Characterization of novel monoclonal antibodies against MERS-coronavirus spike protein
Identifieur interne : 002482 ( Ncbi/Merge ); précédent : 002481; suivant : 002483Characterization of novel monoclonal antibodies against MERS-coronavirus spike protein
Auteurs : Junghyun Goo [Corée du Sud] ; Yuji Jeong [Corée du Sud] ; Young-Shin Park [Corée du Sud] ; Eunji Yang [Corée du Sud] ; Dae-Im Jung [Corée du Sud] ; Semi Rho [Corée du Sud] ; Uni Park [Corée du Sud] ; Hyeyeong Sung [Corée du Sud] ; Pil-Gu Park [Corée du Sud] ; Jung-Ah Choi [Corée du Sud] ; Sang Hwan Seo [Corée du Sud] ; Nam Hyuck Cho [Corée du Sud] ; Hyeja Lee [Corée du Sud] ; Jae Myun Lee [Corée du Sud] ; Jae-Ouk Kim [Corée du Sud] ; Manki Song [Corée du Sud]Source :
- Virus Research [ 0168-1702 ] ; 2020.
Abstract
Identification of neutralizing mAbs using MERS-CoV spike-pseudotyped virus. Transmembrane domain-deleted spike subunit protein induced neutralizing antibodies. Neutralizing antibodies could bind to RBD of MERS-CoV spike, but not vice versa. Mutation in residue 506–509 or 529 of S elicits neutralization escape of MERS-CoV. Our mAbs can be utilized for identification of specific mutation of MERS-CoV.
Url:
DOI: 10.1016/j.virusres.2020.197863
PubMed: 31945421
PubMed Central: 7114870
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Sud</country><wicri:regionArea>Department of Microbiology and Immunology, Brain Korea 21 PLUS Project for Medical Science, Institute for Immunology and Immunological Diseases, Yonsei University College of Medicine, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Choi, Jung Ah" sort="Choi, Jung Ah" uniqKey="Choi J" first="Jung-Ah" last="Choi">Jung-Ah Choi</name><affiliation wicri:level="3"><nlm:aff id="aff0005">Science Unit, International Vaccine Institute, Seoul, South Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Science Unit, International Vaccine Institute, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Seo, Sang Hwan" sort="Seo, Sang Hwan" uniqKey="Seo S" first="Sang 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Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Jeong, Yuji" sort="Jeong, Yuji" uniqKey="Jeong Y" first="Yuji" last="Jeong">Yuji Jeong</name><affiliation wicri:level="3"><nlm:aff id="aff0005">Science Unit, International Vaccine Institute, Seoul, South Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Science Unit, International Vaccine Institute, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Park, Young Shin" sort="Park, Young Shin" uniqKey="Park Y" first="Young-Shin" last="Park">Young-Shin Park</name><affiliation wicri:level="3"><nlm:aff id="aff0005">Science Unit, International Vaccine Institute, Seoul, South Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Science Unit, International Vaccine Institute, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Yang, Eunji" sort="Yang, Eunji" uniqKey="Yang E" first="Eunji" last="Yang">Eunji Yang</name><affiliation wicri:level="3"><nlm:aff id="aff0005">Science Unit, International Vaccine Institute, Seoul, South Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Science Unit, International Vaccine Institute, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Jung, Dae Im" sort="Jung, Dae Im" uniqKey="Jung D" first="Dae-Im" last="Jung">Dae-Im Jung</name><affiliation wicri:level="3"><nlm:aff id="aff0005">Science Unit, International Vaccine Institute, Seoul, South Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Science Unit, International Vaccine Institute, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Rho, Semi" sort="Rho, Semi" uniqKey="Rho S" first="Semi" last="Rho">Semi Rho</name><affiliation wicri:level="3"><nlm:aff id="aff0005">Science Unit, International Vaccine Institute, Seoul, South Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Science Unit, International Vaccine Institute, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Park, Uni" sort="Park, Uni" uniqKey="Park U" first="Uni" last="Park">Uni Park</name><affiliation wicri:level="1"><nlm:aff id="aff0010">Department of Microbiology and Immunology, South Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Microbiology and Immunology</wicri:regionArea></affiliation><affiliation wicri:level="3"><nlm:aff id="aff0015">Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, South Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Sung, Hyeyeong" sort="Sung, Hyeyeong" uniqKey="Sung H" first="Hyeyeong" last="Sung">Hyeyeong Sung</name><affiliation wicri:level="1"><nlm:aff id="aff0025">NKMAX Co., Ltd., Seongnam, South Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>NKMAX Co., Ltd., Seongnam</wicri:regionArea><wicri:noRegion>Seongnam</wicri:noRegion></affiliation></author><author><name sortKey="Park, Pil Gu" sort="Park, Pil Gu" uniqKey="Park P" first="Pil-Gu" last="Park">Pil-Gu Park</name><affiliation wicri:level="3"><nlm:aff id="aff0030">Department of Microbiology and Immunology, Brain Korea 21 PLUS Project for Medical Science, Institute for Immunology and Immunological Diseases, Yonsei University College of Medicine, Seoul, South Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Microbiology