Middle East Respiratory Syndrome Coronavirus Transmission in Extended Family, Saudi Arabia, 2014
Identifieur interne : 000A84 ( Pmc/Checkpoint ); précédent : 000A83; suivant : 000A85Middle East Respiratory Syndrome Coronavirus Transmission in Extended Family, Saudi Arabia, 2014
Auteurs : M. Allison Arwady ; Basem Alraddadi ; Colin Basler ; Esam I. Azhar ; Eltayb Abuelzein ; Abdulfattah I. Sindy ; Bakr M. Bin Sadiq ; Abdulhakeem O. Althaqafi ; Omaima Shabouni ; Ayman Banjar ; Lia M. Haynes ; Susan I. Gerber ; Daniel R. Feikin ; Tariq A. MadaniSource :
- Emerging Infectious Diseases [ 1080-6040 ] ; 2016.
Abstract
Casual contact was not associated with transmission, and serologic methods were more sensitive than real-time reverse transcription-PCR.
Url:
DOI: 10.3201/eid2208.152015
PubMed: 27191038
PubMed Central: 4982159
Affiliations:
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Azhar</name></author><author><name sortKey="Abuelzein, Eltayb" sort="Abuelzein, Eltayb" uniqKey="Abuelzein E" first="Eltayb" last="Abuelzein">Eltayb Abuelzein</name></author><author><name sortKey="Sindy, Abdulfattah I" sort="Sindy, Abdulfattah I" uniqKey="Sindy A" first="Abdulfattah I." last="Sindy">Abdulfattah I. Sindy</name></author><author><name sortKey="Sadiq, Bakr M Bin" sort="Sadiq, Bakr M Bin" uniqKey="Sadiq B" first="Bakr M. Bin" last="Sadiq">Bakr M. Bin Sadiq</name></author><author><name sortKey="Althaqafi, Abdulhakeem O" sort="Althaqafi, Abdulhakeem O" uniqKey="Althaqafi A" first="Abdulhakeem O." last="Althaqafi">Abdulhakeem O. Althaqafi</name></author><author><name sortKey="Shabouni, Omaima" sort="Shabouni, Omaima" uniqKey="Shabouni O" first="Omaima" last="Shabouni">Omaima Shabouni</name></author><author><name sortKey="Banjar, Ayman" sort="Banjar, Ayman" uniqKey="Banjar A" first="Ayman" last="Banjar">Ayman Banjar</name></author><author><name sortKey="Haynes, Lia M" sort="Haynes, Lia M" uniqKey="Haynes L" first="Lia M." last="Haynes">Lia M. Haynes</name></author><author><name sortKey="Gerber, Susan I" sort="Gerber, Susan I" uniqKey="Gerber S" first="Susan I." last="Gerber">Susan I. Gerber</name></author><author><name sortKey="Feikin, Daniel R" sort="Feikin, Daniel R" uniqKey="Feikin D" first="Daniel R." last="Feikin">Daniel R. Feikin</name></author><author><name sortKey="Madani, Tariq A" sort="Madani, Tariq A" uniqKey="Madani T" first="Tariq A." last="Madani">Tariq A. 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Allison" last="Arwady">M. Allison Arwady</name></author><author><name sortKey="Alraddadi, Basem" sort="Alraddadi, Basem" uniqKey="Alraddadi B" first="Basem" last="Alraddadi">Basem Alraddadi</name></author><author><name sortKey="Basler, Colin" sort="Basler, Colin" uniqKey="Basler C" first="Colin" last="Basler">Colin Basler</name></author><author><name sortKey="Azhar, Esam I" sort="Azhar, Esam I" uniqKey="Azhar E" first="Esam I." last="Azhar">Esam I. Azhar</name></author><author><name sortKey="Abuelzein, Eltayb" sort="Abuelzein, Eltayb" uniqKey="Abuelzein E" first="Eltayb" last="Abuelzein">Eltayb Abuelzein</name></author><author><name sortKey="Sindy, Abdulfattah I" sort="Sindy, Abdulfattah I" uniqKey="Sindy A" first="Abdulfattah I." last="Sindy">Abdulfattah I. Sindy</name></author><author><name sortKey="Sadiq, Bakr M Bin" sort="Sadiq, Bakr M Bin" uniqKey="Sadiq B" first="Bakr M. Bin" last="Sadiq">Bakr M. Bin Sadiq</name></author><author><name sortKey="Althaqafi, Abdulhakeem O" sort="Althaqafi, Abdulhakeem O" uniqKey="Althaqafi A" first="Abdulhakeem O." last="Althaqafi">Abdulhakeem O. Althaqafi</name></author><author><name sortKey="Shabouni, Omaima" sort="Shabouni, Omaima" uniqKey="Shabouni O" first="Omaima" last="Shabouni">Omaima Shabouni</name></author><author><name sortKey="Banjar, Ayman" sort="Banjar, Ayman" uniqKey="Banjar A" first="Ayman" last="Banjar">Ayman Banjar</name></author><author><name sortKey="Haynes, Lia M" sort="Haynes, Lia M" uniqKey="Haynes L" first="Lia M." last="Haynes">Lia M. Haynes</name></author><author><name sortKey="Gerber, Susan