Comparative pathogenesis of COVID-19, MERS, and SARS in a nonhuman primate model.
Identifieur interne : 002830 ( Ncbi/Merge ); précédent : 002829; suivant : 002831Comparative pathogenesis of COVID-19, MERS, and SARS in a nonhuman primate model.
Auteurs : Barry Rockx [Pays-Bas] ; Thijs Kuiken [Pays-Bas] ; Sander Herfst [Pays-Bas] ; Theo Bestebroer [Pays-Bas] ; Mart M. Lamers [Pays-Bas] ; Bas B. Oude Munnink [Pays-Bas] ; Dennis De Meulder [Pays-Bas] ; Geert Van Amerongen [Pays-Bas] ; Judith Van Den Brand [Pays-Bas] ; Nisreen M A. Okba [Pays-Bas] ; Debby Schipper [Pays-Bas] ; Peter Van Run [Pays-Bas] ; Lonneke Leijten [Pays-Bas] ; Reina Sikkema [Pays-Bas] ; Ernst Verschoor [Pays-Bas] ; Babs Verstrepen [Pays-Bas] ; Willy Bogers [Pays-Bas] ; Jan Langermans [Pays-Bas] ; Christian Drosten [Allemagne] ; Martje Fentener Van Vlissingen [Pays-Bas] ; Ron Fouchier [Pays-Bas] ; Rik De Swart [Pays-Bas] ; Marion Koopmans [Pays-Bas] ; Bart L. Haagmans [Pays-Bas]Source :
- Science (New York, N.Y.) [ 1095-9203 ] ; 2020.
Abstract
The current pandemic coronavirus, SARS-CoV-2, was recently identified in patients with an acute respiratory syndrome, COVID-19. To compare its pathogenesis with that of previously emerging coronaviruses, we inoculated cynomolgus macaques with SARS-CoV-2 or MERS-CoV and compared the pathology and virology with historical reports of SARS-CoV infections. In SARS-CoV-2-infected macaques, virus was excreted from nose and throat in the absence of clinical signs, and detected in type I and II pneumocytes in foci of diffuse alveolar damage and in ciliated epithelial cells of nasal, bronchial, and bronchiolar mucosae. In SARS-CoV-infection, lung lesions were typically more severe, while they were milder in MERS-CoV infection, where virus was detected mainly in type II pneumocytes. These data show that SARS-CoV-2 causes COVID-19-like disease in macaques, and provides a new model to test preventive and therapeutic strategies.
DOI: 10.1126/science.abb7314
PubMed: 32303590
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<author><name sortKey="Van Den Brand, Judith" sort="Van Den Brand, Judith" uniqKey="Van Den Brand J" first="Judith" last="Van Den Brand">Judith Van Den Brand</name>
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<author><name sortKey="Schipper, Debby" sort="Schipper, Debby" uniqKey="Schipper D" first="Debby" last="Schipper">Debby Schipper</name>
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<author><name sortKey="Koopmans, Marion" sort="Koopmans, Marion" uniqKey="Koopmans M" first="Marion" last="Koopmans">Marion Koopmans</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Viroscience, Erasmus University Medical Center, Rotterdam, Netherlands.</nlm:affiliation>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Viroscience, Erasmus University Medical Center, Rotterdam</wicri:regionArea>
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<author><name sortKey="Haagmans, Bart L" sort="Haagmans, Bart L" uniqKey="Haagmans B" first="Bart L" last="Haagmans">Bart L. Haagmans</name>
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<country xml:lang="fr">Pays-Bas</country>
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<author><name sortKey="Oude Munnink, Bas B" sort="Oude Munnink, Bas B" uniqKey="Oude Munnink B" first="Bas B" last="Oude Munnink">Bas B. Oude Munnink</name>
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<author><name sortKey="De Meulder, Dennis" sort="De Meulder, Dennis" uniqKey="De Meulder D" first="Dennis" last="De Meulder">Dennis De Meulder</name>
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<author><name sortKey="Van Amerongen, Geert" sort="Van Amerongen, Geert" uniqKey="Van Amerongen G" first="Geert" last="Van Amerongen">Geert Van Amerongen</name>
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<author><name sortKey="Van Den Brand, Judith" sort="Van Den Brand, Judith" uniqKey="Van Den Brand J" first="Judith" last="Van Den Brand">Judith Van Den Brand</name>
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<author><name sortKey="Okba, Nisreen M A" sort="Okba, Nisreen M A" uniqKey="Okba N" first="Nisreen M A" last="Okba">Nisreen M A. Okba</name>
