SARS-CoV-2 and COVID-19 in older adults: what we may expect regarding pathogenesis, immune responses, and outcomes
Identifieur interne : 000029 ( Pmc/Checkpoint ); précédent : 000028; suivant : 000030SARS-CoV-2 and COVID-19 in older adults: what we may expect regarding pathogenesis, immune responses, and outcomes
Auteurs : Janko Nikolich-Zugich [États-Unis] ; Kenneth S. Knox [États-Unis] ; Carlos Tafich Rios [États-Unis] ; Bhupinder Natt [États-Unis] ; Deepta Bhattacharya [États-Unis] ; Mindy J. Fain [États-Unis]Source :
- GeroScience [ 2509-2715 ] ; 2020.
Abstract
SARS-CoV-2 virus, the causative agent of the coronavirus infectious disease-19 (COVID-19), is taking the globe by storm, approaching 500,000 confirmed cases and over 21,000 deaths as of March 25, 2020. While under control in some affected Asian countries (Taiwan, Singapore, Vietnam), the virus demonstrated an exponential phase of infectivity in several large countries (China in late January and February and many European countries and the USA in March), with cases exploding by 30–50,000/day in the third and fourth weeks of March, 2020. SARS-CoV-2 has proven to be particularly deadly to older adults and those with certain underlying medical conditions, many of whom are of advanced age. Here, we briefly review the virus, its structure and evolution, epidemiology and pathogenesis, immunogenicity and immune, and clinical response in older adults, using available knowledge on SARS-CoV-2 and its highly pathogenic relatives MERS-CoV and SARS-CoV-1. We conclude by discussing clinical and basic science approaches to protect older adults against this disease.
Url:
DOI: 10.1007/s11357-020-00186-0
PubMed: NONE
PubMed Central: 7145538
Affiliations:
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<front><div type="abstract" xml:lang="en"><p id="Par1">SARS-CoV-2 virus, the causative agent of the coronavirus infectious disease-19 (COVID-19), is taking the globe by storm, approaching 500,000 confirmed cases and over 21,000 deaths as of March 25, 2020. While under control in some affected Asian countries (Taiwan, Singapore, Vietnam), the virus demonstrated an exponential phase of infectivity in several large countries (China in late January and February and many European countries and the USA in March), with cases exploding by 30–50,000/day in the third and fourth weeks of March, 2020. SARS-CoV-2 has proven to be particularly deadly to older adults and those with certain underlying medical conditions, many of whom are of advanced age. Here, we briefly review the virus, its structure and evolution, epidemiology and pathogenesis, immunogenicity and immune, and clinical response in older adults, using available knowledge on SARS-CoV-2 and its highly pathogenic relatives MERS-CoV and SARS-CoV-1. We conclude by discussing clinical and basic science approaches to protect older adults against this disease.</p>
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<back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Alsaad, Ko" uniqKey="Alsaad K">KO Alsaad</name>
</author>
<author><name sortKey="Hajeer, Ah" uniqKey="Hajeer A">AH Hajeer</name>
</author>
<author><name sortKey="Al Balwi, M" uniqKey="Al Balwi M">M Al Balwi</name>
</author>
<author><name sortKey="Al Moaiqel, M" uniqKey="Al Moaiqel M">M Al Moaiqel</name>
</author>
<author><name sortKey="Al Oudah, N" uniqKey="Al Oudah N">N Al Oudah</name>
</author>
<author><name sortKey="Al Ajlan, A" uniqKey="Al Ajlan A">A Al Ajlan</name>
</author>
<author><name sortKey="Aljohani, S" uniqKey="Aljohani S">S AlJohani</name>
</author>
<author><name sortKey="Alsolamy, S" uniqKey="Alsolamy S">S Alsolamy</name>
</author>
<author><name sortKey="Gmati, Ge" uniqKey="Gmati G">GE Gmati</name>
</author>
<author><name sortKey="Balkhy, H" uniqKey="Balkhy H">H Balkhy</name>
</author>
<author><name sortKey="Al Jahdali, Hh" uniqKey="Al Jahdali H">HH Al-Jahdali</name>
</author>
<author><name sortKey="Baharoon, Sa" uniqKey="Baharoon S">SA Baharoon</name>
</author>
<author><name sortKey="Arabi, Ym" uniqKey="Arabi Y">YM Arabi</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Brian, Da" uniqKey="Brian D">DA Brian</name>
</author>
<author><name sortKey="Baric, Rs" uniqKey="Baric R">RS Baric</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Brien, Jd" uniqKey="Brien J">JD Brien</name>
</author>
<author><name sortKey="Uhrlaub, Jl" uniqKey="Uhrlaub J">JL Uhrlaub</name>
</author>
<author><name sortKey="Hirsch, A" uniqKey="Hirsch A">A Hirsch</name>
</author>
<author><name sortKey="Wiley, Ca" uniqKey="Wiley C">CA Wiley</name>
</author>
<author><name sortKey="Nikolich Zugich, J" uniqKey="Nikolich Zugich J">J Nikolich-Zugich</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Cameron, Mj" uniqKey="Cameron M">MJ Cameron</name>
</author>
<author><name sortKey="Ran, L" uniqKey="Ran L">L Ran</name>
</author>
<author><name sortKey="Xu, L" uniqKey="Xu L">L Xu</name>
</author>
<author><name sortKey="Danesh, A" uniqKey="Danesh A">A Danesh</name>
</author>
<author><name sortKey="Bermejo Martin, Jf" uniqKey="Bermejo Martin J">JF Bermejo-Martin</name>
</author>
<author><name sortKey="Cameron, Cm" uniqKey="Cameron C">CM Cameron</name>
</author>
<author><name sortKey="Muller, Mp" uniqKey="Muller M">MP Muller</name>
</author>
<author><name sortKey="Gold, Wl" uniqKey="Gold W">WL Gold</name>
</author>
<author><name sortKey="Richardson, Se" uniqKey="Richardson S">SE Richardson</name>
</author>
<author><name sortKey="Poutanen, Sm" uniqKey="Poutanen S">SM Poutanen</name>
</author>
<author><name sortKey="Willey, Bm" uniqKey="Willey B">BM Willey</name>
</author>
<author><name sortKey="Devries, Me" uniqKey="Devries M">ME DeVries</name>
</author>
<author><name sortKey="Fang, Y" uniqKey="Fang Y">Y Fang</name>
</author>
