Clinical outcomes among hospital patients with Middle East respiratory syndrome coronavirus (MERS-CoV) infection
Identifieur interne : 000373 ( Pmc/Checkpoint ); précédent : 000372; suivant : 000374Clinical outcomes among hospital patients with Middle East respiratory syndrome coronavirus (MERS-CoV) infection
Auteurs : Abdulrahman Mohammed G. Habib ; Mohamed Abd Elghafour Ali ; Baha R. Zouaoui ; Mustafa Ahmed H. Taha ; Bassem Sahsah Mohammed [Arabie saoudite] ; Nazmus SaquibSource :
- BMC Infectious Diseases [ 1471-2334 ] ; 2019.
Abstract
Mortality is high among patients with Middle East Respiratory Syndrome Coronavirus (MERS-CoV) infection. We aimed to determine hospital mortality and the factors associated with it in a cohort of MERS-CoV patients.
We reviewed hospital records of confirmed cases (detection of virus by polymerase chain reaction from respiratory tract samples) of MERS-CoV patients (
The mean age was 60 years (SD = 18.2); most patients were male (74.6%) and Saudi citizens (81%). All but two patients were treated with Ribavirin plus Interferon. Hospital mortality was 25.4%. Patients who were admitted with septic shock and/or organ failure were significantly more likely to die than patients who were admitted with pneumonia and/or acute respiratory distress syndrome (OR = 47.9, 95% CI = 3.9, 585.5,
Hospital mortality was 25%; septic shock/organ failure at admittance was a significant predictor of mortality.
Url:
DOI: 10.1186/s12879-019-4555-5
PubMed: 31640578
PubMed Central: 6805532
Affiliations:
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Box 777, Bukayriah, Al-Qassim Zip code 51941 Saudi Arabia</nlm:aff><wicri:noCountry code="subfield">Al-Qassim Zip code 51941 Saudi Arabia</wicri:noCountry></affiliation></author><author><name sortKey="Ali, Mohamed Abd Elghafour" sort="Ali, Mohamed Abd Elghafour" uniqKey="Ali M" first="Mohamed Abd Elghafour" last="Ali">Mohamed Abd Elghafour Ali</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.459460.a</institution-id><institution>College of Medicine,</institution><institution>Sulaiman Al Rajhi Colleges,</institution></institution-wrap>P.O. Box 777, Bukayriah, Al-Qassim Zip code 51941 Saudi Arabia</nlm:aff><wicri:noCountry code="subfield">Al-Qassim Zip code 51941 Saudi Arabia</wicri:noCountry></affiliation></author><author><name sortKey="Zouaoui, Baha R" sort="Zouaoui, Baha R" uniqKey="Zouaoui B" first="Baha R." last="Zouaoui">Baha R. Zouaoui</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.459460.a</institution-id><institution>College of Medicine,</institution><institution>Sulaiman Al Rajhi Colleges,</institution></institution-wrap>P.O. Box 777, Bukayriah, Al-Qassim Zip code 51941 Saudi Arabia</nlm:aff><wicri:noCountry code="subfield">Al-Qassim Zip code 51941 Saudi Arabia</wicri:noCountry></affiliation></author><author><name sortKey="Taha, Mustafa Ahmed H" sort="Taha, Mustafa Ahmed H" uniqKey="Taha M" first="Mustafa Ahmed H." last="Taha">Mustafa Ahmed H. Taha</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.459460.a</institution-id><institution>College of Medicine,</institution><institution>Sulaiman Al Rajhi Colleges,</institution></institution-wrap>P.O. Box 777, Bukayriah, Al-Qassim Zip code 51941 Saudi Arabia</nlm:aff><wicri:noCountry code="subfield">Al-Qassim Zip code 51941 Saudi Arabia</wicri:noCountry></affiliation></author><author><name sortKey="Mohammed, Bassem Sahsah" sort="Mohammed, Bassem Sahsah" uniqKey="Mohammed B" first="Bassem Sahsah" last="Mohammed">Bassem Sahsah Mohammed</name><affiliation wicri:level="1"><nlm:aff id="Aff2">Buraidah Central Hospital, Buraidah, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Buraidah Central Hospital, Buraidah</wicri:regionArea><wicri:noRegion>Buraidah</wicri:noRegion></affiliation></author><author><name sortKey="Saquib, Nazmus" sort="Saquib, Nazmus" uniqKey="Saquib N" first="Nazmus" last="Saquib">Nazmus Saquib</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.459460.a</institution-id><institution>College of Medicine,</institution><institution>Sulaiman Al Rajhi Colleges,</institution></institution-wrap>P.O. Box 777, Bukayriah, Al-Qassim Zip code 51941 Saudi Arabia</nlm:aff><wicri:noCountry code="subfield">Al-Qassim Zip code 51941 Saudi