Broad Spectrum Antiviral Agent Niclosamide and Its Therapeutic Potential
Identifieur interne : 000118 ( Pmc/Checkpoint ); précédent : 000117; suivant : 000119Broad Spectrum Antiviral Agent Niclosamide and Its Therapeutic Potential
Auteurs : Jimin Xu ; Pei-Yong Shi [États-Unis] ; Hongmin Li [États-Unis] ; Jia Zhou [États-Unis]Source :
- ACS Infectious Diseases [ 2373-8227 ] ; 2020.
Abstract
The recent outbreak of coronavirus disease 2019 (COVID-19) highlights an urgent need for therapeutics. Through a series of drug repurposing screening campaigns, niclosamide, an FDA-approved anthelminthic drug, was found to be effective against various viral infections with nanomolar to micromolar potency such as SARS-CoV, MERS-CoV, ZIKV, HCV, and human adenovirus, indicating its potential as an antiviral agent. In this brief review, we summarize the broad antiviral activity of niclosamide and highlight its potential clinical use in the treatment of COVID-19.
Url:
DOI: 10.1021/acsinfecdis.0c00052
PubMed: 32125140
PubMed Central: 7098069
Affiliations:
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PMC:7098069Le document en format XML
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<author><name sortKey="Zhou, Jia" sort="Zhou, Jia" uniqKey="Zhou J" first="Jia" last="Zhou">Jia Zhou</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Broad Spectrum Antiviral Agent Niclosamide and Its Therapeutic
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<author><name sortKey="Xu, Jimin" sort="Xu, Jimin" uniqKey="Xu J" first="Jimin" last="Xu">Jimin Xu</name>
<affiliation><nlm:aff id="aff1">Chemical Biology Program, Department of Pharmacology and Toxicology,</nlm:aff>
<wicri:noCountry code="subfield">Department of Pharmacology and Toxicology</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Shi, Pei Yong" sort="Shi, Pei Yong" uniqKey="Shi P" first="Pei-Yong" last="Shi">Pei-Yong Shi</name>
<affiliation><nlm:aff wicri:cut=", and" id="aff1">Department of Biochemistry and Molecular Biology</nlm:aff>
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<affiliation wicri:level="1"><nlm:aff id="aff1">Sealy Center for Structural Biology & Molecular Biophysics,<institution>University of Texas Medical Branch</institution>
, Galveston, Texas 77555,<country>United States</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
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<author><name sortKey="Li, Hongmin" sort="Li, Hongmin" uniqKey="Li H" first="Hongmin" last="Li">Hongmin Li</name>
<affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Wadsworth Center, New York State Department of Health</institution>
, 120 New Scotland Avenue, Albany, New York 12208,<country>United States</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
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<author><name sortKey="Zhou, Jia" sort="Zhou, Jia" uniqKey="Zhou J" first="Jia" last="Zhou">Jia Zhou</name>
<affiliation><nlm:aff id="aff1">Chemical Biology Program, Department of Pharmacology and Toxicology,</nlm:aff>
<wicri:noCountry code="subfield">Department of Pharmacology and Toxicology</wicri:noCountry>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff1">Sealy Center for Structural Biology & Molecular Biophysics,<institution>University of Texas Medical Branch</institution>
, Galveston, Texas 77555,<country>United States</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
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<series><title level="j">ACS Infectious Diseases</title>
<idno type="eISSN">2373-8227</idno>
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<front><div type="abstract" xml:lang="en"><p content-type="toc-graphic"><graphic xlink:href="id0c00052_0003" id="ab-tgr1"></graphic>
</p>
<p>The recent outbreak of coronavirus disease 2019 (COVID-19) highlights an urgent need
for therapeutics. Through a series of drug repurposing screening campaigns, niclosamide,
an FDA-approved anthelminthic drug, was found to be effective against various viral
infections with nanomolar to micromolar potency such as SARS-CoV, MERS-CoV, ZIKV, HCV,
and human adenovirus, indicating its potential as an antiviral agent. In this brief
review, we summarize the broad antiviral activity of niclosamide and highlight its
potential clinical use in the treatment of COVID-19.</p>
</div>
</front>
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</TEI>
<pmc article-type="review-article" xml:lang="EN"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">ACS Infect Dis</journal-id>
<journal-id journal-id-type="iso-abbrev">ACS Infect Dis</journal-id>
<journal-id journal-id-type="publisher-id">id</journal-id>
<journal-id journal-id-type="coden">aidcbc</journal-id>
<journal-title-group><journal-title>ACS Infectious Diseases</journal-title>
</journal-title-group>
<issn pub-type="epub">2373-8227</issn>
<publisher><publisher-name>American Chemical Society</publisher-name>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">32125140</article-id>
<article-id pub-id-type="pmc">7098069</article-id>
