Verification with the utility of an established rapid assessment of brain safety for newly developed vaccines
Identifieur interne : 002656 ( Ncbi/Merge ); précédent : 002655; suivant : 002657Verification with the utility of an established rapid assessment of brain safety for newly developed vaccines
Auteurs : Gwang-Ho Kim ; Sun Shin YiSource :
- Laboratory Animal Research [ 1738-6055 ] ; 2019.
Abstract
In the twenty-first century, high contagious infectious diseases such as SARS (Severe Acute Respiratory Syndrome), MERS (Middle East Respiratory Syndrome), FMD (Foot-and-Mouth Disease) and AI (Avian Influenza) have become very prevalent, causing treat harm to humans and animals in aspect of public health, and economical issues. The critical problem is that newly-reported infectious diseases that humans firstly experience are expected to continue to emerge, and these diseases will be spreading out rapidly. Therefore, rapid and safe supplies of effective vaccines are most pivotal to prevent the rapid prevalent of new infection, but international standards or assessing protocol the safety of urgent vaccines are not established well. In our previous study, since we established a module to assess the brain safety of urgent vaccines, therefore, it is necessary to verify that this established module for assessing brain safety could work effectively in commercially available two vaccines (one killed- and on live-vaccines). We compared the results of Evans blue (EB) assay and qPCR analysis by injection of two kinds of vaccines, PBS and Lipopolysaccharide (LPS) under the condition of the module previously reported. We confirmed that the brain safety test module for urgent vaccine we established is very reproducible. Therefore, it is believed that this vaccine safety testing method can be used to validate brain safety when prompt supply of a newly developed vaccines is needed.
Url:
DOI: 10.1186/s42826-019-0027-8
PubMed: 32219059
PubMed Central: 7081575
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The critical problem is that newly-reported infectious diseases that humans firstly experience are expected to continue to emerge, and these diseases will be spreading out rapidly. Therefore, rapid and safe supplies of effective vaccines are most pivotal to prevent the rapid prevalent of new infection, but international standards or assessing protocol the safety of urgent vaccines are not established well. In our previous study, since we established a module to assess the brain safety of urgent vaccines, therefore, it is necessary to verify that this established module for assessing brain safety could work effectively in commercially available two vaccines (one killed- and on live-vaccines). We compared the results of Evans blue (EB) assay and qPCR analysis by injection of two kinds of vaccines, PBS and Lipopolysaccharide (LPS) under the condition of the module previously reported. We confirmed that the brain safety test module for urgent vaccine we established is very reproducible. Therefore, it is believed that this vaccine safety testing method can be used to validate brain safety when prompt supply of a newly developed vaccines is needed.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Baek, H" uniqKey="Baek H">H Baek</name></author><author><name sortKey="Kim, Kh" uniqKey="Kim K">KH Kim</name></author><author><name sortKey="Park, My" uniqKey="Park M">MY Park</name></author><author><name sortKey="Kim, K" uniqKey="Kim K">K Kim</name></author><author><name sortKey="Ko, B" uniqKey="Ko B">B Ko</name></author><author><name sortKey="Seo, Hs" uniqKey="Seo H">HS Seo</name></author><author><name sortKey="Kim, Bs" uniqKey="Kim B">BS Kim</name></author><author><name sortKey="Hahn, Tw" uniqKey="Hahn T">TW Hahn</name></author><author><name sortKey="Yi, Ss" uniqKey="Yi S">SS Yi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ballabh, P" uniqKey="Ballabh P">P 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Qin</name></author><author><name sortKey="Huang, W" uniqKey="Huang W">W Huang</name></author><author><name sortKey="Mo, Xa" uniqKey="Mo X">XA Mo</name></author><author><name sortKey="Chen, Yl" uniqKey="Chen Y">YL Chen</name></author><author><name sortKey="Wu, Xh" uniqKey="Wu X">XH Wu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Stamatovic, Sm" uniqKey="Stamatovic S">SM Stamatovic</name></author><author><name sortKey="Keep, Rf" uniqKey="Keep R">RF Keep</name></author><author><name sortKey="Andjelkovic, Av" uniqKey="Andjelkovic A">AV Andjelkovic</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Waterson, Mj" uniqKey="Waterson