2019-novel Coronavirus severe adult respiratory distress syndrome in two cases in Italy: An uncommon radiological presentation
Identifieur interne : 000130 ( Pmc/Checkpoint ); précédent : 000129; suivant : 0001312019-novel Coronavirus severe adult respiratory distress syndrome in two cases in Italy: An uncommon radiological presentation
Auteurs : Fabrizio Albarello [Italie] ; Elisa Pianura [Italie] ; Federica Di Stefano [Italie] ; Massimo Cristofaro [Italie] ; Ada Petrone [Italie] ; Luisa Marchioni [Italie] ; Claudia Palazzolo [Italie] ; Vincenzo Schininà [Italie] ; Emanuele Nicastri [Italie] ; Nicola Petrosillo [Italie] ; Paolo Campioni [Italie] ; Petersen Eskild [Oman, Danemark, Suisse] ; Alimuddin Zumla [Royaume-Uni] ; Giuseppe Ippolito [Italie]Source :
- International Journal of Infectious Diseases [ 1201-9712 ] ; 2020.
Abstract
The first two patients identified in Italy with COVID-19 presented remarkable imaging findings who progressed in adult respiratory distress syndrome. Uncommon elements such as pleural effusions, a tubular and enlarged appearance of pulmonary vessels with a sudden caliber reduction and mediastinal lymphadenopathy were noted during the follow-up. The vessels appearance during the follow up, resembling a “feeding vessel sign”, could be an early alert radiological sign to predict initial lung deterioration.
Url:
DOI: 10.1016/j.ijid.2020.02.043
PubMed: 32112966
PubMed Central: 7110436
Affiliations:
- Danemark, Italie, Oman, Royaume-Uni, Suisse
- Angleterre, Grand Londres
- Londres
- University College de Londres
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Rome</wicri:noRegion></affiliation></author><author><name sortKey="Campioni, Paolo" sort="Campioni, Paolo" uniqKey="Campioni P" first="Paolo" last="Campioni">Paolo Campioni</name><affiliation wicri:level="1"><nlm:aff id="aff0005">Lazzaro Spallanzani, National Institute for Infectious Diseases – IRCCS, Via Portuense, 292, cap 00148 Rome, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Lazzaro Spallanzani, National Institute for Infectious Diseases – IRCCS, Via Portuense, 292, cap 00148 Rome</wicri:regionArea><wicri:noRegion>cap 00148 Rome</wicri:noRegion></affiliation></author><author><name sortKey="Eskild, Petersen" sort="Eskild, Petersen" uniqKey="Eskild P" first="Petersen" last="Eskild">Petersen Eskild</name><affiliation wicri:level="1"><nlm:aff id="aff0010">Directorate General for Disease Surveillance and Control, Ministry of Health, Muscat, Oman</nlm:aff><country xml:lang="fr">Oman</country><wicri:regionArea>Directorate General for Disease Surveillance and Control, Ministry of Health, Muscat</wicri:regionArea><wicri:noRegion>Muscat</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff0015">Institute for Clinical Medicine, Faculty of Health Science, University of Aarhus, Denmark</nlm:aff><country xml:lang="fr">Danemark</country><wicri:regionArea>Institute for Clinical Medicine, Faculty of Health Science, University of Aarhus</wicri:regionArea><wicri:noRegion>University of Aarhus</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff0020">ESCMID Emerging Infections Task Force, Basel, Switzerland</nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>ESCMID Emerging Infections Task Force, Basel</wicri:regionArea><wicri:noRegion>Basel</wicri:noRegion></affiliation></author><author><name sortKey="Zumla, Alimuddin" sort="Zumla, Alimuddin" uniqKey="Zumla A" first="Alimuddin" last="Zumla">Alimuddin Zumla</name><affiliation wicri:level="4"><nlm:aff id="aff0025">Department of Infection, Division of Infection and Immunity, University College London, and NIHR Biomedical Research Centre, University College London Hospitals NHS Foundation Trust, London, United Kingdom</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Infection, Division of Infection and Immunity, University College London, and NIHR Biomedical Research Centre, University College London Hospitals NHS Foundation Trust, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName><orgName type="university">University College de Londres</orgName></affiliation></author><author><name sortKey="Ippolito, Giuseppe" sort="Ippolito, Giuseppe" uniqKey="Ippolito G" first="Giuseppe" last="Ippolito">Giuseppe Ippolito</name><affiliation wicri:level="1"><nlm:aff id="aff0005">Lazzaro Spallanzani, National Institute for Infectious Diseases – IRCCS, Via Portuense, 292, cap 00148 Rome, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Lazzaro Spallanzani, National Institute for Infectious Diseases – IRCCS, Via Portuense, 292, cap 00148 Rome</wicri:regionArea><wicri:noRegion>cap 00148 