and Immunology, Brain Korea 21 PLUS Project for Medical Science, Institute for Immunology and Immunological Diseases, Yonsei University College of Medicine, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Choi, Jung Ah" sort="Choi, Jung Ah" uniqKey="Choi J" first="Jung-Ah" last="Choi">Jung-Ah Choi</name><affiliation wicri:level="3"><nlm:aff id="aff0005">Science Unit, International Vaccine Institute, Seoul, South Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Science Unit, International Vaccine Institute, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Seo, Sang Hwan" sort="Seo, Sang Hwan" uniqKey="Seo S" first="Sang Hwan" last="Seo">Sang Hwan Seo</name><affiliation wicri:level="3"><nlm:aff id="aff0005">Science Unit, International Vaccine Institute, Seoul, South Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Science Unit, International Vaccine Institute, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Cho, Nam Hyuck" sort="Cho, Nam Hyuck" uniqKey="Cho N" first="Nam Hyuck" last="Cho">Nam Hyuck Cho</name><affiliation wicri:level="1"><nlm:aff id="aff0010">Department of Microbiology and Immunology, South Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Microbiology and Immunology</wicri:regionArea></affiliation><affiliation wicri:level="3"><nlm:aff id="aff0015">Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, South Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff0020">Institute of Endemic Disease, Seoul National University Medical Research Center and Bundang Hospital, Seoul, South Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Institute of Endemic Disease, Seoul National University Medical Research Center and Bundang Hospital, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Lee, Hyeja" sort="Lee, Hyeja" uniqKey="Lee H" first="Hyeja" last="Lee">Hyeja Lee</name><affiliation wicri:level="1"><nlm:aff id="aff0025">NKMAX Co., Ltd., Seongnam, South Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>NKMAX Co., Ltd., Seongnam</wicri:regionArea><wicri:noRegion>Seongnam</wicri:noRegion></affiliation></author><author><name sortKey="Lee, Jae Myun" sort="Lee, Jae Myun" uniqKey="Lee J" first="Jae Myun" last="Lee">Jae Myun Lee</name><affiliation wicri:level="3"><nlm:aff id="aff0030">Department of Microbiology and Immunology, Brain Korea 21 PLUS Project for Medical Science, Institute for Immunology and Immunological Diseases, Yonsei University College of Medicine, Seoul, South Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Microbiology and Immunology, Brain Korea 21 PLUS Project for Medical Science, Institute for Immunology and Immunological Diseases, Yonsei University College of Medicine, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Kim, Jae Ouk" sort="Kim, Jae Ouk" uniqKey="Kim J" first="Jae-Ouk" last="Kim">Jae-Ouk Kim</name><affiliation wicri:level="3"><nlm:aff id="aff0005">Science Unit, International Vaccine Institute, Seoul, South Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Science Unit, International Vaccine Institute, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Song, Manki" sort="Song, Manki" uniqKey="Song M" first="Manki" last="Song">Manki Song</name><affiliation wicri:level="3"><nlm:aff id="aff0005">Science Unit, International Vaccine Institute, Seoul, South Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Science Unit, International Vaccine Institute, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author></analytic><series><title level="j">Virus Research</title><idno type="ISSN">0168-1702</idno><idno type="eISSN">1872-7492</idno><imprint><date when="2020">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Highlights</title><p><list list-type="simple" id="lis0005"><list-item id="lsti0005"><label>•</label><p id="par0005">Identification of neutralizing mAbs using MERS-CoV spike-pseudotyped virus.</p></list-item><list-item id="lsti0010"><label>•</label><p id="par0010">Transmembrane domain-deleted spike subunit protein induced neutralizing antibodies.</p></list-item><list-item id="lsti0015"><label>•</label><p id="par0015">Neutralizing antibodies could bind to RBD of MERS-CoV spike, but not vice versa.</p></list-item><list-item id="lsti0020"><label>•</label><p id="par0020">Mutation in residue 506–509 or 529 of S elicits neutralization escape of MERS-CoV.</p></list-item><list-item id="lsti0025"><label>•</label><p id="par0025">Our mAbs can be utilized for identification of specific mutation of MERS-CoV.</p></list-item></list></p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Chen, Y" uniqKey="Chen Y">Y. 