An updated roadmap for MERS-CoV research and product development: focus on diagnostics
Identifieur interne : 000402 ( Pmc/Checkpoint ); précédent : 000401; suivant : 000403An updated roadmap for MERS-CoV research and product development: focus on diagnostics
Auteurs : Cassandra Kelly-Cirino [Suisse] ; Laura T. Mazzola [Suisse] ; Arlene Chua [Suisse] ; Christopher J. Oxenford [France] ; Maria D. Van Kerkhove [Suisse]Source :
- BMJ Global Health [ 2059-7908 ] ; 2019.
Abstract
Diagnostics play a central role in the early detection and control of outbreaks and can enable a more nuanced understanding of the disease kinetics and risk factors for the Middle East respiratory syndrome-coronavirus (MERS-CoV), one of the high-priority pathogens identified by the WHO. In this review we identified sources for molecular and serological diagnostic tests used in MERS-CoV detection, case management and outbreak investigations, as well as surveillance for humans and animals (camels), and summarised the performance of currently available tests, diagnostic needs, and associated challenges for diagnostic test development and implementation. A more detailed understanding of the kinetics of infection of MERS-CoV is needed in order to optimise the use of existing assays. Notably, MERS-CoV point-of-care tests are needed in order to optimise supportive care and to minimise transmission risk. However, for new test development, sourcing clinical material continues to be a major challenge to achieving assay validation. Harmonisation and standardisation of laboratory methods are essential for surveillance and for a rapid and effective international response to emerging diseases. Routine external quality assessment, along with well-characterised and up-to-date proficiency panels, would provide insight into MERS-CoV diagnostic performance worldwide. A defined set of Target Product Profiles for diagnostic technologies will be developed by WHO to address these gaps in MERS-CoV outbreak management.
Url:
DOI: 10.1136/bmjgh-2018-001105
PubMed: 30815285
PubMed Central: 6361340
Affiliations:
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PMC:6361340Le document en format XML
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<front><div type="abstract" xml:lang="en"><p>Diagnostics play a central role in the early detection and control of outbreaks and can enable a more nuanced understanding of the disease kinetics and risk factors for the Middle East respiratory syndrome-coronavirus (MERS-CoV), one of the high-priority pathogens identified by the WHO. In this review we identified sources for molecular and serological diagnostic tests used in MERS-CoV detection, case management and outbreak investigations, as well as surveillance for humans and animals (camels), and summarised the performance of currently available tests, diagnostic needs, and associated challenges for diagnostic test development and implementation. A more detailed understanding of the kinetics of infection of MERS-CoV is needed in order to optimise the use of existing assays. Notably, MERS-CoV point-of-care tests are needed in order to optimise supportive care and to minimise transmission risk. However, for new test development, sourcing clinical material continues to be a major challenge to achieving assay validation. Harmonisation and standardisation of laboratory methods are essential for surveillance and for a rapid and effective international response to emerging diseases. Routine external quality assessment, along with well-characterised and up-to-date proficiency panels, would provide insight into MERS-CoV diagnostic performance worldwide. A defined set of Target Product Profiles for diagnostic technologies will be developed by WHO to address these gaps in MERS-CoV outbreak management.</p>
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<pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">BMJ Glob Health</journal-id>
<journal-id journal-id-type="iso-abbrev">BMJ Glob Health</journal-id>
<journal-id journal-id-type="hwp">bmjgh</journal-id>
<journal-id journal-id-type="publisher-id">bmjgh</journal-id>
<journal-title-group><journal-title>BMJ Global Health</journal-title>
</journal-title-group>
<issn pub-type="epub">2059-7908</issn>
<publisher><publisher-name>BMJ Publishing Group</publisher-name>
<publisher-loc>BMA House, Tavistock Square, London, WC1H 9JR</publisher-loc>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">30815285</article-id>
<article-id pub-id-type="pmc">6361340</article-id>
<article-id pub-id-type="publisher-id">bmjgh-2018-001105</article-id>
<article-id pub-id-type="doi">10.1136/bmjgh-2018-001105</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Analysis</subject>
</subj-group>
<subj-group subj-group-type="hwp-journal-coll"><subject>1506</subject>
</subj-group>
</article-categories>
<title-group><article-title>An updated roadmap for MERS-CoV research and product development: focus on diagnostics</article-title>
</title-group>
<contrib-group><contrib id="author-64312145" contrib-type="author"><name><surname>Kelly-Cirino</surname>
<given-names>Cassandra</given-names>
</name>
<xref ref-type="aff" rid="aff1">1</xref>
</contrib>
<contrib id="author-64312186" contrib-type="author"><name><surname>Mazzola</surname>
<given-names>Laura T</given-names>
</name>
<xref ref-type="aff" rid="aff1">1</xref>
</contrib>
<contrib id="author-64312437" contrib-type="author"><name><surname>Chua</surname>
<given-names>Arlene</given-names>
</name>
<xref ref-type="aff" rid="aff2">2</xref>
<xref ref-type="aff" rid="aff3">3</xref>
</contrib>
<contrib id="author-64377212" contrib-type="author"><name><surname>Oxenford</surname>
<given-names>Christopher J</given-names>
</name>
