Prophylaxis With a Middle East Respiratory Syndrome Coronavirus (MERS-CoV)–Specific Human Monoclonal Antibody Protects Rabbits From MERS-CoV Infection
Identifieur interne : 000A27 ( Pmc/Checkpoint ); précédent : 000A26; suivant : 000A28Prophylaxis With a Middle East Respiratory Syndrome Coronavirus (MERS-CoV)–Specific Human Monoclonal Antibody Protects Rabbits From MERS-CoV Infection
Auteurs : Katherine V. Houser ; Lisa Gretebeck ; Tianlei Ying [République populaire de Chine] ; Yanping Wang [États-Unis] ; Leatrice Vogel ; Elaine W. Lamirande ; Kevin W. Bock ; Ian N. Moore ; Dimiter S. Dimitrov [États-Unis] ; Kanta SubbaraoSource :
- The Journal of Infectious Diseases [ 0022-1899 ] ; 2016.
Abstract
With >1600 documented human infections with Middle East respiratory syndrome coronavirus (MERS-CoV) and a case fatality rate of approximately 36%, medical countermeasures are needed to prevent and limit the disease. We examined the in vivo efficacy of the human monoclonal antibody m336, which has high neutralizing activity against MERS-CoV in vitro. m336 was administered to rabbits intravenously or intranasally before infection with MERS-CoV. Prophylaxis with m336 resulted in a reduction of pulmonary viral RNA titers by 40–9000-fold, compared with an irrelevant control antibody with little to no inflammation or viral antigen detected. This protection in rabbits supports further clinical development of m336.
Url:
DOI: 10.1093/infdis/jiw080
PubMed: 26941283
PubMed Central: 4837915
Affiliations:
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Houser</name><affiliation><nlm:aff id="af1"><addr-line>Laboratory of Infectious Diseases</addr-line></nlm:aff></affiliation></author><author><name sortKey="Gretebeck, Lisa" sort="Gretebeck, Lisa" uniqKey="Gretebeck L" first="Lisa" last="Gretebeck">Lisa Gretebeck</name><affiliation><nlm:aff id="af1"><addr-line>Laboratory of Infectious Diseases</addr-line></nlm:aff></affiliation></author><author><name sortKey="Ying, Tianlei" sort="Ying, Tianlei" uniqKey="Ying T" first="Tianlei" last="Ying">Tianlei Ying</name><affiliation wicri:level="1"><nlm:aff id="af4"><addr-line>Key Laboratory of Medical Molecular Virology of Ministries of Education and Health</addr-line>,<institution>Shanghai Medical College, Fudan University</institution>,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Wang, Yanping" sort="Wang, Yanping" uniqKey="Wang Y" first="Yanping" last="Wang">Yanping Wang</name><affiliation wicri:level="2"><nlm:aff id="af3"><addr-line>Protein Interactions Section, Cancer and Inflammation Program</addr-line>,<institution>Center for Cancer Research, National Cancer Institute, NIH</institution>,<addr-line>Frederick, Maryland</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Frederick</wicri:cityArea></affiliation></author><author><name sortKey="Vogel, Leatrice" sort="Vogel, Leatrice" uniqKey="Vogel L" first="Leatrice" last="Vogel">Leatrice Vogel</name><affiliation><nlm:aff id="af1"><addr-line>Laboratory of Infectious Diseases</addr-line></nlm:aff></affiliation></author><author><name sortKey="Lamirande, Elaine W" sort="Lamirande, Elaine W" uniqKey="Lamirande E" first="Elaine W." last="Lamirande">Elaine W. 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Houser</name><affiliation><nlm:aff id="af1"><addr-line>Laboratory of Infectious Diseases</addr-line></nlm:aff></affiliation></author><author><name sortKey="Gretebeck, Lisa" sort="Gretebeck, Lisa" uniqKey="Gretebeck L" first="Lisa" last="Gretebeck">Lisa Gretebeck</name><affiliation><nlm:aff id="af1"><addr-line>Laboratory of Infectious Diseases</addr-line></nlm:aff></affiliation></author><author><name sortKey="Ying, Tianlei" sort="Ying, Tianlei" uniqKey="Ying T" first="Tianlei" last="Ying">Tianlei Ying</name><affiliation wicri:level="1"><nlm:aff id="af4"><addr-line>Key Laboratory of Medical Molecular Virology of Ministries of Education and