Absence of neutralizing activity in serum 1 year after successful treatment with antivirals and recovery from MERS in South Korea
Identifieur interne : 000411 ( Pmc/Checkpoint ); précédent : 000410; suivant : 000412Absence of neutralizing activity in serum 1 year after successful treatment with antivirals and recovery from MERS in South Korea
Auteurs : Jun Yong Choi [Corée du Sud] ; Jin Ok Oh [Corée du Sud] ; Jin Young Ahn [Corée du Sud] ; Heun Choi [Corée du Sud] ; Jung Ho Kim [Corée du Sud] ; Hye Seong [Corée du Sud] ; Su Jin Jeong [Corée du Sud] ; Nam Su Ku [Corée du Sud] ; Joon-Sup Yeom [Corée du Sud] ; Jae-Phil Choi [Corée du Sud]Source :
- Clinical and Experimental Vaccine Research [ 2287-3651 ] ; 2019.
Abstract
We evaluated the neutralizing activity in serum from three patients >1 year after recovery from Middle East respiratory syndrome (MERS) associated with mild pneumonia treated with antivirals during the MERS outbreak in South Korea at 2015. The neutralizing activity in serum was measured by pseudovirus inhibition assays. Three-fold diluted serum of subjects showed only 9.7%, 10.3%, and 2.2% reductions in relative light units. So, significant neutralizing activity was not demonstrated in any sera of three patients with mild pneumonia >1 year after being successfully treated with antiviral agents and recovering from MERS coronavirus infection.
Url:
DOI: 10.7774/cevr.2019.8.1.86
PubMed: 30775355
PubMed Central: 6369131
Affiliations:
Links toward previous steps (curation, corpus...)
Links to Exploration step
PMC:6369131Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Absence of neutralizing activity in serum 1 year after successful treatment with antivirals and recovery from MERS in South Korea</title>
<author><name sortKey="Choi, Jun Yong" sort="Choi, Jun Yong" uniqKey="Choi J" first="Jun Yong" last="Choi">Jun Yong Choi</name>
<affiliation wicri:level="1"><nlm:aff id="A1">Department of Internal Medicine, Yonsei University College of Medicine, Seoul,<country>Korea</country>
.</nlm:aff>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A2">AIDS Research Institute, Yonsei University College of Medicine, Seoul,<country>Korea</country>
.</nlm:aff>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Oh, Jin Ok" sort="Oh, Jin Ok" uniqKey="Oh J" first="Jin Ok" last="Oh">Jin Ok Oh</name>
<affiliation wicri:level="1"><nlm:aff id="A1">Department of Internal Medicine, Yonsei University College of Medicine, Seoul,<country>Korea</country>
.</nlm:aff>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Ahn, Jin Young" sort="Ahn, Jin Young" uniqKey="Ahn J" first="Jin Young" last="Ahn">Jin Young Ahn</name>
<affiliation wicri:level="1"><nlm:aff id="A3">Department of Internal Medicine, Seoul Medical Center, Seoul,<country>Korea</country>
.</nlm:aff>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Choi, Heun" sort="Choi, Heun" uniqKey="Choi H" first="Heun" last="Choi">Heun Choi</name>
<affiliation wicri:level="1"><nlm:aff id="A1">Department of Internal Medicine, Yonsei University College of Medicine, Seoul,<country>Korea</country>
.</nlm:aff>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kim, Jung Ho" sort="Kim, Jung Ho" uniqKey="Kim J" first="Jung Ho" last="Kim">Jung Ho Kim</name>
<affiliation wicri:level="1"><nlm:aff id="A1">Department of Internal Medicine, Yonsei University College of Medicine, Seoul,<country>Korea</country>
.</nlm:aff>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Seong, Hye" sort="Seong, Hye" uniqKey="Seong H" first="Hye" last="Seong">Hye Seong</name>
<affiliation wicri:level="1"><nlm:aff id="A1">Department of Internal Medicine, Yonsei University College of Medicine, Seoul,<country>Korea</country>
