Newcastle disease virus-based MERS-CoV candidate vaccine elicits high-level and lasting neutralizing antibodies in Bactrian camels
Identifieur interne : 002C92 ( Ncbi/Merge ); précédent : 002C91; suivant : 002C93Newcastle disease virus-based MERS-CoV candidate vaccine elicits high-level and lasting neutralizing antibodies in Bactrian camels
Auteurs : Ren-Qiang Liu [République populaire de Chine] ; Jin-Ying Ge [République populaire de Chine] ; Jin-Ling Wang [République populaire de Chine] ; Yu Shao [République populaire de Chine] ; Hui-Lei Zhang [République populaire de Chine] ; Jin-Liang Wang [République populaire de Chine] ; Zhi-Yuan Wen [République populaire de Chine] ; Zhi-Gao Bu [République populaire de Chine]Source :
- Journal of Integrative Agriculture [ 2095-3119 ] ; 2017.
Abstract
Middle East respiratory syndrome coronavirus (MERS-CoV), a member of the
Url:
DOI: 10.1016/S2095-3119(17)61660-5
PubMed: NONE
PubMed Central: 7128255
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Newcastle disease virus-based MERS-CoV candidate vaccine elicits high-level and lasting neutralizing antibodies in Bactrian camels</title><author><name sortKey="Liu, Ren Qiang" sort="Liu, Ren Qiang" uniqKey="Liu R" first="Ren-Qiang" last="Liu">Ren-Qiang Liu</name><affiliation wicri:level="1"><nlm:aff id="aff1">State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150069, P.R.China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150069</wicri:regionArea><wicri:noRegion>Harbin 150069</wicri:noRegion></affiliation></author><author><name sortKey="Ge, Jin Ying" sort="Ge, Jin Ying" uniqKey="Ge J" first="Jin-Ying" last="Ge">Jin-Ying Ge</name><affiliation wicri:level="1"><nlm:aff id="aff1">State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150069, P.R.China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150069</wicri:regionArea><wicri:noRegion>Harbin 150069</wicri:noRegion></affiliation></author><author><name sortKey="Wang, Jin Ling" sort="Wang, Jin Ling" uniqKey="Wang J" first="Jin-Ling" last="Wang">Jin-Ling Wang</name><affiliation wicri:level="1"><nlm:aff id="aff2">College of Veterinary Medicine, Inner Mongolia Agricultural University, Hohhot 010018, P.R.China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>College of Veterinary Medicine, Inner Mongolia Agricultural University, Hohhot 010018</wicri:regionArea><wicri:noRegion>Hohhot 010018</wicri:noRegion></affiliation></author><author><name sortKey="Shao, Yu" sort="Shao, Yu" uniqKey="Shao Y" first="Yu" last="Shao">Yu Shao</name><affiliation wicri:level="1"><nlm:aff id="aff1">State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150069, P.R.China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150069</wicri:regionArea><wicri:noRegion>Harbin 150069</wicri:noRegion></affiliation></author><author><name sortKey="Zhang, Hui Lei" sort="Zhang, Hui Lei" uniqKey="Zhang H" first="Hui-Lei" last="Zhang">Hui-Lei Zhang</name><affiliation wicri:level="1"><nlm:aff id="aff1">State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150069, P.R.China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150069</wicri:regionArea><wicri:noRegion>Harbin 150069</wicri:noRegion></affiliation></author><author><name sortKey="Wang, Jin Liang" sort="Wang, Jin Liang" uniqKey="Wang J" first="Jin-Liang" last="Wang">Jin-Liang Wang</name><affiliation wicri:level="1"><nlm:aff id="aff1">State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150069, P.R.China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150069</wicri:regionArea><wicri:noRegion>Harbin 150069</wicri:noRegion></affiliation></author><author><name sortKey="Wen, Zhi Yuan" sort="Wen, Zhi Yuan" uniqKey="Wen Z" first="Zhi-Yuan" last="Wen">Zhi-Yuan Wen</name><affiliation wicri:level="1"><nlm:aff id="aff1">State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150069, P.R.China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150069</wicri:regionArea><wicri:noRegion>Harbin 150069</wicri:noRegion></affiliation></author><author><name sortKey="Bu, Zhi Gao" sort="Bu, Zhi Gao" uniqKey="Bu Z" first="Zhi-Gao" last="Bu">Zhi-Gao