Health</addr-line>,<institution>Shanghai Medical College, Fudan University</institution>,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Wang, Yanping" sort="Wang, Yanping" uniqKey="Wang Y" first="Yanping" last="Wang">Yanping Wang</name><affiliation wicri:level="2"><nlm:aff id="af3"><addr-line>Protein Interactions Section, Cancer and Inflammation Program</addr-line>,<institution>Center for Cancer Research, National Cancer Institute, NIH</institution>,<addr-line>Frederick, Maryland</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Frederick</wicri:cityArea></affiliation></author><author><name sortKey="Vogel, Leatrice" sort="Vogel, Leatrice" uniqKey="Vogel L" first="Leatrice" last="Vogel">Leatrice Vogel</name><affiliation><nlm:aff id="af1"><addr-line>Laboratory of Infectious Diseases</addr-line></nlm:aff></affiliation></author><author><name sortKey="Lamirande, Elaine W" sort="Lamirande, Elaine W" uniqKey="Lamirande E" first="Elaine W." last="Lamirande">Elaine W. Lamirande</name><affiliation><nlm:aff id="af1"><addr-line>Laboratory of Infectious Diseases</addr-line></nlm:aff></affiliation></author><author><name sortKey="Bock, Kevin W" sort="Bock, Kevin W" uniqKey="Bock K" first="Kevin W." last="Bock">Kevin W. Bock</name><affiliation><nlm:aff id="af2"><addr-line>Comparative Medicine Branch, Infectious Disease Pathogenesis Section</addr-line>,<institution>National Institute of Allergy and Infectious Disease, National Institutes of Health (NIH)</institution>,<addr-line>Bethesda</addr-line></nlm:aff></affiliation></author><author><name sortKey="Moore, Ian N" sort="Moore, Ian N" uniqKey="Moore I" first="Ian N." last="Moore">Ian N. 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Dimitrov</name><affiliation wicri:level="2"><nlm:aff id="af3"><addr-line>Protein Interactions Section, Cancer and Inflammation Program</addr-line>,<institution>Center for Cancer Research, National Cancer Institute, NIH</institution>,<addr-line>Frederick, Maryland</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Frederick</wicri:cityArea></affiliation></author><author><name sortKey="Subbarao, Kanta" sort="Subbarao, Kanta" uniqKey="Subbarao K" first="Kanta" last="Subbarao">Kanta Subbarao</name><affiliation><nlm:aff id="af1"><addr-line>Laboratory of Infectious Diseases</addr-line></nlm:aff></affiliation></author></analytic><series><title level="j">The Journal of Infectious Diseases</title><idno type="ISSN">0022-1899</idno><idno type="eISSN">1537-6613</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Abstract</title><p>With >1600 documented human infections with Middle East respiratory syndrome coronavirus (MERS-CoV) and a case fatality rate of approximately 36%, medical countermeasures are needed to prevent and limit the disease. We examined the in vivo efficacy of the human monoclonal antibody m336, which has high neutralizing activity against MERS-CoV in vitro. m336 was administered to rabbits intravenously or intranasally before infection with MERS-CoV. Prophylaxis with m336 resulted in a reduction of pulmonary viral RNA titers by 40–9000-fold, compared with an irrelevant control antibody with little to no inflammation or viral antigen detected. This protection in rabbits supports further clinical development of m336.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Assiri, A" uniqKey="Assiri A">A Assiri</name></author><author><name sortKey="Al Tawfiq, Ja" uniqKey="Al Tawfiq J">JA Al-Tawfiq</name></author><author><name sortKey="Al Rabeeah, Aa" uniqKey="Al Rabeeah A">AA Al-Rabeeah</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Saad, M" uniqKey="Saad M">M Saad</name></author><author><name sortKey="Omrani, As" uniqKey="Omrani A">AS Omrani</name></author><author><name sortKey="Baig, K" uniqKey="Baig K">K Baig</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Assiri, A" uniqKey="Assiri A">A Assiri</name></author><author><name