.</nlm:aff>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Jeong, Su Jin" sort="Jeong, Su Jin" uniqKey="Jeong S" first="Su Jin" last="Jeong">Su Jin Jeong</name>
<affiliation wicri:level="1"><nlm:aff id="A1">Department of Internal Medicine, Yonsei University College of Medicine, Seoul,<country>Korea</country>
.</nlm:aff>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A2">AIDS Research Institute, Yonsei University College of Medicine, Seoul,<country>Korea</country>
.</nlm:aff>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Ku, Nam Su" sort="Ku, Nam Su" uniqKey="Ku N" first="Nam Su" last="Ku">Nam Su Ku</name>
<affiliation wicri:level="1"><nlm:aff id="A1">Department of Internal Medicine, Yonsei University College of Medicine, Seoul,<country>Korea</country>
.</nlm:aff>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A2">AIDS Research Institute, Yonsei University College of Medicine, Seoul,<country>Korea</country>
.</nlm:aff>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Yeom, Joon Sup" sort="Yeom, Joon Sup" uniqKey="Yeom J" first="Joon-Sup" last="Yeom">Joon-Sup Yeom</name>
<affiliation wicri:level="1"><nlm:aff id="A1">Department of Internal Medicine, Yonsei University College of Medicine, Seoul,<country>Korea</country>
.</nlm:aff>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Choi, Jae Phil" sort="Choi, Jae Phil" uniqKey="Choi J" first="Jae-Phil" last="Choi">Jae-Phil Choi</name>
<affiliation wicri:level="1"><nlm:aff id="A3">Department of Internal Medicine, Seoul Medical Center, Seoul,<country>Korea</country>
.</nlm:aff>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">30775355</idno>
<idno type="pmc">6369131</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369131</idno>
<idno type="RBID">PMC:6369131</idno>
<idno type="doi">10.7774/cevr.2019.8.1.86</idno>
<date when="2019">2019</date>
<idno type="wicri:Area/Pmc/Corpus">000666</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000666</idno>
<idno type="wicri:Area/Pmc/Curation">000666</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000666</idno>
<idno type="wicri:Area/Pmc/Checkpoint">000411</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000411</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Absence of neutralizing activity in serum 1 year after successful treatment with antivirals and recovery from MERS in South Korea</title>
<author><name sortKey="Choi, Jun Yong" sort="Choi, Jun Yong" uniqKey="Choi J" first="Jun Yong" last="Choi">Jun Yong Choi</name>
<affiliation wicri:level="1"><nlm:aff id="A1">Department of Internal Medicine, Yonsei University College of Medicine, Seoul,<country>Korea</country>
.</nlm:aff>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A2">AIDS Research Institute, Yonsei University College of Medicine, Seoul,<country>Korea</country>
.</nlm:aff>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Oh, Jin Ok" sort="Oh, Jin Ok" uniqKey="Oh J" first="Jin Ok" last="Oh">Jin Ok Oh</name>
<affiliation wicri:level="1"><nlm:aff id="A1">Department of Internal Medicine, Yonsei University College of Medicine, Seoul,<country>Korea</country>
.</nlm:aff>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Ahn, Jin Young" sort="Ahn, Jin Young" uniqKey="Ahn J" first="Jin Young" last="Ahn">Jin Young Ahn</name>
<affiliation wicri:level="1"><nlm:aff id="A3">Department of Internal Medicine, Seoul Medical Center, Seoul,<country>Korea</country>
.</nlm:aff>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Choi, Heun" sort="Choi, Heun" uniqKey="Choi H" first="Heun" last="Choi">Heun Choi</name>