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<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Viroscience, Erasmus University Medical Center, Rotterdam</wicri:regionArea>
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<author><name sortKey="Schipper, Debby" sort="Schipper, Debby" uniqKey="Schipper D" first="Debby" last="Schipper">Debby Schipper</name>
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</affiliation>
</author>
<author><name sortKey="Van Run, Peter" sort="Van Run, Peter" uniqKey="Van Run P" first="Peter" last="Van Run">Peter Van Run</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Viroscience, Erasmus University Medical Center, Rotterdam, Netherlands.</nlm:affiliation>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Viroscience, Erasmus University Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Leijten, Lonneke" sort="Leijten, Lonneke" uniqKey="Leijten L" first="Lonneke" last="Leijten">Lonneke Leijten</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Viroscience, Erasmus University Medical Center, Rotterdam, Netherlands.</nlm:affiliation>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Viroscience, Erasmus University Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Sikkema, Reina" sort="Sikkema, Reina" uniqKey="Sikkema R" first="Reina" last="Sikkema">Reina Sikkema</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Viroscience, Erasmus University Medical Center, Rotterdam, Netherlands.</nlm:affiliation>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Viroscience, Erasmus University Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Verschoor, Ernst" sort="Verschoor, Ernst" uniqKey="Verschoor E" first="Ernst" last="Verschoor">Ernst Verschoor</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Virology, Biomedical Primate Research Centre, Rijswijk, Netherlands.</nlm:affiliation>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Virology, Biomedical Primate Research Centre, Rijswijk</wicri:regionArea>
<wicri:noRegion>Rijswijk</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Verstrepen, Babs" sort="Verstrepen, Babs" uniqKey="Verstrepen B" first="Babs" last="Verstrepen">Babs Verstrepen</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Virology, Biomedical Primate Research Centre, Rijswijk, Netherlands.</nlm:affiliation>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Virology, Biomedical Primate Research Centre, Rijswijk</wicri:regionArea>
<wicri:noRegion>Rijswijk</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Bogers, Willy" sort="Bogers, Willy" uniqKey="Bogers W" first="Willy" last="Bogers">Willy Bogers</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Virology, Biomedical Primate Research Centre, Rijswijk, Netherlands.</nlm:affiliation>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Virology, Biomedical Primate Research Centre, Rijswijk</wicri:regionArea>
<wicri:noRegion>Rijswijk</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Langermans, Jan" sort="Langermans, Jan" uniqKey="Langermans J" first="Jan" last="Langermans">Jan Langermans</name>
<affiliation wicri:level="1"><nlm:affiliation>Animal Science Department, Biomedical Primate Research Centre, Rijswijk, Netherlands.</nlm:affiliation>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Animal Science Department, Biomedical Primate Research Centre, Rijswijk</wicri:regionArea>
<wicri:noRegion>Rijswijk</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Drosten, Christian" sort="Drosten, Christian" uniqKey="Drosten C" first="Christian" last="Drosten">Christian Drosten</name>
<affiliation wicri:level="3"><nlm:affiliation>Institute of Virology, Charité-Universitätsmedizin, Berlin, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Virology, Charité-Universitätsmedizin, Berlin</wicri:regionArea>
<placeName><region type="land" nuts="3">Berlin</region>
<settlement type="city">Berlin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Fentener Van Vlissingen, Martje" sort="Fentener Van Vlissingen, Martje" uniqKey="Fentener Van Vlissingen M" first="Martje" last="Fentener Van Vlissingen">Martje Fentener Van Vlissingen</name>
