MersV1, PascalFrancis, Corpus, bibRecord, 000015

Middle East Respiratory Syndrome Coronavirus: A Case-Control Study of Hospitalized Patients

Identifieur interne : 000015 ( PascalFrancis/Corpus ); précédent : 000014; suivant : 000016

Middle East Respiratory Syndrome Coronavirus: A Case-Control Study of Hospitalized Patients

Auteurs : Jaffar A. Al-Tawfiq ; Kareem Hinedi ; Jihad Ghandour ; Hanan Khairalla ; Samir Musleh ; Alaa Ujayli ; Ziad A. Memish

Source :

Clinical infectious diseases [ 1058-4838 ] ; 2014.

RBID : Pascal:14-0183590

Descripteurs français

Pascal (Inist)
- Etude cas témoin, Hospitalisation, Infection, Coronavirus, Homme, Syndrome respiratoire du Moyen-Orient.

English descriptors

KwdEn :
- Case control study, Coronavirus, Hospitalization, Human, Infection, Middle East respiratory syndrome.

Abstract

Background. There is a paucity of data regarding the differentiating characteristics of patients with laboratory-confirmed and those negative for Middle East respiratory syndrome coronavirus (MERS-CoV). Methods. This is a hospital-based case-control study comparing MERS-CoV-positive patients (cases) with MERS-CoV-negative controls. Results. A total of 17 case patients and 82 controls with a mean age of 60.7 years and 57 years, respectively (P = .553), were included. No statistical differences were observed in relation to sex, the presence of a fever or cough, and the presence of a single or multilobar infiltrate on chest radiography. The case patients were more likely to be overweight than the control group (mean body mass index, 32 vs 27.8; P = .035), to have diabetes mellitus (87% vs 47%; odds ratio [OR], 7.24; P = .015), and to have end-stage renal disease (33% vs 7%; OR, 7; P = .012). At the time of admission, tachypnea (27% vs 60%; OR, 0.24; P=.031) and respiratory distress (15% vs 51%; OR, 0.15; P = .012) were less frequent among case patients. MERS-CoV patients were more likely to have a normal white blood cell count than the control group (82% vs 52%; OR, 4.33; P = .029). Admission chest radiography with interstitial infiltrates was more frequent in case patients than in controls (67% vs 20%; OR, 8.13; P=.001). Case patients were more likely to be admitted to the intensive care unit (53% vs 20%; OR, 4.65; P = .025) and to have a high mortality rate (76% vs 15%; OR, 18.96; P < .001). Conclusions. Few clinical predictors could enhance the ability to predict which patients with pneumonia would have MERS-CoV. However, further prospective analysis and matched case-control studies may shed light on other predictors of infection.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

