xref>
<xref ref-type="aff" rid="Aff3">3</xref>
<xref ref-type="aff" rid="Aff4">4</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Chan</surname>
<given-names>Tak-Mao</given-names>
</name>
<xref ref-type="aff" rid="Aff6">6</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Yung</surname>
<given-names>Susan</given-names>
</name>
<xref ref-type="aff" rid="Aff6">6</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Zheng</surname>
<given-names>Bo-Jian</given-names>
</name>
<xref ref-type="aff" rid="Aff1">1</xref>
<xref ref-type="aff" rid="Aff2">2</xref>
<xref ref-type="aff" rid="Aff3">3</xref>
<xref ref-type="aff" rid="Aff4">4</xref>
</contrib>
<contrib contrib-type="author"><contrib-id contrib-id-type="orcid">http://orcid.org/0000-0002-2778-3530</contrib-id>
<name><surname>Jin</surname>
<given-names>Dong-Yan</given-names>
</name>
<xref ref-type="aff" rid="Aff8">8</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Mathieson</surname>
<given-names>Peter W.</given-names>
</name>
<xref ref-type="aff" rid="Aff6">6</xref>
<xref ref-type="aff" rid="Aff9">9</xref>
</contrib>
<contrib contrib-type="author" corresp="yes"><name><surname>Qin</surname>
<given-names>Chuan</given-names>
</name>
<address><email>qinchuan@pumc.edu.cn</email>
</address>
<xref ref-type="aff" rid="Aff5">5</xref>
</contrib>
<contrib contrib-type="author" corresp="yes"><name><surname>Yuen</surname>
<given-names>Kwok-Yung</given-names>
</name>
<address><email>kyyuen@hku.hk</email>
</address>
<xref ref-type="aff" rid="Aff1">1</xref>
<xref ref-type="aff" rid="Aff2">2</xref>
<xref ref-type="aff" rid="Aff3">3</xref>
<xref ref-type="aff" rid="Aff4">4</xref>
</contrib>
<aff id="Aff1"><label>1</label>
<institution-wrap><institution-id institution-id-type="GRID">grid.194645.b</institution-id>
<institution-id institution-id-type="ISNI">0000000121742757</institution-id>
<institution>State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Hong Kong Special Administrative Region, Hong Kong,</institution>
</institution-wrap>
China</aff>
<aff id="Aff2"><label>2</label>
<institution-wrap><institution-id institution-id-type="GRID">grid.194645.b</institution-id>
<institution-id institution-id-type="ISNI">0000000121742757</institution-id>
<institution>Department of Microbiology,</institution>
<institution>The University of Hong Kong, Hong Kong Special Administrative Region, Hong Kong,</institution>
</institution-wrap>
China</aff>
<aff id="Aff3"><label>3</label>
<institution-wrap><institution-id institution-id-type="GRID">grid.194645.b</institution-id>
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<institution>Research Centre of Infection and Immunology, The University of Hong Kong, Hong Kong Special Administrative Region, Hong Kong,</institution>
</institution-wrap>
China</aff>
<aff id="Aff4"><label>4</label>
<institution-wrap><institution-id institution-id-type="GRID">grid.194645.b</institution-id>
<institution-id institution-id-type="ISNI">0000000121742757</institution-id>
<institution>Carol Yu Centre for Infection, The University of Hong Kong, Hong Kong Special Administrative Region, Hong Kong,</institution>
</institution-wrap>
China</aff>
<aff id="Aff5"><label>5</label>
<institution-wrap><institution-id institution-id-type="GRID">grid.482592.0</institution-id>
<institution>Institute of Laboratory Animal Sciences, Chinese Academy of Medical Sciences,</institution>
</institution-wrap>
Chaoyang District, 100021 Beijing China</aff>
<aff id="Aff6"><label>6</label>
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<institution-id institution-id-type="ISNI">0000000121742757</institution-id>
<institution>Department of Medicine,</institution>
<institution>The University of Hong Kong, Hong Kong Special Administrative Region, Hong Kong,</institution>
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China</aff>
<aff id="Aff7"><label>7</label>
