MERS-CoV spike nanoparticles protect mice from MERS-CoV infection
Identifieur interne : 000800 ( Pmc/Checkpoint ); précédent : 000799; suivant : 000801MERS-CoV spike nanoparticles protect mice from MERS-CoV infection
Auteurs : Christopher M. Coleman [États-Unis] ; Thiagarajan Venkataraman [États-Unis] ; Ye V. Liu [États-Unis] ; Gregory M. Glenn [États-Unis] ; Gale E. Smith [États-Unis] ; David C. Flyer [États-Unis] ; Matthew B. Frieman [États-Unis]Source :
- Vaccine [ 0264-410X ] ; 2017.
Abstract
The Middle East respiratory syndrome coronavirus (MERS-CoV) was first discovered in late 2012 and has gone on to cause over 1800 infections and 650 deaths. There are currently no approved therapeutics or vaccinations for MERS-CoV. The MERS-CoV spike (S) protein is responsible for receptor binding and virion entry to cells, is immunodominant and induces neutralizing antibodies
Url:
DOI: 10.1016/j.vaccine.2017.02.012
PubMed: 28237499
PubMed Central: 5423355
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">MERS-CoV spike nanoparticles protect mice from MERS-CoV infection</title><author><name sortKey="Coleman, Christopher M" sort="Coleman, Christopher M" uniqKey="Coleman C" first="Christopher M." last="Coleman">Christopher M. Coleman</name><affiliation wicri:level="4"><nlm:aff id="af005">University of Maryland, School of Medicine, 685 West Baltimore St, Baltimore, MD 21201, United States</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Maryland, School of Medicine, 685 West Baltimore St, Baltimore, MD 21201</wicri:regionArea><placeName><region type="state">Maryland</region><settlement type="city">College Park (Maryland)</settlement></placeName><orgName type="university">Université du Maryland</orgName></affiliation></author><author><name sortKey="Venkataraman, Thiagarajan" sort="Venkataraman, Thiagarajan" uniqKey="Venkataraman T" first="Thiagarajan" last="Venkataraman">Thiagarajan Venkataraman</name><affiliation wicri:level="4"><nlm:aff id="af005">University of Maryland, School of Medicine, 685 West Baltimore St, Baltimore, MD 21201, United States</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Maryland, School of Medicine, 685 West Baltimore St, Baltimore, MD 21201</wicri:regionArea><placeName><region type="state">Maryland</region><settlement type="city">College Park (Maryland)</settlement></placeName><orgName type="university">Université du Maryland</orgName></affiliation></author><author><name sortKey="Liu, Ye V" sort="Liu, Ye V" uniqKey="Liu Y" first="Ye V." last="Liu">Ye V. Liu</name><affiliation wicri:level="2"><nlm:aff id="af010">Novavax, Inc., 22 Firstfield Rd, Gaithersburg, MD 20852, United States</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Novavax, Inc., 22 Firstfield Rd, Gaithersburg, MD 20852</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Glenn, Gregory M" sort="Glenn, Gregory M" uniqKey="Glenn G" first="Gregory M." last="Glenn">Gregory M. Glenn</name><affiliation wicri:level="2"><nlm:aff id="af010">Novavax, Inc., 22 Firstfield Rd, Gaithersburg, MD 20852, United States</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Novavax, Inc., 22 Firstfield Rd, Gaithersburg, MD 20852</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Smith, Gale E" sort="Smith, Gale E" uniqKey="Smith G" first="Gale E." last="Smith">Gale E. Smith</name><affiliation wicri:level="2"><nlm:aff id="af010">Novavax, Inc., 22 Firstfield Rd, Gaithersburg, MD 20852, United States</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Novavax, Inc., 22 Firstfield Rd, Gaithersburg, MD 20852</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Flyer, David C" sort="Flyer, David C" uniqKey="Flyer D" first="David C." last="Flyer">David C. Flyer</name><affiliation wicri:level="2"><nlm:aff id="af010">Novavax, Inc., 22 Firstfield Rd, Gaithersburg, MD 20852, United States</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Novavax, Inc., 22 Firstfield Rd, Gaithersburg, MD 