A01	`01`	`1`		`@0 1058-4838`
A02	`01`			`@0 CIDIEL`
A03		`1`		`@0 Clin. infect. dis.`
A05				`@2 59`
A06				`@2 2`
A08	`01`	`1`	`ENG`	`@1 Middle East Respiratory Syndrome Coronavirus: A Case-Control Study of Hospitalized Patients`
A11	`01`	`1`		`@1 AL-TAWFIQ (Jaffar A.)`
A11	`02`	`1`		`@1 HINEDI (Kareem)`
A11	`03`	`1`		`@1 GHANDOUR (Jihad)`
A11	`04`	`1`		`@1 KHAIRALLA (Hanan)`
A11	`05`	`1`		`@1 MUSLEH (Samir)`
A11	`06`	`1`		`@1 UJAYLI (Alaa)`
A11	`07`	`1`		`@1 MEMISH (Ziad A.)`
A14	`01`			`@1 Medical Department, Saudi Aramco Medical Services Organization @2 Dhahran @3 SAU @Z 1 aut. @Z 2 aut. @Z 3 aut. @Z 4 aut. @Z 5 aut. @Z 6 aut.`
A14	`02`			`@1 Indiana University School of Medicine @2 Indianapolis @3 USA @Z 1 aut.`
A14	`03`			`@1 World Health Organization Collaborating Center for Mass Gathering Medicine, Saudi Arabian Ministry of Health @2 Riyadh @3 SAU @Z 7 aut.`
A14	`04`			`@1 Al-Faisal University @2 Riyadh @3 SAU @Z 7 aut.`
A20				`@1 160-165`
A21				`@1 2014`
A23	`01`			`@0 ENG`
A43	`01`			`@1 INIST @2 18407 @5 354000501898370020`
A44				`@0 0000 @1 © 2014 INIST-CNRS. All rights reserved.`
A45				`@0 24 ref.`
A47	`01`	`1`		`@0 14-0183590`
A60				`@1 P`
A61				`@0 A`
A64	`01`	`1`		`@0 Clinical infectious diseases`
A66	`01`			`@0 GBR`
C01	`01`		`ENG`	@0 Background. There is a paucity of data regarding the differentiating characteristics of patients with laboratory-confirmed and those negative for Middle East respiratory syndrome coronavirus (MERS-CoV). Methods. This is a hospital-based case-control study comparing MERS-CoV-positive patients (cases) with MERS-CoV-negative controls. Results. A total of 17 case patients and 82 controls with a mean age of 60.7 years and 57 years, respectively (P = .553), were included. No statistical differences were observed in relation to sex, the presence of a fever or cough, and the presence of a single or multilobar infiltrate on chest radiography. The case patients were more likely to be overweight than the control group (mean body mass index, 32 vs 27.8; P = .035), to have diabetes mellitus (87% vs 47%; odds ratio [OR], 7.24; P = .015), and to have end-stage renal disease (33% vs 7%; OR, 7; P = .012). At the time of admission, tachypnea (27% vs 60%; OR, 0.24; P=.031) and respiratory distress (15% vs 51%; OR, 0.15; P = .012) were less frequent among case patients. MERS-CoV patients were more likely to have a normal white blood cell count than the control group (82% vs 52%; OR, 4.33; P = .029). Admission chest radiography with interstitial infiltrates was more frequent in case patients than in controls (67% vs 20%; OR, 8.13; P=.001). Case patients were more likely to be admitted to the intensive care unit (53% vs 20%; OR, 4.65; P = .025) and to have a high mortality rate (76% vs 15%; OR, 18.96; P < .001). Conclusions. Few clinical predictors could enhance the ability to predict which patients with pneumonia would have MERS-CoV. However, further prospective analysis and matched case-control studies may shed light on other predictors of infection.
C02	`01`	`X`		`@0 002B05C02C`
C03	`01`	`X`	`FRE`	`@0 Etude cas témoin @5 07`
C03	`01`	`X`	`ENG`	`@0 Case control study @5 07`
C03	`01`	`X`	`SPA`	`@0 Estudio caso control @5 07`
C03	`02`	`X`	`FRE`	`@0 Hospitalisation @5 08`
C03	`02`	`X`	`ENG`	`@0 Hospitalization @5 08`
C03	`02`	`X`	`SPA`	`@0 Hospitalización @5 08`
C03	`03`	`X`	`FRE`	`@0 Infection @5 09`
C03	`03`	`X`	`ENG`	`@0 Infection @5 09`
C03	`03`	`X`	`SPA`	`@0 Infección @5 09`
C03	`04`	`X`	`FRE`	`@0 Coronavirus @2 NW @5 10`
C03	`04`	`X`	`ENG`	`@0 Coronavirus @2 NW @5 10`
C03	`04`	`X`	`SPA`	`@0 Coronavirus @2 NW @5 10`
C03	`05`	`X`	`FRE`	`@0 Homme @5 11`
C03	`05`	`X`	`ENG`	`@0 Human @5 11`
C03	`05`	`X`	`SPA`	`@0 Hombre @5 11`
C03	`06`	`X`	`FRE`	`@0 Syndrome respiratoire du Moyen-Orient @4 CD @5 96`
C03	`06`	`X`	`ENG`	`@0 Middle East respiratory syndrome @4 CD @5 96`
C07	`01`	`X`	`FRE`	`@0 Coronaviridae @2 NW`
C07	`01`	`X`	`ENG`	`@0 Coronaviridae @2 NW`
C07	`01`	`X`	`SPA`	`@0 Coronaviridae @2 NW`
C07	`02`	`X`	`FRE`	`@0 Nidovirales @2 NW`
C07	`02`	`X`	`ENG`	`@0 Nidovirales @2 NW`
C07	`02`	`X`	`SPA`	`@0 Nidovirales @2 NW`
C07	`03`	`X`	`FRE`	`@0 Virus @2 NW`
C07	`03`	`X`	`ENG`	`@0 Virus @2 NW`
C07	`03`	`X`	`SPA`	`@0 Virus @2 NW`
C07	`04`	`X`	`FRE`	`@0 Pathologie de l'appareil respiratoire @5 37`
C07	`04`	`X`	`ENG`	`@0 Respiratory disease @5 37`
C07	`04`	`X`	`SPA`	`@0 Aparato respiratorio patología @5 37`
C07	`05`	`X`	`FRE`	`@0 Virose @5 38`
C07	`05`	`X`	`ENG`	`@0 Viral disease @5 38`
C07	`05`	`X`	`SPA`	`@0 Virosis @5 38`
N21				`@1 230`
N44	`01`			`@1 OTO`
N82				`@1 OTO`