<institution-wrap><institution-id institution-id-type="GRID">grid.194645.b</institution-id>
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<institution>Department of Surgery,</institution>
<institution>The University of Hong Kong, Hong Kong Special Administrative Region, Hong Kong,</institution>
</institution-wrap>
China</aff>
<aff id="Aff8"><label>8</label>
<institution-wrap><institution-id institution-id-type="GRID">grid.194645.b</institution-id>
<institution-id institution-id-type="ISNI">0000000121742757</institution-id>
<institution>Department of Biochemistry,</institution>
<institution>The University of Hong Kong, Hong Kong Special Administrative Region, Hong Kong,</institution>
</institution-wrap>
China</aff>
<aff id="Aff9"><label>9</label>
<institution-wrap><institution-id institution-id-type="GRID">grid.194645.b</institution-id>
<institution-id institution-id-type="ISNI">0000000121742757</institution-id>
<institution>President's Office, The University of Hong Kong, Hong Kong Special Administrative Region, Hong Kong,</institution>
</institution-wrap>
China</aff>
</contrib-group>
<pub-date pub-type="epub"><day>22</day>
<month>2</month>
<year>2016</year>
</pub-date>
<pub-date pub-type="ppub"><year>2016</year>
</pub-date>
<volume>1</volume>
<issue>3</issue>
<elocation-id>16004</elocation-id>
<history><date date-type="received"><day>1</day>
<month>6</month>
<year>2015</year>
</date>
<date date-type="accepted"><day>12</day>
<month>1</month>
<year>2016</year>
</date>
</history>
<permissions><copyright-statement>© Macmillan Publishers Limited 2016</copyright-statement>
<license><license-p>This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.</license-p>
</license>
</permissions>
<abstract id="Abs1"><p id="Par1">Middle East respiratory syndrome coronavirus (MERS-CoV) causes sporadic zoonotic disease and healthcare-associated outbreaks in human. MERS is often complicated by acute respiratory distress syndrome (ARDS) and multi-organ failure<sup><xref ref-type="bibr" rid="CR1">1</xref>
,<xref ref-type="bibr" rid="CR2">2</xref>
</sup>
. The high incidence of renal failure in MERS is a unique clinical feature not often found in other human coronavirus infections<sup><xref ref-type="bibr" rid="CR3">3</xref>
,<xref ref-type="bibr" rid="CR4">4</xref>
</sup>
. Whether MERS-CoV infects the kidney and how it triggers renal failure are not understood<sup><xref ref-type="bibr" rid="CR5">5</xref>
,<xref ref-type="bibr" rid="CR6">6</xref>
</sup>
. Here, we demonstrated renal infection and apoptotic induction by MERS-CoV in human <italic>ex vivo</italic>
organ culture and a nonhuman primate model. High-throughput analysis revealed that the cellular genes most significantly perturbed by MERS-CoV have previously been implicated in renal diseases. Furthermore, MERS-CoV induced apoptosis through upregulation of Smad7 and fibroblast growth factor 2 (FGF2) expression in both kidney and lung cells. Conversely, knockdown of Smad7 effectively inhibited MERS-CoV replication and protected cells from virus-induced cytopathic effects. We further demonstrated that hyperexpression of Smad7 or FGF2 induced a strong apoptotic response in kidney cells. Common marmosets infected by MERS-CoV developed ARDS and disseminated infection in kidneys and other organs. Smad7 and FGF2 expression were elevated in the lungs and kidneys of the infected animals. Our results provide insights into the pathogenesis of MERS-CoV and host targets for treatment.</p>
<sec><title>Supplementary information</title>
<p>The online version of this article (doi:10.1038/nmicrobiol.2016.4) contains supplementary material, which is available to authorized users.</p>
</sec>
</abstract>
<abstract id="Abs2" abstract-type="web-summary"><p id="Par2">Renal infection with Middle East respiratory syndrome coronavirus (MERS-CoV) leads to both the induction of apoptosis through upregulation of Smad7 and FGF2 and to renal failure.</p>
