Identification of a Promiscuous Epitope Peptide Derived From HSP70
Identifieur interne : 000280 ( Pmc/Checkpoint ); précédent : 000279; suivant : 000281Identification of a Promiscuous Epitope Peptide Derived From HSP70
Auteurs : Hiroto Matsui ; Shoichi Hazama ; Koji Tamada ; Keiko Udaka ; Atsushi Irie ; Yasuharu Nishimura ; Tomoya Miyakawa [Japon] ; Shun Doi [Japon] ; Masao Nakajima ; Shinsuke Kanekiyo ; Yukio Tokumitsu ; Yoshitaro Shindo ; Shinobu Tomochika ; Shin Yoshida ; Michihisa Iida ; Nobuaki Suzuki ; Shigeru Takeda ; Shigeru Yamamoto ; Shigefumi Yoshino ; Tomio Ueno [Japon] ; Hiroaki NaganoSource :
- Journal of Immunotherapy (Hagerstown, Md. : 1997) [ 1524-9557 ] ; 2019.
Abstract
Supplemental Digital Content is available in the text.
Url:
DOI: 10.1097/CJI.0000000000000274
PubMed: 31398179
PubMed Central: 6727952
Affiliations:
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Medicine</wicri:noCountry></affiliation></author><author><name sortKey="Udaka, Keiko" sort="Udaka, Keiko" uniqKey="Udaka K" first="Keiko" last="Udaka">Keiko Udaka</name><affiliation><nlm:aff id="aff5">Department of Immunology, Kochi Medical School, Kochi</nlm:aff><wicri:noCountry code="subfield">Kochi</wicri:noCountry></affiliation></author><author><name sortKey="Irie, Atsushi" sort="Irie, Atsushi" uniqKey="Irie A" first="Atsushi" last="Irie">Atsushi Irie</name><affiliation><nlm:aff id="aff6">Department of Immunogenetics, Graduate School of Medical Sciences, Kumamoto University, Kumamoto</nlm:aff><wicri:noCountry code="subfield">Kumamoto</wicri:noCountry></affiliation></author><author><name sortKey="Nishimura, Yasuharu" sort="Nishimura, Yasuharu" uniqKey="Nishimura Y" first="Yasuharu" last="Nishimura">Yasuharu Nishimura</name><affiliation><nlm:aff id="aff6">Department of Immunogenetics, Graduate School of Medical Sciences, Kumamoto University, Kumamoto</nlm:aff><wicri:noCountry 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first="Shin" last="Yoshida">Shin Yoshida</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Iida, Michihisa" sort="Iida, Michihisa" uniqKey="Iida M" first="Michihisa" last="Iida">Michihisa Iida</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Suzuki, Nobuaki" sort="Suzuki, Nobuaki" uniqKey="Suzuki N" first="Nobuaki" last="Suzuki">Nobuaki Suzuki</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Takeda, Shigeru" sort="Takeda, Shigeru" uniqKey="Takeda S" first="Shigeru" last="Takeda">Shigeru Takeda</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Yamamoto, Shigeru" sort="Yamamoto, Shigeru" uniqKey="Yamamoto S" first="Shigeru" last="Yamamoto">Shigeru Yamamoto</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Yoshino, Shigefumi" sort="Yoshino, Shigefumi" uniqKey="Yoshino S" first="Shigefumi" last="Yoshino">Shigefumi Yoshino</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation><affiliation><nlm:aff id="aff4">Yamaguchi University Hospital Cancer Center, Yamaguchi</nlm:aff><wicri:noCountry code="subfield">Yamaguchi</wicri:noCountry></affiliation></author><author><name sortKey="Ueno, Tomio" sort="Ueno, Tomio" uniqKey="Ueno T" first="Tomio" last="Ueno">Tomio Ueno</name><affiliation wicri:level="1"><nlm:aff id="aff8">Department of Digestive Surgery, Kawasaki Medical School, Kurashiki, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Digestive Surgery, Kawasaki Medical School, Kurashiki</wicri:regionArea><wicri:noRegion>Kurashiki</wicri:noRegion></affiliation></author><author><name sortKey="Nagano, Hiroaki" sort="Nagano, Hiroaki" uniqKey="Nagano