Serum and cerebrospinal fluid cytokines in children with acute encephalopathy.
Identifieur interne : 002416 ( Ncbi/Merge ); précédent : 002415; suivant : 002417Serum and cerebrospinal fluid cytokines in children with acute encephalopathy.
Auteurs : Yuta Kawahara [Japon] ; Akira Morimoto [Japon] ; Yukiko Oh [Japon] ; Rieko Furukawa [Japon] ; Kei Wakabayashi [Japon] ; Yukifumi Monden [Japon] ; Hitoshi Osaka [Japon] ; Takanori Yamagata [Japon]Source :
- Brain & development [ 1872-7131 ] ; 2020.
Abstract
The pathogenesis of acute encephalopathy (AE) remains unclear, and a biomarker has not been identified.
DOI: 10.1016/j.braindev.2019.11.002
PubMed: 31787380
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 000348
- to stream PubMed, to step Curation: 000348
- to stream PubMed, to step Checkpoint: 000083
Links to Exploration step
pubmed:31787380Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Serum and cerebrospinal fluid cytokines in children with acute encephalopathy.</title><author><name sortKey="Kawahara, Yuta" sort="Kawahara, Yuta" uniqKey="Kawahara Y" first="Yuta" last="Kawahara">Yuta Kawahara</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pediatrics, Jichi Medical University School of Medicine, Japan. Electronic address: r0716yk@jichi.ac.jp.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Pediatrics, Jichi Medical University School of Medicine</wicri:regionArea><wicri:noRegion>Jichi Medical University School of Medicine</wicri:noRegion></affiliation></author><author><name sortKey="Morimoto, Akira" sort="Morimoto, Akira" uniqKey="Morimoto A" first="Akira" last="Morimoto">Akira Morimoto</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pediatrics, Jichi Medical University School of Medicine, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Pediatrics, Jichi Medical University School of Medicine</wicri:regionArea><wicri:noRegion>Jichi Medical University School of Medicine</wicri:noRegion></affiliation></author><author><name sortKey="Oh, Yukiko" sort="Oh, Yukiko" uniqKey="Oh Y" first="Yukiko" last="Oh">Yukiko Oh</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pediatrics, Jichi Medical University School of Medicine, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Pediatrics, Jichi Medical University School of Medicine</wicri:regionArea><wicri:noRegion>Jichi Medical University School of Medicine</wicri:noRegion></affiliation></author><author><name sortKey="Furukawa, Rieko" sort="Furukawa, Rieko" uniqKey="Furukawa R" first="Rieko" last="Furukawa">Rieko Furukawa</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pediatric Medical Imaging, Jichi Medical University School of Medicine, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Pediatric Medical Imaging, Jichi Medical University School of Medicine</wicri:regionArea><wicri:noRegion>Jichi Medical University School of Medicine</wicri:noRegion></affiliation></author><author><name sortKey="Wakabayashi, Kei" sort="Wakabayashi, Kei" uniqKey="Wakabayashi K" first="Kei" last="Wakabayashi">Kei Wakabayashi</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pediatrics, Jichi Medical University School of Medicine, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Pediatrics, Jichi Medical University School of Medicine</wicri:regionArea><wicri:noRegion>Jichi Medical University School of Medicine</wicri:noRegion></affiliation></author><author><name sortKey="Monden, Yukifumi" sort="Monden, Yukifumi" uniqKey="Monden Y" first="Yukifumi" last="Monden">Yukifumi Monden</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pediatrics, Jichi Medical University School of Medicine, Japan; Department of Pediatrics, International University of Health and Welfare, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Pediatrics, Jichi Medical University School of Medicine, Japan; Department of Pediatrics, International University of Health and Welfare</wicri:regionArea><wicri:noRegion>International University of Health and Welfare</wicri:noRegion></affiliation></author><author><name sortKey="Osaka, Hitoshi" sort="Osaka, Hitoshi" uniqKey="Osaka H" first="Hitoshi" last="Osaka">Hitoshi Osaka</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pediatrics, Jichi Medical University School of Medicine, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Pediatrics, Jichi Medical University School of