M">MJ Waterson</name></author><author><name sortKey="Horvath, Tl" uniqKey="Horvath T">TL Horvath</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yi, Ss" uniqKey="Yi S">SS 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last="Kim">Gwang-Ho Kim</name><affiliation><nlm:aff id="Aff1"></nlm:aff></affiliation></author><author><name sortKey="Yi, Sun Shin" sort="Yi, Sun Shin" uniqKey="Yi S" first="Sun Shin" last="Yi">Sun Shin Yi</name><affiliation><nlm:aff id="Aff1"></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">32219059</idno><idno type="pmc">7081575</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7081575</idno><idno type="RBID">PMC:7081575</idno><idno type="doi">10.1186/s42826-019-0027-8</idno><date when="2019">2019</date><idno type="wicri:Area/Pmc/Corpus">000395</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000395</idno><idno type="wicri:Area/Pmc/Curation">000395</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000395</idno><idno type="wicri:Area/Pmc/Checkpoint">000142</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000142</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Verification with the utility of an established rapid assessment of brain safety for newly developed vaccines</title><author><name sortKey="Kim, Gwang Ho" sort="Kim, Gwang Ho" uniqKey="Kim G" first="Gwang-Ho" last="Kim">Gwang-Ho Kim</name><affiliation><nlm:aff id="Aff1"></nlm:aff></affiliation></author><author><name sortKey="Yi, Sun Shin" sort="Yi, Sun Shin" uniqKey="Yi S" first="Sun Shin" last="Yi">Sun Shin Yi</name><affiliation><nlm:aff id="Aff1"></nlm:aff></affiliation></author></analytic><series><title level="j">Laboratory Animal Research</title><idno type="ISSN">1738-6055</idno><idno type="eISSN">2233-7660</idno><imprint><date when="2019">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="Par1">In the twenty-first century, high contagious infectious diseases such as SARS (Severe Acute Respiratory Syndrome), MERS (Middle East Respiratory Syndrome), FMD (Foot-and-Mouth Disease) and AI (Avian Influenza) have become very prevalent, causing treat harm to humans and animals in aspect of public health, and economical issues. The critical problem is that newly-reported infectious diseases that humans firstly experience are expected to continue to emerge, and these diseases will be spreading out rapidly. Therefore, rapid and safe supplies of effective vaccines are most pivotal to prevent the rapid prevalent of new infection, but international standards or assessing protocol the safety of urgent vaccines are not established well. In our previous study, since we established a module to assess the brain safety of urgent vaccines, therefore, it is necessary to verify that this established module for assessing brain safety could work effectively in commercially available two vaccines (one killed- and on live-vaccines). We compared the results of Evans blue (EB) assay and qPCR analysis by injection of two kinds of vaccines, PBS and Lipopolysaccharide (LPS) under the condition of the module previously reported. We confirmed that the brain safety test module for urgent vaccine we established is very reproducible. Therefore, it is believed that this vaccine safety testing method can be used to validate brain safety when prompt supply of a newly developed vaccines is needed.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Baek, H" uniqKey="Baek H">H Baek</name></author><author><name sortKey="Kim, Kh" uniqKey="Kim K">KH Kim</name></author><author><name sortKey="Park, My" uniqKey="Park M">MY Park</name></author><author><name sortKey="Kim, K" uniqKey="Kim K">K Kim</name></author><author><name sortKey="Ko, B" uniqKey="Ko B">B Ko</name></author><author><name sortKey="Seo, Hs" uniqKey="Seo H">HS Seo</name></author><author><name sortKey="Kim, Bs" uniqKey="Kim B">BS Kim</name></author><author><name sortKey="Hahn, Tw" uniqKey="Hahn T">TW Hahn</name></author><author><name sortKey="Yi, Ss" uniqKey="Yi S">SS Yi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ballabh, P" uniqKey="Ballabh P">P Ballabh</name></author><author><name sortKey="Braun, A" uniqKey="Braun A">A Braun</name></author><author><name sortKey="Nedergaard, M" uniqKey="Nedergaard M">M Nedergaard</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Banks, Wa" uniqKey="Banks W">WA Banks</name></author><author><name sortKey="Gray, Am" uniqKey="Gray A">AM Gray</name></author><author><name sortKey="Erickson, Ma" uniqKey="Erickson M">MA Erickson</name></author><author><name sortKey="Salameh, Ts" uniqKey="Salameh