H" first="Hiroaki" last="Nagano">Hiroaki Nagano</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">31398179</idno><idno type="pmc">6727952</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6727952</idno><idno type="RBID">PMC:6727952</idno><idno type="doi">10.1097/CJI.0000000000000274</idno><date when="2019">2019</date><idno type="wicri:Area/Pmc/Corpus">000E15</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000E15</idno><idno type="wicri:Area/Pmc/Curation">000E15</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000E15</idno><idno type="wicri:Area/Pmc/Checkpoint">000280</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000280</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Identification of a Promiscuous Epitope Peptide Derived From HSP70</title><author><name sortKey="Matsui, Hiroto" sort="Matsui, Hiroto" uniqKey="Matsui H" first="Hiroto" last="Matsui">Hiroto Matsui</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Hazama, Shoichi" sort="Hazama, Shoichi" uniqKey="Hazama S" first="Shoichi" last="Hazama">Shoichi Hazama</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation><affiliation><nlm:aff id="aff3">Translational Research and Developmental Therapeutics against Cancer</nlm:aff></affiliation></author><author><name sortKey="Tamada, Koji" sort="Tamada, Koji" uniqKey="Tamada K" first="Koji" last="Tamada">Koji Tamada</name><affiliation><nlm:aff id="aff2">Immunology, Yamaguchi University Graduate School of Medicine</nlm:aff><wicri:noCountry code="subfield">Yamaguchi University Graduate School of Medicine</wicri:noCountry></affiliation></author><author><name sortKey="Udaka, Keiko" sort="Udaka, Keiko" uniqKey="Udaka K" first="Keiko" last="Udaka">Keiko Udaka</name><affiliation><nlm:aff id="aff5">Department of Immunology, Kochi Medical School, Kochi</nlm:aff><wicri:noCountry code="subfield">Kochi</wicri:noCountry></affiliation></author><author><name sortKey="Irie, Atsushi" sort="Irie, Atsushi" uniqKey="Irie A" first="Atsushi" last="Irie">Atsushi Irie</name><affiliation><nlm:aff id="aff6">Department of Immunogenetics, Graduate School of Medical Sciences, Kumamoto University, Kumamoto</nlm:aff><wicri:noCountry code="subfield">Kumamoto</wicri:noCountry></affiliation></author><author><name sortKey="Nishimura, Yasuharu" sort="Nishimura, Yasuharu" uniqKey="Nishimura Y" first="Yasuharu" last="Nishimura">Yasuharu Nishimura</name><affiliation><nlm:aff id="aff6">Department of Immunogenetics, Graduate School of Medical Sciences, Kumamoto University, Kumamoto</nlm:aff><wicri:noCountry code="subfield">Kumamoto</wicri:noCountry></affiliation></author><author><name sortKey="Miyakawa, Tomoya" sort="Miyakawa, Tomoya" uniqKey="Miyakawa T" first="Tomoya" last="Miyakawa">Tomoya Miyakawa</name><affiliation wicri:level="3"><nlm:aff id="aff7">NEC Corporation, 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id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Tokumitsu, Yukio" sort="Tokumitsu, Yukio" uniqKey="Tokumitsu Y" first="Yukio" last="Tokumitsu">Yukio Tokumitsu</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Shindo, Yoshitaro" sort="Shindo, Yoshitaro" uniqKey="Shindo Y" first="Yoshitaro" last="Shindo">Yoshitaro Shindo</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Tomochika, Shinobu" sort="Tomochika, Shinobu" uniqKey="Tomochika S" first="Shinobu" last="Tomochika">Shinobu Tomochika</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Yoshida, Shin" sort="Yoshida, Shin" uniqKey="Yoshida