Format Inist (serveur)

NO :	PASCAL 14-0183590 INIST
ET :	Middle East Respiratory Syndrome Coronavirus: A Case-Control Study of Hospitalized Patients
AU :	AL-TAWFIQ (Jaffar A.); HINEDI (Kareem); GHANDOUR (Jihad); KHAIRALLA (Hanan); MUSLEH (Samir); UJAYLI (Alaa); MEMISH (Ziad A.)
AF :	Medical Department, Saudi Aramco Medical Services Organization/Dhahran/Arabie Saoudite (1 aut., 2 aut., 3 aut., 4 aut., 5 aut., 6 aut.); Indiana University School of Medicine/Indianapolis/Etats-Unis (1 aut.); World Health Organization Collaborating Center for Mass Gathering Medicine, Saudi Arabian Ministry of Health/Riyadh/Arabie Saoudite (7 aut.); Al-Faisal University/Riyadh/Arabie Saoudite (7 aut.)
DT :	Publication en série; Niveau analytique
SO :	Clinical infectious diseases; ISSN 1058-4838; Coden CIDIEL; Royaume-Uni; Da. 2014; Vol. 59; No. 2; Pp. 160-165; Bibl. 24 ref.
LA :	Anglais
EA :	Background. There is a paucity of data regarding the differentiating characteristics of patients with laboratory-confirmed and those negative for Middle East respiratory syndrome coronavirus (MERS-CoV). Methods. This is a hospital-based case-control study comparing MERS-CoV-positive patients (cases) with MERS-CoV-negative controls. Results. A total of 17 case patients and 82 controls with a mean age of 60.7 years and 57 years, respectively (P = .553), were included. No statistical differences were observed in relation to sex, the presence of a fever or cough, and the presence of a single or multilobar infiltrate on chest radiography. The case patients were more likely to be overweight than the control group (mean body mass index, 32 vs 27.8; P = .035), to have diabetes mellitus (87% vs 47%; odds ratio [OR], 7.24; P = .015), and to have end-stage renal disease (33% vs 7%; OR, 7; P = .012). At the time of admission, tachypnea (27% vs 60%; OR, 0.24; P=.031) and respiratory distress (15% vs 51%; OR, 0.15; P = .012) were less frequent among case patients. MERS-CoV patients were more likely to have a normal white blood cell count than the control group (82% vs 52%; OR, 4.33; P = .029). Admission chest radiography with interstitial infiltrates was more frequent in case patients than in controls (67% vs 20%; OR, 8.13; P=.001). Case patients were more likely to be admitted to the intensive care unit (53% vs 20%; OR, 4.65; P = .025) and to have a high mortality rate (76% vs 15%; OR, 18.96; P < .001). Conclusions. Few clinical predictors could enhance the ability to predict which patients with pneumonia would have MERS-CoV. However, further prospective analysis and matched case-control studies may shed light on other predictors of infection.
CC :	002B05C02C
FD :	Etude cas témoin; Hospitalisation; Infection; Coronavirus; Homme; Syndrome respiratoire du Moyen-Orient
FG :	Coronaviridae; Nidovirales; Virus; Pathologie de l'appareil respiratoire; Virose
ED :	Case control study; Hospitalization; Infection; Coronavirus; Human; Middle East respiratory syndrome
EG :	Coronaviridae; Nidovirales; Virus; Respiratory disease; Viral disease
SD :	Estudio caso control; Hospitalización; Infección; Coronavirus; Hombre
LO :	INIST-18407.354000501898370020
ID :	14-0183590