Rome</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">32112966</idno><idno type="pmc">7110436</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7110436</idno><idno type="RBID">PMC:7110436</idno><idno type="doi">10.1016/j.ijid.2020.02.043</idno><date when="2020">2020</date><idno type="wicri:Area/Pmc/Corpus">000D61</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000D61</idno><idno type="wicri:Area/Pmc/Curation">000D61</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000D61</idno><idno type="wicri:Area/Pmc/Checkpoint">000130</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000130</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">2019-novel Coronavirus severe adult respiratory distress syndrome in two cases in Italy: An uncommon radiological presentation</title><author><name sortKey="Albarello, Fabrizio" sort="Albarello, Fabrizio" uniqKey="Albarello F" first="Fabrizio" last="Albarello">Fabrizio Albarello</name><affiliation wicri:level="1"><nlm:aff id="aff0005">Lazzaro Spallanzani, National Institute for Infectious Diseases – IRCCS, Via Portuense, 292, cap 00148 Rome, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Lazzaro Spallanzani, National Institute for Infectious Diseases – IRCCS, Via Portuense, 292, cap 00148 Rome</wicri:regionArea><wicri:noRegion>cap 00148 Rome</wicri:noRegion></affiliation></author><author><name sortKey="Pianura, Elisa" sort="Pianura, Elisa" uniqKey="Pianura E" first="Elisa" last="Pianura">Elisa Pianura</name><affiliation wicri:level="1"><nlm:aff id="aff0005">Lazzaro Spallanzani, National Institute for Infectious Diseases – IRCCS, Via Portuense, 292, cap 00148 Rome, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Lazzaro Spallanzani, National Institute for Infectious Diseases – IRCCS, Via Portuense, 292, cap 00148 Rome</wicri:regionArea><wicri:noRegion>cap 00148 Rome</wicri:noRegion></affiliation></author><author><name sortKey="Di Stefano, Federica" sort="Di Stefano, Federica" uniqKey="Di Stefano F" first="Federica" last="Di Stefano">Federica Di Stefano</name><affiliation wicri:level="1"><nlm:aff id="aff0005">Lazzaro Spallanzani, National Institute for Infectious Diseases – IRCCS, Via Portuense, 292, cap 00148 Rome, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Lazzaro Spallanzani, National Institute for Infectious Diseases – IRCCS, Via Portuense, 292, cap 00148 Rome</wicri:regionArea><wicri:noRegion>cap 00148 Rome</wicri:noRegion></affiliation></author><author><name sortKey="Cristofaro, Massimo" sort="Cristofaro, Massimo" uniqKey="Cristofaro M" first="Massimo" last="Cristofaro">Massimo Cristofaro</name><affiliation wicri:level="1"><nlm:aff id="aff0005">Lazzaro Spallanzani, National Institute for Infectious Diseases – IRCCS, Via Portuense, 292, cap 00148 Rome, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Lazzaro Spallanzani, National Institute for Infectious Diseases – IRCCS, Via Portuense, 292, cap 00148 Rome</wicri:regionArea><wicri:noRegion>cap 00148 Rome</wicri:noRegion></affiliation></author><author><name sortKey="Petrone, Ada" sort="Petrone, Ada" uniqKey="Petrone A" first="Ada" last="Petrone">Ada Petrone</name><affiliation wicri:level="1"><nlm:aff id="aff0005">Lazzaro Spallanzani, National Institute for Infectious Diseases – IRCCS, Via Portuense, 292, cap 00148 Rome, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Lazzaro Spallanzani, National Institute for Infectious Diseases – IRCCS, Via Portuense, 292, cap 00148 Rome</wicri:regionArea><wicri:noRegion>cap 00148 Rome</wicri:noRegion></affiliation></author><author><name sortKey="Marchioni, Luisa" sort="Marchioni, Luisa" uniqKey="Marchioni L" first="Luisa" last="Marchioni">Luisa Marchioni</name><affiliation wicri:level="1"><nlm:aff id="aff0005">Lazzaro Spallanzani, National Institute for Infectious Diseases – IRCCS, Via Portuense, 292, cap 00148 Rome, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Lazzaro Spallanzani, National Institute for Infectious Diseases – IRCCS, Via Portuense, 292, cap 00148 Rome</wicri:regionArea><wicri:noRegion>cap 00148 Rome</wicri:noRegion></affiliation></author><author><name sortKey="Palazzolo, Claudia" sort="Palazzolo, Claudia" uniqKey="Palazzolo C" first="Claudia" last="Palazzolo">Claudia Palazzolo</name><affiliation wicri:level="1"><nlm:aff id="aff0005">Lazzaro Spallanzani, National Institute for Infectious Diseases – IRCCS, Via Portuense, 292, cap 00148 Rome, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Lazzaro Spallanzani, National Institute for Infectious Diseases – IRCCS, Via Portuense, 292, cap 00148 Rome</wicri:regionArea><wicri:noRegion>cap 00148 Rome</wicri:noRegion></affiliation></author><author><name