S" first="Shin" last="Yoshida">Shin Yoshida</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Iida, Michihisa" sort="Iida, Michihisa" uniqKey="Iida M" first="Michihisa" last="Iida">Michihisa 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K">K Akahoshi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Takashima, M" uniqKey="Takashima M">M Takashima</name></author><author><name sortKey="Kuramitsu, Y" uniqKey="Kuramitsu Y">Y Kuramitsu</name></author><author><name sortKey="Yokoyama, Y" uniqKey="Yokoyama Y">Y Yokoyama</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yoshida, S" uniqKey="Yoshida S">S Yoshida</name></author><author><name sortKey="Hazama, S" uniqKey="Hazama S">S Hazama</name></author><author><name sortKey="Tokuno, K" uniqKey="Tokuno K">K Tokuno</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Maeda, Y" uniqKey="Maeda Y">Y Maeda</name></author><author><name sortKey="Yoshimura, K" uniqKey="Yoshimura K">K Yoshimura</name></author><author><name sortKey="Matsui, H" uniqKey="Matsui H">H Matsui</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Udaka, K" uniqKey="Udaka K">K Udaka</name></author><author><name sortKey="Mamitsuka, H" uniqKey="Mamitsuka H">H Mamitsuka</name></author><author><name sortKey="Nakaseko, Y" uniqKey="Nakaseko Y">Y Nakaseko</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Imanishi, T" uniqKey="Imanishi T">T Imanishi</name></author><author><name sortKey="Akaza, T" uniqKey="Akaza T">T Akaza</name></author><author><name sortKey="Kimura, A" uniqKey="Kimura A">A Kimura</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Browning, M" uniqKey="Browning M">M Browning</name></author><author><name sortKey="Krausa, P" uniqKey="Krausa P">P Krausa</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ikeda Moore, Y" uniqKey="Ikeda Moore Y">Y Ikeda-Moore</name></author><author><name sortKey="Tomiyama, H" uniqKey="Tomiyama H">H Tomiyama</name></author><author><name sortKey="Miwa, K" uniqKey="Miwa K">K Miwa</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tsomides, Tj" uniqKey="Tsomides T">TJ Tsomides</name></author><author><name sortKey="Aldovini, A" uniqKey="Aldovini A">A Aldovini</name></author><author><name sortKey="Johnson, Rp" uniqKey="Johnson R">RP Johnson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kantakamalakul, W" uniqKey="Kantakamalakul W">W Kantakamalakul</name></author><author><name sortKey="De Souza, M" uniqKey="De Souza M">M de Souza</name></author><author><name sortKey="Bejrachandra, S" uniqKey="Bejrachandra S">S Bejrachandra</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zeh, Hj" uniqKey="Zeh H">HJ Zeh</name></author><author><name sortKey="Leder, Gh" uniqKey="Leder G">GH Leder</name></author><author><name sortKey="Lotze, Mt" uniqKey="Lotze M">MT Lotze</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tahara, T" uniqKey="Tahara T">T Tahara</name></author><author><name sortKey="Yang, Sy" uniqKey="Yang S">SY Yang</name></author><author><name sortKey="Khan, R" uniqKey="Khan R">R Khan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Udaka, K" uniqKey="Udaka K">K Udaka</name></author><author><name sortKey="Wiesmuller, Kh" uniqKey="Wiesmuller K">KH Wiesmuller</name></author><author><name sortKey="Kienle, S" uniqKey="Kienle S">S Kienle</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Erskine, Cl" uniqKey="Erskine C">CL Erskine</name></author><author><name sortKey="Henle, Am" uniqKey="Henle A">AM Henle</name></author><author><name sortKey="Knutson, Kl" uniqKey="Knutson