<author><name sortKey="Seneviratne, C" uniqKey="Seneviratne C">C Seneviratne</name>
</author>
<author><name sortKey="Bosinger, Se" uniqKey="Bosinger S">SE Bosinger</name>
</author>
<author><name sortKey="Persad, D" uniqKey="Persad D">D Persad</name>
</author>
<author><name sortKey="Wilkinson, P" uniqKey="Wilkinson P">P Wilkinson</name>
</author>
<author><name sortKey="Greller, Ld" uniqKey="Greller L">LD Greller</name>
</author>
<author><name sortKey="Somogyi, R" uniqKey="Somogyi R">R Somogyi</name>
</author>
<author><name sortKey="Humar, A" uniqKey="Humar A">A Humar</name>
</author>
<author><name sortKey="Keshavjee, S" uniqKey="Keshavjee S">S Keshavjee</name>
</author>
<author><name sortKey="Louie, M" uniqKey="Louie M">M Louie</name>
</author>
<author><name sortKey="Loeb, Mb" uniqKey="Loeb M">MB Loeb</name>
</author>
<author><name sortKey="Brunton, J" uniqKey="Brunton J">J Brunton</name>
</author>
<author><name sortKey="Mcgeer, Aj" uniqKey="Mcgeer A">AJ McGeer</name>
</author>
<author><name sortKey="Canadian, Srn" uniqKey="Canadian S">SRN Canadian</name>
</author>
<author><name sortKey="Kelvin, Dj" uniqKey="Kelvin D">DJ Kelvin</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Cameron, Mj" uniqKey="Cameron M">MJ Cameron</name>
</author>
<author><name sortKey="Bermejo Martin, Jf" uniqKey="Bermejo Martin J">JF Bermejo-Martin</name>
</author>
<author><name sortKey="Danesh, A" uniqKey="Danesh A">A Danesh</name>
</author>
<author><name sortKey="Muller, Mp" uniqKey="Muller M">MP Muller</name>
</author>
<author><name sortKey="Kelvin, Dj" uniqKey="Kelvin D">DJ Kelvin</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Cervantes Barragan, L" uniqKey="Cervantes Barragan L">L Cervantes-Barragan</name>
</author>
<author><name sortKey="Zust, R" uniqKey="Zust R">R Zust</name>
</author>
<author><name sortKey="Weber, F" uniqKey="Weber F">F Weber</name>
</author>
<author><name sortKey="Spiegel, M" uniqKey="Spiegel M">M Spiegel</name>
</author>
<author><name sortKey="Lang, Ks" uniqKey="Lang K">KS Lang</name>
</author>
<author><name sortKey="Akira, S" uniqKey="Akira S">S Akira</name>
</author>
<author><name sortKey="Thiel, V" uniqKey="Thiel V">V Thiel</name>
</author>
<author><name sortKey="Ludewig, B" uniqKey="Ludewig B">B Ludewig</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Channappanavar, R" uniqKey="Channappanavar R">R Channappanavar</name>
</author>
<author><name sortKey="Fehr, Ar" uniqKey="Fehr A">AR Fehr</name>
</author>
<author><name sortKey="Zheng, J" uniqKey="Zheng J">J Zheng</name>
</author>
<author><name sortKey="Wohlford Lenane, C" uniqKey="Wohlford Lenane C">C Wohlford-Lenane</name>
</author>
<author><name sortKey="Abrahante, Je" uniqKey="Abrahante J">JE Abrahante</name>
</author>
<author><name sortKey="Mack, M" uniqKey="Mack M">M Mack</name>
</author>
<author><name sortKey="Sompallae, R" uniqKey="Sompallae R">R Sompallae</name>
</author>
<author><name sortKey="Mccray, Pb" uniqKey="Mccray P">PB McCray</name>
</author>
<author><name sortKey="Meyerholz, Dk" uniqKey="Meyerholz D">DK Meyerholz</name>
</author>
<author><name sortKey="Perlman, S" uniqKey="Perlman S">S Perlman</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chen, J" uniqKey="Chen J">J Chen</name>
</author>
<author><name sortKey="Lau, Yf" uniqKey="Lau Y">YF Lau</name>
</author>
<author><name sortKey="Lamirande, Ew" uniqKey="Lamirande E">EW Lamirande</name>
</author>
<author><name sortKey="Paddock, Cd" uniqKey="Paddock C">CD Paddock</name>
</author>
<author><name sortKey="Bartlett, Jh" uniqKey="Bartlett J">JH Bartlett</name>
</author>
<author><name sortKey="Zaki, Sr" uniqKey="Zaki S">SR Zaki</name>
</author>
<author><name sortKey="Subbarao, K" uniqKey="Subbarao K">K Subbarao</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chen, N" uniqKey="Chen N">N Chen</name>
</author>
<author><name sortKey="Zhou, M" uniqKey="Zhou M">M Zhou</name>
</author>
<author><name sortKey="Dong, X" uniqKey="Dong X">X Dong</name>
</author>
<author><name sortKey="Qu, J" uniqKey="Qu J">J Qu</name>
</author>
<author><name sortKey="Gong, F" uniqKey="Gong F">F Gong</name>
</author>
<author><name sortKey="Han, Y" uniqKey="Han Y">Y Han</name>
</author>
<author><name sortKey="Qiu, Y" uniqKey="Qiu Y">Y Qiu</name>
</author>
<author><name sortKey="Wang, J" uniqKey="Wang J">J Wang</name>
</author>
<author><name sortKey="Liu, Y" uniqKey="Liu Y">Y Liu</name>
</author>
<author><name sortKey="Wei, Y" uniqKey="Wei Y">Y Wei</name>
</author>
<author><name sortKey="Xia, J" uniqKey="Xia J">J Xia</name>
</author>
<author><name sortKey="Yu, T" uniqKey="Yu T">T Yu</name>
</author>
<author><name sortKey="Zhang, X" uniqKey="Zhang X">X Zhang</name>
</author>
<author><name sortKey="Zhang, L" uniqKey="Zhang L">L Zhang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chinn, Ik" uniqKey="Chinn I">IK Chinn</name>
</author>
<author><name sortKey="Blackburn, Cc" uniqKey="Blackburn C">CC Blackburn</name>
</author>
<author><name sortKey="Manley, Nr" uniqKey="Manley N">NR Manley</name>
</author>
<author><name sortKey="Sempowski, Gd" uniqKey="Sempowski G">GD Sempowski</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="De Wit, E" uniqKey="De Wit E">E de Wit</name>
</author>
<author><name sortKey="Van Doremalen, N" uniqKey="Van Doremalen N">N van Doremalen</name>
</author>
<author><name sortKey="Falzarano, D" uniqKey="Falzarano D">D Falzarano</name>
</author>
<author><name sortKey="Munster, Vj" uniqKey="Munster V">VJ Munster</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Decroly, E" uniqKey="Decroly E">E Decroly</name>
</author>
<author><name sortKey="Imbert, I" uniqKey="Imbert I">I Imbert</name>
</author>
<author><name sortKey="Coutard, B" uniqKey="Coutard B">B Coutard</name>
</author>
<author><name sortKey="Bouvet, M" uniqKey="Bouvet M">M Bouvet</name>