I" sort="Gerber, Susan I" uniqKey="Gerber S" first="Susan I." last="Gerber">Susan I. Gerber</name></author><author><name sortKey="Feikin, Daniel R" sort="Feikin, Daniel R" uniqKey="Feikin D" first="Daniel R." last="Feikin">Daniel R. Feikin</name></author><author><name sortKey="Madani, Tariq A" sort="Madani, Tariq A" uniqKey="Madani T" first="Tariq A." last="Madani">Tariq A. Madani</name></author></analytic><series><title level="j">Emerging Infectious Diseases</title><idno type="ISSN">1080-6040</idno><idno type="eISSN">1080-6059</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Casual contact was not associated with transmission, and serologic methods were more sensitive than real-time reverse transcription-PCR.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct></listBibl></div1></back></TEI><pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Emerg Infect Dis</journal-id><journal-id journal-id-type="iso-abbrev">Emerging Infect. Dis</journal-id><journal-id journal-id-type="publisher-id">EID</journal-id><journal-title-group><journal-title>Emerging Infectious Diseases</journal-title></journal-title-group><issn pub-type="ppub">1080-6040</issn><issn pub-type="epub">1080-6059</issn><publisher><publisher-name>Centers for Disease Control and Prevention</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">27191038</article-id><article-id pub-id-type="pmc">4982159</article-id><article-id pub-id-type="publisher-id">15-2015</article-id><article-id pub-id-type="doi">10.3201/eid2208.152015</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research</subject></subj-group><subj-group subj-group-type="TOC-title"><subject>Middle East Respiratory Syndrome Coronavirus Transmission in Extended Family, Saudi Arabia, 2014</subject></subj-group></article-categories><title-group><article-title>Middle East Respiratory Syndrome Coronavirus Transmission in Extended Family, Saudi Arabia, 2014</article-title><alt-title alt-title-type="running-head">MERS-CoV Transmission in Extended Family</alt-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Arwady</surname><given-names>M. Allison</given-names></name></contrib><contrib contrib-type="author"><name><surname>Alraddadi</surname><given-names>Basem</given-names></name></contrib><contrib contrib-type="author"><name><surname>Basler</surname><given-names>Colin</given-names></name></contrib><contrib contrib-type="author"><name><surname>Azhar</surname><given-names>Esam I.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Abuelzein</surname><given-names>Eltayb</given-names></name></contrib><contrib contrib-type="author"><name><surname>Sindy</surname><given-names>Abdulfattah I.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Sadiq</surname><given-names>Bakr M. Bin</given-names></name></contrib><contrib contrib-type="author"><name><surname>Althaqafi</surname><given-names>Abdulhakeem O.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Shabouni</surname><given-names>Omaima</given-names></name></contrib><contrib contrib-type="author"><name><surname>Banjar</surname><given-names>Ayman</given-names></name></contrib><contrib contrib-type="author"><name><surname>Haynes</surname><given-names>Lia M.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Gerber</surname><given-names>Susan I.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Feikin</surname><given-names>Daniel R.</given-names></name></contrib><contrib contrib-type="author" corresp="yes"><name><surname>Madani</surname><given-names>Tariq A.