Links to Exploration step

Pascal:14-0183590

Le document en format XML

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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Middle East Respiratory Syndrome Coronavirus: A Case-Control Study of Hospitalized Patients</title>
<author><name sortKey="Al Tawfiq, Jaffar A" sort="Al Tawfiq, Jaffar A" uniqKey="Al Tawfiq J" first="Jaffar A." last="Al-Tawfiq">Jaffar A. Al-Tawfiq</name>
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<author><name sortKey="Hinedi, Kareem" sort="Hinedi, Kareem" uniqKey="Hinedi K" first="Kareem" last="Hinedi">Kareem Hinedi</name>
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<author><name sortKey="Ujayli, Alaa" sort="Ujayli, Alaa" uniqKey="Ujayli A" first="Alaa" last="Ujayli">Alaa Ujayli</name>
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<author><name sortKey="Memish, Ziad A" sort="Memish, Ziad A" uniqKey="Memish Z" first="Ziad A." last="Memish">Ziad A. Memish</name>
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<series><title level="j" type="main">Clinical infectious diseases</title>
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<seriesStmt><title level="j" type="main">Clinical infectious diseases</title>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Case control study</term>
<term>Coronavirus</term>
<term>Hospitalization</term>
<term>Human</term>
<term>Infection</term>
<term>Middle East respiratory syndrome</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Etude cas témoin</term>
<term>Hospitalisation</term>
<term>Infection</term>
<term>Coronavirus</term>
<term>Homme</term>
<term>Syndrome respiratoire du Moyen-Orient</term>
</keywords>
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<front><div type="abstract" xml:lang="en">Background. There is a paucity of data regarding the differentiating characteristics of patients with laboratory-confirmed and those negative for Middle East respiratory syndrome coronavirus (MERS-CoV). Methods. This is a hospital-based case-control study comparing MERS-CoV-positive patients (cases) with MERS-CoV-negative controls. Results. A total of 17 case patients and 82 controls with a mean age of 60.7 years and 57 years, respectively (P = .553), were included. No statistical differences were observed in relation to sex, the presence of a fever or cough, and the presence of a single or multilobar infiltrate on chest radiography. The case patients were more likely to be overweight than the control group (mean body mass index, 32 vs 27.8; P = .035), to have diabetes mellitus (87% vs 47%; odds ratio [OR], 7.24; P = .015), and to have end-stage renal disease (33% vs 7%; OR, 7; P = .012). At the time of admission, tachypnea (27% vs 60%; OR, 0.24; P=.031) and respiratory distress (15% vs 51%; OR, 0.15; P = .012) were less frequent among case patients. MERS-CoV patients were more likely to have a normal white blood cell count than the control group (82% vs 52%; OR, 4.33; P = .029). Admission chest radiography with interstitial infiltrates was more frequent in case patients than in controls (67% vs 20%; OR, 8.13; P=.001). Case patients were more likely to be admitted to the intensive care unit (53% vs 20%; OR, 4.65; P = .025) and to have a high mortality rate (76% vs 15%; OR, 18.96; P < .001). Conclusions. Few clinical predictors could enhance the ability to predict which patients with pneumonia would have MERS-CoV. However, further prospective analysis and matched case-control studies may shed light on other predictors of infection.</div>