</author>
<author><name sortKey="Selisko, B" uniqKey="Selisko B">B Selisko</name>
</author>
<author><name sortKey="Alvarez, K" uniqKey="Alvarez K">K Alvarez</name>
</author>
<author><name sortKey="Gorbalenya, Ae" uniqKey="Gorbalenya A">AE Gorbalenya</name>
</author>
<author><name sortKey="Snijder, Ej" uniqKey="Snijder E">EJ Snijder</name>
</author>
<author><name sortKey="Canard, B" uniqKey="Canard B">B Canard</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="El Sahly, Hm" uniqKey="El Sahly H">HM El-Sahly</name>
</author>
<author><name sortKey="Atmar, Rl" uniqKey="Atmar R">RL Atmar</name>
</author>
<author><name sortKey="Glezen, Wp" uniqKey="Glezen W">WP Glezen</name>
</author>
<author><name sortKey="Greenberg, Sb" uniqKey="Greenberg S">SB Greenberg</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Falsey, Ar" uniqKey="Falsey A">AR Falsey</name>
</author>
<author><name sortKey="Mccann, Rm" uniqKey="Mccann R">RM McCann</name>
</author>
<author><name sortKey="Hall, Wj" uniqKey="Hall W">WJ Hall</name>
</author>
<author><name sortKey="Criddle, Mm" uniqKey="Criddle M">MM Criddle</name>
</author>
<author><name sortKey="Formica, Ma" uniqKey="Formica M">MA Formica</name>
</author>
<author><name sortKey="Wycoff, D" uniqKey="Wycoff D">D Wycoff</name>
</author>
<author><name sortKey="Kolassa, Je" uniqKey="Kolassa J">JE Kolassa</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Gralinski, Le" uniqKey="Gralinski L">LE Gralinski</name>
</author>
<author><name sortKey="Ferris, Mt" uniqKey="Ferris M">MT Ferris</name>
</author>
<author><name sortKey="Aylor, Dl" uniqKey="Aylor D">DL Aylor</name>
</author>
<author><name sortKey="Whitmore, Ac" uniqKey="Whitmore A">AC Whitmore</name>
</author>
<author><name sortKey="Green, R" uniqKey="Green R">R Green</name>
</author>
<author><name sortKey="Frieman, Mb" uniqKey="Frieman M">MB Frieman</name>
</author>
<author><name sortKey="Deming, D" uniqKey="Deming D">D Deming</name>
</author>
<author><name sortKey="Menachery, Vd" uniqKey="Menachery V">VD Menachery</name>
</author>
<author><name sortKey="Miller, Dr" uniqKey="Miller D">DR Miller</name>
</author>
<author><name sortKey="Buus, Rj" uniqKey="Buus R">RJ Buus</name>
</author>
<author><name sortKey="Bell, Ta" uniqKey="Bell T">TA Bell</name>
</author>
<author><name sortKey="Churchill, Ga" uniqKey="Churchill G">GA Churchill</name>
</author>
<author><name sortKey="Threadgill, Dw" uniqKey="Threadgill D">DW Threadgill</name>
</author>
<author><name sortKey="Katze, Mg" uniqKey="Katze M">MG Katze</name>
</author>
<author><name sortKey="Mcmillan, L" uniqKey="Mcmillan L">L McMillan</name>
</author>
<author><name sortKey="Valdar, W" uniqKey="Valdar W">W Valdar</name>
</author>
<author><name sortKey="Heise, Mt" uniqKey="Heise M">MT Heise</name>
</author>
<author><name sortKey="Pardo Manuel De Villena, F" uniqKey="Pardo Manuel De Villena F">F Pardo-Manuel de Villena</name>
</author>
<author><name sortKey="Baric, Rs" uniqKey="Baric R">RS Baric</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Greenberg, Sb" uniqKey="Greenberg S">SB Greenberg</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="High, Kp" uniqKey="High K">KP High</name>
</author>
<author><name sortKey="Bradley, Sf" uniqKey="Bradley S">SF Bradley</name>
</author>
<author><name sortKey="Gravenstein, S" uniqKey="Gravenstein S">S Gravenstein</name>
</author>
<author><name sortKey="Mehr, Dr" uniqKey="Mehr D">DR Mehr</name>
</author>
<author><name sortKey="Quagliarello, Vj" uniqKey="Quagliarello V">VJ Quagliarello</name>
</author>
<author><name sortKey="Richards, C" uniqKey="Richards C">C Richards</name>
</author>
<author><name sortKey="Yoshikawa, Tt" uniqKey="Yoshikawa T">TT Yoshikawa</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Huang, Kj" uniqKey="Huang K">KJ Huang</name>
</author>
<author><name sortKey="Su, Ij" uniqKey="Su I">IJ Su</name>
</author>
<author><name sortKey="Theron, M" uniqKey="Theron M">M Theron</name>
</author>
<author><name sortKey="Wu, Yc" uniqKey="Wu Y">YC Wu</name>
</author>
<author><name sortKey="Lai, Sk" uniqKey="Lai S">SK Lai</name>
</author>
<author><name sortKey="Liu, Cc" uniqKey="Liu C">CC Liu</name>
</author>
<author><name sortKey="Lei, Hy" uniqKey="Lei H">HY Lei</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Huang, C" uniqKey="Huang C">C Huang</name>
</author>
<author><name sortKey="Wang, Y" uniqKey="Wang Y">Y Wang</name>
</author>
<author><name sortKey="Li, X" uniqKey="Li X">X Li</name>
</author>
<author><name sortKey="Ren, L" uniqKey="Ren L">L Ren</name>
</author>
<author><name sortKey="Zhao, J" uniqKey="Zhao J">J Zhao</name>
</author>
<author><name sortKey="Hu, Y" uniqKey="Hu Y">Y Hu</name>
</author>
<author><name sortKey="Zhang, L" uniqKey="Zhang L">L Zhang</name>
</author>
<author><name sortKey="Fan, G" uniqKey="Fan G">G Fan</name>
</author>
<author><name sortKey="Xu, J" uniqKey="Xu J">J Xu</name>
</author>
<author><name sortKey="Gu, X" uniqKey="Gu X">X Gu</name>
</author>
<author><name sortKey="Cheng, Z" uniqKey="Cheng Z">Z Cheng</name>
</author>
<author><name sortKey="Yu, T" uniqKey="Yu T">T Yu</name>
</author>
<author><name sortKey="Xia, J" uniqKey="Xia J">J Xia</name>
</author>
<author><name sortKey="Wei, Y" uniqKey="Wei Y">Y Wei</name>
</author>
<author><name sortKey="Wu, W" uniqKey="Wu W">W Wu</name>
</author>
<author><name sortKey="Xie, X" uniqKey="Xie X">X Xie</name>
</author>
<author><name sortKey="Yin, W" uniqKey="Yin W">W Yin</name>
</author>
<author><name sortKey="Li, H" uniqKey="Li H">H Li</name>
</author>
<author><name sortKey="Liu, M" uniqKey="Liu M">M Liu</name>
</author>
<author><name sortKey="Xiao, Y" uniqKey="Xiao Y">Y Xiao</name>
</author>
<author><name sortKey="Gao, H" uniqKey="Gao H">H Gao</name>
</author>
<author><name sortKey="Guo, L" uniqKey="Guo L">L Guo</name>