<affiliation wicri:level="3"><nlm:affiliation>Erasmus Laboratory Animal Science Center, Erasmus University Medical Center, Rotterdam, Netherlands.</nlm:affiliation>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Erasmus Laboratory Animal Science Center, Erasmus University Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Fouchier, Ron" sort="Fouchier, Ron" uniqKey="Fouchier R" first="Ron" last="Fouchier">Ron Fouchier</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Viroscience, Erasmus University Medical Center, Rotterdam, Netherlands.</nlm:affiliation>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Viroscience, Erasmus University Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="De Swart, Rik" sort="De Swart, Rik" uniqKey="De Swart R" first="Rik" last="De Swart">Rik De Swart</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Viroscience, Erasmus University Medical Center, Rotterdam, Netherlands.</nlm:affiliation>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Viroscience, Erasmus University Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Koopmans, Marion" sort="Koopmans, Marion" uniqKey="Koopmans M" first="Marion" last="Koopmans">Marion Koopmans</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Viroscience, Erasmus University Medical Center, Rotterdam, Netherlands.</nlm:affiliation>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Viroscience, Erasmus University Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Haagmans, Bart L" sort="Haagmans, Bart L" uniqKey="Haagmans B" first="Bart L" last="Haagmans">Bart L. Haagmans</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Viroscience, Erasmus University Medical Center, Rotterdam, Netherlands. b.rockx@erasmusmc.nl b.haagmans@erasmusmc.nl.</nlm:affiliation>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Viroscience, Erasmus University Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">Science (New York, N.Y.)</title>
<idno type="eISSN">1095-9203</idno>
<imprint><date when="2020" type="published">2020</date>
</imprint>
</series>
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<front><div type="abstract" xml:lang="en">The current pandemic coronavirus, SARS-CoV-2, was recently identified in patients with an acute respiratory syndrome, COVID-19. To compare its pathogenesis with that of previously emerging coronaviruses, we inoculated cynomolgus macaques with SARS-CoV-2 or MERS-CoV and compared the pathology and virology with historical reports of SARS-CoV infections. In SARS-CoV-2-infected macaques, virus was excreted from nose and throat in the absence of clinical signs, and detected in type I and II pneumocytes in foci of diffuse alveolar damage and in ciliated epithelial cells of nasal, bronchial, and bronchiolar mucosae. In SARS-CoV-infection, lung lesions were typically more severe, while they were milder in MERS-CoV infection, where virus was detected mainly in type II pneumocytes. These data show that SARS-CoV-2 causes COVID-19-like disease in macaques, and provides a new model to test preventive and therapeutic strategies.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="Publisher" Owner="NLM"><PMID Version="1">32303590</PMID>
<DateRevised><Year>2020</Year>
<Month>04</Month>
<Day>18</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1095-9203</ISSN>
<JournalIssue CitedMedium="Internet"><PubDate><Year>2020</Year>
<Month>Apr</Month>
<Day>17</Day>
</PubDate>
</JournalIssue>
<Title>Science (New York, N.Y.)</Title>
<ISOAbbreviation>Science</ISOAbbreviation>
</Journal>
<ArticleTitle>Comparative pathogenesis of COVID-19, MERS, and SARS in a nonhuman primate model.</ArticleTitle>
<ELocationID EIdType="pii" ValidYN="Y">eabb7314</ELocationID>
<ELocationID EIdType="doi" ValidYN="Y">10.1126/science.abb7314</ELocationID>