</front>
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<fA08 i1="01" i2="1" l="ENG"><s1>Middle East Respiratory Syndrome Coronavirus: A Case-Control Study of Hospitalized Patients</s1>
</fA08>
<fA11 i1="01" i2="1"><s1>AL-TAWFIQ (Jaffar A.)</s1>
</fA11>
<fA11 i1="02" i2="1"><s1>HINEDI (Kareem)</s1>
</fA11>
<fA11 i1="03" i2="1"><s1>GHANDOUR (Jihad)</s1>
</fA11>
<fA11 i1="04" i2="1"><s1>KHAIRALLA (Hanan)</s1>
</fA11>
<fA11 i1="05" i2="1"><s1>MUSLEH (Samir)</s1>
</fA11>
<fA11 i1="06" i2="1"><s1>UJAYLI (Alaa)</s1>
</fA11>
<fA11 i1="07" i2="1"><s1>MEMISH (Ziad A.)</s1>
</fA11>
<fA14 i1="01"><s1>Medical Department, Saudi Aramco Medical Services Organization</s1>
<s2>Dhahran</s2>
<s3>SAU</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
</fA14>
<fA14 i1="02"><s1>Indiana University School of Medicine</s1>
<s2>Indianapolis</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
</fA14>
<fA14 i1="03"><s1>World Health Organization Collaborating Center for Mass Gathering Medicine, Saudi Arabian Ministry of Health</s1>
<s2>Riyadh</s2>
<s3>SAU</s3>
<sZ>7 aut.</sZ>
</fA14>
<fA14 i1="04"><s1>Al-Faisal University</s1>
<s2>Riyadh</s2>
<s3>SAU</s3>
<sZ>7 aut.</sZ>
</fA14>
<fA20><s1>160-165</s1>
</fA20>
<fA21><s1>2014</s1>
</fA21>
<fA23 i1="01"><s0>ENG</s0>
</fA23>
<fA43 i1="01"><s1>INIST</s1>
<s2>18407</s2>
<s5>354000501898370020</s5>
</fA43>
<fA44><s0>0000</s0>
<s1>© 2014 INIST-CNRS. All rights reserved.</s1>
</fA44>
<fA45><s0>24 ref.</s0>
</fA45>
<fA47 i1="01" i2="1"><s0>14-0183590</s0>
</fA47>
<fA60><s1>P</s1>
</fA60>
<fA61><s0>A</s0>
</fA61>
<fA64 i1="01" i2="1"><s0>Clinical infectious diseases</s0>
</fA64>
<fA66 i1="01"><s0>GBR</s0>
</fA66>
<fC01 i1="01" l="ENG"><s0>Background. There is a paucity of data regarding the differentiating characteristics of patients with laboratory-confirmed and those negative for Middle East respiratory syndrome coronavirus (MERS-CoV). Methods. This is a hospital-based case-control study comparing MERS-CoV-positive patients (cases) with MERS-CoV-negative controls. Results. A total of 17 case patients and 82 controls with a mean age of 60.7 years and 57 years, respectively (P = .553), were included. No statistical differences were observed in relation to sex, the presence of a fever or cough, and the presence of a single or multilobar infiltrate on chest radiography. The case patients were more likely to be overweight than the control group (mean body mass index, 32 vs 27.8; P = .035), to have diabetes mellitus (87% vs 47%; odds ratio [OR], 7.24; P = .015), and to have end-stage renal disease (33% vs 7%; OR, 7; P = .012). At the time of admission, tachypnea (27% vs 60%; OR, 0.24; P=.031) and respiratory distress (15% vs 51%; OR, 0.15; P = .012) were less frequent among case patients. MERS-CoV patients were more likely to have a normal white blood cell count than the control group (82% vs 52%; OR, 4.33; P = .029). Admission chest radiography with interstitial infiltrates was more frequent in case patients than in controls (67% vs 20%; OR, 8.13; P=.001). Case patients were more likely to be admitted to the intensive care unit (53% vs 20%; OR, 4.65; P = .025) and to have a high mortality rate (76% vs 15%; OR, 18.96; P < .001). Conclusions. Few clinical predictors could enhance the ability to predict which patients with pneumonia would have MERS-CoV. However, further prospective analysis and matched case-control studies may shed light on other predictors of infection.</s0>
