In vivo primary induction of virus-specific CTL by immunization with 9-mer synthetic peptides
Identifieur interne : 000110 ( PascalFrancis/Checkpoint ); précédent : 000109; suivant : 000111In vivo primary induction of virus-specific CTL by immunization with 9-mer synthetic peptides
Auteurs : X. Zhou [Suède] ; L. Berg ; U. M. Abdel Motal ; M. JondalSource :
- Journal of immunological methods [ 0022-1759 ] ; 1992.
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Abstract
A primary cytotoxic T lymphocyte (CTL) response in vivo requires antigen presentation by cytosolic processing and can not in general be obtained by vaccination with soluble proteins. In the present work we have found that vaccination of mice with pre-processed synthetic peptides, corresponding to endogenous 9-mers produced in influenza A virus-infected cells, resulted in strong primary CTL responses. The generated CTL efficiently killed virus-infected target cells with preference for viral strains having the identical amino acid sequences to the peptides used for immunization
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Jondal</name></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">93-0035362</idno><date when="1992">1992</date><idno type="stanalyst">PASCAL 93-0035362 INIST</idno><idno type="RBID">Pascal:93-0035362</idno><idno type="wicri:Area/PascalFrancis/Corpus">000111</idno><idno type="wicri:Area/PascalFrancis/Curation">000103</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">000110</idno><idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">000110</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">In vivo primary induction of virus-specific CTL by immunization with 9-mer synthetic peptides</title><author><name sortKey="Zhou, X" sort="Zhou, X" uniqKey="Zhou X" first="X." last="Zhou">X. Zhou</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Karolinska inst., dep. immunology</s1><s2>104 01 Stockholm</s2><s3>SWE</s3></inist:fA14><country>Suède</country><wicri:noRegion>104 01 Stockholm</wicri:noRegion></affiliation></author><author><name sortKey="Berg, L" sort="Berg, L" uniqKey="Berg L" first="L." last="Berg">L. Berg</name></author><author><name sortKey="Abdel Motal, U M" sort="Abdel Motal, U M" uniqKey="Abdel Motal U" first="U. M." last="Abdel Motal">U. M. Abdel Motal</name></author><author><name sortKey="Jondal, M" sort="Jondal, M" uniqKey="Jondal M" first="M." last="Jondal">M. Jondal</name></author></analytic><series><title level="j" type="main">Journal of immunological methods</title><title level="j" type="abbreviated">J. immunol. methods</title><idno type="ISSN">0022-1759</idno><imprint><date when="1992">1992</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Journal of immunological methods</title><title level="j" type="abbreviated">J. immunol. methods</title><idno type="ISSN">0022-1759</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Cytotoxicity</term><term>Immunization</term><term>In vivo</term><term>Induction</term><term>Influenzavirus A</term><term>Mouse</term><term>Peptides</term><term>Synthetic product</term><term>T-Lymphocyte</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Souris</term><term>Influenzavirus A</term><term>Lymphocyte T</term><term>Cytotoxicité</term><term>Immunisation</term><term>Peptide</term><term>Produit synthétique</term><term>Induction</term><term>In vivo</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">A primary cytotoxic T lymphocyte (CTL) response in vivo requires antigen presentation by cytosolic processing and can not in general be obtained by vaccination with soluble proteins. 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M." last="Abdel Motal">U. M. Abdel Motal</name><name sortKey="Berg, L" sort="Berg, L" uniqKey="Berg L" first="L." last="Berg">L. Berg</name><name sortKey="Jondal, M" sort="Jondal, M" uniqKey="Jondal M" first="M." last="Jondal">M. Jondal</name></noCountry><country name="Suède"><noRegion><name sortKey="Zhou, X" sort="Zhou, X" uniqKey="Zhou X" first="X." last="Zhou">X. Zhou</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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