<Abstract><AbstractText>The current pandemic coronavirus, SARS-CoV-2, was recently identified in patients with an acute respiratory syndrome, COVID-19. To compare its pathogenesis with that of previously emerging coronaviruses, we inoculated cynomolgus macaques with SARS-CoV-2 or MERS-CoV and compared the pathology and virology with historical reports of SARS-CoV infections. In SARS-CoV-2-infected macaques, virus was excreted from nose and throat in the absence of clinical signs, and detected in type I and II pneumocytes in foci of diffuse alveolar damage and in ciliated epithelial cells of nasal, bronchial, and bronchiolar mucosae. In SARS-CoV-infection, lung lesions were typically more severe, while they were milder in MERS-CoV infection, where virus was detected mainly in type II pneumocytes. These data show that SARS-CoV-2 causes COVID-19-like disease in macaques, and provides a new model to test preventive and therapeutic strategies.</AbstractText>
<CopyrightInformation>Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Rockx</LastName>
<ForeName>Barry</ForeName>
<Initials>B</Initials>
<Identifier Source="ORCID">https://orcid.org/0000-0003-2463-027X</Identifier>
<AffiliationInfo><Affiliation>Department of Viroscience, Erasmus University Medical Center, Rotterdam, Netherlands. b.rockx@erasmusmc.nl b.haagmans@erasmusmc.nl.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Kuiken</LastName>
<ForeName>Thijs</ForeName>
<Initials>T</Initials>
<Identifier Source="ORCID">https://orcid.org/0000-0001-5501-9049</Identifier>
<AffiliationInfo><Affiliation>Department of Viroscience, Erasmus University Medical Center, Rotterdam, Netherlands.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Herfst</LastName>
<ForeName>Sander</ForeName>
<Initials>S</Initials>
<Identifier Source="ORCID">https://orcid.org/0000-0001-9866-8903</Identifier>
<AffiliationInfo><Affiliation>Department of Viroscience, Erasmus University Medical Center, Rotterdam, Netherlands.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Bestebroer</LastName>
<ForeName>Theo</ForeName>
<Initials>T</Initials>
<AffiliationInfo><Affiliation>Department of Viroscience, Erasmus University Medical Center, Rotterdam, Netherlands.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Lamers</LastName>
<ForeName>Mart M</ForeName>
<Initials>MM</Initials>
<AffiliationInfo><Affiliation>Department of Viroscience, Erasmus University Medical Center, Rotterdam, Netherlands.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Oude Munnink</LastName>
<ForeName>Bas B</ForeName>
<Initials>BB</Initials>
<AffiliationInfo><Affiliation>Department of Viroscience, Erasmus University Medical Center, Rotterdam, Netherlands.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>de Meulder</LastName>
<ForeName>Dennis</ForeName>
<Initials>D</Initials>
<Identifier Source="ORCID">https://orcid.org/0000-0002-3631-4189</Identifier>
<AffiliationInfo><Affiliation>Department of Viroscience, Erasmus University Medical Center, Rotterdam, Netherlands.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>van Amerongen</LastName>
<ForeName>Geert</ForeName>
<Initials>G</Initials>
<AffiliationInfo><Affiliation>Viroclinics Xplore, Schaijk, Netherlands.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>van den Brand</LastName>
<ForeName>Judith</ForeName>
<Initials>J</Initials>
<Identifier Source="ORCID">https://orcid.org/0000-0001-8420-5406</Identifier>
<AffiliationInfo><Affiliation>Department of Viroscience, Erasmus University Medical Center, Rotterdam, Netherlands.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Okba</LastName>
<ForeName>Nisreen M A</ForeName>
<Initials>NMA</Initials>
<Identifier Source="ORCID">https://orcid.org/0000-0002-2394-1079</Identifier>
<AffiliationInfo><Affiliation>Department of Viroscience, Erasmus University Medical Center, Rotterdam, Netherlands.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Schipper</LastName>
<ForeName>Debby</ForeName>
<Initials>D</Initials>
<Identifier Source="ORCID">https://orcid.org/0000-0001-6449-4765</Identifier>
<AffiliationInfo><Affiliation>Department of Viroscience, Erasmus University Medical Center, Rotterdam, Netherlands.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>van Run</LastName>
<ForeName>Peter</ForeName>
<Initials>P</Initials>
<Identifier Source="ORCID">https://orcid.org/0000-0001-6963-4165</Identifier>
<AffiliationInfo><Affiliation>Department of Viroscience, Erasmus University Medical Center, Rotterdam, Netherlands.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Leijten</LastName>