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Seoul, South Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Science Unit, International Vaccine Institute, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Park, Young Shin" sort="Park, Young Shin" uniqKey="Park Y" first="Young-Shin" last="Park">Young-Shin Park</name><affiliation wicri:level="3"><nlm:aff id="aff0005">Science Unit, International Vaccine Institute, Seoul, South Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Science Unit, International Vaccine Institute, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Yang, Eunji" sort="Yang, Eunji" uniqKey="Yang E" first="Eunji" last="Yang">Eunji Yang</name><affiliation wicri:level="3"><nlm:aff id="aff0005">Science Unit, International Vaccine Institute, Seoul, South Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Science Unit, International Vaccine Institute, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Jung, Dae Im" sort="Jung, Dae Im" uniqKey="Jung D" first="Dae-Im" last="Jung">Dae-Im Jung</name><affiliation wicri:level="3"><nlm:aff id="aff0005">Science Unit, International Vaccine Institute, Seoul, South Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Science Unit, International Vaccine Institute, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Rho, Semi" sort="Rho, Semi" uniqKey="Rho S" first="Semi" last="Rho">Semi Rho</name><affiliation wicri:level="3"><nlm:aff id="aff0005">Science Unit, International Vaccine Institute, Seoul, South Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Science Unit, International Vaccine Institute, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Park, Uni" sort="Park, Uni" uniqKey="Park U" first="Uni" last="Park">Uni Park</name><affiliation wicri:level="1"><nlm:aff id="aff0010">Department of Microbiology and Immunology, South Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Microbiology and Immunology</wicri:regionArea></affiliation><affiliation wicri:level="3"><nlm:aff id="aff0015">Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, South Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Sung, Hyeyeong" sort="Sung, Hyeyeong" uniqKey="Sung H" first="Hyeyeong" last="Sung">Hyeyeong Sung</name><affiliation wicri:level="1"><nlm:aff id="aff0025">NKMAX Co., Ltd., Seongnam, South Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>NKMAX Co., Ltd., Seongnam</wicri:regionArea><wicri:noRegion>Seongnam</wicri:noRegion></affiliation></author><author><name sortKey="Park, Pil Gu" sort="Park, Pil Gu" uniqKey="Park P" first="Pil-Gu" last="Park">Pil-Gu Park</name><affiliation wicri:level="3"><nlm:aff id="aff0030">Department of Microbiology and Immunology, Brain Korea 21 PLUS Project for Medical Science, Institute for Immunology and Immunological Diseases, Yonsei University College of Medicine, Seoul, South Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Microbiology and Immunology, Brain Korea 21 PLUS Project for Medical Science, Institute for Immunology and Immunological Diseases, Yonsei University College of Medicine, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Choi, Jung Ah" sort="Choi, Jung Ah" uniqKey="Choi J" first="Jung-Ah" last="Choi">Jung-Ah Choi</name><affiliation wicri:level="3"><nlm:aff id="aff0005">Science Unit, International Vaccine Institute, Seoul, South Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Science Unit, International Vaccine Institute, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Seo, Sang Hwan" sort="Seo, Sang Hwan" uniqKey="Seo S" first="Sang Hwan" last="Seo">Sang Hwan Seo</name><affiliation wicri:level="3"><nlm:aff id="aff0005">Science Unit, International Vaccine Institute, Seoul, South Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Science Unit, International Vaccine Institute, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Cho, Nam Hyuck" sort="Cho, Nam Hyuck" uniqKey="Cho N" first="Nam Hyuck" last="Cho">Nam Hyuck Cho</name><affiliation wicri:level="1"><nlm:aff id="aff0010">Department of Microbiology and Immunology, South Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Microbiology and Immunology</wicri:regionArea></affiliation><affiliation wicri:level="3"><nlm:aff id="aff0015">Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, South Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff0020">Institute of Endemic Disease, Seoul National University Medical Research Center and Bundang Hospital, Seoul, South Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Institute of Endemic Disease, Seoul National University Medical Research Center and Bundang Hospital, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Lee, Hyeja" sort="Lee, Hyeja" uniqKey="Lee H" first="Hyeja" last="Lee">Hyeja Lee</name><affiliation wicri:level="1"><nlm:aff id="aff0025">NKMAX Co., Ltd., Seongnam, South Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>NKMAX Co., Ltd., Seongnam</wicri:regionArea><wicri:noRegion>Seongnam</wicri:noRegion></affiliation></author><author><name sortKey="Lee, Jae Myun" sort="Lee, Jae Myun" uniqKey="Lee J" first="Jae Myun" last="Lee">Jae Myun Lee</name><affiliation wicri:level="3"><nlm:aff id="aff0030">Department of Microbiology and Immunology, Brain Korea 21 PLUS Project for Medical Science, Institute for Immunology and Immunological Diseases, Yonsei University College of Medicine, Seoul, South Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Microbiology and Immunology, Brain Korea 21 PLUS Project for Medical Science, Institute for Immunology and Immunological Diseases, Yonsei University College of Medicine, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Kim, Jae Ouk" sort="Kim, Jae