sortKey="Schinina, Vincenzo" sort="Schinina, Vincenzo" uniqKey="Schinina V" first="Vincenzo" last="Schininà">Vincenzo Schininà</name><affiliation wicri:level="1"><nlm:aff id="aff0005">Lazzaro Spallanzani, National Institute for Infectious Diseases – IRCCS, Via Portuense, 292, cap 00148 Rome, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Lazzaro Spallanzani, National Institute for Infectious Diseases – IRCCS, Via Portuense, 292, cap 00148 Rome</wicri:regionArea><wicri:noRegion>cap 00148 Rome</wicri:noRegion></affiliation></author><author><name sortKey="Nicastri, Emanuele" sort="Nicastri, Emanuele" uniqKey="Nicastri E" first="Emanuele" last="Nicastri">Emanuele Nicastri</name><affiliation wicri:level="1"><nlm:aff id="aff0005">Lazzaro Spallanzani, National Institute for Infectious Diseases – IRCCS, Via Portuense, 292, cap 00148 Rome, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Lazzaro Spallanzani, National Institute for Infectious Diseases – IRCCS, Via Portuense, 292, cap 00148 Rome</wicri:regionArea><wicri:noRegion>cap 00148 Rome</wicri:noRegion></affiliation></author><author><name sortKey="Petrosillo, Nicola" sort="Petrosillo, Nicola" uniqKey="Petrosillo N" first="Nicola" last="Petrosillo">Nicola Petrosillo</name><affiliation wicri:level="1"><nlm:aff id="aff0005">Lazzaro Spallanzani, National Institute for Infectious Diseases – IRCCS, Via Portuense, 292, cap 00148 Rome, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Lazzaro Spallanzani, National Institute for Infectious Diseases – IRCCS, Via Portuense, 292, cap 00148 Rome</wicri:regionArea><wicri:noRegion>cap 00148 Rome</wicri:noRegion></affiliation></author><author><name sortKey="Campioni, Paolo" sort="Campioni, Paolo" uniqKey="Campioni P" first="Paolo" last="Campioni">Paolo Campioni</name><affiliation wicri:level="1"><nlm:aff id="aff0005">Lazzaro Spallanzani, National Institute for Infectious Diseases – IRCCS, Via Portuense, 292, cap 00148 Rome, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Lazzaro Spallanzani, National Institute for Infectious Diseases – IRCCS, Via Portuense, 292, cap 00148 Rome</wicri:regionArea><wicri:noRegion>cap 00148 Rome</wicri:noRegion></affiliation></author><author><name sortKey="Eskild, Petersen" sort="Eskild, Petersen" uniqKey="Eskild P" first="Petersen" last="Eskild">Petersen Eskild</name><affiliation wicri:level="1"><nlm:aff id="aff0010">Directorate General for Disease Surveillance and Control, Ministry of Health, Muscat, Oman</nlm:aff><country xml:lang="fr">Oman</country><wicri:regionArea>Directorate General for Disease Surveillance and Control, Ministry of Health, Muscat</wicri:regionArea><wicri:noRegion>Muscat</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff0015">Institute for Clinical Medicine, Faculty of Health Science, University of Aarhus, Denmark</nlm:aff><country xml:lang="fr">Danemark</country><wicri:regionArea>Institute for Clinical Medicine, Faculty of Health Science, University of Aarhus</wicri:regionArea><wicri:noRegion>University of Aarhus</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff0020">ESCMID Emerging Infections Task Force, Basel, Switzerland</nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>ESCMID Emerging Infections Task Force, Basel</wicri:regionArea><wicri:noRegion>Basel</wicri:noRegion></affiliation></author><author><name sortKey="Zumla, Alimuddin" sort="Zumla, Alimuddin" uniqKey="Zumla A" first="Alimuddin" last="Zumla">Alimuddin Zumla</name><affiliation wicri:level="4"><nlm:aff id="aff0025">Department of Infection, Division of Infection and Immunity, University College London, and NIHR Biomedical Research Centre, University College London Hospitals NHS Foundation Trust, London, United Kingdom</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Infection, Division of Infection and Immunity, University College London, and NIHR Biomedical Research Centre, University College London Hospitals NHS Foundation Trust, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName><orgName type="university">University College de Londres</orgName></affiliation></author><author><name sortKey="Ippolito, Giuseppe" sort="Ippolito, Giuseppe" uniqKey="Ippolito G" first="Giuseppe" last="Ippolito">Giuseppe Ippolito</name><affiliation wicri:level="1"><nlm:aff id="aff0005">Lazzaro Spallanzani, National Institute for Infectious Diseases – IRCCS, Via Portuense, 292, cap 00148 Rome, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Lazzaro Spallanzani, National Institute for Infectious Diseases – IRCCS, Via Portuense, 292, cap 00148 Rome</wicri:regionArea><wicri:noRegion>cap 00148 Rome</wicri:noRegion></affiliation></author></analytic><series><title level="j">International Journal of Infectious Diseases</title><idno type="ISSN">1201-9712</idno><idno type="eISSN">1878-3511</idno><imprint><date when="2020">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Highlights</title><p><list list-type="simple" id="lis0005"><list-item id="lsti0005"><label>•</label><p id="par0005">The first two patients identified in Italy with COVID-19 presented remarkable imaging findings who progressed in adult respiratory distress syndrome.