K">KL Knutson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kano, Y" uniqKey="Kano Y">Y Kano</name></author><author><name sortKey="Iguchi, T" uniqKey="Iguchi T">T Iguchi</name></author><author><name sortKey="Matsui, H" uniqKey="Matsui H">H Matsui</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tokunaga, K" uniqKey="Tokunaga K">K Tokunaga</name></author><author><name sortKey="Ishikawa, Y" uniqKey="Ishikawa Y">Y Ishikawa</name></author><author><name sortKey="Ogawa, A" uniqKey="Ogawa A">A Ogawa</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Menez Jamet, J" uniqKey="Menez Jamet J">J Menez-Jamet</name></author><author><name sortKey="Gallou, C" uniqKey="Gallou C">C Gallou</name></author><author><name sortKey="Rougeot, A" uniqKey="Rougeot A">A Rougeot</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sidney, J" uniqKey="Sidney J">J Sidney</name></author><author><name sortKey="Southwood, S" uniqKey="Southwood S">S Southwood</name></author><author><name sortKey="Mann, Dl" uniqKey="Mann D">DL Mann</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhang, Hg" uniqKey="Zhang H">HG Zhang</name></author><author><name sortKey="Pang, Xw" uniqKey="Pang X">XW Pang</name></author><author><name sortKey="Shang, Xy" uniqKey="Shang X">XY Shang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cerignoli, F" uniqKey="Cerignoli F">F Cerignoli</name></author><author><name sortKey="Abassi, Ya" uniqKey="Abassi Y">YA Abassi</name></author><author><name sortKey="Lamarche, Bj" uniqKey="Lamarche B">BJ Lamarche</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Banday, Ah" uniqKey="Banday A">AH Banday</name></author><author><name sortKey="Jeelani, S" uniqKey="Jeelani S">S Jeelani</name></author><author><name sortKey="Hruby, Vj" uniqKey="Hruby V">VJ Hruby</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kissick, Ht" uniqKey="Kissick H">HT Kissick</name></author><author><name sortKey="Sanda, Mg" uniqKey="Sanda M">MG Sanda</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rosenberg, Sa" uniqKey="Rosenberg S">SA Rosenberg</name></author><author><name sortKey="Yang, Jc" uniqKey="Yang J">JC Yang</name></author><author><name sortKey="Restifo, Np" uniqKey="Restifo N">NP Restifo</name></author></analytic></biblStruct></listBibl></div1></back></TEI><pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">J Immunother</journal-id><journal-id journal-id-type="iso-abbrev">J. Immunother</journal-id><journal-id journal-id-type="publisher-id">CJI</journal-id><journal-title-group><journal-title>Journal of Immunotherapy (Hagerstown, Md. : 1997)</journal-title></journal-title-group><issn pub-type="ppub">1524-9557</issn><issn pub-type="epub">1537-4513</issn><publisher><publisher-name>Lippincott Williams & Wilkins</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">31398179</article-id><article-id pub-id-type="pmc">6727952</article-id><article-id pub-id-type="doi">10.1097/CJI.0000000000000274</article-id><article-id pub-id-type="art-access-id">00002</article-id><article-categories><subj-group subj-group-type="heading"><subject>Basic Studies</subject></subj-group></article-categories><title-group><article-title>Identification of a Promiscuous Epitope Peptide Derived From HSP70</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Matsui</surname><given-names>Hiroto</given-names></name><xref ref-type="aff" rid="aff1">*</xref></contrib><contrib contrib-type="author"><name><surname>Hazama</surname><given-names>Shoichi</given-names></name><xref