sortKey="Mcgeer, A" uniqKey="Mcgeer A">A McGeer</name></author><author><name sortKey="Perl, Tm" uniqKey="Perl T">TM Perl</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Al Abdallat, Mm" uniqKey="Al Abdallat M">MM Al-Abdallat</name></author><author><name sortKey="Payne, Dc" uniqKey="Payne D">DC Payne</name></author><author><name sortKey="Alqasrawi, S" uniqKey="Alqasrawi S">S Alqasrawi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Van Doremalen, N" uniqKey="Van Doremalen N">N van Doremalen</name></author><author><name sortKey="Munster, Vj" uniqKey="Munster V">VJ Munster</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Haagmans, Bl" uniqKey="Haagmans B">BL Haagmans</name></author><author><name sortKey="Van Den Brand, Jm" uniqKey="Van Den Brand J">JM van den Brand</name></author><author><name sortKey="Provacia, Lb" uniqKey="Provacia L">LB Provacia</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pascal, Ke" uniqKey="Pascal K">KE Pascal</name></author><author><name sortKey="Coleman, Cm" uniqKey="Coleman C">CM Coleman</name></author><author><name sortKey="Mujica, Ao" uniqKey="Mujica A">AO Mujica</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ying, T" uniqKey="Ying T">T Ying</name></author><author><name sortKey="Du, L" uniqKey="Du L">L Du</name></author><author><name sortKey="Ju, Tw" uniqKey="Ju T">TW Ju</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Reed, Lj" uniqKey="Reed L">LJ Reed</name></author><author><name sortKey="Muench, H" uniqKey="Muench H">H Muench</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lu, X" uniqKey="Lu X">X Lu</name></author><author><name sortKey="Whitaker, B" uniqKey="Whitaker B">B Whitaker</name></author><author><name sortKey="Sakthivel, Sk" uniqKey="Sakthivel S">SK Sakthivel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Marasco, Wa" uniqKey="Marasco W">WA Marasco</name></author><author><name sortKey="Sui, J" uniqKey="Sui J">J Sui</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhu, Z" uniqKey="Zhu Z">Z Zhu</name></author><author><name sortKey="Chakraborti, S" uniqKey="Chakraborti S">S Chakraborti</name></author><author><name sortKey="He, Y" uniqKey="He Y">Y He</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Leyva Grado, Vh" uniqKey="Leyva Grado V">VH Leyva-Grado</name></author><author><name sortKey="Tan, Gs" uniqKey="Tan G">GS Tan</name></author><author><name sortKey="Leon, Pe" uniqKey="Leon P">PE Leon</name></author><author><name sortKey="Yondola, M" uniqKey="Yondola M">M Yondola</name></author><author><name sortKey="Palese, P" uniqKey="Palese P">P Palese</name></author></analytic></biblStruct></listBibl></div1></back></TEI><pmc article-type="brief-report"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">J Infect Dis</journal-id><journal-id journal-id-type="iso-abbrev">J. Infect. Dis</journal-id><journal-id journal-id-type="publisher-id">jid</journal-id><journal-id journal-id-type="hwp">jinfdis</journal-id><journal-title-group><journal-title>The Journal of Infectious Diseases</journal-title></journal-title-group><issn pub-type="ppub">0022-1899</issn><issn pub-type="epub">1537-6613</issn><publisher><publisher-name>Oxford University Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">26941283</article-id><article-id pub-id-type="pmc">4837915</article-id><article-id pub-id-type="doi">10.1093/infdis/jiw080</article-id><article-id pub-id-type="publisher-id">jiw080</article-id><article-categories><subj-group subj-group-type="heading"><subject>Major Articles and Brief Reports</subject><subj-group subj-group-type="category-toc-heading"><subject>Viruses</subject></subj-group></subj-group></article-categories><title-group><article-title>Prophylaxis With a Middle East Respiratory Syndrome Coronavirus (MERS-CoV)–Specific Human Monoclonal Antibody Protects Rabbits From MERS-CoV Infection</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Houser</surname><given-names>Katherine V.</given-names></name><xref ref-type="aff" rid="af1">1</xref><pmc-comment>ksubbarao@niaid.nih.gov </pmc-comment>