</given-names></name></contrib><aff id="aff1">Centers for Disease Control and Prevention, Atlanta, Georgia, USA (M.A. Arwady, C. Basler, L.M. Haynes, S.I. Gerber, D.R. Feikin);</aff><aff id="aff2">King Faisal Specialist Hospital and Research Center, Jeddah (B. Alraddadi);</aff><aff id="aff3">Ministry of Health, Jeddah, Saudi Arabia (B. Alraddadi, E.I. Azhar, E. Abuelzein, A.I. Sindy, B.M. Bin Sadiq, A.O. Althaqafi, O. Shabouni, A. Banjar, T.A. Madani);</aff><aff id="aff4">King Abdulaziz University, Jeddah (E.I. Azhar, T.A. Madani);</aff><aff id="aff5">Ministry of National Guard, Jeddah (A.O. Althaqafi)</aff></contrib-group><author-notes><corresp id="cor1">Address for correspondence: Tariq A. Madani, Department of Medicine, Faculty of Medicine, King Abdulaziz University, PO Box 80215, Jeddah 21589, Saudi Arabia; email: <email xlink:href="tmadani@kau.edu.sa">tmadani@kau.edu.sa</email></corresp></author-notes><pub-date pub-type="ppub"><month>8</month><year>2016</year></pub-date><volume>22</volume><issue>8</issue><fpage>1395</fpage><lpage>1402</lpage><abstract abstract-type="toc"><p>Casual contact was not associated with transmission, and serologic methods were more sensitive than real-time reverse transcription-PCR.</p></abstract><abstract><p>Risk factors for human-to-human transmission of Middle East respiratory syndrome coronavirus (MERS-CoV) are largely unknown. After MERS-CoV infections occurred in an extended family in Saudi Arabia in 2014, relatives were tested by using real-time reverse transcription PCR (rRT-PCR) and serologic methods. Among 79 relatives, 19 (24%) were MERS-CoV positive; 11 were hospitalized, and 2 died. Eleven (58%) tested positive by rRT-PCR; 8 (42%) tested negative by rRT-PCR but positive by serology. Compared with MERS-CoV–negative adult relatives, MERS-CoV–positive adult relatives were older and more likely to be male and to have chronic medical conditions. Risk factors for household transmission included sleeping in an index patient’s room and touching respiratory secretions from an index patient. Casual contact and simple proximity were not associated with transmission. Serology was more sensitive than standard rRT-PCR for identifying infected relatives, highlighting the value of including serology in future investigations.</p></abstract><kwd-group kwd-group-type="author"><title>Keywords: </title><kwd>Middle East respiratory syndrome coronavirus</kwd><kwd>disease transmission</kwd><kwd>infectious</kwd><kwd>serologic tests</kwd><kwd>RT-PCR</kwd><kwd>viruses</kwd><kwd>Saudi Arabia</kwd></kwd-group></article-meta></front></pmc><affiliations><list></list><tree><noCountry><name sortKey="Abuelzein, Eltayb" sort="Abuelzein, Eltayb" uniqKey="Abuelzein E" first="Eltayb" last="Abuelzein">Eltayb Abuelzein</name><name sortKey="Alraddadi, Basem" sort="Alraddadi, Basem" uniqKey="Alraddadi B" first="Basem" last="Alraddadi">Basem Alraddadi</name><name sortKey="Althaqafi, Abdulhakeem O" sort="Althaqafi, Abdulhakeem O" uniqKey="Althaqafi A" first="Abdulhakeem O." last="Althaqafi">Abdulhakeem O. Althaqafi</name><name sortKey="Arwady, M Allison" sort="Arwady, M Allison" uniqKey="Arwady M" first="M. Allison" last="Arwady">M. Allison Arwady</name><name sortKey="Azhar, Esam I" sort="Azhar, Esam I" uniqKey="Azhar E" first="Esam I." last="Azhar">Esam I. Azhar</name><name sortKey="Banjar, Ayman" sort="Banjar, Ayman" uniqKey="Banjar A" first="Ayman" last="Banjar">Ayman Banjar</name><name sortKey="Basler, Colin" sort="Basler, Colin" uniqKey="Basler C" first="Colin" last="Basler">Colin Basler</name><name sortKey="Feikin, Daniel R" sort="Feikin, Daniel R" uniqKey="Feikin D" first="Daniel R." last="Feikin">Daniel R. Feikin</name><name sortKey="Gerber, Susan I" sort="Gerber, Susan I" uniqKey="Gerber S" first="Susan I." last="Gerber">Susan I. Gerber</name><name sortKey="Haynes, Lia M" sort="Haynes, Lia M" uniqKey="Haynes L" first="Lia M." last="Haynes">Lia M. Haynes</name><name sortKey="Madani, Tariq A" sort="Madani, Tariq A" uniqKey="Madani T" first="Tariq A." last="Madani">Tariq A. Madani</name><name sortKey="Sadiq, Bakr M Bin" sort="Sadiq, Bakr M Bin" uniqKey="Sadiq B" first="Bakr M. Bin" last="Sadiq">Bakr M. Bin Sadiq</name><name sortKey="Shabouni, Omaima" sort="Shabouni, Omaima" uniqKey="Shabouni O" first="Omaima" last="Shabouni">Omaima Shabouni</name><name sortKey="Sindy, Abdulfattah I" sort="Sindy, Abdulfattah I" uniqKey="Sindy A" first="Abdulfattah I." last="Sindy">Abdulfattah I. Sindy</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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