</author>
<author><name sortKey="Xie, J" uniqKey="Xie J">J Xie</name>
</author>
<author><name sortKey="Wang, G" uniqKey="Wang G">G Wang</name>
</author>
<author><name sortKey="Jiang, R" uniqKey="Jiang R">R Jiang</name>
</author>
<author><name sortKey="Gao, Z" uniqKey="Gao Z">Z Gao</name>
</author>
<author><name sortKey="Jin, Q" uniqKey="Jin Q">Q Jin</name>
</author>
<author><name sortKey="Wang, J" uniqKey="Wang J">J Wang</name>
</author>
<author><name sortKey="Cao, B" uniqKey="Cao B">B Cao</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Imai, Y" uniqKey="Imai Y">Y Imai</name>
</author>
<author><name sortKey="Kuba, K" uniqKey="Kuba K">K Kuba</name>
</author>
<author><name sortKey="Rao, S" uniqKey="Rao S">S Rao</name>
</author>
<author><name sortKey="Huan, Y" uniqKey="Huan Y">Y Huan</name>
</author>
<author><name sortKey="Guo, F" uniqKey="Guo F">F Guo</name>
</author>
<author><name sortKey="Guan, B" uniqKey="Guan B">B Guan</name>
</author>
<author><name sortKey="Yang, P" uniqKey="Yang P">P Yang</name>
</author>
<author><name sortKey="Sarao, R" uniqKey="Sarao R">R Sarao</name>
</author>
<author><name sortKey="Wada, T" uniqKey="Wada T">T Wada</name>
</author>
<author><name sortKey="Leong Poi, H" uniqKey="Leong Poi H">H Leong-Poi</name>
</author>
<author><name sortKey="Crackower, Ma" uniqKey="Crackower M">MA Crackower</name>
</author>
<author><name sortKey="Fukamizu, A" uniqKey="Fukamizu A">A Fukamizu</name>
</author>
<author><name sortKey="Hui, Cc" uniqKey="Hui C">CC Hui</name>
</author>
<author><name sortKey="Hein, L" uniqKey="Hein L">L Hein</name>
</author>
<author><name sortKey="Uhlig, S" uniqKey="Uhlig S">S Uhlig</name>
</author>
<author><name sortKey="Slutsky, As" uniqKey="Slutsky A">AS Slutsky</name>
</author>
<author><name sortKey="Jiang, C" uniqKey="Jiang C">C Jiang</name>
</author>
<author><name sortKey="Penninger, Jm" uniqKey="Penninger J">JM Penninger</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kogut, I" uniqKey="Kogut I">I Kogut</name>
</author>
<author><name sortKey="Scholz, Jl" uniqKey="Scholz J">JL Scholz</name>
</author>
<author><name sortKey="Cancro, Mp" uniqKey="Cancro M">MP Cancro</name>
</author>
<author><name sortKey="Cambier, Jc" uniqKey="Cambier J">JC Cambier</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kuiken, T" uniqKey="Kuiken T">T Kuiken</name>
</author>
<author><name sortKey="Fouchier, Ra" uniqKey="Fouchier R">RA Fouchier</name>
</author>
<author><name sortKey="Schutten, M" uniqKey="Schutten M">M Schutten</name>
</author>
<author><name sortKey="Rimmelzwaan, Gf" uniqKey="Rimmelzwaan G">GF Rimmelzwaan</name>
</author>
<author><name sortKey="Van Amerongen, G" uniqKey="Van Amerongen G">G van Amerongen</name>
</author>
<author><name sortKey="Van Riel, D" uniqKey="Van Riel D">D van Riel</name>
</author>
<author><name sortKey="Laman, Jd" uniqKey="Laman J">JD Laman</name>
</author>
<author><name sortKey="De Jong, T" uniqKey="De Jong T">T de Jong</name>
</author>
<author><name sortKey="Van Doornum, G" uniqKey="Van Doornum G">G van Doornum</name>
</author>
<author><name sortKey="Lim, W" uniqKey="Lim W">W Lim</name>
</author>
<author><name sortKey="Ling, Ae" uniqKey="Ling A">AE Ling</name>
</author>
<author><name sortKey="Chan, Pk" uniqKey="Chan P">PK Chan</name>
</author>
<author><name sortKey="Tam, Js" uniqKey="Tam J">JS Tam</name>
</author>
<author><name sortKey="Zambon, Mc" uniqKey="Zambon M">MC Zambon</name>
</author>
<author><name sortKey="Gopal, R" uniqKey="Gopal R">R Gopal</name>
</author>
<author><name sortKey="Drosten, C" uniqKey="Drosten C">C Drosten</name>
</author>
<author><name sortKey="Van Der Werf, S" uniqKey="Van Der Werf S">S van der Werf</name>
</author>
<author><name sortKey="Escriou, N" uniqKey="Escriou N">N Escriou</name>
</author>
<author><name sortKey="Manuguerra, Jc" uniqKey="Manuguerra J">JC Manuguerra</name>
</author>
<author><name sortKey="Stohr, K" uniqKey="Stohr K">K Stohr</name>
</author>
<author><name sortKey="Peiris, Js" uniqKey="Peiris J">JS Peiris</name>
</author>
<author><name sortKey="Osterhaus, Ad" uniqKey="Osterhaus A">AD Osterhaus</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lal, H" uniqKey="Lal H">H Lal</name>
</author>
<author><name sortKey="Cunningham, Al" uniqKey="Cunningham A">AL Cunningham</name>
</author>
<author><name sortKey="Godeaux, O" uniqKey="Godeaux O">O Godeaux</name>
</author>
<author><name sortKey="Chlibek, R" uniqKey="Chlibek R">R Chlibek</name>
</author>
<author><name sortKey="Diez Domingo, J" uniqKey="Diez Domingo J">J Diez-Domingo</name>
</author>
<author><name sortKey="Hwang, Sj" uniqKey="Hwang S">SJ Hwang</name>
</author>
<author><name sortKey="Levin, Mj" uniqKey="Levin M">MJ Levin</name>
</author>
<author><name sortKey="Mcelhaney, Je" uniqKey="Mcelhaney J">JE McElhaney</name>
</author>
<author><name sortKey="Poder, A" uniqKey="Poder A">A Poder</name>
</author>
<author><name sortKey="Puig Barbera, J" uniqKey="Puig Barbera J">J Puig-Barbera</name>
</author>
<author><name sortKey="Vesikari, T" uniqKey="Vesikari T">T Vesikari</name>
</author>
<author><name sortKey="Watanabe, D" uniqKey="Watanabe D">D Watanabe</name>
</author>
<author><name sortKey="Weckx, L" uniqKey="Weckx L">L Weckx</name>
</author>
<author><name sortKey="Zahaf, T" uniqKey="Zahaf T">T Zahaf</name>
</author>
<author><name sortKey="Heineman, Tc" uniqKey="Heineman T">TC Heineman</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Li, C" uniqKey="Li C">C Li</name>
</author>
<author><name sortKey="Yang, Y" uniqKey="Yang Y">Y Yang</name>
</author>
<author><name sortKey="Ren, L" uniqKey="Ren L">L Ren</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Luk, Hkh" uniqKey="Luk H">HKH Luk</name>
</author>
<author><name sortKey="Li, X" uniqKey="Li X">X Li</name>
</author>