</p></list-item><list-item id="lsti0010"><label>•</label><p id="par0010">Uncommon elements such as pleural effusions, a tubular and enlarged appearance of pulmonary vessels with a sudden caliber reduction and mediastinal lymphadenopathy were noted during the follow-up.</p></list-item><list-item id="lsti0015"><label>•</label><p id="par0015">The vessels appearance during the follow up, resembling a “feeding vessel sign”, could be an early alert radiological sign to predict initial lung deterioration.</p></list-item></list></p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Chan, J F" uniqKey="Chan J">J.F. 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<front><journal-meta><journal-id journal-id-type="nlm-ta">Int J Infect Dis</journal-id><journal-id journal-id-type="iso-abbrev">Int. J. Infect. Dis</journal-id><journal-title-group><journal-title>International Journal of Infectious Diseases</journal-title></journal-title-group><issn pub-type="ppub">1201-9712</issn><issn pub-type="epub">1878-3511</issn><publisher><publisher-name>The Authors. Published by Elsevier Ltd on behalf of International Society for Infectious Diseases.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">32112966</article-id><article-id pub-id-type="pmc">7110436</article-id><article-id pub-id-type="publisher-id">S1201-9712(20)30101-6</article-id><article-id pub-id-type="doi">10.1016/j.ijid.2020.02.043</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>2019-novel Coronavirus severe adult respiratory distress syndrome in two cases in Italy: An uncommon radiological presentation</article-title></title-group><contrib-group><contrib contrib-type="author" id="aut0005"><name><surname>Albarello</surname><given-names>Fabrizio</given-names></name><xref rid="aff0005" ref-type="aff">a</xref></contrib><contrib contrib-type="author" id="aut0010"><name><surname>Pianura</surname><given-names>Elisa</given-names></name><xref rid="aff0005" ref-type="aff">a</xref></contrib><contrib contrib-type="author" id="aut0015"><name><surname>Di Stefano</surname><given-names>Federica</given-names></name><xref rid="aff0005" ref-type="aff">a</xref></contrib><contrib contrib-type="author" id="aut0020"><name><surname>Cristofaro</surname><given-names>Massimo</given-names></name><xref rid="aff0005" ref-type="aff">a</xref></contrib><contrib contrib-type="author" id="aut0025"><name><surname>Petrone</surname><given-names>Ada</given-names></name><xref rid="aff0005" ref-type="aff">a</xref></contrib><contrib contrib-type="author" id="aut0030"><name><surname>Marchioni</surname><given-names>Luisa</given-names></name><xref rid="aff0005" ref-type="aff">a</xref></contrib><contrib contrib-type="author" id="aut0035"><name><surname>Palazzolo</surname><given-names>Claudia</given-names></name><xref rid="aff0005" ref-type="aff">a</xref></contrib><contrib contrib-type="author" id="aut0040"><name><surname>Schininà</surname><given-names>Vincenzo</given-names></name><email>vincenzo.schinina@inmi.it</email><xref rid="aff0005" ref-type="aff">a</xref><xref rid="cor0005" ref-type="corresp">⁎</xref></contrib><contrib contrib-type="author" id="aut0045"><name><surname>Nicastri</surname><given-names>Emanuele</given-names></name><xref rid="aff0005" ref-type="aff">a</xref></contrib><contrib contrib-type="author" id="aut0050"><name><surname>Petrosillo</surname><given-names>Nicola</given-names></name><xref rid="aff0005" ref-type="aff">a</xref></contrib><contrib contrib-type="author" id="aut0055"><name><surname>Campioni</surname><given-names>Paolo</given-names></name><xref rid="aff0005" ref-type="aff">a</xref></contrib><contrib contrib-type="author" id="aut0060"><name><surname>Eskild</surname><given-names>Petersen</given-names></name><xref rid="aff0010" ref-type="aff">b</xref><xref rid="aff0015" ref-type="aff">c</xref><xref rid="aff0020" ref-type="aff">d</xref></contrib><contrib contrib-type="author" id="aut0065"><name><surname>Zumla</surname><given-names>Alimuddin</given-names></name><xref rid="aff0025" ref-type="aff">e</xref></contrib><contrib contrib-type="author" id="aut0070"><name><surname>Ippolito</surname><given-names>Giuseppe</given-names></name><xref