ref-type="aff" rid="aff1">*</xref><xref ref-type="aff" rid="aff3">†</xref></contrib><contrib contrib-type="author"><name><surname>Tamada</surname><given-names>Koji</given-names></name><xref ref-type="aff" rid="aff2">‡</xref></contrib><contrib contrib-type="author"><name><surname>Udaka</surname><given-names>Keiko</given-names></name><xref ref-type="aff" rid="aff5">§</xref></contrib><contrib contrib-type="author"><name><surname>Irie</surname><given-names>Atsushi</given-names></name><xref ref-type="aff" rid="aff6">∥</xref></contrib><contrib contrib-type="author"><name><surname>Nishimura</surname><given-names>Yasuharu</given-names></name><xref ref-type="aff" rid="aff6">∥</xref></contrib><contrib contrib-type="author"><name><surname>Miyakawa</surname><given-names>Tomoya</given-names></name><xref ref-type="aff" rid="aff7">¶</xref></contrib><contrib contrib-type="author"><name><surname>Doi</surname><given-names>Shun</given-names></name><xref ref-type="aff" rid="aff7">¶</xref></contrib><contrib contrib-type="author"><name><surname>Nakajima</surname><given-names>Masao</given-names></name><xref ref-type="aff" rid="aff1">*</xref></contrib><contrib contrib-type="author"><name><surname>Kanekiyo</surname><given-names>Shinsuke</given-names></name><xref ref-type="aff" rid="aff1">*</xref></contrib><contrib contrib-type="author"><name><surname>Tokumitsu</surname><given-names>Yukio</given-names></name><xref ref-type="aff" rid="aff1">*</xref></contrib><contrib contrib-type="author"><name><surname>Shindo</surname><given-names>Yoshitaro</given-names></name><xref ref-type="aff" rid="aff1">*</xref></contrib><contrib contrib-type="author"><name><surname>Tomochika</surname><given-names>Shinobu</given-names></name><xref ref-type="aff" rid="aff1">*</xref></contrib><contrib contrib-type="author"><name><surname>Yoshida</surname><given-names>Shin</given-names></name><xref ref-type="aff" rid="aff1">*</xref></contrib><contrib contrib-type="author"><name><surname>Iida</surname><given-names>Michihisa</given-names></name><xref ref-type="aff" rid="aff1">*</xref></contrib><contrib contrib-type="author"><name><surname>Suzuki</surname><given-names>Nobuaki</given-names></name><xref ref-type="aff" rid="aff1">*</xref></contrib><contrib contrib-type="author"><name><surname>Takeda</surname><given-names>Shigeru</given-names></name><xref ref-type="aff" rid="aff1">*</xref></contrib><contrib contrib-type="author"><name><surname>Yamamoto</surname><given-names>Shigeru</given-names></name><xref ref-type="aff" rid="aff1">*</xref></contrib><contrib contrib-type="author"><name><surname>Yoshino</surname><given-names>Shigefumi</given-names></name><xref ref-type="aff" rid="aff1">*</xref><xref ref-type="aff" rid="aff4">#</xref></contrib><contrib contrib-type="author"><name><surname>Ueno</surname><given-names>Tomio</given-names></name><xref ref-type="aff" rid="aff8">**</xref></contrib><contrib contrib-type="author" corresp="yes"><name><surname>Nagano</surname><given-names>Hiroaki</given-names></name><xref ref-type="aff" rid="aff1">*</xref></contrib></contrib-group><aff id="aff1">Departments of<label>*</label>Gastroenterological, Breast, and Endocrine Surgery</aff><aff id="aff3"><label>†</label>Translational Research and Developmental Therapeutics against Cancer</aff><aff id="aff2"><label>‡</label>Immunology, Yamaguchi University Graduate School of Medicine</aff><aff id="aff4"><label>#</label>Yamaguchi University Hospital Cancer Center, Yamaguchi</aff><aff id="aff5"><label>§</label>Department of Immunology, Kochi Medical