<ForeName>Lonneke</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>Department of Viroscience, Erasmus University Medical Center, Rotterdam, Netherlands.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Sikkema</LastName>
<ForeName>Reina</ForeName>
<Initials>R</Initials>
<AffiliationInfo><Affiliation>Department of Viroscience, Erasmus University Medical Center, Rotterdam, Netherlands.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Verschoor</LastName>
<ForeName>Ernst</ForeName>
<Initials>E</Initials>
<AffiliationInfo><Affiliation>Department of Virology, Biomedical Primate Research Centre, Rijswijk, Netherlands.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Verstrepen</LastName>
<ForeName>Babs</ForeName>
<Initials>B</Initials>
<Identifier Source="ORCID">https://orcid.org/0000-0002-4666-0798</Identifier>
<AffiliationInfo><Affiliation>Department of Virology, Biomedical Primate Research Centre, Rijswijk, Netherlands.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Bogers</LastName>
<ForeName>Willy</ForeName>
<Initials>W</Initials>
<AffiliationInfo><Affiliation>Department of Virology, Biomedical Primate Research Centre, Rijswijk, Netherlands.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Langermans</LastName>
<ForeName>Jan</ForeName>
<Initials>J</Initials>
<Identifier Source="ORCID">https://orcid.org/0000-0002-4806-4412</Identifier>
<AffiliationInfo><Affiliation>Animal Science Department, Biomedical Primate Research Centre, Rijswijk, Netherlands.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Population Health Sciences, Unit Animals in Science and Society, Faculty of Veterinary Medicine, Utrecht University, Netherlands.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Drosten</LastName>
<ForeName>Christian</ForeName>
<Initials>C</Initials>
<Identifier Source="ORCID">https://orcid.org/0000-0001-7923-0519</Identifier>
<AffiliationInfo><Affiliation>Institute of Virology, Charité-Universitätsmedizin, Berlin, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Fentener van Vlissingen</LastName>
<ForeName>Martje</ForeName>
<Initials>M</Initials>
<Identifier Source="ORCID">https://orcid.org/0000-0003-2213-5910</Identifier>
<AffiliationInfo><Affiliation>Erasmus Laboratory Animal Science Center, Erasmus University Medical Center, Rotterdam, Netherlands.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Fouchier</LastName>
<ForeName>Ron</ForeName>
<Initials>R</Initials>
<Identifier Source="ORCID">https://orcid.org/0000-0001-8095-2869</Identifier>
<AffiliationInfo><Affiliation>Department of Viroscience, Erasmus University Medical Center, Rotterdam, Netherlands.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>de Swart</LastName>
<ForeName>Rik</ForeName>
<Initials>R</Initials>
<Identifier Source="ORCID">https://orcid.org/0000-0003-3599-8969</Identifier>
<AffiliationInfo><Affiliation>Department of Viroscience, Erasmus University Medical Center, Rotterdam, Netherlands.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Koopmans</LastName>
<ForeName>Marion</ForeName>
<Initials>M</Initials>
<Identifier Source="ORCID">https://orcid.org/0000-0002-5204-2312</Identifier>
<AffiliationInfo><Affiliation>Department of Viroscience, Erasmus University Medical Center, Rotterdam, Netherlands.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Haagmans</LastName>
<ForeName>Bart L</ForeName>
<Initials>BL</Initials>
<Identifier Source="ORCID">https://orcid.org/0000-0001-6221-2015</Identifier>
<AffiliationInfo><Affiliation>Department of Viroscience, Erasmus University Medical Center, Rotterdam, Netherlands. b.rockx@erasmusmc.nl b.haagmans@erasmusmc.nl.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2020</Year>
<Month>04</Month>
<Day>17</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>United States</Country>
<MedlineTA>Science</MedlineTA>
<NlmUniqueID>0404511</NlmUniqueID>
<ISSNLinking>0036-8075</ISSNLinking>
</MedlineJournalInfo>
<CitationSubset>IM</CitationSubset>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="received"><Year>2020</Year>
<Month>03</Month>
<Day>15</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="accepted"><Year>2020</Year>
<Month>04</Month>
<Day>15</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="entrez"><Year>2020</Year>