<author><name sortKey="Fung, J" uniqKey="Fung J">J Fung</name>
</author>
<author><name sortKey="Lau, Skp" uniqKey="Lau S">SKP Lau</name>
</author>
<author><name sortKey="Woo, Pcy" uniqKey="Woo P">PCY Woo</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mccray, Pb" uniqKey="Mccray P">PB McCray</name>
</author>
<author><name sortKey="Pewe, L" uniqKey="Pewe L">L Pewe</name>
</author>
<author><name sortKey="Wohlford Lenane, C" uniqKey="Wohlford Lenane C">C Wohlford-Lenane</name>
</author>
<author><name sortKey="Hickey, M" uniqKey="Hickey M">M Hickey</name>
</author>
<author><name sortKey="Manzel, L" uniqKey="Manzel L">L Manzel</name>
</author>
<author><name sortKey="Shi, L" uniqKey="Shi L">L Shi</name>
</author>
<author><name sortKey="Netland, J" uniqKey="Netland J">J Netland</name>
</author>
<author><name sortKey="Jia, Hp" uniqKey="Jia H">HP Jia</name>
</author>
<author><name sortKey="Halabi, C" uniqKey="Halabi C">C Halabi</name>
</author>
<author><name sortKey="Sigmund, Cd" uniqKey="Sigmund C">CD Sigmund</name>
</author>
<author><name sortKey="Meyerholz, Dk" uniqKey="Meyerholz D">DK Meyerholz</name>
</author>
<author><name sortKey="Kirby, P" uniqKey="Kirby P">P Kirby</name>
</author>
<author><name sortKey="Look, Dc" uniqKey="Look D">DC Look</name>
</author>
<author><name sortKey="Perlman, S" uniqKey="Perlman S">S Perlman</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Metcalf, Tu" uniqKey="Metcalf T">TU Metcalf</name>
</author>
<author><name sortKey="Cubas, Ra" uniqKey="Cubas R">RA Cubas</name>
</author>
<author><name sortKey="Ghneim, K" uniqKey="Ghneim K">K Ghneim</name>
</author>
<author><name sortKey="Cartwright, Mj" uniqKey="Cartwright M">MJ Cartwright</name>
</author>
<author><name sortKey="Grevenynghe, Jv" uniqKey="Grevenynghe J">JV Grevenynghe</name>
</author>
<author><name sortKey="Richner, Jm" uniqKey="Richner J">JM Richner</name>
</author>
<author><name sortKey="Olagnier, Dp" uniqKey="Olagnier D">DP Olagnier</name>
</author>
<author><name sortKey="Wilkinson, Pa" uniqKey="Wilkinson P">PA Wilkinson</name>
</author>
<author><name sortKey="Cameron, Mj" uniqKey="Cameron M">MJ Cameron</name>
</author>
<author><name sortKey="Park, Bs" uniqKey="Park B">BS Park</name>
</author>
<author><name sortKey="Hiscott, Jb" uniqKey="Hiscott J">JB Hiscott</name>
</author>
<author><name sortKey="Diamond, Ms" uniqKey="Diamond M">MS Diamond</name>
</author>
<author><name sortKey="Wertheimer, Am" uniqKey="Wertheimer A">AM Wertheimer</name>
</author>
<author><name sortKey="Nikolich Zugich, J" uniqKey="Nikolich Zugich J">J Nikolich-Zugich</name>
</author>
<author><name sortKey="Haddad, Ek" uniqKey="Haddad E">EK Haddad</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Naylor, K" uniqKey="Naylor K">K Naylor</name>
</author>
<author><name sortKey="Li, G" uniqKey="Li G">G Li</name>
</author>
<author><name sortKey="Vallejo, An" uniqKey="Vallejo A">AN Vallejo</name>
</author>
<author><name sortKey="Lee, Ww" uniqKey="Lee W">WW Lee</name>
</author>
<author><name sortKey="Koetz, K" uniqKey="Koetz K">K Koetz</name>
</author>
<author><name sortKey="Bryl, E" uniqKey="Bryl E">E Bryl</name>
</author>
<author><name sortKey="Witkowski, J" uniqKey="Witkowski J">J Witkowski</name>
</author>
<author><name sortKey="Fulbright, J" uniqKey="Fulbright J">J Fulbright</name>
</author>
<author><name sortKey="Weyand, Cm" uniqKey="Weyand C">CM Weyand</name>
</author>
<author><name sortKey="Goronzy, Jj" uniqKey="Goronzy J">JJ Goronzy</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ng, Dl" uniqKey="Ng D">DL Ng</name>
</author>
<author><name sortKey="Al Hosani, F" uniqKey="Al Hosani F">F Al Hosani</name>
</author>
<author><name sortKey="Keating, Mk" uniqKey="Keating M">MK Keating</name>
</author>
<author><name sortKey="Gerber, Si" uniqKey="Gerber S">SI Gerber</name>
</author>
<author><name sortKey="Jones, Tl" uniqKey="Jones T">TL Jones</name>
</author>
<author><name sortKey="Metcalfe, Mg" uniqKey="Metcalfe M">MG Metcalfe</name>
</author>
<author><name sortKey="Tong, S" uniqKey="Tong S">S Tong</name>
</author>
<author><name sortKey="Tao, Y" uniqKey="Tao Y">Y Tao</name>
</author>
<author><name sortKey="Alami, Nn" uniqKey="Alami N">NN Alami</name>
</author>
<author><name sortKey="Haynes, Lm" uniqKey="Haynes L">LM Haynes</name>
</author>
<author><name sortKey="Mutei, Ma" uniqKey="Mutei M">MA Mutei</name>
</author>
<author><name sortKey="Abdel Wareth, L" uniqKey="Abdel Wareth L">L Abdel-Wareth</name>
</author>
<author><name sortKey="Uyeki, Tm" uniqKey="Uyeki T">TM Uyeki</name>
</author>
<author><name sortKey="Swerdlow, Dl" uniqKey="Swerdlow D">DL Swerdlow</name>
</author>
<author><name sortKey="Barakat, M" uniqKey="Barakat M">M Barakat</name>
</author>
<author><name sortKey="Zaki, Sr" uniqKey="Zaki S">SR Zaki</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Nikolich Zugich, J" uniqKey="Nikolich Zugich J">J Nikolich-Zugich</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Prompetchara, E" uniqKey="Prompetchara E">E Prompetchara</name>
</author>
<author><name sortKey="Ketloy, C" uniqKey="Ketloy C">C Ketloy</name>
</author>
<author><name sortKey="Palaga, T" uniqKey="Palaga T">T Palaga</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Rockx, B" uniqKey="Rockx B">B Rockx</name>
</author>
<author><name sortKey="Baas, T" uniqKey="Baas T">T Baas</name>
</author>
<author><name sortKey="Zornetzer, Ga" uniqKey="Zornetzer G">GA Zornetzer</name>
</author>
<author><name sortKey="Haagmans, B" uniqKey="Haagmans B">B Haagmans</name>
</author>
<author><name sortKey="Sheahan, T" uniqKey="Sheahan T">T Sheahan</name>
</author>
<author><name sortKey="Frieman, M" uniqKey="Frieman M">M Frieman</name>
</author>
<author><name sortKey="Dyer, Md" uniqKey="Dyer M">MD Dyer</name>
</author>
<author><name sortKey="Teal, Th" uniqKey="Teal T">TH Teal</name>
