Multimodal Long Noncoding RNA Interaction Networks: Control Panels for Cell Fate Specification.
Identifieur interne : 002420 ( Ncbi/Merge ); précédent : 002419; suivant : 002421Multimodal Long Noncoding RNA Interaction Networks: Control Panels for Cell Fate Specification.
Auteurs : Keriayn N. Smith [États-Unis] ; Sarah C. Miller [États-Unis] ; Gabriele Varani [États-Unis] ; J Mauro Calabrese [États-Unis] ; Terry Magnuson [États-Unis]Source :
- Genetics [ 1943-2631 ] ; 2019.
Abstract
Lineage specification in early development is the basis for the exquisitely precise body plan of multicellular organisms. It is therefore critical to understand cell fate decisions in early development. Moreover, for regenerative medicine, the accurate specification of cell types to replace damaged/diseased tissue is strongly dependent on identifying determinants of cell identity. Long noncoding RNAs (lncRNAs) have been shown to regulate cellular plasticity, including pluripotency establishment and maintenance, differentiation and development, yet broad phenotypic analysis and the mechanistic basis of their function remains lacking. As components of molecular condensates, lncRNAs interact with almost all classes of cellular biomolecules, including proteins, DNA, mRNAs, and microRNAs. With functions ranging from controlling alternative splicing of mRNAs, to providing scaffolding upon which chromatin modifiers are assembled, it is clear that at least a subset of lncRNAs are far from the transcriptional noise they were once deemed. This review highlights the diversity of lncRNA interactions in the context of cell fate specification, and provides examples of each type of interaction in relevant developmental contexts. Also highlighted are experimental and computational approaches to study lncRNAs.
DOI: 10.1534/genetics.119.302661
PubMed: 31796550
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Smith</name><affiliation wicri:level="1"><nlm:affiliation>Department of Genetics, University of North Carolina, Chapel Hill, North Carolina 27599 kns@email.unc.edu.</nlm:affiliation><country wicri:rule="url">États-Unis</country><wicri:regionArea>Department of Genetics, University of North Carolina, Chapel Hill</wicri:regionArea><wicri:noRegion>Chapel Hill</wicri:noRegion></affiliation></author><author><name sortKey="Miller, Sarah C" sort="Miller, Sarah C" uniqKey="Miller S" first="Sarah C" last="Miller">Sarah C. Miller</name><affiliation wicri:level="2"><nlm:affiliation>Department of Genetics, University of North Carolina, Chapel Hill, North Carolina 27599.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName><wicri:cityArea>Department of Genetics, University of North Carolina, Chapel Hill</wicri:cityArea></affiliation></author><author><name sortKey="Varani, Gabriele" sort="Varani, Gabriele" uniqKey="Varani G" first="Gabriele" last="Varani">Gabriele Varani</name><affiliation wicri:level="2"><nlm:affiliation>Department of Chemistry, University of Washington, Seattle, Washington 98195.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>Department of Chemistry, University of Washington, Seattle</wicri:cityArea></affiliation></author><author><name sortKey="Calabrese, J Mauro" sort="Calabrese, J Mauro" uniqKey="Calabrese J" first="J Mauro" last="Calabrese">J Mauro Calabrese</name><affiliation wicri:level="2"><nlm:affiliation>Department of Pharmacology, University of North Carolina, Chapel Hill, North Carolina 27599.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName><wicri:cityArea>Department of Pharmacology, University of North Carolina, Chapel Hill</wicri:cityArea></affiliation></author><author><name sortKey="Magnuson, Terry" sort="Magnuson, Terry" uniqKey="Magnuson T" first="Terry" last="Magnuson">Terry Magnuson</name><affiliation wicri:level="2"><nlm:affiliation>Department of Genetics, University of North Carolina, Chapel Hill, North Carolina 27599.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName><wicri:cityArea>Department of Genetics, University of North Carolina, Chapel Hill</wicri:cityArea></affiliation></author></analytic><series><title level="j">Genetics</title><idno type="eISSN">1943-2631</idno><imprint><date when="2019" type="published">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Lineage specification in early development is the basis for the exquisitely precise body plan of multicellular organisms. It is therefore critical to understand cell fate decisions in early development. Moreover, for regenerative medicine, the accurate specification of cell types to replace damaged/diseased tissue is strongly dependent on identifying determinants of cell identity. Long noncoding RNAs (lncRNAs) have been shown