School, Kochi</aff><aff id="aff6"><label>∥</label>Department of Immunogenetics, Graduate School of Medical Sciences, Kumamoto University, Kumamoto</aff><aff id="aff7"><label>¶</label>NEC Corporation, Tokyo</aff><aff id="aff8"><label>**</label>Department of Digestive Surgery, Kawasaki Medical School, Kurashiki, Japan</aff><author-notes><corresp>Reprints: Hiroaki Nagano, Department of Gastroenterological, Breast and Endocrine Surgery, Yamaguchi University Graduate School of Medicine, 1-1-1 Minami-Kogushi, Ube 755-8505, Yamaguchi Prefecture, Japan (e-mail: <email>hnagano@yamaguchi-u.ac.jp</email>).</corresp></author-notes><pub-date pub-type="ppub"><month>9</month><year>2019</year></pub-date><pub-date pub-type="epub"><day>05</day><month>6</month><year>2019</year></pub-date><volume>42</volume><issue>7</issue><fpage>244</fpage><lpage>250</lpage><history><date date-type="received"><day>2</day><month>2</month><year>2019</year></date><date date-type="accepted"><day>18</day><month>4</month><year>2019</year></date></history><permissions><copyright-statement>Copyright © 2019 The Author(s). Published by Wolters Kluwer Health, Inc.</copyright-statement><copyright-year>2019</copyright-year><license license-type="open-access"><license-p>This is an open-access article distributed under the terms of the <ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by-nc-nd/4.0/">Creative Commons Attribution-Non Commercial-No Derivatives License 4.0</ext-link> (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. <ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by-nc-nd/4.0/">http://creativecommons.org/licenses/by-nc-nd/4.0/</ext-link></license-p></license></permissions><self-uri xlink:type="simple" xlink:href="cji-42-244.pdf"></self-uri><abstract abstract-type="toc"><p>Supplemental Digital Content is available in the text.</p></abstract><abstract><p>We previously found that heat-shock protein 70 (HSP70) is expressed on hepatocellular carcinoma cells and developed an HSP70 mRNA-transfected dendritic cell therapy for treating unresectable or recurrent hepatocellular carcinoma. The phase I trial was completed successfully. The purpose of this study is to identify a promiscuous epitope peptide derived from HSP70 for the purpose of developing a novel cancer peptide vaccine. Using a computational algorithm to analyze the specificity of previously reported major histocompatibility complex class I–binding peptides, we selected candidates that bound to >2 of the 3 HLA types. Twenty-nine HSP70-derived peptides (9-mers) that bound to HLA-class I was selected. The peptides were prioritized based on the results of peptide binding experiments. Using dendritic cells stimulated with the candidate peptide described previously as stimulators and CD8<sup>+</sup> T cells as effectors, an ELISPOT assay was performed. Cytotoxicity of CD8 lymphocytes stimulated with the candidate peptides toward HSP70-expressing cancer cells was analyzed using an xCELLigence System. Peptides were administered to HLA-A 24 transgenic mice as vaccines, and peptide-specific T-cell induction was measured in vivo. We identified a multi-HLA-class I–binding epitope peptide that bound to HLA-A*02:01, *02:06, and *24:02 in vitro using an interferon-γ ELISPOT immune response induction assay. Cytotoxicity was confirmed in vitro, and safety and immune response induction were confirmed in vivo using HLA-A 24 transgenic mice. Our study demonstrated that the promiscuous HSP70-derived peptide is applicable to cancer immunotherapy in patients with HLA-A*24:02-positive, *02:01-positive, and *02:06-positive HSP70-expressing cancers.