</author>
<author><name sortKey="Proll, S" uniqKey="Proll S">S Proll</name>
</author>
<author><name sortKey="Van Den Brand, J" uniqKey="Van Den Brand J">J van den Brand</name>
</author>
<author><name sortKey="Baric, R" uniqKey="Baric R">R Baric</name>
</author>
<author><name sortKey="Katze, Mg" uniqKey="Katze M">MG Katze</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Schneider, Wm" uniqKey="Schneider W">WM Schneider</name>
</author>
<author><name sortKey="Chevillotte, Md" uniqKey="Chevillotte M">MD Chevillotte</name>
</author>
<author><name sortKey="Rice, Cm" uniqKey="Rice C">CM Rice</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Sheahan, T" uniqKey="Sheahan T">T Sheahan</name>
</author>
<author><name sortKey="Morrison, Te" uniqKey="Morrison T">TE Morrison</name>
</author>
<author><name sortKey="Funkhouser, W" uniqKey="Funkhouser W">W Funkhouser</name>
</author>
<author><name sortKey="Uematsu, S" uniqKey="Uematsu S">S Uematsu</name>
</author>
<author><name sortKey="Akira, S" uniqKey="Akira S">S Akira</name>
</author>
<author><name sortKey="Baric, Rs" uniqKey="Baric R">RS Baric</name>
</author>
<author><name sortKey="Heise, Mt" uniqKey="Heise M">MT Heise</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Solana, R" uniqKey="Solana R">R Solana</name>
</author>
<author><name sortKey="Pawelec, G" uniqKey="Pawelec G">G Pawelec</name>
</author>
<author><name sortKey="Tarazona, R" uniqKey="Tarazona R">R Tarazona</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Sun, B" uniqKey="Sun B">B Sun</name>
</author>
<author><name sortKey="Sundstrom, Kb" uniqKey="Sundstrom K">KB Sundstrom</name>
</author>
<author><name sortKey="Chew, Jj" uniqKey="Chew J">JJ Chew</name>
</author>
<author><name sortKey="Bist, P" uniqKey="Bist P">P Bist</name>
</author>
<author><name sortKey="Gan, Es" uniqKey="Gan E">ES Gan</name>
</author>
<author><name sortKey="Tan, Hc" uniqKey="Tan H">HC Tan</name>
</author>
<author><name sortKey="Goh, Kc" uniqKey="Goh K">KC Goh</name>
</author>
<author><name sortKey="Chawla, T" uniqKey="Chawla T">T Chawla</name>
</author>
<author><name sortKey="Tang, Ck" uniqKey="Tang C">CK Tang</name>
</author>
<author><name sortKey="Ooi, Ee" uniqKey="Ooi E">EE Ooi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ter Meulen, J" uniqKey="Ter Meulen J">J ter Meulen</name>
</author>
<author><name sortKey="Van Den Brink, En" uniqKey="Van Den Brink E">EN van den Brink</name>
</author>
<author><name sortKey="Poon, Ll" uniqKey="Poon L">LL Poon</name>
</author>
<author><name sortKey="Marissen, We" uniqKey="Marissen W">WE Marissen</name>
</author>
<author><name sortKey="Leung, Cs" uniqKey="Leung C">CS Leung</name>
</author>
<author><name sortKey="Cox, F" uniqKey="Cox F">F Cox</name>
</author>
<author><name sortKey="Cheung, Cy" uniqKey="Cheung C">CY Cheung</name>
</author>
<author><name sortKey="Bakker, Aq" uniqKey="Bakker A">AQ Bakker</name>
</author>
<author><name sortKey="Bogaards, Ja" uniqKey="Bogaards J">JA Bogaards</name>
</author>
<author><name sortKey="Van Deventer, E" uniqKey="Van Deventer E">E van Deventer</name>
</author>
<author><name sortKey="Preiser, W" uniqKey="Preiser W">W Preiser</name>
</author>
<author><name sortKey="Doerr, Hw" uniqKey="Doerr H">HW Doerr</name>
</author>
<author><name sortKey="Chow, Vt" uniqKey="Chow V">VT Chow</name>
</author>
<author><name sortKey="De Kruif, J" uniqKey="De Kruif J">J de Kruif</name>
</author>
<author><name sortKey="Peiris, Js" uniqKey="Peiris J">JS Peiris</name>
</author>
<author><name sortKey="Goudsmit, J" uniqKey="Goudsmit J">J Goudsmit</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Thompson, Hl" uniqKey="Thompson H">HL Thompson</name>
</author>
<author><name sortKey="Smithey, Mj" uniqKey="Smithey M">MJ Smithey</name>
</author>
<author><name sortKey="Surh, Cd" uniqKey="Surh C">CD Surh</name>
</author>
<author><name sortKey="Nikolich Zugich, J" uniqKey="Nikolich Zugich J">J Nikolich-Zugich</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Tse, Gm" uniqKey="Tse G">GM Tse</name>
</author>
<author><name sortKey="To, Kf" uniqKey="To K">KF To</name>
</author>
<author><name sortKey="Chan, Pk" uniqKey="Chan P">PK Chan</name>
</author>
<author><name sortKey="Lo, Aw" uniqKey="Lo A">AW Lo</name>
</author>
<author><name sortKey="Ng, Kc" uniqKey="Ng K">KC Ng</name>
</author>
<author><name sortKey="Wu, A" uniqKey="Wu A">A Wu</name>
</author>
<author><name sortKey="Lee, N" uniqKey="Lee N">N Lee</name>
</author>
<author><name sortKey="Wong, Hc" uniqKey="Wong H">HC Wong</name>
</author>
<author><name sortKey="Mak, Sm" uniqKey="Mak S">SM Mak</name>
</author>
<author><name sortKey="Chan, Kf" uniqKey="Chan K">KF Chan</name>
</author>
<author><name sortKey="Hui, Ds" uniqKey="Hui D">DS Hui</name>
</author>
<author><name sortKey="Sung, Jj" uniqKey="Sung J">JJ Sung</name>
</author>
<author><name sortKey="Ng, Hk" uniqKey="Ng H">HK Ng</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Van Den Brink, En" uniqKey="Van Den Brink E">EN van den Brink</name>
</author>
<author><name sortKey="Ter Meulen, J" uniqKey="Ter Meulen J">J Ter Meulen</name>
</author>
<author><name sortKey="Cox, F" uniqKey="Cox F">F Cox</name>
</author>
<author><name sortKey="Jongeneelen, Ma" uniqKey="Jongeneelen M">MA Jongeneelen</name>
</author>
<author><name sortKey="Thijsse, A" uniqKey="Thijsse A">A Thijsse</name>
</author>
<author><name sortKey="Throsby, M" uniqKey="Throsby M">M Throsby</name>
</author>
<author><name sortKey="Marissen, We" uniqKey="Marissen W">WE Marissen</name>
</author>
<author><name sortKey="Rood, Pm" uniqKey="Rood P">PM Rood</name>
</author>
<author><name sortKey="Bakker, Ab" uniqKey="Bakker A">AB Bakker</name>
</author>
<author><name sortKey="Gelderblom, Hr" uniqKey="Gelderblom H">HR Gelderblom</name>
</author>