to regulate cellular plasticity, including pluripotency establishment and maintenance, differentiation and development, yet broad phenotypic analysis and the mechanistic basis of their function remains lacking. As components of molecular condensates, lncRNAs interact with almost all classes of cellular biomolecules, including proteins, DNA, mRNAs, and microRNAs. With functions ranging from controlling alternative splicing of mRNAs, to providing scaffolding upon which chromatin modifiers are assembled, it is clear that at least a subset of lncRNAs are far from the transcriptional noise they were once deemed. This review highlights the diversity of lncRNA interactions in the context of cell fate specification, and provides examples of each type of interaction in relevant developmental contexts. Also highlighted are experimental and computational approaches to study lncRNAs.</div></front></TEI><pubmed><MedlineCitation Status="In-Process" Owner="NLM"><PMID Version="1">31796550</PMID><DateRevised><Year>2020</Year><Month>02</Month><Day>05</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1943-2631</ISSN><JournalIssue CitedMedium="Internet"><Volume>213</Volume><Issue>4</Issue><PubDate><Year>2019</Year><Month>12</Month></PubDate></JournalIssue><Title>Genetics</Title><ISOAbbreviation>Genetics</ISOAbbreviation></Journal><ArticleTitle>Multimodal Long Noncoding RNA Interaction Networks: Control Panels for Cell Fate Specification.</ArticleTitle><Pagination><MedlinePgn>1093-1110</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1534/genetics.119.302661</ELocationID><Abstract><AbstractText>Lineage specification in early development is the basis for the exquisitely precise body plan of multicellular organisms. It is therefore critical to understand cell fate decisions in early development. Moreover, for regenerative medicine, the accurate specification of cell types to replace damaged/diseased tissue is strongly dependent on identifying determinants of cell identity. Long noncoding RNAs (lncRNAs) have been shown to regulate cellular plasticity, including pluripotency establishment and maintenance, differentiation and development, yet broad phenotypic analysis and the mechanistic basis of their function remains lacking. As components of molecular condensates, lncRNAs interact with almost all classes of cellular biomolecules, including proteins, DNA, mRNAs, and microRNAs. With functions ranging from controlling alternative splicing of mRNAs, to providing scaffolding upon which chromatin modifiers are assembled, it is clear that at least a subset of lncRNAs are far from the transcriptional noise they were once deemed. This review highlights the diversity of lncRNA interactions in the context of cell fate specification, and provides examples of each type of interaction in relevant developmental contexts. Also highlighted are experimental and computational approaches to study lncRNAs.</AbstractText><CopyrightInformation>Copyright © 2019 by the Genetics Society of America.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y" EqualContrib="Y"><LastName>Smith</LastName><ForeName>Keriayn N</ForeName><Initials>KN</Initials><Identifier Source="ORCID">0000-0002-4351-2765</Identifier><AffiliationInfo><Affiliation>Department of Genetics, University of North Carolina, Chapel Hill, North Carolina 27599 kns@email.unc.edu.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y" EqualContrib="Y"><LastName>Miller</LastName><ForeName>Sarah C</ForeName><Initials>SC</Initials><Identifier Source="ORCID">0000-0003-3470-8798</Identifier><AffiliationInfo><Affiliation>Department of Genetics, University of North Carolina, Chapel Hill, North Carolina 27599.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Varani</LastName><ForeName>Gabriele</ForeName><Initials>G</Initials><Identifier Source="ORCID">0000-0001-6642-7144</Identifier><AffiliationInfo><Affiliation>Department of Chemistry, University of Washington, Seattle, Washington 98195.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Calabrese</LastName><ForeName>J Mauro</ForeName><Initials>JM</Initials><Identifier Source="ORCID">0000-0002-1213-2540</Identifier><AffiliationInfo><Affiliation>Department of Pharmacology, University of North Carolina, Chapel Hill, North Carolina 27599.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Magnuson</LastName><ForeName>Terry</ForeName><Initials>T</Initials><Identifier Source="ORCID">0000-0002-0792-835X</Identifier><AffiliationInfo><Affiliation>Department of Genetics, University of North Carolina, Chapel Hill, North Carolina 27599.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><GrantList 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