<Month>4</Month>
<Day>19</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="pubmed"><Year>2020</Year>
<Month>4</Month>
<Day>19</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2020</Year>
<Month>4</Month>
<Day>19</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>aheadofprint</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">32303590</ArticleId>
<ArticleId IdType="pii">science.abb7314</ArticleId>
<ArticleId IdType="doi">10.1126/science.abb7314</ArticleId>
</ArticleIdList>
</PubmedData>
</pubmed>
<affiliations><list><country><li>Allemagne</li>
<li>Pays-Bas</li>
</country>
<region><li>Berlin</li>
<li>Hollande-Méridionale</li>
</region>
<settlement><li>Berlin</li>
<li>Rotterdam</li>
</settlement>
</list>
<tree><country name="Pays-Bas"><region name="Hollande-Méridionale"><name sortKey="Rockx, Barry" sort="Rockx, Barry" uniqKey="Rockx B" first="Barry" last="Rockx">Barry Rockx</name>
</region>
<name sortKey="Bestebroer, Theo" sort="Bestebroer, Theo" uniqKey="Bestebroer T" first="Theo" last="Bestebroer">Theo Bestebroer</name>
<name sortKey="Bogers, Willy" sort="Bogers, Willy" uniqKey="Bogers W" first="Willy" last="Bogers">Willy Bogers</name>
<name sortKey="De Meulder, Dennis" sort="De Meulder, Dennis" uniqKey="De Meulder D" first="Dennis" last="De Meulder">Dennis De Meulder</name>
<name sortKey="De Swart, Rik" sort="De Swart, Rik" uniqKey="De Swart R" first="Rik" last="De Swart">Rik De Swart</name>
<name sortKey="Fentener Van Vlissingen, Martje" sort="Fentener Van Vlissingen, Martje" uniqKey="Fentener Van Vlissingen M" first="Martje" last="Fentener Van Vlissingen">Martje Fentener Van Vlissingen</name>
<name sortKey="Fouchier, Ron" sort="Fouchier, Ron" uniqKey="Fouchier R" first="Ron" last="Fouchier">Ron Fouchier</name>
<name sortKey="Haagmans, Bart L" sort="Haagmans, Bart L" uniqKey="Haagmans B" first="Bart L" last="Haagmans">Bart L. Haagmans</name>
<name sortKey="Herfst, Sander" sort="Herfst, Sander" uniqKey="Herfst S" first="Sander" last="Herfst">Sander Herfst</name>
<name sortKey="Koopmans, Marion" sort="Koopmans, Marion" uniqKey="Koopmans M" first="Marion" last="Koopmans">Marion Koopmans</name>
<name sortKey="Kuiken, Thijs" sort="Kuiken, Thijs" uniqKey="Kuiken T" first="Thijs" last="Kuiken">Thijs Kuiken</name>
<name sortKey="Lamers, Mart M" sort="Lamers, Mart M" uniqKey="Lamers M" first="Mart M" last="Lamers">Mart M. Lamers</name>
<name sortKey="Langermans, Jan" sort="Langermans, Jan" uniqKey="Langermans J" first="Jan" last="Langermans">Jan Langermans</name>
<name sortKey="Leijten, Lonneke" sort="Leijten, Lonneke" uniqKey="Leijten L" first="Lonneke" last="Leijten">Lonneke Leijten</name>
<name sortKey="Okba, Nisreen M A" sort="Okba, Nisreen M A" uniqKey="Okba N" first="Nisreen M A" last="Okba">Nisreen M A. Okba</name>
<name sortKey="Oude Munnink, Bas B" sort="Oude Munnink, Bas B" uniqKey="Oude Munnink B" first="Bas B" last="Oude Munnink">Bas B. Oude Munnink</name>
<name sortKey="Schipper, Debby" sort="Schipper, Debby" uniqKey="Schipper D" first="Debby" last="Schipper">Debby Schipper</name>
<name sortKey="Sikkema, Reina" sort="Sikkema, Reina" uniqKey="Sikkema R" first="Reina" last="Sikkema">Reina Sikkema</name>
<name sortKey="Van Amerongen, Geert" sort="Van Amerongen, Geert" uniqKey="Van Amerongen G" first="Geert" last="Van Amerongen">Geert Van Amerongen</name>
<name sortKey="Van Den Brand, Judith" sort="Van Den Brand, Judith" uniqKey="Van Den Brand J" first="Judith" last="Van Den Brand">Judith Van Den Brand</name>
<name sortKey="Van Run, Peter" sort="Van Run, Peter" uniqKey="Van Run P" first="Peter" last="Van Run">Peter Van Run</name>
<name sortKey="Verschoor, Ernst" sort="Verschoor, Ernst" uniqKey="Verschoor E" first="Ernst" last="Verschoor">Ernst Verschoor</name>
<name sortKey="Verstrepen, Babs" sort="Verstrepen, Babs" uniqKey="Verstrepen B" first="Babs" last="Verstrepen">Babs Verstrepen</name>
</country>
<country name="Allemagne"><region name="Berlin"><name sortKey="Drosten, Christian" sort="Drosten, Christian" uniqKey="Drosten C" first="Christian" last="Drosten">Christian Drosten</name>
</region>
</country>
</tree>
</affiliations>
</record>
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