</fC01>
<fC02 i1="01" i2="X"><s0>002B05C02C</s0>
</fC02>
<fC03 i1="01" i2="X" l="FRE"><s0>Etude cas témoin</s0>
<s5>07</s5>
</fC03>
<fC03 i1="01" i2="X" l="ENG"><s0>Case control study</s0>
<s5>07</s5>
</fC03>
<fC03 i1="01" i2="X" l="SPA"><s0>Estudio caso control</s0>
<s5>07</s5>
</fC03>
<fC03 i1="02" i2="X" l="FRE"><s0>Hospitalisation</s0>
<s5>08</s5>
</fC03>
<fC03 i1="02" i2="X" l="ENG"><s0>Hospitalization</s0>
<s5>08</s5>
</fC03>
<fC03 i1="02" i2="X" l="SPA"><s0>Hospitalización</s0>
<s5>08</s5>
</fC03>
<fC03 i1="03" i2="X" l="FRE"><s0>Infection</s0>
<s5>09</s5>
</fC03>
<fC03 i1="03" i2="X" l="ENG"><s0>Infection</s0>
<s5>09</s5>
</fC03>
<fC03 i1="03" i2="X" l="SPA"><s0>Infección</s0>
<s5>09</s5>
</fC03>
<fC03 i1="04" i2="X" l="FRE"><s0>Coronavirus</s0>
<s2>NW</s2>
<s5>10</s5>
</fC03>
<fC03 i1="04" i2="X" l="ENG"><s0>Coronavirus</s0>
<s2>NW</s2>
<s5>10</s5>
</fC03>
<fC03 i1="04" i2="X" l="SPA"><s0>Coronavirus</s0>
<s2>NW</s2>
<s5>10</s5>
</fC03>
<fC03 i1="05" i2="X" l="FRE"><s0>Homme</s0>
<s5>11</s5>
</fC03>
<fC03 i1="05" i2="X" l="ENG"><s0>Human</s0>
<s5>11</s5>
</fC03>
<fC03 i1="05" i2="X" l="SPA"><s0>Hombre</s0>
<s5>11</s5>
</fC03>
<fC03 i1="06" i2="X" l="FRE"><s0>Syndrome respiratoire du Moyen-Orient</s0>
<s4>CD</s4>
<s5>96</s5>
</fC03>
<fC03 i1="06" i2="X" l="ENG"><s0>Middle East respiratory syndrome</s0>
<s4>CD</s4>
<s5>96</s5>
</fC03>
<fC07 i1="01" i2="X" l="FRE"><s0>Coronaviridae</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="01" i2="X" l="ENG"><s0>Coronaviridae</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="01" i2="X" l="SPA"><s0>Coronaviridae</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="02" i2="X" l="FRE"><s0>Nidovirales</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="02" i2="X" l="ENG"><s0>Nidovirales</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="02" i2="X" l="SPA"><s0>Nidovirales</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="03" i2="X" l="FRE"><s0>Virus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="03" i2="X" l="ENG"><s0>Virus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="03" i2="X" l="SPA"><s0>Virus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="04" i2="X" l="FRE"><s0>Pathologie de l'appareil respiratoire</s0>
<s5>37</s5>
</fC07>
<fC07 i1="04" i2="X" l="ENG"><s0>Respiratory disease</s0>
<s5>37</s5>
</fC07>
<fC07 i1="04" i2="X" l="SPA"><s0>Aparato respiratorio patología</s0>
<s5>37</s5>
</fC07>
<fC07 i1="05" i2="X" l="FRE"><s0>Virose</s0>
<s5>38</s5>
</fC07>
<fC07 i1="05" i2="X" l="ENG"><s0>Viral disease</s0>
<s5>38</s5>
</fC07>
<fC07 i1="05" i2="X" l="SPA"><s0>Virosis</s0>
<s5>38</s5>
</fC07>
<fN21><s1>230</s1>
</fN21>
<fN44 i1="01"><s1>OTO</s1>
</fN44>
<fN82><s1>OTO</s1>
</fN82>
</pA>
</standard>
<server><NO>PASCAL 14-0183590 INIST</NO>
<ET>Middle East Respiratory Syndrome Coronavirus: A Case-Control Study of Hospitalized Patients</ET>