T">TS Salameh</name></author><author><name sortKey="Damodarasamy, M" uniqKey="Damodarasamy M">M Damodarasamy</name></author><author><name sortKey="Sheibani, N" uniqKey="Sheibani N">N Sheibani</name></author><author><name sortKey="Meabon, Js" uniqKey="Meabon J">JS Meabon</name></author><author><name sortKey="Wing, Ee" uniqKey="Wing E">EE Wing</name></author><author><name sortKey="Morofuji, Y" uniqKey="Morofuji Y">Y Morofuji</name></author><author><name sortKey="Cook, Dg" uniqKey="Cook D">DG Cook</name></author><author><name sortKey="Reed, Mj" uniqKey="Reed M">MJ Reed</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Barreto, Ml" uniqKey="Barreto M">ML Barreto</name></author><author><name sortKey="Teixeira, Mg" uniqKey="Teixeira M">MG Teixeira</name></author><author><name sortKey="Carmo, Eh" uniqKey="Carmo E">EH Carmo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cereijido, M" uniqKey="Cereijido M">M Cereijido</name></author><author><name sortKey="Contreras, Rg" uniqKey="Contreras R">RG Contreras</name></author><author><name sortKey="Shoshani, L" uniqKey="Shoshani L">L Shoshani</name></author><author><name sortKey="Flores Benitez, D" uniqKey="Flores Benitez D">D Flores-Benitez</name></author><author><name sortKey="Larre, I" uniqKey="Larre I">I Larre</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cummins, Pm" uniqKey="Cummins P">PM Cummins</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Edelblum, Kl" uniqKey="Edelblum K">KL Edelblum</name></author><author><name sortKey="Turner, Jr" uniqKey="Turner J">JR Turner</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Elia, L" uniqKey="Elia L">L Elia</name></author><author><name sortKey="Quintavalle, M" uniqKey="Quintavalle M">M Quintavalle</name></author><author><name sortKey="Zhang, J" uniqKey="Zhang J">J Zhang</name></author><author><name sortKey="Contu, R" uniqKey="Contu R">R Contu</name></author><author><name sortKey="Cossu, L" uniqKey="Cossu L">L Cossu</name></author><author><name sortKey="Latronico, Mv" uniqKey="Latronico M">MV Latronico</name></author><author><name sortKey="Peterson, Kl" uniqKey="Peterson K">KL Peterson</name></author><author><name sortKey="Indolfi, C" uniqKey="Indolfi C">C Indolfi</name></author><author><name sortKey="Catalucci, D" uniqKey="Catalucci D">D Catalucci</name></author><author><name sortKey="Chen, J" uniqKey="Chen J">J Chen</name></author><author><name sortKey="Courtneidge, Sa" uniqKey="Courtneidge S">SA Courtneidge</name></author><author><name sortKey="Condorelli, G" uniqKey="Condorelli G">G Condorelli</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fanning, As" uniqKey="Fanning A">AS Fanning</name></author><author><name sortKey="Jameson, Bj" uniqKey="Jameson B">BJ Jameson</name></author><author><name sortKey="Jesaitis, La" uniqKey="Jesaitis L">LA Jesaitis</name></author><author><name sortKey="Anderson, Jm" uniqKey="Anderson J">JM Anderson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fu, Bm" uniqKey="Fu B">BM Fu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gunzel, D" uniqKey="Gunzel D">D Gunzel</name></author><author><name sortKey="Yu, As" uniqKey="Yu A">AS Yu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Huber, Jd" uniqKey="Huber J">JD Huber</name></author><author><name sortKey="Egleton, Rd" uniqKey="Egleton R">RD Egleton</name></author><author><name sortKey="Davis, Tp" uniqKey="Davis T">TP Davis</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jangula, A" uniqKey="Jangula A">A Jangula</name></author><author><name sortKey="Murphy, Ej" uniqKey="Murphy E">EJ Murphy</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kim, Jh" uniqKey="Kim J">JH Kim</name></author><author><name sortKey="Yu, Je" uniqKey="Yu J">JE Yu</name></author><author><name sortKey="Chang, Bj" uniqKey="Chang B">BJ Chang</name></author><author><name sortKey="Nahm, Ss" uniqKey="Nahm S">SS Nahm</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kitler, Me" uniqKey="Kitler M">ME Kitler</name></author><author><name sortKey="Gavinio, P" 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Yi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yi, Ss" uniqKey="Yi S">SS Yi</name></author><author><name sortKey="Hwang, Ik" uniqKey="Hwang I">IK Hwang</name></author><author><name sortKey="Kim, Yn" uniqKey="Kim Y">YN Kim</name></author><author><name sortKey="Kim, Iy" uniqKey="Kim I">IY Kim</name></author><author><name sortKey="Pak, Si" uniqKey="Pak S">SI Pak</name></author><author><name sortKey="Lee, Is" uniqKey="Lee I">IS Lee</name></author><author><name sortKey="Seong, Jk" uniqKey="Seong J">JK Seong</name></author><author><name sortKey="Yoon, Ys" uniqKey="Yoon Y">YS Yoon</name></author></analytic></biblStruct></listBibl></div1></back></TEI></pmc><pubmed><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Verification with the utility of an established rapid assessment of brain safety for newly developed vaccines.