<xref ref-type="aff" rid="aff4">4</xref>
</contrib>
<contrib id="author-64377239" contrib-type="author" corresp="yes"><name><surname>Van Kerkhove</surname>
<given-names>Maria D</given-names>
</name>
<xref ref-type="aff" rid="aff5">5</xref>
</contrib>
</contrib-group>
<aff id="aff1"><label>1</label>
<institution content-type="department">Emerging Threats Programme</institution>
,<institution>FIND</institution>
,<addr-line content-type="city">Geneva</addr-line>
,<country>Switzerland</country>
</aff>
<aff id="aff2"><label>2</label>
<institution content-type="department">Department of Information, Evidence and Research</institution>
,<institution>WHO</institution>
,<addr-line content-type="city">Geneva</addr-line>
,<country>Switzerland</country>
</aff>
<aff id="aff3"><label>3</label>
<institution>Medecins Sans Frontières</institution>
,<addr-line content-type="city">Geneva</addr-line>
,<country>Switzerland</country>
</aff>
<aff id="aff4"><label>4</label>
<institution content-type="department">Health Emergencies Programme</institution>
,<institution>WHO</institution>
,<addr-line content-type="city">Lyon</addr-line>
,<country>France</country>
</aff>
<aff id="aff5"><label>5</label>
<institution content-type="department">Health Emergencies Programme</institution>
,<institution>WHO</institution>
,<addr-line content-type="city">Geneva</addr-line>
,<country>Switzerland</country>
</aff>
<author-notes><corresp><label>Correspondence to</label>
Dr Maria D Van Kerkhove; <email>vankerkhovem@who.int</email>
</corresp>
</author-notes>
<pub-date pub-type="collection"><year>2019</year>
</pub-date>
<pub-date pub-type="epub"><day>1</day>
<month>2</month>
<year>2019</year>
</pub-date>
<volume>4</volume>
<issue>Suppl 2</issue>
<elocation-id>e001105</elocation-id>
<history><date date-type="received"><day>10</day>
<month>8</month>
<year>2018</year>
</date>
<date date-type="rev-recd"><day>13</day>
<month>10</month>
<year>2018</year>
</date>
<date date-type="accepted"><day>23</day>
<month>10</month>
<year>2018</year>
</date>
</history>
<permissions><copyright-statement>© Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.</copyright-statement>
<copyright-year>2019</copyright-year>
<license license-type="open-access"><license-p>This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: <ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by-nc/4.0">http://creativecommons.org/licenses/by-nc/4.0</ext-link>
</license-p>
</license>
</permissions>
<self-uri xlink:title="pdf" xlink:href="bmjgh-2018-001105.pdf"></self-uri>
<abstract><p>Diagnostics play a central role in the early detection and control of outbreaks and can enable a more nuanced understanding of the disease kinetics and risk factors for the Middle East respiratory syndrome-coronavirus (MERS-CoV), one of the high-priority pathogens identified by the WHO. In this review we identified sources for molecular and serological diagnostic tests used in MERS-CoV detection, case management and outbreak investigations, as well as surveillance for humans and animals (camels), and summarised the performance of currently available tests, diagnostic needs, and associated challenges for diagnostic test development and implementation. A more detailed understanding of the kinetics of infection of MERS-CoV is needed in order to optimise the use of existing assays. Notably, MERS-CoV point-of-care tests are needed in order to optimise supportive care and to minimise transmission risk. However, for new test development, sourcing clinical material continues to be a major challenge to achieving assay validation. Harmonisation and standardisation of laboratory methods are essential for surveillance and for a rapid and effective international response to emerging diseases. Routine external quality assessment, along with well-characterised and up-to-date proficiency panels, would provide insight into MERS-CoV diagnostic performance worldwide. A defined set of Target Product Profiles for diagnostic technologies will be developed by WHO to address these gaps in MERS-CoV outbreak management.</p>
</abstract>
<kwd-group><kwd>middle east respiratory syndrome-coronavirus</kwd>
<kwd>MERS-CoV</kwd>
<kwd>in vitro diagnostics</kwd>
<kwd>outbreak</kwd>
</kwd-group>
<funding-group><award-group id="funding-1"><funding-source><institution-wrap><institution>UK Government</institution>
</institution-wrap>
</funding-source>
<award-id>UK AID</award-id>
</award-group>
</funding-group>
<custom-meta-group><custom-meta><meta-name>special-feature</meta-name>
<meta-value>unlocked</meta-value>
</custom-meta>
</custom-meta-group>
</article-meta>
</front>
</pmc>
<affiliations><list><country><li>France</li>
<li>Suisse</li>
</country>
</list>
<tree><country name="Suisse"><noRegion><name sortKey="Kelly Cirino, Cassandra" sort="Kelly Cirino, Cassandra" uniqKey="Kelly Cirino C" first="Cassandra" last="Kelly-Cirino">Cassandra Kelly-Cirino</name>
</noRegion>
<name sortKey="Chua, Arlene" sort="Chua, Arlene" uniqKey="Chua A" first="Arlene" last="Chua">Arlene Chua</name>
<name sortKey="Chua, Arlene" sort="Chua, Arlene" uniqKey="Chua A" first="Arlene" last="Chua">Arlene Chua</name>
<name sortKey="Mazzola, Laura T" sort="Mazzola, Laura T" uniqKey="Mazzola L" first="Laura T" last="Mazzola">Laura T. Mazzola</name>
<name sortKey="Van Kerkhove, Maria D" sort="Van Kerkhove, Maria D" uniqKey="Van Kerkhove M" first="Maria D" last="Van Kerkhove">Maria D. Van Kerkhove</name>
</country>
<country name="France"><noRegion><name sortKey="Oxenford, Christopher J" sort="Oxenford, Christopher J" uniqKey="Oxenford C" first="Christopher J" last="Oxenford">Christopher J. Oxenford</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>
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