Ouk" uniqKey="Kim J" first="Jae-Ouk" last="Kim">Jae-Ouk Kim</name><affiliation wicri:level="3"><nlm:aff id="aff0005">Science Unit, International Vaccine Institute, Seoul, South Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Science Unit, International Vaccine Institute, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Song, Manki" sort="Song, Manki" uniqKey="Song M" first="Manki" last="Song">Manki Song</name><affiliation wicri:level="3"><nlm:aff id="aff0005">Science Unit, International Vaccine Institute, Seoul, South Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Science Unit, International Vaccine Institute, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">31945421</idno><idno type="pmc">7114870</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7114870</idno><idno type="RBID">PMC:7114870</idno><idno type="doi">10.1016/j.virusres.2020.197863</idno><date when="2020">2020</date><idno type="wicri:Area/Pmc/Corpus">001203</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001203</idno><idno type="wicri:Area/Pmc/Curation">001203</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">001203</idno><idno type="wicri:Area/Pmc/Checkpoint">000109</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000109</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Characterization of novel monoclonal antibodies against MERS-coronavirus spike protein</title><author><name sortKey="Goo, Junghyun" sort="Goo, Junghyun" uniqKey="Goo J" first="Junghyun" last="Goo">Junghyun Goo</name><affiliation wicri:level="3"><nlm:aff id="aff0005">Science Unit, International Vaccine Institute, Seoul, South Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Science Unit, International Vaccine Institute, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Jeong, Yuji" sort="Jeong, Yuji" uniqKey="Jeong Y" first="Yuji" last="Jeong">Yuji Jeong</name><affiliation wicri:level="3"><nlm:aff id="aff0005">Science Unit, International Vaccine Institute, Seoul, South Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Science Unit, International Vaccine Institute, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Park, Young Shin" sort="Park, Young Shin" uniqKey="Park Y" first="Young-Shin" last="Park">Young-Shin Park</name><affiliation wicri:level="3"><nlm:aff id="aff0005">Science Unit, International Vaccine Institute, Seoul, South Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Science Unit, International Vaccine Institute, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Yang, Eunji" sort="Yang, Eunji" uniqKey="Yang E" first="Eunji" last="Yang">Eunji Yang</name><affiliation wicri:level="3"><nlm:aff id="aff0005">Science Unit, International Vaccine Institute, Seoul, South Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Science Unit, International Vaccine Institute, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Jung, Dae Im" sort="Jung, Dae Im" uniqKey="Jung D" first="Dae-Im" last="Jung">Dae-Im Jung</name><affiliation wicri:level="3"><nlm:aff id="aff0005">Science Unit, International Vaccine Institute, Seoul, South Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Science Unit, International Vaccine Institute, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Rho, Semi" sort="Rho, Semi" uniqKey="Rho S" first="Semi" last="Rho">Semi Rho</name><affiliation wicri:level="3"><nlm:aff id="aff0005">Science Unit, International Vaccine Institute, Seoul, South Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Science Unit, International Vaccine Institute, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Park, Uni" sort="Park, Uni" uniqKey="Park U" first="Uni" last="Park">Uni Park</name><affiliation wicri:level="1"><nlm:aff id="aff0010">Department of Microbiology and Immunology, South Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Microbiology and Immunology</wicri:regionArea></affiliation><affiliation wicri:level="3"><nlm:aff id="aff0015">Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, South Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Sung, Hyeyeong" sort="Sung, Hyeyeong" uniqKey="Sung H" first="Hyeyeong" last="Sung">Hyeyeong Sung</name><affiliation wicri:level="1"><nlm:aff id="aff0025">NKMAX Co., Ltd., Seongnam, South Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>NKMAX Co., Ltd., Seongnam</wicri:regionArea><wicri:noRegion>Seongnam</wicri:noRegion></affiliation></author><author><name sortKey="Park, Pil Gu" sort="Park, Pil Gu" uniqKey="Park P" first="Pil-Gu" last="Park">Pil-Gu Park</name><affiliation wicri:level="3"><nlm:aff id="aff0030">Department of Microbiology and Immunology, Brain Korea 21 PLUS Project for Medical Science, Institute for Immunology and Immunological Diseases, Yonsei University College of Medicine, Seoul, South Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Microbiology and Immunology, Brain Korea 21 PLUS Project for Medical Science, Institute for Immunology and Immunological Diseases, Yonsei University College of Medicine, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Choi, Jung Ah" sort="Choi, Jung Ah" uniqKey="Choi J" first="Jung-Ah" last="Choi">Jung-Ah Choi</name><affiliation