<author><name sortKey="Martina, Be" uniqKey="Martina B">BE Martina</name>
</author>
<author><name sortKey="Osterhaus, Ad" uniqKey="Osterhaus A">AD Osterhaus</name>
</author>
<author><name sortKey="Preiser, W" uniqKey="Preiser W">W Preiser</name>
</author>
<author><name sortKey="Doerr, Hw" uniqKey="Doerr H">HW Doerr</name>
</author>
<author><name sortKey="De Kruif, J" uniqKey="De Kruif J">J de Kruif</name>
</author>
<author><name sortKey="Goudsmit, J" uniqKey="Goudsmit J">J Goudsmit</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Wrapp, D" uniqKey="Wrapp D">D Wrapp</name>
</author>
<author><name sortKey="Wang, N" uniqKey="Wang N">N Wang</name>
</author>
<author><name sortKey="Corbett, Ks" uniqKey="Corbett K">KS Corbett</name>
</author>
<author><name sortKey="Goldsmith, Ja" uniqKey="Goldsmith J">JA Goldsmith</name>
</author>
<author><name sortKey="Hsieh, Cl" uniqKey="Hsieh C">CL Hsieh</name>
</author>
<author><name sortKey="Abiona, O" uniqKey="Abiona O">O Abiona</name>
</author>
<author><name sortKey="Graham, Bs" uniqKey="Graham B">BS Graham</name>
</author>
<author><name sortKey="Mclellan, Js" uniqKey="Mclellan J">JS McLellan</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Zaki, Am" uniqKey="Zaki A">AM Zaki</name>
</author>
<author><name sortKey="Van Boheemen, S" uniqKey="Van Boheemen S">S van Boheemen</name>
</author>
<author><name sortKey="Bestebroer, Tm" uniqKey="Bestebroer T">TM Bestebroer</name>
</author>
<author><name sortKey="Osterhaus, Ad" uniqKey="Osterhaus A">AD Osterhaus</name>
</author>
<author><name sortKey="Fouchier, Ra" uniqKey="Fouchier R">RA Fouchier</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zhao, J" uniqKey="Zhao J">J Zhao</name>
</author>
<author><name sortKey="Zhao, J" uniqKey="Zhao J">J Zhao</name>
</author>
<author><name sortKey="Perlman, S" uniqKey="Perlman S">S Perlman</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zhao, Wm" uniqKey="Zhao W">WM Zhao</name>
</author>
<author><name sortKey="Song, Sh" uniqKey="Song S">SH Song</name>
</author>
<author><name sortKey="Chen, Ml" uniqKey="Chen M">ML Chen</name>
</author>
<author><name sortKey="Zou, D" uniqKey="Zou D">D Zou</name>
</author>
<author><name sortKey="Ma, Ln" uniqKey="Ma L">LN Ma</name>
</author>
<author><name sortKey="Ma, Yk" uniqKey="Ma Y">YK Ma</name>
</author>
<author><name sortKey="Li, Rj" uniqKey="Li R">RJ Li</name>
</author>
<author><name sortKey="Hao, Ll" uniqKey="Hao L">LL Hao</name>
</author>
<author><name sortKey="Li, Cp" uniqKey="Li C">CP Li</name>
</author>
<author><name sortKey="Tian, Dm" uniqKey="Tian D">DM Tian</name>
</author>
<author><name sortKey="Tang, Bx" uniqKey="Tang B">BX Tang</name>
</author>
<author><name sortKey="Wang, Yq" uniqKey="Wang Y">YQ Wang</name>
</author>
<author><name sortKey="Zhu, Jw" uniqKey="Zhu J">JW Zhu</name>
</author>
<author><name sortKey="Chen, Hx" uniqKey="Chen H">HX Chen</name>
</author>
<author><name sortKey="Zhang, Z" uniqKey="Zhang Z">Z Zhang</name>
</author>
<author><name sortKey="Xue, Yb" uniqKey="Xue Y">YB Xue</name>
</author>
<author><name sortKey="Bao, Ym" uniqKey="Bao Y">YM Bao</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zinkernagel, Rm" uniqKey="Zinkernagel R">RM Zinkernagel</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Zust, R" uniqKey="Zust R">R Zust</name>
</author>
<author><name sortKey="Cervantes Barragan, L" uniqKey="Cervantes Barragan L">L Cervantes-Barragan</name>
</author>
<author><name sortKey="Habjan, M" uniqKey="Habjan M">M Habjan</name>
</author>
<author><name sortKey="Maier, R" uniqKey="Maier R">R Maier</name>
</author>
<author><name sortKey="Neuman, Bw" uniqKey="Neuman B">BW Neuman</name>
</author>
<author><name sortKey="Ziebuhr, J" uniqKey="Ziebuhr J">J Ziebuhr</name>
</author>
<author><name sortKey="Szretter, Kj" uniqKey="Szretter K">KJ Szretter</name>
</author>
<author><name sortKey="Baker, Sc" uniqKey="Baker S">SC Baker</name>
</author>
<author><name sortKey="Barchet, W" uniqKey="Barchet W">W Barchet</name>
</author>
<author><name sortKey="Diamond, Ms" uniqKey="Diamond M">MS Diamond</name>
</author>
<author><name sortKey="Siddell, Sg" uniqKey="Siddell S">SG Siddell</name>
</author>
<author><name sortKey="Ludewig, B" uniqKey="Ludewig B">B Ludewig</name>
</author>
<author><name sortKey="Thiel, V" uniqKey="Thiel V">V Thiel</name>
</author>
</analytic>
</biblStruct>
</listBibl>
</div1>
</back>
</TEI>
<pmc article-type="review-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">GeroScience</journal-id>
<journal-id journal-id-type="iso-abbrev">Geroscience</journal-id>
<journal-title-group><journal-title>GeroScience</journal-title>
</journal-title-group>
<issn pub-type="ppub">2509-2715</issn>
<issn pub-type="epub">2509-2723</issn>
<publisher><publisher-name>Springer International Publishing</publisher-name>
<publisher-loc>Cham</publisher-loc>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmc">7145538</article-id>
<article-id pub-id-type="publisher-id">186</article-id>
<article-id pub-id-type="doi">10.1007/s11357-020-00186-0</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Review</subject>
</subj-group>
</article-categories>
<title-group><article-title>SARS-CoV-2 and COVID-19 in older adults: what we may expect regarding pathogenesis, immune responses, and outcomes</article-title>
</title-group>
<contrib-group><contrib contrib-type="author" corresp="yes"><name><surname>Nikolich-Zugich</surname>
<given-names>Janko</given-names>
</name>
<address><email>nikolich@arizona.edu</email>
</address>
<xref ref-type="aff" rid="Aff1">1</xref>
<xref ref-type="aff" rid="Aff2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Knox</surname>
<given-names>Kenneth S.</given-names>
</name>
<xref ref-type="aff" rid="Aff3">3</xref>
<xref ref-type="aff" rid="Aff4">4</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Rios</surname>