20852</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Frieman, Matthew B" sort="Frieman, Matthew B" uniqKey="Frieman M" first="Matthew B." last="Frieman">Matthew B. Frieman</name><affiliation wicri:level="4"><nlm:aff id="af005">University of Maryland, School of Medicine, 685 West Baltimore St, Baltimore, MD 21201, United States</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Maryland, School of Medicine, 685 West Baltimore St, Baltimore, MD 21201</wicri:regionArea><placeName><region type="state">Maryland</region><settlement type="city">College Park (Maryland)</settlement></placeName><orgName type="university">Université du Maryland</orgName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">28237499</idno><idno type="pmc">5423355</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5423355</idno><idno type="RBID">PMC:5423355</idno><idno type="doi">10.1016/j.vaccine.2017.02.012</idno><date when="2017">2017</date><idno type="wicri:Area/Pmc/Corpus">000739</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000739</idno><idno type="wicri:Area/Pmc/Curation">000739</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000739</idno><idno type="wicri:Area/Pmc/Checkpoint">000800</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000800</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">MERS-CoV spike nanoparticles protect mice from MERS-CoV infection</title><author><name sortKey="Coleman, Christopher M" sort="Coleman, Christopher M" uniqKey="Coleman C" first="Christopher M." last="Coleman">Christopher M. Coleman</name><affiliation wicri:level="4"><nlm:aff id="af005">University of Maryland, School of Medicine, 685 West Baltimore St, Baltimore, MD 21201, United States</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Maryland, School of Medicine, 685 West Baltimore St, Baltimore, MD 21201</wicri:regionArea><placeName><region type="state">Maryland</region><settlement type="city">College Park (Maryland)</settlement></placeName><orgName type="university">Université du Maryland</orgName></affiliation></author><author><name sortKey="Venkataraman, Thiagarajan" sort="Venkataraman, Thiagarajan" uniqKey="Venkataraman T" first="Thiagarajan" last="Venkataraman">Thiagarajan Venkataraman</name><affiliation wicri:level="4"><nlm:aff id="af005">University of Maryland, School of Medicine, 685 West Baltimore St, Baltimore, MD 21201, United States</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Maryland, School of Medicine, 685 West Baltimore St, Baltimore, MD 21201</wicri:regionArea><placeName><region type="state">Maryland</region><settlement type="city">College Park (Maryland)</settlement></placeName><orgName type="university">Université du Maryland</orgName></affiliation></author><author><name sortKey="Liu, Ye V" sort="Liu, Ye V" uniqKey="Liu Y" first="Ye V." last="Liu">Ye V. Liu</name><affiliation wicri:level="2"><nlm:aff id="af010">Novavax, Inc., 22 Firstfield Rd, Gaithersburg, MD 20852, United States</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Novavax, Inc., 22 Firstfield Rd, Gaithersburg, MD 20852</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Glenn, Gregory M" sort="Glenn, Gregory M" uniqKey="Glenn G" first="Gregory M." last="Glenn">Gregory M. Glenn</name><affiliation wicri:level="2"><nlm:aff id="af010">Novavax, Inc., 22 Firstfield Rd, Gaithersburg, MD 20852, United States</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Novavax, Inc., 22 Firstfield Rd, Gaithersburg, MD 20852</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Smith, Gale E" sort="Smith, Gale E" uniqKey="Smith G" first="Gale E." last="Smith">Gale E. Smith</name><affiliation wicri:level="2"><nlm:aff id="af010">Novavax, Inc., 22 Firstfield Rd, Gaithersburg, MD 20852, United States</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Novavax, Inc., 22 Firstfield Rd, Gaithersburg, MD 20852</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Flyer, David C" sort="Flyer, David C" uniqKey="Flyer D" first="David C." last="Flyer">David