<AU>AL-TAWFIQ (Jaffar A.); HINEDI (Kareem); GHANDOUR (Jihad); KHAIRALLA (Hanan); MUSLEH (Samir); UJAYLI (Alaa); MEMISH (Ziad A.)</AU>
<AF>Medical Department, Saudi Aramco Medical Services Organization/Dhahran/Arabie Saoudite (1 aut., 2 aut., 3 aut., 4 aut., 5 aut., 6 aut.); Indiana University School of Medicine/Indianapolis/Etats-Unis (1 aut.); World Health Organization Collaborating Center for Mass Gathering Medicine, Saudi Arabian Ministry of Health/Riyadh/Arabie Saoudite (7 aut.); Al-Faisal University/Riyadh/Arabie Saoudite (7 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>Clinical infectious diseases; ISSN 1058-4838; Coden CIDIEL; Royaume-Uni; Da. 2014; Vol. 59; No. 2; Pp. 160-165; Bibl. 24 ref.</SO>
<LA>Anglais</LA>
<EA>Background. There is a paucity of data regarding the differentiating characteristics of patients with laboratory-confirmed and those negative for Middle East respiratory syndrome coronavirus (MERS-CoV). Methods. This is a hospital-based case-control study comparing MERS-CoV-positive patients (cases) with MERS-CoV-negative controls. Results. A total of 17 case patients and 82 controls with a mean age of 60.7 years and 57 years, respectively (P = .553), were included. No statistical differences were observed in relation to sex, the presence of a fever or cough, and the presence of a single or multilobar infiltrate on chest radiography. The case patients were more likely to be overweight than the control group (mean body mass index, 32 vs 27.8; P = .035), to have diabetes mellitus (87% vs 47%; odds ratio [OR], 7.24; P = .015), and to have end-stage renal disease (33% vs 7%; OR, 7; P = .012). At the time of admission, tachypnea (27% vs 60%; OR, 0.24; P=.031) and respiratory distress (15% vs 51%; OR, 0.15; P = .012) were less frequent among case patients. MERS-CoV patients were more likely to have a normal white blood cell count than the control group (82% vs 52%; OR, 4.33; P = .029). Admission chest radiography with interstitial infiltrates was more frequent in case patients than in controls (67% vs 20%; OR, 8.13; P=.001). Case patients were more likely to be admitted to the intensive care unit (53% vs 20%; OR, 4.65; P = .025) and to have a high mortality rate (76% vs 15%; OR, 18.96; P < .001). Conclusions. Few clinical predictors could enhance the ability to predict which patients with pneumonia would have MERS-CoV. However, further prospective analysis and matched case-control studies may shed light on other predictors of infection.</EA>
<CC>002B05C02C</CC>
<FD>Etude cas témoin; Hospitalisation; Infection; Coronavirus; Homme; Syndrome respiratoire du Moyen-Orient</FD>
<FG>Coronaviridae; Nidovirales; Virus; Pathologie de l'appareil respiratoire; Virose</FG>
<ED>Case control study; Hospitalization; Infection; Coronavirus; Human; Middle East respiratory syndrome</ED>
<EG>Coronaviridae; Nidovirales; Virus; Respiratory disease; Viral disease</EG>
<SD>Estudio caso control; Hospitalización; Infección; Coronavirus; Hombre</SD>
<LO>INIST-18407.354000501898370020</LO>
<ID>14-0183590</ID>
</server>
</inist>
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Middle East Respiratory Syndrome Coronavirus: A Case-Control Study of Hospitalized Patients

Middle East Respiratory Syndrome Coronavirus: A Case-Control Study of Hospitalized Patients

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