Focus on Middle East respiratory syndrome coronavirus (MERS-CoV)
Identifieur interne : 000305 ( Pmc/Checkpoint ); précédent : 000304; suivant : 000306Focus on Middle East respiratory syndrome coronavirus (MERS-CoV)
Auteurs : A. Bleibtreu [France] ; M. Bertine [France] ; C. Bertin [France] ; N. Houhou-Fidouh [France] ; B. Visseaux [France]Source :
- Medecine et Maladies Infectieuses [ 0399-077X ] ; 2019.
Abstract
MERS-CoV was first detected in June 2012 in Saudi Arabia. On October 16, 2018, 2260 cases and 803 related deaths had been reported in 27 countries. Although this emerging virus seems unlikely to become endemic in humans, it is still present and has not disappeared rapidly in less than 2 years like the SARS coronavirus. In this review, we discuss the main findings about the origin, emergence and virological characteristics of this virus, as well as preventive measures, the typical clinical picture, and currently available therapeutic options.
Url:
DOI: 10.1016/j.medmal.2019.10.004
PubMed: 31727466
PubMed Central: 7125975
Affiliations:
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Bertine</name><affiliation wicri:level="3"><nlm:aff id="aff0010">Inserm, Laboratoire de Virologie, IAME, UMR 1137, Hôpital Bichat, Sorbonne Paris Cité, Université Paris Diderot, AP–HP, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Inserm, Laboratoire de Virologie, IAME, UMR 1137, Hôpital Bichat, Sorbonne Paris Cité, Université Paris Diderot, AP–HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Bertin, C" sort="Bertin, C" uniqKey="Bertin C" first="C." last="Bertin">C. Bertin</name><affiliation wicri:level="3"><nlm:aff id="aff0005">Service des maladies infectieuses et tropicales, hôpitaux universitaires Pitié-Salpêtrière Charles Foix, AP–HP, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Service des maladies infectieuses et tropicales, hôpitaux universitaires Pitié-Salpêtrière Charles Foix, AP–HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Houhou Fidouh, N" sort="Houhou Fidouh, N" uniqKey="Houhou Fidouh N" first="N." last="Houhou-Fidouh">N. Houhou-Fidouh</name><affiliation wicri:level="3"><nlm:aff id="aff0010">Inserm, Laboratoire de Virologie, IAME, UMR 1137, Hôpital Bichat, Sorbonne Paris Cité, Université Paris Diderot, AP–HP, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Inserm, Laboratoire de Virologie, IAME, UMR 1137, Hôpital Bichat, Sorbonne Paris Cité, Université Paris Diderot, AP–HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Visseaux, B" sort="Visseaux, B" uniqKey="Visseaux B" first="B." last="Visseaux">B. 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Bleibtreu</name><affiliation wicri:level="3"><nlm:aff id="aff0005">Service des maladies infectieuses et tropicales, hôpitaux universitaires Pitié-Salpêtrière Charles Foix, AP–HP, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Service des maladies infectieuses et tropicales, hôpitaux universitaires Pitié-Salpêtrière Charles Foix, AP–HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Bertine, M" sort="Bertine, M" uniqKey="Bertine M" first="M." last="Bertine">M. Bertine</name><affiliation wicri:level="3"><nlm:aff id="aff0010">Inserm, Laboratoire de Virologie, IAME, UMR 1137, Hôpital Bichat, Sorbonne Paris Cité, Université Paris Diderot, AP–HP, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Inserm, Laboratoire de Virologie, IAME, UMR 1137, Hôpital Bichat, Sorbonne Paris Cité, Université Paris Diderot, AP–HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Bertin, C" sort="Bertin, C" uniqKey="Bertin C" first="C." last="Bertin">C. Bertin</name><affiliation wicri:level="3"><nlm:aff id="aff0005">Service des maladies infectieuses et tropicales, hôpitaux universitaires Pitié-Salpêtrière Charles Foix, AP–HP, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Service des maladies infectieuses et tropicales, hôpitaux universitaires Pitié-Salpêtrière Charles Foix, AP–HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Houhou Fidouh, N" sort="Houhou Fidouh, N" uniqKey="Houhou Fidouh N" first="N." last="Houhou-Fidouh">N. Houhou-Fidouh</name><affiliation wicri:level="3"><nlm:aff id="aff0010">Inserm, Laboratoire de Virologie, IAME, UMR 1137, Hôpital Bichat, Sorbonne Paris Cité, Université Paris Diderot, AP–HP, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Inserm, Laboratoire de Virologie, IAME, UMR 1137, Hôpital Bichat, Sorbonne Paris Cité, Université Paris Diderot, AP–HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Visseaux, B" sort="Visseaux, B" uniqKey="Visseaux B" first="B." last="Visseaux">B. Visseaux</name><affiliation wicri:level="3"><nlm:aff id="aff0010">Inserm, Laboratoire de