<given-names>Carlos Tafich</given-names>
</name>
<xref ref-type="aff" rid="Aff5">5</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Natt</surname>
<given-names>Bhupinder</given-names>
</name>
<xref ref-type="aff" rid="Aff3">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Bhattacharya</surname>
<given-names>Deepta</given-names>
</name>
<xref ref-type="aff" rid="Aff1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Fain</surname>
<given-names>Mindy J.</given-names>
</name>
<xref ref-type="aff" rid="Aff2">2</xref>
<xref ref-type="aff" rid="Aff5">5</xref>
</contrib>
<aff id="Aff1"><label>1</label>
<institution-wrap><institution-id institution-id-type="GRID">grid.134563.6</institution-id>
<institution-id institution-id-type="ISNI">0000 0001 2168 186X</institution-id>
<institution>Department of Immunobiology,</institution>
<institution>University of Arizona College of Medicine-Tucson,</institution>
</institution-wrap>
Tucson, AZ 85724 USA</aff>
<aff id="Aff2"><label>2</label>
<institution-wrap><institution-id institution-id-type="GRID">grid.134563.6</institution-id>
<institution-id institution-id-type="ISNI">0000 0001 2168 186X</institution-id>
<institution>University of Arizona Center on Aging,</institution>
<institution>University of Arizona College of Medicine-Tucson,</institution>
</institution-wrap>
P.O. Box 249221, 1501 N. Campbell Ave, Tucson, AZ 8524 USA</aff>
<aff id="Aff3"><label>3</label>
<institution-wrap><institution-id institution-id-type="GRID">grid.134563.6</institution-id>
<institution-id institution-id-type="ISNI">0000 0001 2168 186X</institution-id>
<institution>Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Medicine,</institution>
<institution>University of Arizona College of Medicine-Tucson,</institution>
</institution-wrap>
Tucson, AZ 85724 USA</aff>
<aff id="Aff4"><label>4</label>
<institution-wrap><institution-id institution-id-type="GRID">grid.134563.6</institution-id>
<institution-id institution-id-type="ISNI">0000 0001 2168 186X</institution-id>
<institution>Department of Medicine,</institution>
<institution>University of Arizona-Phoenix,</institution>
</institution-wrap>
Phoenix, AZ 85004 USA</aff>
<aff id="Aff5"><label>5</label>
<institution-wrap><institution-id institution-id-type="GRID">grid.134563.6</institution-id>
<institution-id institution-id-type="ISNI">0000 0001 2168 186X</institution-id>
<institution>Division of Geriatrics, General and Palliative Medicine, Department of Medicine,</institution>
<institution>University of Arizona College of Medicine-Tucson,</institution>
</institution-wrap>
Tucson, AZ 85724 USA</aff>
</contrib-group>
<pub-date pub-type="epub"><day>10</day>
<month>4</month>
<year>2020</year>
</pub-date>
<fpage>1</fpage>
<lpage>10</lpage>
<history><date date-type="received"><day>26</day>
<month>3</month>
<year>2020</year>
</date>
<date date-type="accepted"><day>27</day>
<month>3</month>
<year>2020</year>
</date>
</history>
<permissions><copyright-statement>© American Aging Association 2020</copyright-statement>
<license><license-p>This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.</license-p>
</license>
</permissions>
<abstract id="Abs1"><p id="Par1">SARS-CoV-2 virus, the causative agent of the coronavirus infectious disease-19 (COVID-19), is taking the globe by storm, approaching 500,000 confirmed cases and over 21,000 deaths as of March 25, 2020. While under control in some affected Asian countries (Taiwan, Singapore, Vietnam), the virus demonstrated an exponential phase of infectivity in several large countries (China in late January and February and many European countries and the USA in March), with cases exploding by 30–50,000/day in the third and fourth weeks of March, 2020. SARS-CoV-2 has proven to be particularly deadly to older adults and those with certain underlying medical conditions, many of whom are of advanced age. Here, we briefly review the virus, its structure and evolution, epidemiology and pathogenesis, immunogenicity and immune, and clinical response in older adults, using available knowledge on SARS-CoV-2 and its highly pathogenic relatives MERS-CoV and SARS-CoV-1. We conclude by discussing clinical and basic science approaches to protect older adults against this disease.</p>
</abstract>
<kwd-group xml:lang="en"><title>Keywords</title>
<kwd>COVID-19</kwd>
<kwd>SARS-CoV-2</kwd>
<kwd>Older adults</kwd>
<kwd>Care</kwd>
<kwd>Pathogenesis</kwd>
<kwd>Immunity</kwd>
</kwd-group>
</article-meta>
</front>
</pmc>
<affiliations><list><country><li>États-Unis</li>
</country>
<region><li>Arizona</li>
</region>
</list>
<tree><country name="États-Unis"><region name="Arizona"><name sortKey="Nikolich Zugich, Janko" sort="Nikolich Zugich, Janko" uniqKey="Nikolich Zugich J" first="Janko" last="Nikolich-Zugich">Janko Nikolich-Zugich</name>
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<name sortKey="Bhattacharya, Deepta" sort="Bhattacharya, Deepta" uniqKey="Bhattacharya D" first="Deepta" last="Bhattacharya">Deepta Bhattacharya</name>
<name sortKey="Fain, Mindy J" sort="Fain, Mindy J" uniqKey="Fain M" first="Mindy J." last="Fain">Mindy J. Fain</name>
<name sortKey="Knox, Kenneth S" sort="Knox, Kenneth S" uniqKey="Knox K" first="Kenneth S." last="Knox">Kenneth S. Knox</name>
<name sortKey="Knox, Kenneth S" sort="Knox, Kenneth S" uniqKey="Knox K" first="Kenneth S." last="Knox">Kenneth S. Knox</name>
<name sortKey="Natt, Bhupinder" sort="Natt, Bhupinder" uniqKey="Natt B" first="Bhupinder" last="Natt">Bhupinder Natt</name>
<name sortKey="Rios, Carlos Tafich" sort="Rios, Carlos Tafich" uniqKey="Rios C" first="Carlos Tafich" last="Rios">Carlos Tafich Rios</name>
</country>
</tree>
</affiliations>
</record>
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