rid="aff0005" ref-type="aff">a</xref></contrib><contrib contrib-type="author"><collab>COVID 19 INMI Study Group<contrib-group><contrib contrib-type="author" id="aut0075"><name><surname>Abbonizio</surname><given-names>Maria Alessandra</given-names></name></contrib><contrib contrib-type="author" id="aut0080"><name><surname>Agrati</surname><given-names>Chiara</given-names></name></contrib><contrib contrib-type="author" id="aut0085"><name><surname>Albarello</surname><given-names>Fabrizio</given-names></name></contrib><contrib contrib-type="author" id="aut0090"><name><surname>Amadei</surname><given-names>Gioia</given-names></name></contrib><contrib contrib-type="author" id="aut0095"><name><surname>Amendola</surname><given-names>Alessandra</given-names></name></contrib><contrib contrib-type="author" id="aut0100"><name><surname>Antonini</surname><given-names>Mario</given-names></name></contrib><contrib contrib-type="author" id="aut0105"><name><surname>Barbaro</surname><given-names>Raffaella</given-names></name></contrib><contrib contrib-type="author" id="aut0110"><name><surname>Bartolini</surname><given-names>Barbara</given-names></name></contrib><contrib contrib-type="author" id="aut0115"><name><surname>Benigni</surname><given-names>Martina</given-names></name></contrib><contrib contrib-type="author" id="aut0120"><name><surname>Bevilacqua</surname><given-names>Nazario</given-names></name></contrib><contrib contrib-type="author" id="aut0125"><name><surname>Bordi</surname><given-names>Licia</given-names></name></contrib><contrib contrib-type="author" id="aut0130"><name><surname>Bordoni</surname><given-names>Veronica</given-names></name></contrib><contrib contrib-type="author" id="aut0135"><name><surname>Branca</surname><given-names>Marta</given-names></name></contrib><contrib contrib-type="author" id="aut0140"><name><surname>Campioni</surname><given-names>Paolo</given-names></name></contrib><contrib contrib-type="author" id="aut0145"><name><surname>Capobianchi</surname><given-names>Maria Rosaria</given-names></name></contrib><contrib contrib-type="author" id="aut0150"><name><surname>Caporale</surname><given-names>Cinzia</given-names></name></contrib><contrib contrib-type="author" id="aut0155"><name><surname>Caravella</surname><given-names>Ilaria</given-names></name></contrib><contrib contrib-type="author" id="aut0160"><name><surname>Carletti</surname><given-names>Fabrizio</given-names></name></contrib><contrib contrib-type="author" id="aut0165"><name><surname>Castilletti</surname><given-names>Concetta</given-names></name></contrib><contrib contrib-type="author" id="aut0170"><name><surname>Chiappini</surname><given-names>Roberta</given-names></name></contrib><contrib contrib-type="author" id="aut0175"><name><surname>Ciaralli</surname><given-names>Carmine</given-names></name></contrib><contrib contrib-type="author" id="aut0180"><name><surname>Colavita</surname><given-names>Francesca</given-names></name></contrib><contrib contrib-type="author" id="aut0185"><name><surname>Corpolongo</surname><given-names>Angela</given-names></name></contrib><contrib contrib-type="author" id="aut0190"><name><surname>Cristofaro</surname><given-names>Massimo</given-names></name></contrib><contrib contrib-type="author" id="aut0195"><name><surname>Curiale</surname><given-names>Salvatore</given-names></name></contrib><contrib contrib-type="author" id="aut0200"><name><surname>D’Abramo</surname><given-names>Alessandra</given-names></name></contrib><contrib contrib-type="author" id="aut0205"><name><surname>Dantimi</surname><given-names>Cristina</given-names></name></contrib><contrib contrib-type="author" id="aut0210"><name><surname>Angelis</surname><given-names>Alessia De</given-names></name></contrib><contrib contrib-type="author" id="aut0215"><name><surname>Angelis</surname><given-names>Giada De</given-names></name></contrib><contrib contrib-type="author" id="aut0220"><name><surname>Lorenzo</surname><given-names>Rachele Di</given-names></name></contrib><contrib contrib-type="author" id="aut0225"><name><surname>Stefano</surname><given-names>Federica Di</given-names></name></contrib><contrib contrib-type="author" id="aut0230"><name><surname>Ferraro</surname><given-names>Federica</given-names></name></contrib><contrib contrib-type="author" id="aut0235"><name><surname>Fiorentini</surname><given-names>Lorena</given-names></name></contrib><contrib contrib-type="author" id="aut0240"><name><surname>Frustaci</surname><given-names>Andrea</given-names></name></contrib><contrib contrib-type="author" id="aut0245"><name><surname>Gallì</surname><given-names>Paola</given-names></name></contrib><contrib