Virologie, IAME, UMR 1137, Hôpital Bichat, Sorbonne Paris Cité, Université Paris Diderot, AP–HP, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Inserm, Laboratoire de Virologie, IAME, UMR 1137, Hôpital Bichat, Sorbonne Paris Cité, Université Paris Diderot, AP–HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author></analytic><series><title level="j">Medecine et Maladies Infectieuses</title><idno type="ISSN">0399-077X</idno><idno type="eISSN">1769-6690</idno><imprint><date when="2019">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Highlights</title><p><list list-type="simple" id="lis0005"><list-item id="lsti0005"><label>•</label><p id="par0005">MERS-CoV was first detected in June 2012 in Saudi Arabia.</p></list-item><list-item id="lsti0010"><label>•</label><p id="par0010">On October 16, 2018, 2260 cases and 803 related deaths had been reported in 27 countries.</p></list-item><list-item id="lsti0015"><label>•</label><p id="par0015">Although this emerging virus seems unlikely to become endemic in humans, it is still present and has not disappeared rapidly in less than 2 years like the SARS coronavirus.</p></list-item><list-item id="lsti0020"><label>•</label><p id="par0020">In this review, we discuss the main findings about the origin, emergence and virological characteristics of this virus, as well as preventive measures, the typical clinical picture, and currently available therapeutic options.</p></list-item></list></p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Zaki, A M" uniqKey="Zaki A">A.M. 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<front><journal-meta><journal-id journal-id-type="nlm-ta">Med Mal Infect</journal-id><journal-id journal-id-type="iso-abbrev">Med Mal Infect</journal-id><journal-title-group><journal-title>Medecine et Maladies Infectieuses</journal-title></journal-title-group><issn pub-type="ppub">0399-077X</issn><issn pub-type="epub">1769-6690</issn><publisher><publisher-name>Elsevier Masson SAS.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">31727466</article-id><article-id pub-id-type="pmc">7125975</article-id><article-id pub-id-type="publisher-id">S0399-077X(19)31054-6</article-id><article-id pub-id-type="doi">10.1016/j.medmal.2019.10.004</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Focus on Middle East respiratory syndrome coronavirus (MERS-CoV)</article-title></title-group><contrib-group><contrib contrib-type="author" id="aut0005"><name><surname>Bleibtreu</surname><given-names>A.</given-names></name><xref rid="aff0005" ref-type="aff">a</xref></contrib><contrib contrib-type="author" id="aut0010"><name><surname>Bertine</surname><given-names>M.</given-names></name><xref rid="aff0010" ref-type="aff">b</xref></contrib><contrib contrib-type="author" id="aut0015"><name><surname>Bertin</surname><given-names>C.</given-names></name><xref rid="aff0005" ref-type="aff">a</xref></contrib><contrib contrib-type="author" id="aut0020"><name><surname>Houhou-Fidouh</surname><given-names>N.</given-names></name><xref rid="aff0010" ref-type="aff">b</xref></contrib><contrib contrib-type="author" id="aut0025"><name><surname>Visseaux</surname><given-names>B.</given-names></name><email>benoit.visseaux@aphp.fr</email><xref rid="aff0010" ref-type="aff">b</xref><xref rid="cor0005" ref-type="corresp">*</xref></contrib></contrib-group><aff id="aff0005"><label>a</label>Service des maladies infectieuses et tropicales, hôpitaux universitaires Pitié-Salpêtrière Charles Foix, AP–HP, Paris, France</aff><aff id="aff0010"><label>b</label>Inserm, Laboratoire de Virologie, IAME, UMR 1137, Hôpital Bichat, Sorbonne Paris Cité, Université Paris Diderot, AP–HP, Paris, France</aff><author-notes><corresp id="cor0005"><label>⁎</label>Corresponding author. <email>benoit.visseaux@aphp.fr</email></corresp></author-notes><pub-date pub-type="pmc-release"><day>11</day><month>11</month><year>2019</year></pub-date><pmc-comment> PMC Release delay is 0 months and 0 days and was based on .</pmc-comment>