wicri:level="3"><nlm:aff id="aff0005">Science Unit, International Vaccine Institute, Seoul, South Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Science Unit, International Vaccine Institute, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Seo, Sang Hwan" sort="Seo, Sang Hwan" uniqKey="Seo S" first="Sang Hwan" last="Seo">Sang Hwan Seo</name><affiliation wicri:level="3"><nlm:aff id="aff0005">Science Unit, International Vaccine Institute, Seoul, South Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Science Unit, International Vaccine Institute, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Cho, Nam Hyuck" sort="Cho, Nam Hyuck" uniqKey="Cho N" first="Nam Hyuck" last="Cho">Nam Hyuck Cho</name><affiliation wicri:level="1"><nlm:aff id="aff0010">Department of Microbiology and Immunology, South Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Microbiology and Immunology</wicri:regionArea></affiliation><affiliation wicri:level="3"><nlm:aff id="aff0015">Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, South Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff0020">Institute of Endemic Disease, Seoul National University Medical Research Center and Bundang Hospital, Seoul, South Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Institute of Endemic Disease, Seoul National University Medical Research Center and Bundang Hospital, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Lee, Hyeja" sort="Lee, Hyeja" uniqKey="Lee H" first="Hyeja" last="Lee">Hyeja Lee</name><affiliation wicri:level="1"><nlm:aff id="aff0025">NKMAX Co., Ltd., Seongnam, South Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>NKMAX Co., Ltd., Seongnam</wicri:regionArea><wicri:noRegion>Seongnam</wicri:noRegion></affiliation></author><author><name sortKey="Lee, Jae Myun" sort="Lee, Jae Myun" uniqKey="Lee J" first="Jae Myun" last="Lee">Jae Myun Lee</name><affiliation wicri:level="3"><nlm:aff id="aff0030">Department of Microbiology and Immunology, Brain Korea 21 PLUS Project for Medical Science, Institute for Immunology and Immunological Diseases, Yonsei University College of Medicine, Seoul, South Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Microbiology and Immunology, Brain Korea 21 PLUS Project for Medical Science, Institute for Immunology and Immunological Diseases, Yonsei University College of Medicine, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Kim, Jae Ouk" sort="Kim, Jae Ouk" uniqKey="Kim J" first="Jae-Ouk" last="Kim">Jae-Ouk Kim</name><affiliation wicri:level="3"><nlm:aff id="aff0005">Science Unit, International Vaccine Institute, Seoul, South Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Science Unit, International Vaccine Institute, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Song, Manki" sort="Song, Manki" uniqKey="Song M" first="Manki" last="Song">Manki Song</name><affiliation wicri:level="3"><nlm:aff id="aff0005">Science Unit, International Vaccine Institute, Seoul, South Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Science Unit, International Vaccine Institute, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author></analytic><series><title level="j">Virus Research</title><idno type="ISSN">0168-1702</idno><idno type="eISSN">1872-7492</idno><imprint><date when="2020">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Highlights</title><p><list list-type="simple" id="lis0005"><list-item id="lsti0005"><label>•</label><p id="par0005">Identification of neutralizing mAbs using MERS-CoV spike-pseudotyped virus.</p></list-item><list-item id="lsti0010"><label>•</label><p id="par0010">Transmembrane domain-deleted spike subunit protein induced neutralizing antibodies.</p></list-item><list-item id="lsti0015"><label>•</label><p id="par0015">Neutralizing antibodies could bind to RBD of MERS-CoV spike, but not vice versa.</p></list-item><list-item id="lsti0020"><label>•</label><p id="par0020">Mutation in residue 506–509 or 529 of S elicits neutralization escape of MERS-CoV.</p></list-item><list-item id="lsti0025"><label>•</label><p id="par0025">Our mAbs can be utilized for identification of specific mutation of MERS-CoV.</p></list-item></list></p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Chen, Y" uniqKey="Chen Y">Y. 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Zhang</name></author></analytic></biblStruct></listBibl></div1></back></TEI></pmc><pubmed><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Characterization of novel monoclonal antibodies against MERS-coronavirus spike protein.