<affiliation wicri:level="1"><nlm:aff id="A1">Department of Internal Medicine, Yonsei University College of Medicine, Seoul,<country>Korea</country>
.</nlm:aff>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kim, Jung Ho" sort="Kim, Jung Ho" uniqKey="Kim J" first="Jung Ho" last="Kim">Jung Ho Kim</name>
<affiliation wicri:level="1"><nlm:aff id="A1">Department of Internal Medicine, Yonsei University College of Medicine, Seoul,<country>Korea</country>
.</nlm:aff>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Seong, Hye" sort="Seong, Hye" uniqKey="Seong H" first="Hye" last="Seong">Hye Seong</name>
<affiliation wicri:level="1"><nlm:aff id="A1">Department of Internal Medicine, Yonsei University College of Medicine, Seoul,<country>Korea</country>
.</nlm:aff>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Jeong, Su Jin" sort="Jeong, Su Jin" uniqKey="Jeong S" first="Su Jin" last="Jeong">Su Jin Jeong</name>
<affiliation wicri:level="1"><nlm:aff id="A1">Department of Internal Medicine, Yonsei University College of Medicine, Seoul,<country>Korea</country>
.</nlm:aff>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A2">AIDS Research Institute, Yonsei University College of Medicine, Seoul,<country>Korea</country>
.</nlm:aff>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Ku, Nam Su" sort="Ku, Nam Su" uniqKey="Ku N" first="Nam Su" last="Ku">Nam Su Ku</name>
<affiliation wicri:level="1"><nlm:aff id="A1">Department of Internal Medicine, Yonsei University College of Medicine, Seoul,<country>Korea</country>
.</nlm:aff>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A2">AIDS Research Institute, Yonsei University College of Medicine, Seoul,<country>Korea</country>
.</nlm:aff>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Yeom, Joon Sup" sort="Yeom, Joon Sup" uniqKey="Yeom J" first="Joon-Sup" last="Yeom">Joon-Sup Yeom</name>
<affiliation wicri:level="1"><nlm:aff id="A1">Department of Internal Medicine, Yonsei University College of Medicine, Seoul,<country>Korea</country>
.</nlm:aff>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Choi, Jae Phil" sort="Choi, Jae Phil" uniqKey="Choi J" first="Jae-Phil" last="Choi">Jae-Phil Choi</name>
<affiliation wicri:level="1"><nlm:aff id="A3">Department of Internal Medicine, Seoul Medical Center, Seoul,<country>Korea</country>
.</nlm:aff>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
</analytic>
<series><title level="j">Clinical and Experimental Vaccine Research</title>
<idno type="ISSN">2287-3651</idno>
<idno type="eISSN">2287-366X</idno>
<imprint><date when="2019">2019</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p>We evaluated the neutralizing activity in serum from three patients >1 year after recovery from Middle East respiratory syndrome (MERS) associated with mild pneumonia treated with antivirals during the MERS outbreak in South Korea at 2015. The neutralizing activity in serum was measured by pseudovirus inhibition assays. Three-fold diluted serum of subjects showed only 9.7%, 10.3%, and 2.2% reductions in relative light units. So, significant neutralizing activity was not demonstrated in any sera of three patients with mild pneumonia >1 year after being successfully treated with antiviral agents and recovering from MERS coronavirus infection.</p>
</div>
</front>
<back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Choi, Jy" uniqKey="Choi J">JY Choi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chong, Yp" uniqKey="Chong Y">YP Chong</name>
</author>
<author><name sortKey="Song, Jy" uniqKey="Song J">JY Song</name>
</author>
<author><name sortKey="Seo, Yb" uniqKey="Seo Y">YB Seo</name>
</author>