<pub-date pub-type="epub"><day>11</day><month>11</month><year>2019</year></pub-date><elocation-id></elocation-id><history><date date-type="received"><day>16</day><month>9</month><year>2018</year></date><date date-type="rev-recd"><day>22</day><month>10</month><year>2018</year></date><date date-type="accepted"><day>8</day><month>10</month><year>2019</year></date></history><permissions><copyright-statement>© 2019 Elsevier Masson SAS. All rights reserved.</copyright-statement><copyright-year>2019</copyright-year><copyright-holder>Elsevier Masson SAS</copyright-holder><license><license-p>Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.</license-p></license></permissions><abstract abstract-type="author-highlights" id="abs0005"><title>Highlights</title><p><list list-type="simple" id="lis0005"><list-item id="lsti0005"><label>•</label><p id="par0005">MERS-CoV was first detected in June 2012 in Saudi Arabia.</p></list-item><list-item id="lsti0010"><label>•</label><p id="par0010">On October 16, 2018, 2260 cases and 803 related deaths had been reported in 27 countries.</p></list-item><list-item id="lsti0015"><label>•</label><p id="par0015">Although this emerging virus seems unlikely to become endemic in humans, it is still present and has not disappeared rapidly in less than 2 years like the SARS coronavirus.</p></list-item><list-item id="lsti0020"><label>•</label><p id="par0020">In this review, we discuss the main findings about the origin, emergence and virological characteristics of this virus, as well as preventive measures, the typical clinical picture, and currently available therapeutic options.</p></list-item></list></p></abstract><abstract id="abs0015"><p>Since the first case of human infection by the Middle East respiratory syndrome coronavirus (MERS-CoV) in Saudi Arabia in June 2012, more than 2260 cases of confirmed MERS-CoV infection and 803 related deaths have been reported since the 16th of October 2018. The vast majority of these cases (71%) were reported in Saudi Arabia but the epidemic has now spread to 27 countries and has not ceased 6 years later, unlike SARS-CoV that disappeared a little less than 2 years after emerging. Due to the high fatality rate observed in MERS-CoV infected patients (36%), much effort has been put into understanding the origin and pathophysiology of this novel coronavirus to prevent it from becoming endemic in humans. This review focuses in particular on the origin, epidemiology and clinical manifestations of MERS-CoV, as well as the diagnosis and treatment of infected patients. The experience gained over recent years on how to manage the different risks related to this kind of epidemic will be key to being prepared for future outbreaks of communicable disease.</p></abstract><trans-abstract xml:lang="fr"><title>Résumé</title><p>Depuis le premier cas d’infection liée au <italic>Middle East Respiratory Syndrome – Coronavirus</italic> (MERS-CoV), détecté en Arabie Saoudite en juin 2012, le MERS-CoV a donné lieu, au 16 octobre 2018, à plus de 2260 cas d’infections confirmées et à 803 décès. La grande majorité des cas (71 %) ont été déclarés en Arabie Saoudite mais l’épidémie a depuis touché 27 pays et n’est toujours pas enrayée 6 ans après son émergence, contrairement au SRAS-CoV qui a disparu un peu moins de deux ans après sa première détection. En raison du taux important de décès observé parmi les patients infectés par le MERS-CoV (36 %), beaucoup d’efforts ont été déployés pour comprendre l’origine et la physiopathologie de ce nouveau coronavirus ainsi que pour lutter contre une éventuelle installation endémique de ce virus au sein de la population humaine. Cette revue s’attache plus particulièrement à retracer l’origine et l’épidémiologie du MERS-CoV à décrire la clinique observée chez les patients ainsi que la prise en charge diagnostique et thérapeutique des patients infectés. L’expérience acquise au cours des dernières années dans la gestion des différents risques liés à ce type d’épidémie est importante pour pouvoir faire face à la prochaine émergence d’infection transmissible.</p></trans-abstract><kwd-group id="kwd0005"><title>Keywords</title><kwd>Emerging disease</kwd><kwd>MERS-CoV</kwd><kwd>Coronavirus</kwd><kwd>Pneumonia</kwd></kwd-group><kwd-group xml:lang="fr" id="kwd0010"><title>Mots clés</title><kwd>Maladies émergentes</kwd><kwd>MERS-CoV</kwd><kwd>Coronavirus</kwd><kwd>Pneumonie</kwd></kwd-group></article-meta></front></pmc><affiliations><list><country><li>France</li></country><region><li>Île-de-France</li></region><settlement><li>Paris</li></settlement></list><tree><country name="France"><region name="Île-de-France"><name sortKey="Bleibtreu, A" sort="Bleibtreu, A" uniqKey="Bleibtreu A" first="A." last="Bleibtreu">A. Bleibtreu</name></region><name sortKey="Bertin, C" sort="Bertin, C" uniqKey="Bertin C" first="C." last="Bertin">C. Bertin</name><name sortKey="Bertine, M" sort="Bertine, M" uniqKey="Bertine M" first="M." last="Bertine">M. Bertine</name><name sortKey="Houhou Fidouh, N" sort="Houhou Fidouh, N" uniqKey="Houhou Fidouh N" first="N." last="Houhou-Fidouh">N. Houhou-Fidouh</name><name sortKey="Visseaux, B" sort="Visseaux, B" uniqKey="Visseaux B" first="B." last="Visseaux">B. Visseaux</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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