</p></abstract><kwd-group><title>Key Words:</title><kwd>epitope peptide</kwd><kwd>tumor-associated antigen</kwd><kwd>immunotherapy</kwd><kwd>heat-shock protein 70</kwd><kwd>cancer vaccine</kwd></kwd-group><custom-meta-group><custom-meta><meta-name>SDC</meta-name><meta-value>T</meta-value></custom-meta><custom-meta><meta-name>OPEN-ACCESS</meta-name><meta-value>TRUE</meta-value></custom-meta></custom-meta-group></article-meta></front></pmc><affiliations><list><country><li>Japon</li></country><region><li>Région de Kantō</li></region><settlement><li>Tokyo</li></settlement></list><tree><noCountry><name sortKey="Hazama, Shoichi" sort="Hazama, Shoichi" uniqKey="Hazama S" first="Shoichi" last="Hazama">Shoichi Hazama</name><name sortKey="Iida, Michihisa" sort="Iida, Michihisa" uniqKey="Iida M" first="Michihisa" last="Iida">Michihisa Iida</name><name sortKey="Irie, Atsushi" sort="Irie, Atsushi" uniqKey="Irie A" first="Atsushi" last="Irie">Atsushi Irie</name><name sortKey="Kanekiyo, Shinsuke" sort="Kanekiyo, Shinsuke" uniqKey="Kanekiyo S" first="Shinsuke" last="Kanekiyo">Shinsuke Kanekiyo</name><name sortKey="Matsui, Hiroto" sort="Matsui, Hiroto" uniqKey="Matsui H" first="Hiroto" last="Matsui">Hiroto Matsui</name><name sortKey="Nagano, Hiroaki" sort="Nagano, Hiroaki" uniqKey="Nagano H" first="Hiroaki" last="Nagano">Hiroaki Nagano</name><name sortKey="Nakajima, Masao" sort="Nakajima, Masao" uniqKey="Nakajima M" first="Masao" last="Nakajima">Masao Nakajima</name><name sortKey="Nishimura, Yasuharu" sort="Nishimura, Yasuharu" uniqKey="Nishimura Y" first="Yasuharu" last="Nishimura">Yasuharu Nishimura</name><name sortKey="Shindo, Yoshitaro" sort="Shindo, Yoshitaro" uniqKey="Shindo Y" first="Yoshitaro" last="Shindo">Yoshitaro Shindo</name><name sortKey="Suzuki, Nobuaki" sort="Suzuki, Nobuaki" uniqKey="Suzuki N" first="Nobuaki" last="Suzuki">Nobuaki Suzuki</name><name sortKey="Takeda, Shigeru" sort="Takeda, Shigeru" uniqKey="Takeda S" first="Shigeru" last="Takeda">Shigeru Takeda</name><name sortKey="Tamada, Koji" sort="Tamada, Koji" uniqKey="Tamada K" first="Koji" last="Tamada">Koji Tamada</name><name sortKey="Tokumitsu, Yukio" sort="Tokumitsu, Yukio" uniqKey="Tokumitsu Y" first="Yukio" last="Tokumitsu">Yukio Tokumitsu</name><name sortKey="Tomochika, Shinobu" sort="Tomochika, Shinobu" uniqKey="Tomochika S" first="Shinobu" last="Tomochika">Shinobu Tomochika</name><name sortKey="Udaka, Keiko" sort="Udaka, Keiko" uniqKey="Udaka K" first="Keiko" last="Udaka">Keiko Udaka</name><name sortKey="Yamamoto, Shigeru" sort="Yamamoto, Shigeru" uniqKey="Yamamoto S" first="Shigeru" last="Yamamoto">Shigeru Yamamoto</name><name sortKey="Yoshida, Shin" sort="Yoshida, Shin" uniqKey="Yoshida S" first="Shin" last="Yoshida">Shin Yoshida</name><name sortKey="Yoshino, Shigefumi" sort="Yoshino, Shigefumi" uniqKey="Yoshino S" first="Shigefumi" last="Yoshino">Shigefumi Yoshino</name></noCountry><country name="Japon"><region name="Région de Kantō"><name sortKey="Miyakawa, Tomoya" sort="Miyakawa, Tomoya" uniqKey="Miyakawa T" first="Tomoya" last="Miyakawa">Tomoya Miyakawa</name></region><name sortKey="Doi, Shun" sort="Doi, Shun" uniqKey="Doi S" first="Shun" last="Doi">Shun Doi</name><name sortKey="Ueno, Tomio" sort="Ueno, Tomio" uniqKey="Ueno T" first="Tomio" last="Ueno">Tomio Ueno</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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