C. Flyer</name><affiliation wicri:level="2"><nlm:aff id="af010">Novavax, Inc., 22 Firstfield Rd, Gaithersburg, MD 20852, United States</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Novavax, Inc., 22 Firstfield Rd, Gaithersburg, MD 20852</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Frieman, Matthew B" sort="Frieman, Matthew B" uniqKey="Frieman M" first="Matthew B." last="Frieman">Matthew B. Frieman</name><affiliation wicri:level="4"><nlm:aff id="af005">University of Maryland, School of Medicine, 685 West Baltimore St, Baltimore, MD 21201, United States</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Maryland, School of Medicine, 685 West Baltimore St, Baltimore, MD 21201</wicri:regionArea><placeName><region type="state">Maryland</region><settlement type="city">College Park (Maryland)</settlement></placeName><orgName type="university">Université du Maryland</orgName></affiliation></author></analytic><series><title level="j">Vaccine</title><idno type="ISSN">0264-410X</idno><idno type="eISSN">1873-2518</idno><imprint><date when="2017">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>The Middle East respiratory syndrome coronavirus (MERS-CoV) was first discovered in late 2012 and has gone on to cause over 1800 infections and 650 deaths. There are currently no approved therapeutics or vaccinations for MERS-CoV. The MERS-CoV spike (S) protein is responsible for receptor binding and virion entry to cells, is immunodominant and induces neutralizing antibodies <italic>in vivo</italic>, all of which, make the S protein an ideal target for anti-MERS-CoV vaccines. In this study, we demonstrate protection induced by vaccination with a recombinant MERS-CoV S nanoparticle vaccine and Matrix-M1 adjuvant combination in mice. The MERS-CoV S nanoparticle vaccine produced high titer anti-S neutralizing antibody and protected mice from MERS-CoV infection <italic>in vivo</italic>.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Zaki, A M" uniqKey="Zaki A">A.M. Zaki</name></author><author><name sortKey="Van Boheemen, S" uniqKey="Van Boheemen S">S. van Boheemen</name></author><author><name sortKey="Bestebroer, T M" uniqKey="Bestebroer T">T.M. 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<front><journal-meta><journal-id journal-id-type="nlm-ta">Vaccine</journal-id><journal-id journal-id-type="iso-abbrev">Vaccine</journal-id><journal-title-group><journal-title>Vaccine</journal-title></journal-title-group><issn pub-type="ppub">0264-410X</issn><issn pub-type="epub">1873-2518</issn><publisher><publisher-name>Elsevier Ltd.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">28237499</article-id><article-id pub-id-type="pmc">5423355</article-id><article-id pub-id-type="publisher-id">S0264-410X(17)30193-7</article-id><article-id pub-id-type="doi">10.1016/j.vaccine.2017.02.012</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>MERS-CoV spike nanoparticles protect mice from MERS-CoV infection</article-title></title-group><contrib-group><contrib contrib-type="author" id="au005"><name><surname>Coleman</surname><given-names>Christopher M.</given-names></name><xref rid="af005" ref-type="aff">a</xref></contrib><contrib contrib-type="author" id="au010"><name><surname>Venkataraman</surname><given-names>Thiagarajan</given-names></name><xref rid="af005" ref-type="aff">a</xref></contrib><contrib contrib-type="author" id="au015"><name><surname>Liu</surname><given-names>Ye V.</given-names></name><xref rid="af010" ref-type="aff">b</xref></contrib><contrib contrib-type="author" id="au020"><name><surname>Glenn</surname><given-names>Gregory M.</given-names></name><xref rid="af010" ref-type="aff">b</xref></contrib><contrib contrib-type="author" id="au025"><name><surname>Smith</surname><given-names>Gale E.</given-names></name><xref rid="af010" ref-type="aff">b</xref></contrib><contrib contrib-type="author" id="au030"><name><surname>Flyer</surname><given-names>David C.