<author><name sortKey="Choi, Jp" uniqKey="Choi J">JP Choi</name>
</author>
<author><name sortKey="Shin, Hs" uniqKey="Shin H">HS Shin</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Du, L" uniqKey="Du L">L Du</name>
</author>
<author><name sortKey="Zhao, G" uniqKey="Zhao G">G Zhao</name>
</author>
<author><name sortKey="Zhang, X" uniqKey="Zhang X">X Zhang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zhao, G" uniqKey="Zhao G">G Zhao</name>
</author>
<author><name sortKey="Du, L" uniqKey="Du L">L Du</name>
</author>
<author><name sortKey="Ma, C" uniqKey="Ma C">C Ma</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wu, X" uniqKey="Wu X">X Wu</name>
</author>
<author><name sortKey="Mao, Q" uniqKey="Mao Q">Q Mao</name>
</author>
<author><name sortKey="Yao, X" uniqKey="Yao X">X Yao</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wu, Lp" uniqKey="Wu L">LP Wu</name>
</author>
<author><name sortKey="Wang, Nc" uniqKey="Wang N">NC Wang</name>
</author>
<author><name sortKey="Chang, Yh" uniqKey="Chang Y">YH Chang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Payne, Dc" uniqKey="Payne D">DC Payne</name>
</author>
<author><name sortKey="Iblan, I" uniqKey="Iblan I">I Iblan</name>
</author>
<author><name sortKey="Rha, B" uniqKey="Rha B">B Rha</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Drosten, C" uniqKey="Drosten C">C Drosten</name>
</author>
<author><name sortKey="Meyer, B" uniqKey="Meyer B">B Meyer</name>
</author>
<author><name sortKey="Muller, Ma" uniqKey="Muller M">MA Muller</name>
</author>
</analytic>
</biblStruct>
</listBibl>
</div1>
</back>
</TEI>
<pmc article-type="brief-report"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Clin Exp Vaccine Res</journal-id>
<journal-id journal-id-type="iso-abbrev">Clin Exp Vaccine Res</journal-id>
<journal-id journal-id-type="publisher-id">CEVR</journal-id>
<journal-title-group><journal-title>Clinical and Experimental Vaccine Research</journal-title>
</journal-title-group>
<issn pub-type="ppub">2287-3651</issn>
<issn pub-type="epub">2287-366X</issn>
<publisher><publisher-name>The Korean Vaccine Society</publisher-name>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">30775355</article-id>
<article-id pub-id-type="pmc">6369131</article-id>
<article-id pub-id-type="doi">10.7774/cevr.2019.8.1.86</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Brief Communication</subject>
</subj-group>
</article-categories>
<title-group><article-title>Absence of neutralizing activity in serum 1 year after successful treatment with antivirals and recovery from MERS in South Korea</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid" authenticated="true">https://orcid.org/0000-0002-2775-3315</contrib-id>
<name><surname>Choi</surname>
<given-names>Jun Yong</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
<xref ref-type="aff" rid="A2">2</xref>
</contrib>
<contrib contrib-type="author"><contrib-id contrib-id-type="orcid" authenticated="true">http://orcid.org/0000-0002-2086-1751</contrib-id>
<name><surname>Oh</surname>
<given-names>Jin Ok</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>
<contrib contrib-type="author"><contrib-id contrib-id-type="orcid" authenticated="true">https://orcid.org/0000-0002-3740-2826</contrib-id>
<name><surname>Ahn</surname>
<given-names>Jin Young</given-names>
</name>
<xref ref-type="aff" rid="A3">3</xref>
</contrib>
<contrib contrib-type="author"><contrib-id contrib-id-type="orcid" authenticated="true">https://orcid.org/0000-0002-9622-9381</contrib-id>
<name><surname>Choi</surname>
<given-names>Heun</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>
