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ntHash: recursive nucleotide hashing

Identifieur interne : 000955 ( Pmc/Checkpoint ); précédent : 000954; suivant : 000956

ntHash: recursive nucleotide hashing

Auteurs : Hamid Mohamadi ; Justin Chu ; Benjamin P. Vandervalk ; Inanc Birol

Source :

RBID : PMC:5181554

Abstract

Motivation: Hashing has been widely used for indexing, querying and rapid similarity search in many bioinformatics applications, including sequence alignment, genome and transcriptome assembly, k-mer counting and error correction. Hence, expediting hashing operations would have a substantial impact in the field, making bioinformatics applications faster and more efficient.

Results: We present ntHash, a hashing algorithm tuned for processing DNA/RNA sequences. It performs the best when calculating hash values for adjacent k-mers in an input sequence, operating an order of magnitude faster than the best performing alternatives in typical use cases.

Availability and implementation: ntHash is available online at http://www.bcgsc.ca/platform/bioinfo/software/nthash and is free for academic use.

Contacts: hmohamadi@bcgsc.ca or ibirol@bcgsc.ca

Supplementary information:Supplementary data are available at Bioinformatics online.


Url:
DOI: 10.1093/bioinformatics/btw397
PubMed: 27423894
PubMed Central: 5181554


Affiliations:


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PMC:5181554

Le document en format XML

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<name sortKey="Chu, Justin" sort="Chu, Justin" uniqKey="Chu J" first="Justin" last="Chu">Justin Chu</name>
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<name sortKey="Vandervalk, Benjamin P" sort="Vandervalk, Benjamin P" uniqKey="Vandervalk B" first="Benjamin P." last="Vandervalk">Benjamin P. Vandervalk</name>
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<bold>Motivation</bold>
: Hashing has been widely used for indexing, querying and rapid similarity search in many bioinformatics applications, including sequence alignment, genome and transcriptome assembly,
<italic>k</italic>
-mer counting and error correction. Hence, expediting hashing operations would have a substantial impact in the field, making bioinformatics applications faster and more efficient.</p>
<p>
<bold>Results</bold>
: We present ntHash, a hashing algorithm tuned for processing DNA/RNA sequences. It performs the best when calculating hash values for adjacent
<italic>k</italic>
-mers in an input sequence, operating an order of magnitude faster than the best performing alternatives in typical use cases.</p>
<p>
<bold>Availability and implementation</bold>
: ntHash is available online at
<ext-link ext-link-type="uri" xlink:href="http://www.bcgsc.ca/platform/bioinfo/software/nthash">http://www.bcgsc.ca/platform/bioinfo/software/nthash</ext-link>
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<bold>Contacts</bold>
:
<email>hmohamadi@bcgsc.ca</email>
or
<email>ibirol@bcgsc.ca</email>
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<p>
<bold>Supplementary information:</bold>
<ext-link ext-link-type="uri" xlink:href="http://bioinformatics.oxfordjournals.org/lookup/suppl/doi:10.1093/bioinformatics/btw397/-/DC1">Supplementary data</ext-link>
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<given-names>Inanc</given-names>
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<xref ref-type="corresp" rid="btw397-cor1">*</xref>
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<aff id="btw397-aff1">Canada’s Michael Smith Genome Sciences Centre, British Columbia Cancer Agency, Vancouver, BC V5Z 4S6, Canada</aff>
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<corresp id="btw397-cor1">*To whom correspondence should be addressed.</corresp>
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<p>Associate Editor: Bonnie Berger</p>
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<pub-date pub-type="ppub">
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<copyright-statement>© The Author 2016. Published by Oxford University Press.</copyright-statement>
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</license>
</permissions>
<abstract>
<p>
<bold>Motivation</bold>
: Hashing has been widely used for indexing, querying and rapid similarity search in many bioinformatics applications, including sequence alignment, genome and transcriptome assembly,
<italic>k</italic>
-mer counting and error correction. Hence, expediting hashing operations would have a substantial impact in the field, making bioinformatics applications faster and more efficient.</p>
<p>
<bold>Results</bold>
: We present ntHash, a hashing algorithm tuned for processing DNA/RNA sequences. It performs the best when calculating hash values for adjacent
<italic>k</italic>
-mers in an input sequence, operating an order of magnitude faster than the best performing alternatives in typical use cases.</p>
<p>
<bold>Availability and implementation</bold>
: ntHash is available online at
<ext-link ext-link-type="uri" xlink:href="http://www.bcgsc.ca/platform/bioinfo/software/nthash">http://www.bcgsc.ca/platform/bioinfo/software/nthash</ext-link>
and is free for academic use.</p>
<p>
<bold>Contacts</bold>
:
<email>hmohamadi@bcgsc.ca</email>
or
<email>ibirol@bcgsc.ca</email>
</p>
<p>
<bold>Supplementary information:</bold>
<ext-link ext-link-type="uri" xlink:href="http://bioinformatics.oxfordjournals.org/lookup/suppl/doi:10.1093/bioinformatics/btw397/-/DC1">Supplementary data</ext-link>
are available at
<italic>Bioinformatics</italic>
online.</p>
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