Medicine</wicri:regionArea><wicri:noRegion>Jichi Medical University School of Medicine</wicri:noRegion></affiliation></author><author><name sortKey="Yamagata, Takanori" sort="Yamagata, Takanori" uniqKey="Yamagata T" first="Takanori" last="Yamagata">Takanori Yamagata</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pediatrics, Jichi Medical University School of Medicine, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Pediatrics, Jichi Medical University School of Medicine</wicri:regionArea><wicri:noRegion>Jichi Medical University School of Medicine</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2020">2020</date><idno type="RBID">pubmed:31787380</idno><idno type="pmid">31787380</idno><idno type="doi">10.1016/j.braindev.2019.11.002</idno><idno type="wicri:Area/PubMed/Corpus">000348</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000348</idno><idno type="wicri:Area/PubMed/Curation">000348</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000348</idno><idno type="wicri:Area/PubMed/Checkpoint">000083</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000083</idno><idno type="wicri:Area/Ncbi/Merge">002416</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Serum and cerebrospinal fluid cytokines in children with acute encephalopathy.</title><author><name sortKey="Kawahara, Yuta" sort="Kawahara, Yuta" uniqKey="Kawahara Y" first="Yuta" last="Kawahara">Yuta Kawahara</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pediatrics, Jichi Medical University School of Medicine, Japan. Electronic address: r0716yk@jichi.ac.jp.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Pediatrics, Jichi Medical University School of Medicine</wicri:regionArea><wicri:noRegion>Jichi Medical University School of Medicine</wicri:noRegion></affiliation></author><author><name sortKey="Morimoto, Akira" sort="Morimoto, Akira" uniqKey="Morimoto A" first="Akira" last="Morimoto">Akira Morimoto</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pediatrics, Jichi Medical University School of Medicine, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Pediatrics, Jichi Medical University School of Medicine</wicri:regionArea><wicri:noRegion>Jichi Medical University School of Medicine</wicri:noRegion></affiliation></author><author><name sortKey="Oh, Yukiko" sort="Oh, Yukiko" uniqKey="Oh Y" first="Yukiko" last="Oh">Yukiko Oh</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pediatrics, Jichi Medical University School of Medicine, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Pediatrics, Jichi Medical University School of Medicine</wicri:regionArea><wicri:noRegion>Jichi Medical University School of Medicine</wicri:noRegion></affiliation></author><author><name sortKey="Furukawa, Rieko" sort="Furukawa, Rieko" uniqKey="Furukawa R" first="Rieko" last="Furukawa">Rieko Furukawa</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pediatric Medical Imaging, Jichi Medical University School of Medicine, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Pediatric Medical Imaging, Jichi Medical University School of Medicine</wicri:regionArea><wicri:noRegion>Jichi Medical University School of Medicine</wicri:noRegion></affiliation></author><author><name sortKey="Wakabayashi, Kei" sort="Wakabayashi, Kei" uniqKey="Wakabayashi K" first="Kei" last="Wakabayashi">Kei Wakabayashi</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pediatrics, Jichi Medical University School of Medicine, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Pediatrics, Jichi Medical University School of Medicine</wicri:regionArea><wicri:noRegion>Jichi Medical University School of Medicine</wicri:noRegion></affiliation></author><author><name sortKey="Monden, Yukifumi" sort="Monden, Yukifumi" uniqKey="Monden Y" first="Yukifumi" last="Monden">Yukifumi Monden</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pediatrics, Jichi Medical University School of Medicine, Japan; Department of Pediatrics, International University of Health and Welfare, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Pediatrics, Jichi Medical University School of Medicine, Japan; Department of Pediatrics, International University of Health and Welfare</wicri:regionArea><wicri:noRegion>International University of Health and Welfare</wicri:noRegion></affiliation></author><author><name sortKey="Osaka, Hitoshi" sort="Osaka, Hitoshi" uniqKey="Osaka