Addressing the selectivity and toxicity of antiviral nucleosides
Identifieur interne : 000646 ( Pmc/Checkpoint ); précédent : 000645; suivant : 000647Addressing the selectivity and toxicity of antiviral nucleosides
Auteurs : Joy Y. FengSource :
- Antiviral Chemistry & Chemotherapy [ 0956-3202 ] ; 2018.
Abstract
Nucleoside and nucleotide analogs have played significant roles in antiviral therapies and are valued for their impressive potency and high barrier to resistance. They have been approved for treatment of herpes simplex virus-1, HIV, HBV, HCV, and influenza, and new drugs are being developed for the treatment of RSV, Ebola, coronavirus MERS, and other emerging viruses. However, this class of compounds has also experienced a high attrition rate in clinical trials due to toxicity. In this review, we discuss the utility of different biochemical and cell-based assays and provide recommendations for assessing toxicity liability before entering animal toxicity studies.
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DOI: 10.1177/2040206618758524
PubMed: 29534607
PubMed Central: 5890540
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Addressing the selectivity and toxicity of antiviral nucleosides</title><author><name sortKey="Feng, Joy Y" sort="Feng, Joy Y" uniqKey="Feng J" first="Joy Y" last="Feng">Joy Y. Feng</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">29534607</idno><idno type="pmc">5890540</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5890540</idno><idno type="RBID">PMC:5890540</idno><idno type="doi">10.1177/2040206618758524</idno><date when="2018">2018</date><idno type="wicri:Area/Pmc/Corpus">001270</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001270</idno><idno type="wicri:Area/Pmc/Curation">001270</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">001270</idno><idno type="wicri:Area/Pmc/Checkpoint">000646</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000646</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Addressing the selectivity and toxicity of antiviral nucleosides</title><author><name sortKey="Feng, Joy Y" sort="Feng, Joy Y" uniqKey="Feng J" first="Joy Y" last="Feng">Joy Y. Feng</name></author></analytic><series><title level="j">Antiviral Chemistry & Chemotherapy</title><idno type="ISSN">0956-3202</idno><idno type="eISSN">2040-2066</idno><imprint><date when="2018">2018</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Nucleoside and nucleotide analogs have played significant roles in antiviral therapies and are valued for their impressive potency and high barrier to resistance. They have been approved for treatment of herpes simplex virus-1, HIV, HBV, HCV, and influenza, and new drugs are being developed for the treatment of RSV, Ebola, coronavirus MERS, and other emerging viruses. However, this class of compounds has also experienced a high attrition rate in clinical trials due to toxicity. In this review, we discuss the utility of different biochemical and cell-based assays and provide recommendations for assessing toxicity liability before entering animal toxicity studies.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Elion, Gb" uniqKey="Elion G">GB. Elion</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Feng, Jy" uniqKey="Feng J">JY Feng</name></author><author><name sortKey="Furman, Pa" uniqKey="Furman P">PA. Furman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Galmarini, Cm" uniqKey="Galmarini C">CM Galmarini</name></author><author><name sortKey="Mackey, Jr" uniqKey="Mackey J">JR Mackey</name></author><author><name sortKey="Dumontet, C" uniqKey="Dumontet C">C. 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<front><journal-meta><journal-id journal-id-type="nlm-ta">Antivir Chem Chemother</journal-id><journal-id journal-id-type="iso-abbrev">Antivir. Chem. Chemother</journal-id><journal-id journal-id-type="publisher-id">AVC</journal-id><journal-id journal-id-type="hwp">spavc</journal-id><journal-title-group><journal-title>Antiviral Chemistry & Chemotherapy</journal-title></journal-title-group><issn pub-type="ppub">0956-3202</issn><issn pub-type="epub">2040-2066</issn><publisher><publisher-name>SAGE Publications</publisher-name><publisher-loc>Sage UK: London, England</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">29534607</article-id><article-id pub-id-type="pmc">5890540</article-id><article-id pub-id-type="doi">10.1177/2040206618758524</article-id><article-id pub-id-type="publisher-id">10.1177_2040206618758524</article-id><article-categories><subj-group subj-group-type="heading"><subject>Review</subject></subj-group></article-categories><title-group><article-title>Addressing the selectivity and toxicity of antiviral nucleosides</article-title></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid" authenticated="false">http://orcid.org/0000-0003-4837-1911</contrib-id><name><surname>Feng</surname><given-names>Joy Y</given-names></name><xref ref-type="corresp" rid="corresp1-2040206618758524"></xref></contrib><aff id="aff1-2040206618758524"><institution-wrap><institution-id institution-id-type="Ringgold">2158</institution-id><institution content-type="university">Gilead Sciences Inc.</institution></institution-wrap>, Foster City, USA</aff></contrib-group><author-notes><corresp id="corresp1-2040206618758524">Joy Y Feng, Gilead Sciences Inc., Foster City, CA 94404, USA. Email: <email>Joy.Feng@Gilead.com</email></corresp></author-notes><pub-date pub-type="epub"><day>13</day><month>3</month><year>2018</year></pub-date><pub-date pub-type="collection"><year>2018</year></pub-date><volume>26</volume><elocation-id>2040206618758524</elocation-id><history><date date-type="received"><day>17</day><month>10</month><year>2017</year></date><date date-type="accepted"><day>10</day><month>1</month><year>2018</year></date></history><permissions><copyright-statement>© The Author(s) 2018</copyright-statement><copyright-year>2018</copyright-year><copyright-holder content-type="sage">SAGE Publications</copyright-holder><license license-type="creative-commons" xlink:href="http://creativecommons.org/licenses/by-nc/4.0/"><license-p>Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (<ext-link ext-link-type="uri" xlink:href="http://www.creativecommons.org/licenses/by-nc/4.0/">http://www.creativecommons.org/licenses/by-nc/4.0/</ext-link>) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (<ext-link ext-link-type="uri" xlink:href="https://us.sagepub.com/en-us/nam/open-access-at-sage">https://us.sagepub.com/en-us/nam/open-access-at-sage</ext-link>).</license-p></license></permissions><abstract abstract-type="short"><p>Nucleoside and nucleotide analogs have played significant roles in antiviral therapies and are valued for their impressive potency and high barrier to resistance. They have been approved for treatment of herpes simplex virus-1, HIV, HBV, HCV, and influenza, and new drugs are being developed for the treatment of RSV, Ebola, coronavirus MERS, and other emerging viruses. However, this class of compounds has also experienced a high attrition rate in clinical trials due to toxicity. In this review, we discuss the utility of different biochemical and cell-based assays and provide recommendations for assessing toxicity liability before entering animal toxicity studies.</p></abstract><kwd-group><kwd>Nucleosides</kwd><kwd>nucleotides</kwd><kwd>prodrugs</kwd><kwd>antiviral therapy</kwd><kwd>virus</kwd><kwd>polymerase</kwd><kwd>chain termination</kwd><kwd>selectivity</kwd></kwd-group><custom-meta-group><custom-meta><meta-name>cover-date</meta-name><meta-value>January-December 2018</meta-value></custom-meta></custom-meta-group></article-meta></front></pmc><affiliations><list></list><tree><noCountry><name sortKey="Feng, Joy Y" sort="Feng, Joy Y" uniqKey="Feng J" first="Joy Y" last="Feng">Joy Y. Feng</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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