</given-names></name><xref rid="af010" ref-type="aff">b</xref></contrib><contrib contrib-type="author" id="au035"><name><surname>Frieman</surname><given-names>Matthew B.</given-names></name><email>mfrieman@som.umaryland.edu</email><xref rid="af005" ref-type="aff">a</xref><xref rid="cor1" ref-type="corresp">⁎</xref></contrib></contrib-group><aff id="af005"><label>a</label>University of Maryland, School of Medicine, 685 West Baltimore St, Baltimore, MD 21201, United States</aff><aff id="af010"><label>b</label>Novavax, Inc., 22 Firstfield Rd, Gaithersburg, MD 20852, United States</aff><author-notes><corresp id="cor1"><label>⁎</label>Corresponding author. <email>mfrieman@som.umaryland.edu</email></corresp></author-notes><pub-date pub-type="pmc-release"><day>23</day><month>2</month><year>2017</year></pub-date><pmc-comment> PMC Release delay is 0 months and 0 days and was based on .</pmc-comment>
<pub-date pub-type="ppub"><day>14</day><month>3</month><year>2017</year></pub-date><pub-date pub-type="epub"><day>23</day><month>2</month><year>2017</year></pub-date><volume>35</volume><issue>12</issue><fpage>1586</fpage><lpage>1589</lpage><history><date date-type="received"><day>9</day><month>12</month><year>2016</year></date><date date-type="rev-recd"><day>31</day><month>1</month><year>2017</year></date><date date-type="accepted"><day>6</day><month>2</month><year>2017</year></date></history><permissions><copyright-statement>© 2017 Elsevier Ltd. All rights reserved.</copyright-statement><copyright-year>2017</copyright-year><copyright-holder>Elsevier Ltd</copyright-holder><license><license-p>Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.</license-p></license></permissions><abstract id="ab005"><p>The Middle East respiratory syndrome coronavirus (MERS-CoV) was first discovered in late 2012 and has gone on to cause over 1800 infections and 650 deaths. There are currently no approved therapeutics or vaccinations for MERS-CoV. The MERS-CoV spike (S) protein is responsible for receptor binding and virion entry to cells, is immunodominant and induces neutralizing antibodies <italic>in vivo</italic>, all of which, make the S protein an ideal target for anti-MERS-CoV vaccines. In this study, we demonstrate protection induced by vaccination with a recombinant MERS-CoV S nanoparticle vaccine and Matrix-M1 adjuvant combination in mice. The MERS-CoV S nanoparticle vaccine produced high titer anti-S neutralizing antibody and protected mice from MERS-CoV infection <italic>in vivo</italic>.</p></abstract><kwd-group id="kg005"><title>Keywords</title><kwd>MERS-CoV</kwd><kwd>Nanoparticle vaccine</kwd><kwd>Mouse model</kwd><kwd>Coronavirus</kwd></kwd-group></article-meta></front></pmc><affiliations><list><country><li>États-Unis</li></country><region><li>Maryland</li></region><settlement><li>College Park (Maryland)</li></settlement><orgName><li>Université du Maryland</li></orgName></list><tree><country name="États-Unis"><region name="Maryland"><name sortKey="Coleman, Christopher M" sort="Coleman, Christopher M" uniqKey="Coleman C" first="Christopher M." last="Coleman">Christopher M. Coleman</name></region><name sortKey="Flyer, David C" sort="Flyer, David C" uniqKey="Flyer D" first="David C." last="Flyer">David C. Flyer</name><name sortKey="Frieman, Matthew B" sort="Frieman, Matthew B" uniqKey="Frieman M" first="Matthew B." last="Frieman">Matthew B. Frieman</name><name sortKey="Glenn, Gregory M" sort="Glenn, Gregory M" uniqKey="Glenn G" first="Gregory M." last="Glenn">Gregory M. Glenn</name><name sortKey="Liu, Ye V" sort="Liu, Ye V" uniqKey="Liu Y" first="Ye V." last="Liu">Ye V. Liu</name><name sortKey="Smith, Gale E" sort="Smith, Gale E" uniqKey="Smith G" first="Gale E." last="Smith">Gale E. Smith</name><name sortKey="Venkataraman, Thiagarajan" sort="Venkataraman, Thiagarajan" uniqKey="Venkataraman T" first="Thiagarajan" last="Venkataraman">Thiagarajan Venkataraman</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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