</title><author><name sortKey="Kim, Gwang Ho" sort="Kim, Gwang Ho" uniqKey="Kim G" first="Gwang-Ho" last="Kim">Gwang-Ho Kim</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biomedical Laboratory Science, Soonchunhyang University, Asan, 31538 Republic of Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Biomedical Laboratory Science, Soonchunhyang University, Asan</wicri:regionArea><wicri:noRegion>Asan</wicri:noRegion></affiliation></author><author><name sortKey="Yi, Sun Shin" sort="Yi, Sun Shin" uniqKey="Yi S" first="Sun Shin" last="Yi">Sun Shin Yi</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biomedical Laboratory Science, Soonchunhyang University, Asan, 31538 Republic of Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Biomedical Laboratory Science, Soonchunhyang University, Asan</wicri:regionArea><wicri:noRegion>Asan</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2019">2019</date><idno type="RBID">pubmed:32219059</idno><idno type="pmid">32219059</idno><idno type="doi">10.1186/s42826-019-0027-8</idno><idno type="wicri:Area/PubMed/Corpus">000124</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000124</idno><idno type="wicri:Area/PubMed/Curation">000124</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000124</idno><idno type="wicri:Area/PubMed/Checkpoint">000339</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000339</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Verification with the utility of an established rapid assessment of brain safety for newly developed vaccines.</title><author><name sortKey="Kim, Gwang Ho" sort="Kim, Gwang Ho" uniqKey="Kim G" first="Gwang-Ho" last="Kim">Gwang-Ho Kim</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biomedical Laboratory Science, Soonchunhyang University, Asan, 31538 Republic of Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Biomedical Laboratory Science, Soonchunhyang University, Asan</wicri:regionArea><wicri:noRegion>Asan</wicri:noRegion></affiliation></author><author><name sortKey="Yi, Sun Shin" sort="Yi, Sun Shin" uniqKey="Yi S" first="Sun Shin" last="Yi">Sun Shin Yi</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biomedical Laboratory Science, Soonchunhyang University, Asan, 31538 Republic of Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Biomedical Laboratory Science, Soonchunhyang University, Asan</wicri:regionArea><wicri:noRegion>Asan</wicri:noRegion></affiliation></author></analytic><series><title level="j">Laboratory animal research</title><idno type="ISSN">1738-6055</idno><imprint><date when="2019" type="published">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">In the twenty-first century, high contagious infectious diseases such as SARS (Severe Acute Respiratory Syndrome), MERS (Middle East Respiratory Syndrome), FMD (Foot-and-Mouth Disease) and AI (Avian Influenza) have become very prevalent, causing treat harm to humans and animals in aspect of public health, and economical issues. The critical problem is that newly-reported infectious diseases that humans firstly experience are expected to continue to emerge, and these diseases will be spreading out rapidly. Therefore, rapid and safe supplies of effective vaccines are most pivotal to prevent the rapid prevalent of new infection, but international standards or assessing protocol the safety of urgent vaccines are not established well. In our previous study, since we established a module to assess the brain safety of urgent vaccines, therefore, it is necessary to verify that this established module for assessing brain safety could work effectively in commercially available two vaccines (one killed- and on live-vaccines). We compared the results of Evans blue (EB) assay and qPCR analysis by injection of two kinds of vaccines, PBS and Lipopolysaccharide (LPS) under the condition of the module previously reported. We confirmed that the brain safety test module for urgent vaccine we established is very reproducible. Therefore, it is believed that this vaccine safety testing method can be used to validate brain safety when prompt supply of a newly developed vaccines is needed.</div></front></TEI></pubmed></double></record>Pour manipuler ce document sous Unix (Dilib)
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