Arabia</wicri:noCountry></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">31640578</idno><idno type="pmc">6805532</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6805532</idno><idno type="RBID">PMC:6805532</idno><idno type="doi">10.1186/s12879-019-4555-5</idno><date when="2019">2019</date><idno type="wicri:Area/Pmc/Corpus">000324</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000324</idno><idno type="wicri:Area/Pmc/Curation">000324</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000324</idno><idno type="wicri:Area/Pmc/Checkpoint">000373</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000373</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Clinical outcomes among hospital patients with Middle East respiratory syndrome coronavirus (MERS-CoV) infection</title><author><name sortKey="Habib, Abdulrahman Mohammed G" sort="Habib, Abdulrahman Mohammed G" uniqKey="Habib A" first="Abdulrahman Mohammed G." last="Habib">Abdulrahman Mohammed G. Habib</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.459460.a</institution-id><institution>College of Medicine,</institution><institution>Sulaiman Al Rajhi Colleges,</institution></institution-wrap>P.O. Box 777, Bukayriah, Al-Qassim Zip code 51941 Saudi Arabia</nlm:aff><wicri:noCountry code="subfield">Al-Qassim Zip code 51941 Saudi Arabia</wicri:noCountry></affiliation></author><author><name sortKey="Ali, Mohamed Abd Elghafour" sort="Ali, Mohamed Abd Elghafour" uniqKey="Ali M" first="Mohamed Abd Elghafour" last="Ali">Mohamed Abd Elghafour Ali</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.459460.a</institution-id><institution>College of Medicine,</institution><institution>Sulaiman Al Rajhi Colleges,</institution></institution-wrap>P.O. Box 777, Bukayriah, Al-Qassim Zip code 51941 Saudi Arabia</nlm:aff><wicri:noCountry code="subfield">Al-Qassim Zip code 51941 Saudi Arabia</wicri:noCountry></affiliation></author><author><name sortKey="Zouaoui, Baha R" sort="Zouaoui, Baha R" uniqKey="Zouaoui B" first="Baha R." last="Zouaoui">Baha R. Zouaoui</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.459460.a</institution-id><institution>College of Medicine,</institution><institution>Sulaiman Al Rajhi Colleges,</institution></institution-wrap>P.O. Box 777, Bukayriah, Al-Qassim Zip code 51941 Saudi Arabia</nlm:aff><wicri:noCountry code="subfield">Al-Qassim Zip code 51941 Saudi Arabia</wicri:noCountry></affiliation></author><author><name sortKey="Taha, Mustafa Ahmed H" sort="Taha, Mustafa Ahmed H" uniqKey="Taha M" first="Mustafa Ahmed H." last="Taha">Mustafa Ahmed H. Taha</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.459460.a</institution-id><institution>College of Medicine,</institution><institution>Sulaiman Al Rajhi Colleges,</institution></institution-wrap>P.O. Box 777, Bukayriah, Al-Qassim Zip code 51941 Saudi Arabia</nlm:aff><wicri:noCountry code="subfield">Al-Qassim Zip code 51941 Saudi Arabia</wicri:noCountry></affiliation></author><author><name sortKey="Mohammed, Bassem Sahsah" sort="Mohammed, Bassem Sahsah" uniqKey="Mohammed B" first="Bassem Sahsah" last="Mohammed">Bassem Sahsah Mohammed</name><affiliation wicri:level="1"><nlm:aff id="Aff2">Buraidah Central Hospital, Buraidah, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Buraidah Central Hospital, Buraidah</wicri:regionArea><wicri:noRegion>Buraidah</wicri:noRegion></affiliation></author><author><name sortKey="Saquib, Nazmus" sort="Saquib, Nazmus" uniqKey="Saquib N" first="Nazmus" last="Saquib">Nazmus Saquib</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.459460.a</institution-id><institution>College of Medicine,</institution><institution>Sulaiman Al Rajhi Colleges,</institution></institution-wrap>P.O. Box 777, Bukayriah, Al-Qassim Zip code 51941 Saudi Arabia</nlm:aff><wicri:noCountry code="subfield">Al-Qassim Zip code 51941 Saudi Arabia</wicri:noCountry></affiliation></author></analytic><series><title level="j">BMC Infectious Diseases</title><idno type="eISSN">1471-2334</idno><imprint><date when="2019">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p id="Par1">Mortality is high among patients with Middle East Respiratory Syndrome Coronavirus (MERS-CoV) infection. We aimed to determine hospital mortality and the factors associated with it in a cohort of MERS-CoV patients.