contrib-type="author" id="aut0250"><name><surname>Garotto</surname><given-names>Gabriele</given-names></name></contrib><contrib contrib-type="author" id="aut0255"><name><surname>Giancola</surname><given-names>Maria Letizia</given-names></name></contrib><contrib contrib-type="author" id="aut0260"><name><surname>Giansante</surname><given-names>Filippo</given-names></name></contrib><contrib contrib-type="author" id="aut0265"><name><surname>Giombini</surname><given-names>Emanuela</given-names></name></contrib><contrib contrib-type="author" id="aut0270"><name><surname>Greci</surname><given-names>Maria Cristina</given-names></name></contrib><contrib contrib-type="author" id="aut0275"><name><surname>Ippolito</surname><given-names>Giuseppe</given-names></name></contrib><contrib contrib-type="author" id="aut0280"><name><surname>Lalle</surname><given-names>Eleonora</given-names></name></contrib><contrib contrib-type="author" id="aut0285"><name><surname>Lanini</surname><given-names>Simone</given-names></name></contrib><contrib contrib-type="author" id="aut0290"><name><surname>Lapa</surname><given-names>Daniele</given-names></name></contrib><contrib contrib-type="author" id="aut0295"><name><surname>Lepore</surname><given-names>Luciana</given-names></name></contrib><contrib contrib-type="author" id="aut0300"><name><surname>Lucia</surname><given-names>Andrea</given-names></name></contrib><contrib contrib-type="author" id="aut0305"><name><surname>Lufrani</surname><given-names>Franco</given-names></name></contrib><contrib contrib-type="author" id="aut0310"><name><surname>Macchione</surname><given-names>Manuela</given-names></name></contrib><contrib contrib-type="author" id="aut0315"><name><surname>Marani</surname><given-names>Alessandra</given-names></name></contrib><contrib contrib-type="author" id="aut0320"><name><surname>Marchioni</surname><given-names>Luisa</given-names></name></contrib><contrib contrib-type="author" id="aut0325"><name><surname>Mariano</surname><given-names>Andrea</given-names></name></contrib><contrib contrib-type="author" id="aut0330"><name><surname>Marini</surname><given-names>Maria Cristina</given-names></name></contrib><contrib contrib-type="author" id="aut0335"><name><surname>Maritti</surname><given-names>Micaela</given-names></name></contrib><contrib contrib-type="author" id="aut0340"><name><surname>Matusali</surname><given-names>Giulia</given-names></name></contrib><contrib contrib-type="author" id="aut0345"><name><surname>Meschi</surname><given-names>Silvia</given-names></name></contrib><contrib contrib-type="author" id="aut0350"><name><surname>Montaldo</surname><given-names>Francesco Messina Chiara</given-names></name></contrib><contrib contrib-type="author" id="aut0355"><name><surname>Murachelli</surname><given-names>Silvia</given-names></name></contrib><contrib contrib-type="author" id="aut0360"><name><surname>Nicastri</surname><given-names>Emanuele</given-names></name></contrib><contrib contrib-type="author" id="aut0365"><name><surname>Noto</surname><given-names>Roberto</given-names></name></contrib><contrib contrib-type="author" id="aut0370"><name><surname>Palazzolo</surname><given-names>Claudia</given-names></name></contrib><contrib contrib-type="author" id="aut0375"><name><surname>Pallini</surname><given-names>Emanuele</given-names></name></contrib><contrib contrib-type="author" id="aut0380"><name><surname>Passeri</surname><given-names>Virgilio</given-names></name></contrib><contrib contrib-type="author" id="aut0385"><name><surname>Pelliccioni</surname><given-names>Federico</given-names></name></contrib><contrib contrib-type="author" id="aut0390"><name><surname>Petrecchia</surname><given-names>Antonella</given-names></name></contrib><contrib contrib-type="author" id="aut0395"><name><surname>Petrone</surname><given-names>Ada</given-names></name></contrib><contrib contrib-type="author" id="aut0400"><name><surname>Petrosillo</surname><given-names>Nicola</given-names></name></contrib><contrib contrib-type="author" id="aut0405"><name><surname>Pianura</surname><given-names>Elisa</given-names></name></contrib><contrib contrib-type="author" id="aut0410"><name><surname>Pisciotta</surname><given-names>Maria</given-names></name></contrib><contrib contrib-type="author" id="aut0415"><name><surname>Pittalis</surname><given-names>Silvia</given-names></name></contrib><contrib contrib-type="author" id="aut0420"><name><surname>Proietti</surname><given-names>Costanza</given-names></name></contrib><contrib contrib-type="author" id="aut0425"><name><surname>Puro</surname><given-names>Vincenzo</given-names></name></contrib><contrib