</title><author><name sortKey="Goo, Junghyun" sort="Goo, Junghyun" uniqKey="Goo J" first="Junghyun" last="Goo">Junghyun Goo</name><affiliation wicri:level="3"><nlm:affiliation>Science Unit, International Vaccine Institute, Seoul, South Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Science Unit, International Vaccine Institute, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Jeong, Yuji" sort="Jeong, Yuji" uniqKey="Jeong Y" first="Yuji" last="Jeong">Yuji Jeong</name><affiliation wicri:level="3"><nlm:affiliation>Science Unit, International Vaccine Institute, Seoul, South Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Science Unit, International Vaccine Institute, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Park, Young Shin" sort="Park, Young Shin" uniqKey="Park Y" first="Young-Shin" last="Park">Young-Shin Park</name><affiliation wicri:level="3"><nlm:affiliation>Science Unit, International Vaccine Institute, Seoul, South Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Science Unit, International Vaccine Institute, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Yang, Eunji" sort="Yang, Eunji" uniqKey="Yang E" first="Eunji" last="Yang">Eunji Yang</name><affiliation wicri:level="3"><nlm:affiliation>Science Unit, International Vaccine Institute, Seoul, South Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Science Unit, International Vaccine Institute, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Jung, Dae Im" sort="Jung, Dae Im" uniqKey="Jung D" first="Dae-Im" last="Jung">Dae-Im Jung</name><affiliation wicri:level="3"><nlm:affiliation>Science Unit, International Vaccine Institute, Seoul, South Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Science Unit, International Vaccine Institute, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Rho, Semi" sort="Rho, Semi" uniqKey="Rho S" first="Semi" last="Rho">Semi Rho</name><affiliation wicri:level="3"><nlm:affiliation>Science Unit, International Vaccine Institute, Seoul, South Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Science Unit, International Vaccine Institute, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Park, Uni" sort="Park, Uni" uniqKey="Park U" first="Uni" last="Park">Uni Park</name><affiliation wicri:level="3"><nlm:affiliation>Department of Microbiology and Immunology, South Korea; Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, South Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Microbiology and Immunology, South Korea; Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Sung, Hyeyeong" sort="Sung, Hyeyeong" uniqKey="Sung H" first="Hyeyeong" last="Sung">Hyeyeong Sung</name><affiliation wicri:level="1"><nlm:affiliation>NKMAX Co., Ltd., Seongnam, South Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>NKMAX Co., Ltd., Seongnam</wicri:regionArea><wicri:noRegion>Seongnam</wicri:noRegion></affiliation></author><author><name sortKey="Park, Pil Gu" sort="Park, Pil Gu" uniqKey="Park P" first="Pil-Gu" last="Park">Pil-Gu Park</name><affiliation wicri:level="3"><nlm:affiliation>Department of Microbiology and Immunology, Brain Korea 21 PLUS Project for Medical Science, Institute for Immunology and Immunological Diseases, Yonsei University College of Medicine, Seoul, South Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Microbiology and Immunology, Brain Korea 21 PLUS Project for Medical Science, Institute for Immunology and Immunological Diseases, Yonsei University College of Medicine, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Choi, Jung Ah" sort="Choi, Jung Ah" uniqKey="Choi J" first="Jung-Ah" last="Choi">Jung-Ah Choi</name><affiliation wicri:level="3"><nlm:affiliation>Science Unit, International Vaccine Institute, Seoul, South Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Science Unit, International Vaccine Institute, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Seo, Sang Hwan" sort="Seo, Sang Hwan" uniqKey="Seo S" first="Sang Hwan" last="Seo">Sang Hwan Seo</name><affiliation wicri:level="3"><nlm:affiliation>Science Unit, International Vaccine Institute, Seoul, South Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Science Unit, International Vaccine Institute, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Cho, Nam Hyuck" sort="Cho, Nam Hyuck" uniqKey="Cho N" first="Nam Hyuck" last="Cho">Nam Hyuck Cho</name><affiliation wicri:level="3"><nlm:affiliation>Department of Microbiology and Immunology, South Korea; Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, South Korea; Institute of Endemic Disease, Seoul National University Medical Research Center and Bundang Hospital, Seoul, South Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Microbiology and Immunology, South Korea; Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, South Korea; Institute of Endemic Disease, Seoul National University Medical Research Center and Bundang Hospital, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Lee, Hyeja" sort="Lee, Hyeja" uniqKey="Lee H" first="Hyeja" last="Lee">Hyeja Lee</name><affiliation wicri:level="1"><nlm:affiliation>NKMAX Co., Ltd., Seongnam, South Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>NKMAX Co., Ltd., Seongnam</wicri:regionArea><wicri:noRegion>Seongnam</wicri:noRegion></affiliation></author><author><name sortKey="Lee, Jae Myun" sort="Lee, Jae Myun" uniqKey="Lee J" first="Jae Myun" last="Lee">Jae Myun Lee</name><affiliation wicri:level="3"><nlm:affiliation>Department of Microbiology and Immunology, Brain Korea 21 PLUS Project for Medical Science, Institute for Immunology and Immunological Diseases, Yonsei University College of Medicine, Seoul, South Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Microbiology and Immunology, Brain Korea 21 PLUS Project for Medical Science, Institute for Immunology and Immunological Diseases, Yonsei University College of Medicine, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Kim, Jae Ouk" sort="Kim, Jae Ouk" uniqKey="Kim J" first="Jae-Ouk" last="Kim">Jae-Ouk Kim</name><affiliation wicri:level="3"><nlm:affiliation>Science Unit, International Vaccine Institute, Seoul, South Korea. Electronic address: jokim@ivi.int.