<contrib contrib-type="author"><contrib-id contrib-id-type="orcid" authenticated="true">https://orcid.org/0000-0002-5033-3482</contrib-id>
<name><surname>Kim</surname>
<given-names>Jung Ho</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>
<contrib contrib-type="author"><contrib-id contrib-id-type="orcid" authenticated="true">https://orcid.org/0000-0002-5633-7214</contrib-id>
<name><surname>Seong</surname>
<given-names>Hye</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>
<contrib contrib-type="author"><contrib-id contrib-id-type="orcid" authenticated="true">https://orcid.org/0000-0003-4025-4542</contrib-id>
<name><surname>Jeong</surname>
<given-names>Su Jin</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
<xref ref-type="aff" rid="A2">2</xref>
</contrib>
<contrib contrib-type="author"><contrib-id contrib-id-type="orcid" authenticated="true">https://orcid.org/0000-0002-9717-4327</contrib-id>
<name><surname>Ku</surname>
<given-names>Nam Su</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
<xref ref-type="aff" rid="A2">2</xref>
</contrib>
<contrib contrib-type="author"><contrib-id contrib-id-type="orcid" authenticated="true">https://orcid.org/0000-0001-8940-7170</contrib-id>
<name><surname>Yeom</surname>
<given-names>Joon-Sup</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>
<contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid" authenticated="true">https://orcid.org/0000-0003-4805-7930</contrib-id>
<name><surname>Choi</surname>
<given-names>Jae-Phil</given-names>
</name>
<xref ref-type="aff" rid="A3">3</xref>
</contrib>
</contrib-group>
<aff id="A1"><label>1</label>
Department of Internal Medicine, Yonsei University College of Medicine, Seoul,<country>Korea</country>
.</aff>
<aff id="A2"><label>2</label>
AIDS Research Institute, Yonsei University College of Medicine, Seoul,<country>Korea</country>
.</aff>
<aff id="A3"><label>3</label>
Department of Internal Medicine, Seoul Medical Center, Seoul,<country>Korea</country>
.</aff>
<author-notes><corresp>Corresponding author: Jae-Phil Choi, MD. Department of Internal Medicine, Seoul Medical Center, 156 Sinnae-ro, Jungnang-gu, Seoul 02053, Korea. Tel: +82-2-2276-7813, Fax: +82-2-2276-7820, <email>dasole@hanmail.net</email>
</corresp>
</author-notes>
<pub-date pub-type="ppub"><month>1</month>
<year>2019</year>
</pub-date>
<pub-date pub-type="epub"><day>31</day>
<month>1</month>
<year>2019</year>
</pub-date>
<volume>8</volume>
<issue>1</issue>
<fpage>86</fpage>
<lpage>88</lpage>
<history><date date-type="received"><day>06</day>
<month>12</month>
<year>2018</year>
</date>
<date date-type="rev-recd"><day>02</day>
<month>1</month>
<year>2019</year>
</date>
<date date-type="accepted"><day>14</day>
<month>1</month>
<year>2019</year>
</date>
</history>
<permissions><copyright-statement>© Korean Vaccine Society.</copyright-statement>
<copyright-year>2019</copyright-year>
<copyright-holder>Korean Vaccine Society</copyright-holder>
<license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by-nc/4.0/"><license-p>This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by-nc/4.0/">http://creativecommons.org/licenses/by-nc/4.0/</ext-link>
) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p>
</license>
</permissions>
<abstract><p>We evaluated the neutralizing activity in serum from three patients >1 year after recovery from Middle East respiratory syndrome (MERS) associated with mild pneumonia treated with antivirals during the MERS outbreak in South Korea at 2015. The neutralizing activity in serum was measured by pseudovirus inhibition assays. Three-fold diluted serum of subjects showed only 9.7%, 10.3%, and 2.2% reductions in relative light units. So, significant neutralizing activity was not demonstrated in any sera of three patients with mild pneumonia >1 year after being successfully treated with antiviral agents and recovering from MERS coronavirus infection.</p>