<article-id pub-id-type="doi">10.1021/acsinfecdis.0c00052</article-id>
<article-categories><subj-group><subject>Review</subject>
</subj-group>
</article-categories>
<title-group><article-title>Broad Spectrum Antiviral Agent Niclosamide and Its Therapeutic
Potential</article-title>
</title-group>
<contrib-group><contrib contrib-type="author" id="ath1"><name><surname>Xu</surname>
<given-names>Jimin</given-names>
</name>
<xref rid="aff1" ref-type="aff">†</xref>
</contrib>
<contrib contrib-type="author" id="ath2"><name><surname>Shi</surname>
<given-names>Pei-Yong</given-names>
</name>
<xref rid="aff1" ref-type="aff">‡</xref>
<xref rid="aff1" ref-type="aff">§</xref>
</contrib>
<contrib contrib-type="author" id="ath3"><name><surname>Li</surname>
<given-names>Hongmin</given-names>
</name>
<xref rid="aff2" ref-type="aff">∥</xref>
</contrib>
<contrib contrib-type="author" corresp="yes" id="ath4"><name><surname>Zhou</surname>
<given-names>Jia</given-names>
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<xref rid="cor1" ref-type="other">*</xref>
<xref rid="aff1" ref-type="aff">†</xref>
<xref rid="aff1" ref-type="aff">§</xref>
</contrib>
<aff id="aff1"><sup>†</sup>
Chemical Biology Program, Department of Pharmacology and Toxicology,<sup>‡</sup>
Department of Biochemistry and Molecular Biology, and<sup>§</sup>
Sealy Center for Structural Biology & Molecular Biophysics,<institution>University of Texas Medical Branch</institution>
, Galveston, Texas 77555,<country>United States</country>
</aff>
<aff id="aff2"><label>∥</label>
<institution>Wadsworth Center, New York State Department of Health</institution>
, 120 New Scotland Avenue, Albany, New York 12208,<country>United States</country>
</aff>
</contrib-group>
<author-notes><corresp id="cor1"><label>*</label>
E-mail: <email>jizhou@utmb.edu</email>
. Tel: <phone>(409)
772-9748</phone>
.</corresp>
</author-notes>
<pub-date pub-type="epub"><day>03</day>
<month>03</month>
<year>2020</year>
</pub-date>
<elocation-id>acsinfecdis.0c00052</elocation-id>
<history><date date-type="received"><day>04</day>
<month>02</month>
<year>2020</year>
</date>
</history>
<permissions><copyright-statement>Copyright © 2020 American Chemical Society</copyright-statement>
<copyright-year>2020</copyright-year>
<copyright-holder>American Chemical Society</copyright-holder>
<license license-type="open-access"><license-p>This article is made available via the PMC Open Access Subset for unrestricted RESEARCH
re-use and analyses in any form or by any means with acknowledgement of the original
source. These permissions are granted for the duration of the World Health Organization
(WHO) declaration of COVID-19 as a global pandemic.</license-p>
</license>
</permissions>
<abstract><p content-type="toc-graphic"><graphic xlink:href="id0c00052_0003" id="ab-tgr1"></graphic>
</p>
<p>The recent outbreak of coronavirus disease 2019 (COVID-19) highlights an urgent need
for therapeutics. Through a series of drug repurposing screening campaigns, niclosamide,
an FDA-approved anthelminthic drug, was found to be effective against various viral
infections with nanomolar to micromolar potency such as SARS-CoV, MERS-CoV, ZIKV, HCV,
and human adenovirus, indicating its potential as an antiviral agent. In this brief
review, we summarize the broad antiviral activity of niclosamide and highlight its
potential clinical use in the treatment of COVID-19.</p>
</abstract>
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<kwd>broad antiviral agents</kwd>
<kwd>coronavirus</kwd>
<kwd>SARS-CoV</kwd>
<kwd>MERS-CoV</kwd>
<kwd>SARS-CoV-2 (COVID-19)</kwd>
<kwd>flavivirus</kwd>
<kwd>Zika virus</kwd>
<kwd>Ebola virus</kwd>
<kwd>human adenovirus</kwd>
</kwd-group>
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<meta-value>id0c00052</meta-value>
</custom-meta>
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<meta-value>id0c00052</meta-value>
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<notes id="notes-d1e21-autogenerated"><fn-group><fn fn-type="" id="d30e140"><p>This article is made available for a limited time sponsored by ACS under the <ext-link ext-link-type="uri" xlink:href="http://pubs.acs.org/page/policy/freetoread/index.html">ACS Free to Read
License</ext-link>
, which permits copying and redistribution of the article for
non-commercial scholarly purposes.</p>
</fn>
</fn-group>
</notes>
</front>
</pmc>
<affiliations><list><country><li>États-Unis</li>
</country>
</list>
<tree><noCountry><name sortKey="Xu, Jimin" sort="Xu, Jimin" uniqKey="Xu J" first="Jimin" last="Xu">Jimin Xu</name>
</noCountry>
<country name="États-Unis"><noRegion><name sortKey="Shi, Pei Yong" sort="Shi, Pei Yong" uniqKey="Shi P" first="Pei-Yong" last="Shi">Pei-Yong Shi</name>
</noRegion>
<name sortKey="Li, Hongmin" sort="Li, Hongmin" uniqKey="Li H" first="Hongmin" last="Li">Hongmin Li</name>
<name sortKey="Zhou, Jia" sort="Zhou, Jia" uniqKey="Zhou J" first="Jia" last="Zhou">Jia Zhou</name>
</country>
</tree>
</affiliations>
</record>
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