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Science Unit, International Vaccine Institute, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Song, Manki" sort="Song, Manki" uniqKey="Song M" first="Manki" last="Song">Manki Song</name><affiliation wicri:level="3"><nlm:affiliation>Science Unit, International Vaccine Institute, Seoul, South Korea. Electronic address: mksong@ivi.int.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Science Unit, International Vaccine Institute, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2020">2020</date><idno type="RBID">pubmed:31945421</idno><idno type="pmid">31945421</idno><idno type="doi">10.1016/j.virusres.2020.197863</idno><idno type="wicri:Area/PubMed/Corpus">000286</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000286</idno><idno type="wicri:Area/PubMed/Curation">000286</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000286</idno><idno type="wicri:Area/PubMed/Checkpoint">000270</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000270</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Characterization of novel monoclonal antibodies against MERS-coronavirus spike protein.</title><author><name sortKey="Goo, Junghyun" sort="Goo, Junghyun" uniqKey="Goo J" first="Junghyun" last="Goo">Junghyun Goo</name><affiliation wicri:level="3"><nlm:affiliation>Science Unit, International Vaccine Institute, Seoul, South Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Science Unit, International Vaccine Institute, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Jeong, Yuji" sort="Jeong, Yuji" uniqKey="Jeong Y" first="Yuji" last="Jeong">Yuji Jeong</name><affiliation wicri:level="3"><nlm:affiliation>Science Unit, International Vaccine Institute, Seoul, South Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Science Unit, International Vaccine Institute, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Park, Young Shin" sort="Park, Young Shin" uniqKey="Park Y" first="Young-Shin" last="Park">Young-Shin Park</name><affiliation wicri:level="3"><nlm:affiliation>Science Unit, International Vaccine Institute, Seoul, South Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Science Unit, International Vaccine Institute, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Yang, Eunji" sort="Yang, Eunji" uniqKey="Yang E" first="Eunji" last="Yang">Eunji Yang</name><affiliation wicri:level="3"><nlm:affiliation>Science Unit, International Vaccine Institute, Seoul, South Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Science Unit, International Vaccine Institute, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Jung, Dae Im" sort="Jung, Dae Im" uniqKey="Jung D" first="Dae-Im" last="Jung">Dae-Im Jung</name><affiliation wicri:level="3"><nlm:affiliation>Science Unit, International Vaccine Institute, Seoul, South Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Science Unit, International Vaccine Institute, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Rho, Semi" sort="Rho, Semi" uniqKey="Rho S" first="Semi" last="Rho">Semi Rho</name><affiliation wicri:level="3"><nlm:affiliation>Science Unit, International Vaccine Institute, Seoul, South Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Science Unit, International Vaccine Institute, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Park, Uni" sort="Park, Uni" uniqKey="Park U" first="Uni" last="Park">Uni Park</name><affiliation wicri:level="3"><nlm:affiliation>Department of Microbiology and Immunology, South Korea; Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, South Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Microbiology and Immunology, South Korea; Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Sung, Hyeyeong" sort="Sung, Hyeyeong" uniqKey="Sung H" first="Hyeyeong" last="Sung">Hyeyeong Sung</name><affiliation wicri:level="1"><nlm:affiliation>NKMAX Co., Ltd., Seongnam, South Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>NKMAX Co., Ltd., Seongnam</wicri:regionArea><wicri:noRegion>Seongnam</wicri:noRegion></affiliation></author><author><name sortKey="Park, Pil Gu" sort="Park, Pil Gu" uniqKey="Park P" first="Pil-Gu" last="Park">Pil-Gu Park</name><affiliation wicri:level="3"><nlm:affiliation>Department of Microbiology and Immunology, Brain Korea 21 PLUS Project for Medical Science, Institute for Immunology and Immunological Diseases, Yonsei University College of Medicine, Seoul, South Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Microbiology and Immunology, Brain Korea 21 PLUS Project for Medical Science, Institute for Immunology and Immunological Diseases, Yonsei University College of Medicine, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Choi, Jung