</abstract>
<kwd-group><kwd>Middle East respiratory syndrome coronavirus</kwd>
<kwd>Neutralizing antibodies</kwd>
<kwd>Serum</kwd>
</kwd-group>
<funding-group><award-group><funding-source><institution-wrap><institution>Yonsei University College of Medicin</institution>
<institution-id institution-id-type="CrossRef">https://doi.org/10.13039/501100008005</institution-id>
</institution-wrap>
</funding-source>
<award-id>6-2015-0153</award-id>
</award-group>
</funding-group>
</article-meta>
</front>
<floats-group><fig id="F1" orientation="portrait" position="float"><label>Fig. 1</label>
<caption><title>Inhibitory activity of patients' sera against Middle East respiratory syndrome coronavirus pseudovirus infection. Three-fold diluted serum of subjects 1 and 2 showed only 9.7% and 10.3% reductions in relative light unit (RLU), respectively, while that of subject 3 showed only a 2.2% reduction. Control serum was collected from a healthy volunteer.</title>
</caption>
<graphic xlink:href="cevr-8-86-g001"></graphic>
</fig>
</floats-group>
</pmc>
<affiliations><list><country><li>Corée du Sud</li>
</country>
</list>
<tree><country name="Corée du Sud"><noRegion><name sortKey="Choi, Jun Yong" sort="Choi, Jun Yong" uniqKey="Choi J" first="Jun Yong" last="Choi">Jun Yong Choi</name>
</noRegion>
<name sortKey="Ahn, Jin Young" sort="Ahn, Jin Young" uniqKey="Ahn J" first="Jin Young" last="Ahn">Jin Young Ahn</name>
<name sortKey="Choi, Heun" sort="Choi, Heun" uniqKey="Choi H" first="Heun" last="Choi">Heun Choi</name>
<name sortKey="Choi, Jae Phil" sort="Choi, Jae Phil" uniqKey="Choi J" first="Jae-Phil" last="Choi">Jae-Phil Choi</name>
<name sortKey="Choi, Jun Yong" sort="Choi, Jun Yong" uniqKey="Choi J" first="Jun Yong" last="Choi">Jun Yong Choi</name>
<name sortKey="Jeong, Su Jin" sort="Jeong, Su Jin" uniqKey="Jeong S" first="Su Jin" last="Jeong">Su Jin Jeong</name>
<name sortKey="Jeong, Su Jin" sort="Jeong, Su Jin" uniqKey="Jeong S" first="Su Jin" last="Jeong">Su Jin Jeong</name>
<name sortKey="Kim, Jung Ho" sort="Kim, Jung Ho" uniqKey="Kim J" first="Jung Ho" last="Kim">Jung Ho Kim</name>
<name sortKey="Ku, Nam Su" sort="Ku, Nam Su" uniqKey="Ku N" first="Nam Su" last="Ku">Nam Su Ku</name>
<name sortKey="Ku, Nam Su" sort="Ku, Nam Su" uniqKey="Ku N" first="Nam Su" last="Ku">Nam Su Ku</name>
<name sortKey="Oh, Jin Ok" sort="Oh, Jin Ok" uniqKey="Oh J" first="Jin Ok" last="Oh">Jin Ok Oh</name>
<name sortKey="Seong, Hye" sort="Seong, Hye" uniqKey="Seong H" first="Hye" last="Seong">Hye Seong</name>
<name sortKey="Yeom, Joon Sup" sort="Yeom, Joon Sup" uniqKey="Yeom J" first="Joon-Sup" last="Yeom">Joon-Sup Yeom</name>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/MersV1/Data/Pmc/Checkpoint
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000411 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Pmc/Checkpoint/biblio.hfd -nk 000411 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Sante |area= MersV1 |flux= Pmc |étape= Checkpoint |type= RBID |clé= PMC:6369131 |texte= Absence of neutralizing activity in serum 1 year after successful treatment with antivirals and recovery from MERS in South Korea }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Pmc/Checkpoint/RBID.i -Sk "pubmed:30775355" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Pmc/Checkpoint/biblio.hfd \ | NlmPubMed2Wicri -a MersV1
![]() | This area was generated with Dilib version V0.6.33. | ![]() |