<xref ref-type="corresp" rid="d1015e156"></xref></contrib><contrib contrib-type="author"><name><surname>Gretebeck</surname><given-names>Lisa</given-names></name><xref ref-type="aff" rid="af1">1</xref></contrib><contrib contrib-type="author"><name><surname>Ying</surname><given-names>Tianlei</given-names></name><xref ref-type="aff" rid="af4">4</xref></contrib><contrib contrib-type="author"><name><surname>Wang</surname><given-names>Yanping</given-names></name><xref ref-type="aff" rid="af3">3</xref></contrib><contrib contrib-type="author"><name><surname>Vogel</surname><given-names>Leatrice</given-names></name><xref ref-type="aff" rid="af1">1</xref></contrib><contrib contrib-type="author"><name><surname>Lamirande</surname><given-names>Elaine W.</given-names></name><xref ref-type="aff" rid="af1">1</xref></contrib><contrib contrib-type="author"><name><surname>Bock</surname><given-names>Kevin W.</given-names></name><xref ref-type="aff" rid="af2">2</xref></contrib><contrib contrib-type="author"><name><surname>Moore</surname><given-names>Ian N.</given-names></name><xref ref-type="aff" rid="af2">2</xref></contrib><contrib contrib-type="author"><name><surname>Dimitrov</surname><given-names>Dimiter S.</given-names></name><xref ref-type="aff" rid="af3">3</xref></contrib><contrib contrib-type="author"><name><surname>Subbarao</surname><given-names>Kanta</given-names></name><xref ref-type="aff" rid="af1">1</xref></contrib></contrib-group><aff id="af1"><label>1</label><addr-line>Laboratory of Infectious Diseases</addr-line></aff><aff id="af2"><label>2</label><addr-line>Comparative Medicine Branch, Infectious Disease Pathogenesis Section</addr-line>,<institution>National Institute of Allergy and Infectious Disease, National Institutes of Health (NIH)</institution>,<addr-line>Bethesda</addr-line></aff><aff id="af3"><label>3</label><addr-line>Protein Interactions Section, Cancer and Inflammation Program</addr-line>,<institution>Center for Cancer Research, National Cancer Institute, NIH</institution>,<addr-line>Frederick, Maryland</addr-line></aff><aff id="af4"><label>4</label><addr-line>Key Laboratory of Medical Molecular Virology of Ministries of Education and Health</addr-line>,<institution>Shanghai Medical College, Fudan University</institution>,<country>China</country></aff><author-notes><fn id="TN1" fn-type="con"><p>Presented in part: International Society for Influenza and Other Respiratory Virus Diseases, Austin, Texas, June 2015; American Society for Virology, London, Canada, July 2015. Abstract W5-5.</p></fn><corresp id="d1015e156">Correspondence: K. Subbarao, Bldg 33, Rm 3E13C.1, 33 North Dr, MSC 3203 Bethesda, MD 20892-3203 (<email>ksubbarao@niaid.nih.gov</email>).</corresp></author-notes><pub-date pub-type="ppub"><day>15</day><month>5</month><year>2016</year></pub-date><pub-date pub-type="epub" iso-8601-date="2016-03-03"><day>03</day><month>3</month><year>2016</year></pub-date><pub-date pub-type="pmc-release"><day>03</day><month>3</month><year>2016</year></pub-date><pmc-comment> PMC Release delay is 0 months and 0 days and was based on the
<volume>213</volume><issue>10</issue><fpage>1557</fpage><lpage>1561</lpage><history><date date-type="received"><day>6</day><month>11</month><year>2015</year></date><date date-type="accepted"><day>19</day><month>2</month><year>2016</year></date></history><permissions><copyright-statement>Published by Oxford University Press for the Infectious Diseases Society of America 2016. This work is written by (a) US Government employee(s) and is in the public domain in the US.