Bu</name><affiliation wicri:level="1"><nlm:aff id="aff1">State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150069, P.R.China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150069</wicri:regionArea><wicri:noRegion>Harbin 150069</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmc">7128255</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7128255</idno><idno type="RBID">PMC:7128255</idno><idno type="doi">10.1016/S2095-3119(17)61660-5</idno><idno type="pmid">NONE</idno><date when="2017">2017</date><idno type="wicri:Area/Pmc/Corpus">000E67</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000E67</idno><idno type="wicri:Area/Pmc/Curation">000E67</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000E67</idno><idno type="wicri:Area/Pmc/Checkpoint">000767</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000767</idno><idno type="wicri:Area/Ncbi/Merge">002C92</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Newcastle disease virus-based MERS-CoV candidate vaccine elicits high-level and lasting neutralizing antibodies in Bactrian camels</title><author><name sortKey="Liu, Ren Qiang" sort="Liu, Ren Qiang" uniqKey="Liu R" first="Ren-Qiang" last="Liu">Ren-Qiang Liu</name><affiliation wicri:level="1"><nlm:aff id="aff1">State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150069, P.R.China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150069</wicri:regionArea><wicri:noRegion>Harbin 150069</wicri:noRegion></affiliation></author><author><name sortKey="Ge, Jin Ying" sort="Ge, Jin Ying" uniqKey="Ge J" first="Jin-Ying" last="Ge">Jin-Ying Ge</name><affiliation wicri:level="1"><nlm:aff id="aff1">State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150069, P.R.China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150069</wicri:regionArea><wicri:noRegion>Harbin 150069</wicri:noRegion></affiliation></author><author><name sortKey="Wang, Jin Ling" sort="Wang, Jin Ling" uniqKey="Wang J" first="Jin-Ling" last="Wang">Jin-Ling Wang</name><affiliation wicri:level="1"><nlm:aff id="aff2">College of Veterinary Medicine, Inner Mongolia Agricultural University, Hohhot 010018, P.R.China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>College of Veterinary Medicine, Inner Mongolia Agricultural University, Hohhot 010018</wicri:regionArea><wicri:noRegion>Hohhot 010018</wicri:noRegion></affiliation></author><author><name sortKey="Shao, Yu" sort="Shao, Yu" uniqKey="Shao Y" first="Yu" last="Shao">Yu Shao</name><affiliation wicri:level="1"><nlm:aff id="aff1">State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150069, P.R.China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150069</wicri:regionArea><wicri:noRegion>Harbin 150069</wicri:noRegion></affiliation></author><author><name sortKey="Zhang, Hui Lei" sort="Zhang, Hui Lei" uniqKey="Zhang H" first="Hui-Lei" last="Zhang">Hui-Lei Zhang</name><affiliation wicri:level="1"><nlm:aff id="aff1">State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150069, P.R.China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150069</wicri:regionArea><wicri:noRegion>Harbin 150069</wicri:noRegion></affiliation></author><author><name sortKey="Wang, Jin Liang" sort="Wang, Jin Liang" uniqKey="Wang J" first="Jin-Liang" last="Wang">Jin-Liang Wang</name><affiliation wicri:level="1"><nlm:aff id="aff1">State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150069, P.R.China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150069</wicri:regionArea><wicri:noRegion>Harbin 150069</wicri:noRegion></affiliation></author><author><name sortKey="Wen, Zhi Yuan" sort="Wen, Zhi Yuan" uniqKey="Wen Z" first="Zhi-Yuan" last="Wen">Zhi-Yuan Wen</name><affiliation wicri:level="1"><nlm:aff id="aff1">State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150069, P.R.China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150069</wicri:regionArea><wicri:noRegion>Harbin 150069</wicri:noRegion></affiliation></author><author><name sortKey="Bu, Zhi Gao" sort="Bu, Zhi Gao" uniqKey="Bu Z" first="Zhi-Gao" last="Bu">Zhi-Gao Bu</name><affiliation wicri:level="1"><nlm:aff