<sec><title>Supplementary information</title>
<p>The online version of this article (doi:10.1038/nmicrobiol.2016.4) contains supplementary material, which is available to authorized users.</p>
</sec>
</abstract>
<kwd-group kwd-group-type="npg-subject"><title>Subject terms</title>
<kwd>Virology</kwd>
<kwd>Microbial genetics</kwd>
</kwd-group>
<custom-meta-group><custom-meta><meta-name>issue-copyright-statement</meta-name>
<meta-value>© The Author(s), under exclusive licence to Springer Nature Limited 2016</meta-value>
</custom-meta>
</custom-meta-group>
</article-meta>
</front>
</pmc>
<affiliations><list></list>
<tree><noCountry><name sortKey="Chan, Jasper F W" sort="Chan, Jasper F W" uniqKey="Chan J" first="Jasper F. W." last="Chan">Jasper F. W. Chan</name>
<name sortKey="Chan, Kwok Hung" sort="Chan, Kwok Hung" uniqKey="Chan K" first="Kwok-Hung" last="Chan">Kwok-Hung Chan</name>
<name sortKey="Chan, Tak Mao" sort="Chan, Tak Mao" uniqKey="Chan T" first="Tak-Mao" last="Chan">Tak-Mao Chan</name>
<name sortKey="Chen, Honglin" sort="Chen, Honglin" uniqKey="Chen H" first="Honglin" last="Chen">Honglin Chen</name>
<name sortKey="Cheung, Kwok Fan" sort="Cheung, Kwok Fan" uniqKey="Cheung K" first="Kwok-Fan" last="Cheung">Kwok-Fan Cheung</name>
<name sortKey="Chu, Hin" sort="Chu, Hin" uniqKey="Chu H" first="Hin" last="Chu">Hin Chu</name>
<name sortKey="Deng, Wei" sort="Deng, Wei" uniqKey="Deng W" first="Wei" last="Deng">Wei Deng</name>
<name sortKey="Jia, Lilong" sort="Jia, Lilong" uniqKey="Jia L" first="Lilong" last="Jia">Lilong Jia</name>
<name sortKey="Jin, Dong Yan" sort="Jin, Dong Yan" uniqKey="Jin D" first="Dong-Yan" last="Jin">Dong-Yan Jin</name>
<name sortKey="Lau, Johnson Y N" sort="Lau, Johnson Y N" uniqKey="Lau J" first="Johnson Y. N." last="Lau">Johnson Y. N. Lau</name>
<name sortKey="Lau, Susanna K P" sort="Lau, Susanna K P" uniqKey="Lau S" first="Susanna K. P." last="Lau">Susanna K. P. Lau</name>
<name sortKey="Mathieson, Peter W" sort="Mathieson, Peter W" uniqKey="Mathieson P" first="Peter W." last="Mathieson">Peter W. Mathieson</name>
<name sortKey="Poon, Vincent K M" sort="Poon, Vincent K M" uniqKey="Poon V" first="Vincent K. M." last="Poon">Vincent K. M. Poon</name>
<name sortKey="Qin, Chuan" sort="Qin, Chuan" uniqKey="Qin C" first="Chuan" last="Qin">Chuan Qin</name>
<name sortKey="Teng, Jade L L" sort="Teng, Jade L L" uniqKey="Teng J" first="Jade L. L." last="Teng">Jade L. L. Teng</name>
<name sortKey="To, Kelvin K W" sort="To, Kelvin K W" uniqKey="To K" first="Kelvin K. W." last="To">Kelvin K. W. To</name>
<name sortKey="Tsang, Alan K L" sort="Tsang, Alan K L" uniqKey="Tsang A" first="Alan K. L." last="Tsang">Alan K. L. Tsang</name>
<name sortKey="Woo, Patrick C Y" sort="Woo, Patrick C Y" uniqKey="Woo P" first="Patrick C. Y." last="Woo">Patrick C. Y. Woo</name>
<name sortKey="Yao, Yanfeng" sort="Yao, Yanfeng" uniqKey="Yao Y" first="Yanfeng" last="Yao">Yanfeng Yao</name>
<name sortKey="Yeung, Man Lung" sort="Yeung, Man Lung" uniqKey="Yeung M" first="Man-Lung" last="Yeung">Man-Lung Yeung</name>
<name sortKey="Yiu, Ming Kwong" sort="Yiu, Ming Kwong" uniqKey="Yiu M" first="Ming-Kwong" last="Yiu">Ming-Kwong Yiu</name>
<name sortKey="Yuen, Kwok Yung" sort="Yuen, Kwok Yung" uniqKey="Yuen K" first="Kwok-Yung" last="Yuen">Kwok-Yung Yuen</name>
<name sortKey="Yung, Susan" sort="Yung, Susan" uniqKey="Yung S" first="Susan" last="Yung">Susan Yung</name>
<name sortKey="Zhang, Qing" sort="Zhang, Qing" uniqKey="Zhang Q" first="Qing" last="Zhang">Qing Zhang</name>
<name sortKey="Zheng, Bo Jian" sort="Zheng, Bo Jian" uniqKey="Zheng B" first="Bo-Jian" last="Zheng">Bo-Jian Zheng</name>
<name sortKey="Zhou, Jie" sort="Zhou, Jie" uniqKey="Zhou J" first="Jie" last="Zhou">Jie Zhou</name>
</noCountry>
</tree>
</affiliations>
</record>
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