contrib-type="author" id="aut0430"><name><surname>Rinonapoli</surname><given-names>Gabriele</given-names></name></contrib><contrib contrib-type="author" id="aut0435"><name><surname>Rueca</surname><given-names>Martina</given-names></name></contrib><contrib contrib-type="author" id="aut0440"><name><surname>Sacchi</surname><given-names>Alessandra</given-names></name></contrib><contrib contrib-type="author" id="aut0445"><name><surname>Sanasi</surname><given-names>Francesco</given-names></name></contrib><contrib contrib-type="author" id="aut0450"><name><surname>Santagata</surname><given-names>Carmen</given-names></name></contrib><contrib contrib-type="author" id="aut0455"><name><surname>Scarcia</surname><given-names>Silvana</given-names></name></contrib><contrib contrib-type="author" id="aut0460"><name><surname>Schininà</surname><given-names>Vincenzo</given-names></name></contrib><contrib contrib-type="author" id="aut0465"><name><surname>Scognamiglio</surname><given-names>Paola</given-names></name></contrib><contrib contrib-type="author" id="aut0470"><name><surname>Scorzolini</surname><given-names>Laura</given-names></name></contrib><contrib contrib-type="author" id="aut0475"><name><surname>Stazi</surname><given-names>Giulia</given-names></name></contrib><contrib contrib-type="author" id="aut0480"><name><surname>Vaia</surname><given-names>Francesco</given-names></name></contrib><contrib contrib-type="author" id="aut0485"><name><surname>Vairo</surname><given-names>Francesco</given-names></name></contrib><contrib contrib-type="author" id="aut0490"><name><surname>Valli</surname><given-names>Maria Beatrice</given-names></name></contrib></contrib-group></collab><xref rid="fn0005" ref-type="fn">1</xref></contrib></contrib-group><aff id="aff0005"><label>a</label>Lazzaro Spallanzani, National Institute for Infectious Diseases – IRCCS, Via Portuense, 292, cap 00148 Rome, Italy</aff><aff id="aff0010"><label>b</label>Directorate General for Disease Surveillance and Control, Ministry of Health, Muscat, Oman</aff><aff id="aff0015"><label>c</label>Institute for Clinical Medicine, Faculty of Health Science, University of Aarhus, Denmark</aff><aff id="aff0020"><label>d</label>ESCMID Emerging Infections Task Force, Basel, Switzerland</aff><aff id="aff0025"><label>e</label>Department of Infection, Division of Infection and Immunity, University College London, and NIHR Biomedical Research Centre, University College London Hospitals NHS Foundation Trust, London, United Kingdom</aff><author-notes><corresp id="cor0005"><label>⁎</label>Corresponding author at: Via Portuense, 292, cap 00148, Rome, Italy. <email>vincenzo.schinina@inmi.it</email></corresp><fn id="fn0005"><label>1</label><p id="npar0005">Members of COVID 19 INMI Study Group are listed in <xref rid="sec0060" ref-type="sec">Appendix A</xref>.</p></fn></author-notes><pub-date pub-type="pmc-release"><day>26</day><month>2</month><year>2020</year></pub-date><pmc-comment> PMC Release delay is 0 months and 0 days and was based on .</pmc-comment>
<pub-date pub-type="ppub"><month>4</month><year>2020</year></pub-date><pub-date pub-type="epub"><day>26</day><month>2</month><year>2020</year></pub-date><volume>93</volume><fpage>192</fpage><lpage>197</lpage><history><date date-type="received"><day>14</day><month>2</month><year>2020</year></date><date date-type="rev-recd"><day>19</day><month>2</month><year>2020</year></date><date date-type="accepted"><day>20</day><month>2</month><year>2020</year></date></history><permissions><copyright-statement>© 2020 The Authors</copyright-statement><copyright-year>2020</copyright-year><license><license-p>Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.</license-p></license></permissions><abstract abstract-type="author-highlights" id="abs0005"><title>Highlights</title><p><list list-type="simple" id="lis0005"><list-item id="lsti0005"><label>•</label><p id="par0005">The first two patients identified in Italy with COVID-19 presented remarkable imaging findings who progressed in adult respiratory distress syndrome.</p></list-item><list-item id="lsti0010"><label>•</label><p id="par0010">Uncommon elements such as pleural effusions, a tubular and enlarged appearance of pulmonary vessels with a sudden caliber reduction and mediastinal lymphadenopathy were noted during the follow-up.</p></list-item><list-item id="lsti0015"><label>•</label><p id="par0015">The vessels appearance during the follow up, resembling a “feeding vessel sign”, could be an early alert radiological sign to predict initial lung deterioration.