id="aff1">State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150069, P.R.China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150069</wicri:regionArea><wicri:noRegion>Harbin 150069</wicri:noRegion></affiliation></author></analytic><series><title level="j">Journal of Integrative Agriculture</title><idno type="ISSN">2095-3119</idno><idno type="eISSN">2095-3119</idno><imprint><date when="2017">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Abstract</title><p>Middle East respiratory syndrome coronavirus (MERS-CoV), a member of the <italic>Coronaviridae</italic> family, is the causative pathogen for MERS that is characterized by high fever, pneumonia, acute respiratory distress syndrome (ARDS), as well as extrapulmonary manifestations. Currently, there are no approved treatment regimens or vaccines for MERS. Here, we generated recombinant nonvirulent Newcastle disease virus (NDV) LaSota strain expressing MERS-CoV S protein (designated as rLa-MERS-S), and evaluated its immunogenicity in mice and Bactrian camels. The results revealed that rLa-MERS-S showed similar growth properties to those of LaSota in embryonated chicken eggs, while animal immunization studies showed that rLa-MERS-S induced MERS-CoV neutralizing antibodies in mice and camels. Our findings suggest that recombinant rLa-MERS-S may be a potential MERS-CoV veterinary vaccine candidate for camels and other animals affected by MERS.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Oie World Organisation For Animal Health" uniqKey="Oie World Organisation For Animal Health">OIE (World Organisation for Animal Health)</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Annan, A" uniqKey="Annan A">A Annan</name></author><author><name sortKey="Baldwin, H J" uniqKey="Baldwin H">H J Baldwin</name></author><author><name sortKey="Corman, V M" uniqKey="Corman V">V M Corman</name></author><author><name sortKey="Klose, S M" uniqKey="Klose S">S M Klose</name></author><author><name sortKey="Owusu, M" uniqKey="Owusu M">M Owusu</name></author><author><name sortKey="Nkrumah, E E" uniqKey="Nkrumah E">E E Nkrumah</name></author><author><name sortKey="Badu, E K" uniqKey="Badu E">E K 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<front><journal-meta><journal-id journal-id-type="nlm-ta">J Integr Agric</journal-id><journal-id journal-id-type="iso-abbrev">J Integr Agric</journal-id><journal-title-group><journal-title>Journal of Integrative Agriculture</journal-title></journal-title-group><issn pub-type="ppub">2095-3119</issn><issn pub-type="epub">2095-3119</issn><publisher><publisher-name>CAAS. Publishing services by Elsevier B.V. Published by Elsevier B.V.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmc">7128255</article-id><article-id pub-id-type="publisher-id">S2095-3119(17)61660-5</article-id><article-id pub-id-type="doi">10.1016/S2095-3119(17)61660-5</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Newcastle disease virus-based MERS-CoV candidate vaccine elicits high-level and lasting neutralizing antibodies in Bactrian camels</article-title></title-group><contrib-group><contrib contrib-type="author" id="au10"><name><surname>LIU</surname><given-names>Ren-qiang</given-names></name><email>lrq29134@163.com</email><xref rid="aff1" ref-type="aff">a</xref></contrib><contrib contrib-type="author" id="au20"><name><surname>GE</surname><given-names>Jin-ying</given-names></name><xref rid="aff1" ref-type="aff">a</xref></contrib><contrib contrib-type="author" id="au30"><name><surname>WANG</surname><given-names>Jin-ling</given-names></name><xref rid="aff2" ref-type="aff">b</xref></contrib><contrib contrib-type="author" id="au40"><name><surname>SHAO</surname><given-names>Yu</given-names></name><xref rid="aff1" ref-type="aff">a</xref></contrib><contrib contrib-type="author" id="au50"><name><surname>ZHANG</surname><given-names>Hui-lei</given-names></name><xref rid="aff1" ref-type="aff">a</xref></contrib><contrib contrib-type="author" id="au60"><name><surname>WANG</surname><given-names>Jin-liang</given-names></name><xref rid="aff1" ref-type="aff">a</xref></contrib><contrib