</p></sec><sec><title>Methods</title><p id="Par2">We reviewed hospital records of confirmed cases (detection of virus by polymerase chain reaction from respiratory tract samples) of MERS-CoV patients (<italic>n</italic> = 63) admitted to Buraidah Central Hospital in Al-Qassim, Saudi Arabia between 2014 and 2017. We abstracted data on demography, vital signs, associated conditions presented on admission, pre-existing chronic diseases, treatment, and vital status. Bi-variate comparisons and multiple logistic regressions were the choice of data analyses.</p></sec><sec><title>Results</title><p id="Par3">The mean age was 60 years (SD = 18.2); most patients were male (74.6%) and Saudi citizens (81%). All but two patients were treated with Ribavirin plus Interferon. Hospital mortality was 25.4%. Patients who were admitted with septic shock and/or organ failure were significantly more likely to die than patients who were admitted with pneumonia and/or acute respiratory distress syndrome (OR = 47.9, 95% CI = 3.9, 585.5, <italic>p</italic>-value 0.002). Age, sex, and presence of chronic conditions were not significantly associated with mortality.</p></sec><sec><title>Conclusion</title><p id="Par4">Hospital mortality was 25%; septic shock/organ failure at admittance was a significant predictor of mortality.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Su, S" uniqKey="Su S">S Su</name></author><author><name sortKey="Wong, G" uniqKey="Wong G">G Wong</name></author><author><name sortKey="Shi, W" uniqKey="Shi W">W Shi</name></author><author><name sortKey="Liu, J" uniqKey="Liu J">J Liu</name></author><author><name sortKey="Lai, Ack" uniqKey="Lai A">ACK Lai</name></author><author><name sortKey="Zhou, J" uniqKey="Zhou J">J Zhou</name></author><author><name sortKey="Liu, W" uniqKey="Liu W">W Liu</name></author><author><name sortKey="Bi, Y" uniqKey="Bi Y">Y Bi</name></author><author><name sortKey="Gao, Gf" uniqKey="Gao G">GF 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<front><journal-meta><journal-id journal-id-type="nlm-ta">BMC Infect Dis</journal-id><journal-id journal-id-type="iso-abbrev">BMC Infect. Dis</journal-id><journal-title-group><journal-title>BMC Infectious Diseases</journal-title></journal-title-group><issn pub-type="epub">1471-2334</issn><publisher><publisher-name>BioMed Central</publisher-name><publisher-loc>London</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">31640578</article-id><article-id pub-id-type="pmc">6805532</article-id><article-id pub-id-type="publisher-id">4555</article-id><article-id pub-id-type="doi">10.1186/s12879-019-4555-5</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title>Clinical outcomes among hospital patients with Middle East respiratory syndrome coronavirus (MERS-CoV) infection</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Habib</surname><given-names>Abdulrahman Mohammed G.</given-names></name><xref ref-type="aff" rid="Aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Ali</surname><given-names>Mohamed Abd Elghafour</given-names></name><xref ref-type="aff" rid="Aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Zouaoui</surname><given-names>Baha R.</given-names></name><xref ref-type="aff" rid="Aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Taha</surname><given-names>Mustafa Ahmed H.</given-names></name><xref ref-type="aff" rid="Aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Mohammed</surname><given-names>Bassem Sahsah</given-names></name><xref ref-type="aff" rid="Aff2">2</xref></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">http://orcid.org/0000-0002-2819-2839</contrib-id><name><surname>Saquib</surname><given-names>Nazmus</given-names></name><address><phone>00966-533445899</phone><email>a.saquib@sr.edu.sa</email></address><xref ref-type="aff" rid="Aff1">1</xref></contrib><aff id="Aff1"><label>1</label><institution-wrap><institution-id institution-id-type="GRID">grid.459460.a</institution-id><institution>College of Medicine,</institution><institution>Sulaiman Al Rajhi Colleges,</institution></institution-wrap>P.O. Box 777, Bukayriah, Al-Qassim Zip code 51941 Saudi Arabia</aff><aff id="Aff2"><label>2</label>Buraidah Central Hospital, Buraidah, Saudi Arabia</aff></contrib-group><pub-date pub-type="epub"><day>22</day><month>10</month><year>2019</year></pub-date><pub-date pub-type="pmc-release"><day>22</day><month>10</month><year>2019</year></pub-date><pub-date pub-type="collection"><year>2019</year></pub-date><volume>19</volume><elocation-id>870</elocation-id><history><date date-type="received"><day>18</day><month>10</month><year>2018</year></date><date date-type="accepted"><day>10</day><month>10</month><year>2019</year></date></history><permissions><copyright-statement>© The Author(s). 