Ah" sort="Choi, Jung Ah" uniqKey="Choi J" first="Jung-Ah" last="Choi">Jung-Ah Choi</name><affiliation wicri:level="3"><nlm:affiliation>Science Unit, International Vaccine Institute, Seoul, South Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Science Unit, International Vaccine Institute, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Seo, Sang Hwan" sort="Seo, Sang Hwan" uniqKey="Seo S" first="Sang Hwan" last="Seo">Sang Hwan Seo</name><affiliation wicri:level="3"><nlm:affiliation>Science Unit, International Vaccine Institute, Seoul, South Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Science Unit, International Vaccine Institute, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Cho, Nam Hyuck" sort="Cho, Nam Hyuck" uniqKey="Cho N" first="Nam Hyuck" last="Cho">Nam Hyuck Cho</name><affiliation wicri:level="3"><nlm:affiliation>Department of Microbiology and Immunology, South Korea; Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, South Korea; Institute of Endemic Disease, Seoul National University Medical Research Center and Bundang Hospital, Seoul, South Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Microbiology and Immunology, South Korea; Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, South Korea; Institute of Endemic Disease, Seoul National University Medical Research Center and Bundang Hospital, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Lee, Hyeja" sort="Lee, Hyeja" uniqKey="Lee H" first="Hyeja" last="Lee">Hyeja Lee</name><affiliation wicri:level="1"><nlm:affiliation>NKMAX Co., Ltd., Seongnam, South Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>NKMAX Co., Ltd., Seongnam</wicri:regionArea><wicri:noRegion>Seongnam</wicri:noRegion></affiliation></author><author><name sortKey="Lee, Jae Myun" sort="Lee, Jae Myun" uniqKey="Lee J" first="Jae Myun" last="Lee">Jae Myun Lee</name><affiliation wicri:level="3"><nlm:affiliation>Department of Microbiology and Immunology, Brain Korea 21 PLUS Project for Medical Science, Institute for Immunology and Immunological Diseases, Yonsei University College of Medicine, Seoul, South Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Microbiology and Immunology, Brain Korea 21 PLUS Project for Medical Science, Institute for Immunology and Immunological Diseases, Yonsei University College of Medicine, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Kim, Jae Ouk" sort="Kim, Jae Ouk" uniqKey="Kim J" first="Jae-Ouk" last="Kim">Jae-Ouk Kim</name><affiliation wicri:level="3"><nlm:affiliation>Science Unit, International Vaccine Institute, Seoul, South Korea. Electronic address: jokim@ivi.int.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Science Unit, International Vaccine Institute, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Song, Manki" sort="Song, Manki" uniqKey="Song M" first="Manki" last="Song">Manki Song</name><affiliation wicri:level="3"><nlm:affiliation>Science Unit, International Vaccine Institute, Seoul, South Korea. Electronic address: mksong@ivi.int.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Science Unit, International Vaccine Institute, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author></analytic><series><title level="j">Virus research</title><idno type="eISSN">1872-7492</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Middle East Respiratory Syndrome coronavirus (MERS-CoV) causes severe pulmonary infection, with ∼35 % mortality. Spike glycoprotein (S) of MERS-CoV is a key target for vaccines and therapeutics because S mediates viral entry and membrane-fusion to host cells. Here, four different S subunit proteins, receptor-binding domain (RBD; 358-606 aa), S1 (1-751 aa), S2 (752-1296 aa), and SΔTM (1-1296 aa), were generated using the baculoviral system and immunized in mice to develop neutralizing antibodies. We developed 77 hybridomas and selected five neutralizing mAbs by immunization with SΔTM against MERS-CoV EMC/2012 strain S-pseudotyped lentivirus. However, all five monoclonal antibodies (mAb) did not neutralize the pseudotyped V534A mutation. Additionally, one mAb RBD-14F8 did not show neutralizing activity against pseudoviruses with amino acid substitution of L506 F or D509 G (England1 strain, EMC/2012 L506 F, and EMC/2012 D509 G), and RBD-43E4 mAb could not neutralize the pseudotyped I529 T mutation, while three other neutralizing mAbs showed broad neutralizing activity. This implies that the mutation in residue 506-509, 529, and 534 of S is critical to generate neutralization escape variants of MERS-CoV. Interestingly, all five neutralizing mAbs have binding affinity to RBD, although most mAbs generated by RBD did not have neutralizing activity. Additionally, chimeric antibodies of RBD-14F8 and RBD-43E4 with human Fc and light chain showed neutralizing effect against wild type MERS-CoV KOR/KNIH/002, similar to the original mouse mAbs. Thus, our mAbs can be utilized for the identification of specific mutations of MERS-CoV.</div></front></TEI></pubmed></double></record>Pour manipuler ce document sous Unix (Dilib)
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