contrib-type="author" id="au70"><name><surname>WEN</surname><given-names>Zhi-yuan</given-names></name><email>zywen7@yahoo.com</email><xref rid="aff1" ref-type="aff">a</xref></contrib><contrib contrib-type="author" id="au80"><name><surname>BU</surname><given-names>Zhi-gao</given-names></name><email>buzhigao@caas.cn</email><xref rid="aff1" ref-type="aff">a</xref><xref rid="cor1" ref-type="corresp">*</xref></contrib></contrib-group><aff id="aff1"><label>a</label>State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150069, P.R.China</aff><aff id="aff2"><label>b</label>College of Veterinary Medicine, Inner Mongolia Agricultural University, Hohhot 010018, P.R.China</aff><author-notes><corresp id="cor1"><label>*</label>Correspondence BU Zhi-gao <email>buzhigao@caas.cn</email></corresp></author-notes><pub-date pub-type="pmc-release"><day>9</day><month>10</month><year>2017</year></pub-date><pmc-comment> PMC Release delay is 0 months and 0 days and was based on .</pmc-comment>
<pub-date pub-type="ppub"><month>10</month><year>2017</year></pub-date><pub-date pub-type="epub"><day>9</day><month>10</month><year>2017</year></pub-date><volume>16</volume><issue>10</issue><fpage>2264</fpage><lpage>2273</lpage><history><date date-type="received"><day>17</day><month>2</month><year>2017</year></date><date date-type="accepted"><day>10</day><month>5</month><year>2017</year></date></history><permissions><copyright-statement>Copyright © 2017 CAAS. Publishing services by Elsevier B.V. Published by Elsevier B.V. All rights reserved.</copyright-statement><copyright-year>2017</copyright-year><copyright-holder>CAAS. Publishing services by Elsevier B.V</copyright-holder><license><license-p>Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.</license-p></license></permissions><abstract id="ceab10"><title>Abstract</title><p>Middle East respiratory syndrome coronavirus (MERS-CoV), a member of the <italic>Coronaviridae</italic> family, is the causative pathogen for MERS that is characterized by high fever, pneumonia, acute respiratory distress syndrome (ARDS), as well as extrapulmonary manifestations. Currently, there are no approved treatment regimens or vaccines for MERS. Here, we generated recombinant nonvirulent Newcastle disease virus (NDV) LaSota strain expressing MERS-CoV S protein (designated as rLa-MERS-S), and evaluated its immunogenicity in mice and Bactrian camels. The results revealed that rLa-MERS-S showed similar growth properties to those of LaSota in embryonated chicken eggs, while animal immunization studies showed that rLa-MERS-S induced MERS-CoV neutralizing antibodies in mice and camels. Our findings suggest that recombinant rLa-MERS-S may be a potential MERS-CoV veterinary vaccine candidate for camels and other animals affected by MERS.</p></abstract><kwd-group id="cekeyws10"><title>Keywords</title><kwd>Newcastle disease virus</kwd><kwd>MERS-CoV</kwd><kwd>neutralizing antibodies</kwd><kwd>camels</kwd></kwd-group></article-meta></front></pmc><affiliations><list><country><li>République populaire de Chine</li></country></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Liu, Ren Qiang" sort="Liu, Ren Qiang" uniqKey="Liu R" first="Ren-Qiang" last="Liu">Ren-Qiang Liu</name></noRegion><name sortKey="Bu, Zhi Gao" sort="Bu, Zhi Gao" uniqKey="Bu Z" first="Zhi-Gao" last="Bu">Zhi-Gao Bu</name><name sortKey="Ge, Jin Ying" sort="Ge, Jin Ying" uniqKey="Ge J" first="Jin-Ying" last="Ge">Jin-Ying Ge</name><name sortKey="Shao, Yu" sort="Shao, Yu" uniqKey="Shao Y" first="Yu" last="Shao">Yu Shao</name><name sortKey="Wang, Jin Liang" sort="Wang, Jin Liang" uniqKey="Wang J" first="Jin-Liang" last="Wang">Jin-Liang Wang</name><name sortKey="Wang, Jin Ling" sort="Wang, Jin Ling" uniqKey="Wang J" first="Jin-Ling" last="Wang">Jin-Ling Wang</name><name sortKey="Wen, Zhi Yuan" sort="Wen, Zhi Yuan" uniqKey="Wen Z" first="Zhi-Yuan" last="Wen">Zhi-Yuan Wen</name><name sortKey="Zhang, Hui Lei" sort="Zhang, Hui Lei" uniqKey="Zhang H" first="Hui-Lei" last="Zhang">Hui-Lei Zhang</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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