</copyright-statement><copyright-year>2016</copyright-year><license><license-p>This article is made available via the PMC Open Access Subset for unrestricted re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the COVID-19 pandemic or until permissions are revoked in writing. Upon expiration of these permissions, PMC is granted a perpetual license to make this article available via PMC and Europe PMC, consistent with existing copyright protections.</license-p></license></permissions><self-uri xlink:href="jiw080.pdf"></self-uri><abstract><title>Abstract</title><p>With >1600 documented human infections with Middle East respiratory syndrome coronavirus (MERS-CoV) and a case fatality rate of approximately 36%, medical countermeasures are needed to prevent and limit the disease. We examined the in vivo efficacy of the human monoclonal antibody m336, which has high neutralizing activity against MERS-CoV in vitro. m336 was administered to rabbits intravenously or intranasally before infection with MERS-CoV. Prophylaxis with m336 resulted in a reduction of pulmonary viral RNA titers by 40–9000-fold, compared with an irrelevant control antibody with little to no inflammation or viral antigen detected. This protection in rabbits supports further clinical development of m336.</p></abstract><kwd-group><kwd>MERS-CoV</kwd><kwd>prophylaxis</kwd><kwd>m336</kwd><kwd>rabbits</kwd><kwd>human mAb</kwd></kwd-group><funding-group><award-group><funding-source><named-content content-type="funder-name">the Division of Intramural Research</named-content></funding-source></award-group><award-group><funding-source><named-content content-type="funder-name">National Institute of Allergy and Infectious Diseases </named-content><named-content content-type="funder-identifier">http://dx.doi.org/10.13039/100000060</named-content></funding-source></award-group><award-group><funding-source><named-content content-type="funder-name">National Institutes of Health (NIH)</named-content></funding-source></award-group><award-group><funding-source><named-content content-type="funder-name">National Cancer Institute </named-content><named-content content-type="funder-identifier">http://dx.doi.org/10.13039/100000054</named-content></funding-source></award-group><award-group><funding-source><named-content content-type="funder-name">NIH</named-content></funding-source></award-group></funding-group></article-meta></front></pmc><affiliations><list><country><li>République populaire de Chine</li><li>États-Unis</li></country><region><li>Maryland</li></region></list><tree><noCountry><name sortKey="Bock, Kevin W" sort="Bock, Kevin W" uniqKey="Bock K" first="Kevin W." last="Bock">Kevin W. Bock</name><name sortKey="Gretebeck, Lisa" sort="Gretebeck, Lisa" uniqKey="Gretebeck L" first="Lisa" last="Gretebeck">Lisa Gretebeck</name><name sortKey="Houser, Katherine V" sort="Houser, Katherine V" uniqKey="Houser K" first="Katherine V." last="Houser">Katherine V. Houser</name><name sortKey="Lamirande, Elaine W" sort="Lamirande, Elaine W" uniqKey="Lamirande E" first="Elaine W." last="Lamirande">Elaine W. Lamirande</name><name sortKey="Moore, Ian N" sort="Moore, Ian N" uniqKey="Moore I" first="Ian N." last="Moore">Ian N. Moore</name><name sortKey="Subbarao, Kanta" sort="Subbarao, Kanta" uniqKey="Subbarao K" first="Kanta" last="Subbarao">Kanta Subbarao</name><name sortKey="Vogel, Leatrice" sort="Vogel, Leatrice" uniqKey="Vogel L" first="Leatrice" last="Vogel">Leatrice Vogel</name></noCountry><country name="République populaire de Chine"><noRegion><name sortKey="Ying, Tianlei" sort="Ying, Tianlei" uniqKey="Ying T" first="Tianlei" last="Ying">Tianlei Ying</name></noRegion></country><country name="États-Unis"><region name="Maryland"><name sortKey="Wang, Yanping" sort="Wang, Yanping" uniqKey="Wang Y" first="Yanping" last="Wang">Yanping Wang</name></region><name sortKey="Dimitrov, Dimiter S" sort="Dimitrov, Dimiter S" uniqKey="Dimitrov D" first="Dimiter S." last="Dimitrov">Dimiter S. Dimitrov</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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