</p></list-item></list></p></abstract><abstract id="abs0010"><sec><title>Introduction</title><p>Several recent case reports have described common early chest imaging findings of lung pathology caused by 2019 novel Coronavirus (SARS-COV2) which appear to be similar to those seen previously in SARS-CoV and MERS-CoV infected patients.</p></sec><sec><title>Objective</title><p>We present some remarkable imaging findings of the first two patients identified in Italy with COVID-19 infection travelling from Wuhan, China. The follow-up with chest X-Rays and CT scans was also included, showing a progressive adult respiratory distress syndrome (ARDS).</p></sec><sec><title>Results</title><p>Moderate to severe progression of the lung infiltrates, with increasing percentage of high-density infiltrates sustained by a bilateral and multi-segmental extension of lung opacities, were seen. During the follow-up, apart from pleural effusions, a tubular and enlarged appearance of pulmonary vessels with a sudden caliber reduction was seen, mainly found in the dichotomic tracts, where the center of a new insurgent pulmonary lesion was seen. It could be an early alert radiological sign to predict initial lung deterioration. Another uncommon element was the presence of mediastinal lymphadenopathy with short-axis oval nodes.</p></sec><sec><title>Conclusions</title><p>Although only two patients have been studied, these findings are consistent with the radiological pattern described in literature. Finally, the pulmonary vessels enlargement in areas where new lung infiltrates develop in the follow-up CT scan, could describe an early predictor radiological sign of lung impairment.</p></sec></abstract><kwd-group id="kwd0005"><title>Keywords</title><kwd>COVID-19</kwd><kwd>SARS-COV2</kwd><kwd>CT-scan</kwd><kwd>Ground glass opacities</kwd><kwd>Crazy-paving</kwd><kwd>Enlarged pulmonary vessels</kwd></kwd-group></article-meta></front></pmc><affiliations><list><country><li>Danemark</li><li>Italie</li><li>Oman</li><li>Royaume-Uni</li><li>Suisse</li></country><region><li>Angleterre</li><li>Grand Londres</li></region><settlement><li>Londres</li></settlement><orgName><li>University College de Londres</li></orgName></list><tree><country name="Italie"><noRegion><name sortKey="Albarello, Fabrizio" sort="Albarello, Fabrizio" uniqKey="Albarello F" first="Fabrizio" last="Albarello">Fabrizio Albarello</name></noRegion><name sortKey="Campioni, Paolo" sort="Campioni, Paolo" uniqKey="Campioni P" first="Paolo" last="Campioni">Paolo Campioni</name><name sortKey="Cristofaro, Massimo" sort="Cristofaro, Massimo" uniqKey="Cristofaro M" first="Massimo" last="Cristofaro">Massimo Cristofaro</name><name sortKey="Di Stefano, Federica" sort="Di Stefano, Federica" uniqKey="Di Stefano F" first="Federica" last="Di Stefano">Federica Di Stefano</name><name sortKey="Ippolito, Giuseppe" sort="Ippolito, Giuseppe" uniqKey="Ippolito G" first="Giuseppe" last="Ippolito">Giuseppe Ippolito</name><name sortKey="Marchioni, Luisa" sort="Marchioni, Luisa" uniqKey="Marchioni L" first="Luisa" last="Marchioni">Luisa Marchioni</name><name sortKey="Nicastri, Emanuele" sort="Nicastri, Emanuele" uniqKey="Nicastri E" first="Emanuele" last="Nicastri">Emanuele Nicastri</name><name sortKey="Palazzolo, Claudia" sort="Palazzolo, Claudia" uniqKey="Palazzolo C" first="Claudia" last="Palazzolo">Claudia Palazzolo</name><name sortKey="Petrone, Ada" sort="Petrone, Ada" uniqKey="Petrone A" first="Ada" last="Petrone">Ada Petrone</name><name sortKey="Petrosillo, Nicola" sort="Petrosillo, Nicola" uniqKey="Petrosillo N" first="Nicola" last="Petrosillo">Nicola Petrosillo</name><name sortKey="Pianura, Elisa" sort="Pianura, Elisa" uniqKey="Pianura E" first="Elisa" last="Pianura">Elisa Pianura</name><name sortKey="Schinina, Vincenzo" sort="Schinina, Vincenzo" uniqKey="Schinina V" first="Vincenzo" last="Schininà">Vincenzo Schininà</name></country><country name="Oman"><noRegion><name sortKey="Eskild, Petersen" sort="Eskild, Petersen" uniqKey="Eskild P" first="Petersen" last="Eskild">Petersen Eskild</name></noRegion></country><country name="Danemark"><noRegion><name sortKey="Eskild, Petersen" sort="Eskild, Petersen" uniqKey="Eskild P" first="Petersen" last="Eskild">Petersen Eskild</name></noRegion></country><country name="Suisse"><noRegion><name sortKey="Eskild, Petersen" sort="Eskild, Petersen" uniqKey="Eskild P" first="Petersen" last="Eskild">Petersen Eskild</name></noRegion></country><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Zumla, Alimuddin" sort="Zumla, Alimuddin" uniqKey="Zumla A" first="Alimuddin" last="Zumla">Alimuddin Zumla</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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