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Template. Phosphorothioate oligonucleotides duplexes as inhibitors of HIV-1 reverse transcriptase

Identifieur interne : 000113 ( PascalFrancis/Corpus ); précédent : 000112; suivant : 000114

Template. Phosphorothioate oligonucleotides duplexes as inhibitors of HIV-1 reverse transcriptase

Auteurs : G. Maury ; A. El Alaoui ; F. Morvan ; B. Müller ; J.-L. Imbach ; R. S. Goody

Source :

RBID : Pascal:92-0557956

Descripteurs français

English descriptors

Abstract

We have investigated the interaction between a number of 14 mers phosphorothioate oligonucleotides and HIV-1 reverse transcriptase. Two methods were used to measure the affinity of the analogs for the enzyme. In the first, the oligonucleotide or its duplex with Poly(rl) were used as inhibitors of the enzyme using Poly(rA).(dT)14 as template primer. In the second, the oligonucleotides or their duplexes were used to displace a fluorescent template.primer complex of known affinity from its binding site on reverse transcriptase

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

pA  
A01 01  1    @0 0006-291X
A02 01      @0 BBRCA9
A03   1    @0 Biochem. biophys. res. commun.
A05       @2 186
A06       @2 3
A08 01  1  ENG  @1 Template. Phosphorothioate oligonucleotides duplexes as inhibitors of HIV-1 reverse transcriptase
A11 01  1    @1 MAURY (G.)
A11 02  1    @1 EL ALAOUI (A.)
A11 03  1    @1 MORVAN (F.)
A11 04  1    @1 MÜLLER (B.)
A11 05  1    @1 IMBACH (J.-L.)
A11 06  1    @1 GOODY (R. S.)
A14 01      @1 CNRS Univ. Montpellier II, dép. chimie organique fine @2 34095 Montpellier @3 FRA @Z 1 aut., 2 aut., 3 aut., 5 aut.
A20       @1 1249-1256
A21       @1 1992
A23 01      @0 ENG
A43 01      @1 INIST @2 8252 @5 354000020659780100
A44       @0 0000
A45       @0 20 ref.
A47 01  1    @0 92-0557956
A60       @1 P
A61       @0 A
A64   1    @0 Biochemical and biophysical research communications
A66 01      @0 USA
C01 01    ENG  @0 We have investigated the interaction between a number of 14 mers phosphorothioate oligonucleotides and HIV-1 reverse transcriptase. Two methods were used to measure the affinity of the analogs for the enzyme. In the first, the oligonucleotide or its duplex with Poly(rl) were used as inhibitors of the enzyme using Poly(rA).(dT)14 as template primer. In the second, the oligonucleotides or their duplexes were used to displace a fluorescent template.primer complex of known affinity from its binding site on reverse transcriptase
C02 01  X    @0 002A02E03B
C03 01  X  FRE  @0 Virus HIV1 @2 NW
C03 01  X  ENG  @0 HIV-1 virus @2 NW
C03 01  X  SPA  @0 HIV-1 virus @2 NW
C03 02  X  FRE  @0 DNA polymerase RNA-dependent @2 NK @2 FE
C03 02  X  ENG  @0 DNA polymerase RNA-dependent @2 NK @2 FE
C03 02  X  SPA  @0 DNA polymerase RNA-dependent @2 NK @2 FE
C03 03  X  FRE  @0 Oligonucléotide
C03 03  X  ENG  @0 Oligonucleotide
C03 03  X  SPA  @0 Oligonucleótido
C03 04  X  FRE  @0 Interaction moléculaire
C03 04  X  ENG  @0 Molecular interaction
C03 04  X  SPA  @0 Interacción molecular
C03 05  X  FRE  @0 Activité matricielle
C03 05  X  ENG  @0 Template activity
C03 05  X  SPA  @0 Actividad modelo
C03 06  X  FRE  @0 Cinétique
C03 06  X  ENG  @0 Kinetics
C03 06  X  GER  @0 Kinetik
C03 06  X  SPA  @0 Cinética
C03 07  X  FRE  @0 Activité enzymatique
C03 07  X  ENG  @0 Enzymatic activity
C03 07  X  SPA  @0 Actividad enzimática
C07 01  X  FRE  @0 Virus immunodéficience humaine @2 NW
C07 01  X  ENG  @0 Human immunodeficiency virus @2 NW
C07 01  X  SPA  @0 Human immunodeficiency virus @2 NW
C07 02  X  FRE  @0 Lentivirinae @2 NW
C07 02  X  ENG  @0 Lentivirinae @2 NW
C07 02  X  SPA  @0 Lentivirinae @2 NW
C07 03  X  FRE  @0 Retroviridae @2 NW
C07 03  X  ENG  @0 Retroviridae @2 NW
C07 03  X  SPA  @0 Retroviridae @2 NW
C07 04  X  FRE  @0 Virus @2 NW
C07 04  X  ENG  @0 Virus @2 NW
C07 04  X  SPA  @0 Virus @2 NW
C07 05  X  FRE  @0 Enzyme
C07 05  X  ENG  @0 Enzyme
C07 05  X  SPA  @0 Enzima
N21       @1 306

Format Inist (serveur)

NO : PASCAL 92-0557956 INIST
ET : Template. Phosphorothioate oligonucleotides duplexes as inhibitors of HIV-1 reverse transcriptase
AU : MAURY (G.); EL ALAOUI (A.); MORVAN (F.); MÜLLER (B.); IMBACH (J.-L.); GOODY (R. S.)
AF : CNRS Univ. Montpellier II, dép. chimie organique fine/34095 Montpellier/France (1 aut., 2 aut., 3 aut., 5 aut.)
DT : Publication en série; Niveau analytique
SO : Biochemical and biophysical research communications; ISSN 0006-291X; Coden BBRCA9; Etats-Unis; Da. 1992; Vol. 186; No. 3; Pp. 1249-1256; Bibl. 20 ref.
LA : Anglais
EA : We have investigated the interaction between a number of 14 mers phosphorothioate oligonucleotides and HIV-1 reverse transcriptase. Two methods were used to measure the affinity of the analogs for the enzyme. In the first, the oligonucleotide or its duplex with Poly(rl) were used as inhibitors of the enzyme using Poly(rA).(dT)14 as template primer. In the second, the oligonucleotides or their duplexes were used to displace a fluorescent template.primer complex of known affinity from its binding site on reverse transcriptase
CC : 002A02E03B
FD : Virus HIV1; DNA polymerase RNA-dependent; Oligonucléotide; Interaction moléculaire; Activité matricielle; Cinétique; Activité enzymatique
FG : Virus immunodéficience humaine; Lentivirinae; Retroviridae; Virus; Enzyme
ED : HIV-1 virus; DNA polymerase RNA-dependent; Oligonucleotide; Molecular interaction; Template activity; Kinetics; Enzymatic activity
EG : Human immunodeficiency virus; Lentivirinae; Retroviridae; Virus; Enzyme
GD : Kinetik
SD : HIV-1 virus; DNA polymerase RNA-dependent; Oligonucleótido; Interacción molecular; Actividad modelo; Cinética; Actividad enzimática
LO : INIST-8252.354000020659780100
ID : 92-0557956

Links to Exploration step

Pascal:92-0557956

Le document en format XML

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