2019</copyright-statement><license license-type="OpenAccess"><license-p><bold>Open Access</bold>This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/4.0/">http://creativecommons.org/licenses/by/4.0/</ext-link>), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/publicdomain/zero/1.0/">http://creativecommons.org/publicdomain/zero/1.0/</ext-link>) applies to the data made available in this article, unless otherwise stated.</license-p></license></permissions><abstract id="Abs1"><sec><title>Background</title><p id="Par1">Mortality is high among patients with Middle East Respiratory Syndrome Coronavirus (MERS-CoV) infection. We aimed to determine hospital mortality and the factors associated with it in a cohort of MERS-CoV patients.</p></sec><sec><title>Methods</title><p id="Par2">We reviewed hospital records of confirmed cases (detection of virus by polymerase chain reaction from respiratory tract samples) of MERS-CoV patients (<italic>n</italic> = 63) admitted to Buraidah Central Hospital in Al-Qassim, Saudi Arabia between 2014 and 2017. We abstracted data on demography, vital signs, associated conditions presented on admission, pre-existing chronic diseases, treatment, and vital status. Bi-variate comparisons and multiple logistic regressions were the choice of data analyses.</p></sec><sec><title>Results</title><p id="Par3">The mean age was 60 years (SD = 18.2); most patients were male (74.6%) and Saudi citizens (81%). All but two patients were treated with Ribavirin plus Interferon. Hospital mortality was 25.4%. Patients who were admitted with septic shock and/or organ failure were significantly more likely to die than patients who were admitted with pneumonia and/or acute respiratory distress syndrome (OR = 47.9, 95% CI = 3.9, 585.5, <italic>p</italic>-value 0.002). Age, sex, and presence of chronic conditions were not significantly associated with mortality.</p></sec><sec><title>Conclusion</title><p id="Par4">Hospital mortality was 25%; septic shock/organ failure at admittance was a significant predictor of mortality.</p></sec></abstract><kwd-group xml:lang="en"><title>Keywords</title><kwd>Ribavirin</kwd><kwd>Interferon alpha</kwd><kwd>MERS-CoV</kwd><kwd>Mortality</kwd></kwd-group><funding-group><award-group><funding-source><institution>Sulaiman Al Rajhi Colleges</institution></funding-source><award-id>n/a</award-id></award-group></funding-group><custom-meta-group><custom-meta><meta-name>issue-copyright-statement</meta-name><meta-value>© The Author(s) 2019</meta-value></custom-meta></custom-meta-group></article-meta></front></pmc><affiliations><list><country><li>Arabie saoudite</li></country></list><tree><noCountry><name sortKey="Ali, Mohamed Abd Elghafour" sort="Ali, Mohamed Abd Elghafour" uniqKey="Ali M" first="Mohamed Abd Elghafour" last="Ali">Mohamed Abd Elghafour Ali</name><name sortKey="Habib, Abdulrahman Mohammed G" sort="Habib, Abdulrahman Mohammed G" uniqKey="Habib A" first="Abdulrahman Mohammed G." last="Habib">Abdulrahman Mohammed G. Habib</name><name sortKey="Saquib, Nazmus" sort="Saquib, Nazmus" uniqKey="Saquib N" first="Nazmus" last="Saquib">Nazmus Saquib</name><name sortKey="Taha, Mustafa Ahmed H" sort="Taha, Mustafa Ahmed H" uniqKey="Taha M" first="Mustafa Ahmed H." last="Taha">Mustafa Ahmed H. Taha</name><name sortKey="Zouaoui, Baha R" sort="Zouaoui, Baha R" uniqKey="Zouaoui B" first="Baha R." last="Zouaoui">Baha R. Zouaoui</name></noCountry><country name="Arabie saoudite"><noRegion><name sortKey="Mohammed, Bassem Sahsah" sort="Mohammed, Bassem Sahsah" uniqKey="Mohammed B" first="Bassem Sahsah" last="Mohammed">Bassem Sahsah Mohammed</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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