H" first="Hitoshi" last="Osaka">Hitoshi Osaka</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pediatrics, Jichi Medical University School of Medicine, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Pediatrics, Jichi Medical University School of Medicine</wicri:regionArea><wicri:noRegion>Jichi Medical University School of Medicine</wicri:noRegion></affiliation></author><author><name sortKey="Yamagata, Takanori" sort="Yamagata, Takanori" uniqKey="Yamagata T" first="Takanori" last="Yamagata">Takanori Yamagata</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pediatrics, Jichi Medical University School of Medicine, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Pediatrics, Jichi Medical University School of Medicine</wicri:regionArea><wicri:noRegion>Jichi Medical University School of Medicine</wicri:noRegion></affiliation></author></analytic><series><title level="j">Brain & development</title><idno type="eISSN">1872-7131</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The pathogenesis of acute encephalopathy (AE) remains unclear, and a biomarker has not been identified.</div></front></TEI><pubmed><MedlineCitation Status="In-Process" Owner="NLM"><PMID Version="1">31787380</PMID><DateRevised><Year>2020</Year><Month>02</Month><Day>06</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1872-7131</ISSN><JournalIssue CitedMedium="Internet"><Volume>42</Volume><Issue>2</Issue><PubDate><Year>2020</Year><Month>Feb</Month></PubDate></JournalIssue><Title>Brain & development</Title><ISOAbbreviation>Brain Dev.</ISOAbbreviation></Journal><ArticleTitle>Serum and cerebrospinal fluid cytokines in children with acute encephalopathy.</ArticleTitle><Pagination><MedlinePgn>185-191</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">S0387-7604(19)30289-X</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.braindev.2019.11.002</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">The pathogenesis of acute encephalopathy (AE) remains unclear, and a biomarker has not been identified.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">Levels of 49 cytokines and chemokines, including osteopontin (OPN), were measured in serum and cerebrospinal fluid (CSF) of children with AE (n = 17) or febrile convulsion (FC; n = 8; control group). The AE group included acute necrotizing encephalopathy (n = 1), acute encephalopathy with biphasic seizures and late reduced diffusion (AESD; n = 3), clinically mild encephalitis/encephalopathy with a reversible splenial lesion (MERS; n = 4), and unclassified acute encephalopathy (UCAE; n = 9) that does not meet the criteria of syndrome classification. Five individuals with AE had neurological sequelae or death (poor prognosis), whereas 12 were alive without neurological sequelae (good prognosis).</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">The CSF:serum ratios of OPN, CC chemokine ligand (CCL)4, and interleukin (IL)-10 were significantly higher in AE than in FC. The CSF levels of macrophage inhibitory factor (MIF) and leukemia inhibitory factor (LIF) were significantly higher in the poor-prognosis group than in the good-prognosis group. The CSF:serum ratios of OPN were significantly higher in AESD and in MERS than in FC. The CSF:serum ratios of MIF and OPN were higher in MERS than in UCAE or FC.</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">Our results suggest that microglia-related cytokines and chemokines such as OPN, MIF, and LIF could be novel biomarkers of AE, in addition to the previously reported IL-10 and CCL4, and that MIF and LIF may be markers of poor prognosis.</AbstractText><CopyrightInformation>Copyright © 2019 The Japanese Society of Child Neurology. Published by Elsevier B.V. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Kawahara</LastName><ForeName>Yuta</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Department of Pediatrics, Jichi Medical University School of Medicine, Japan. Electronic address: r0716yk@jichi.ac.jp.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Morimoto</LastName><ForeName>Akira</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Pediatrics, Jichi Medical University School of Medicine, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Oh</LastName><ForeName>Yukiko</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Department of Pediatrics, Jichi Medical University School of Medicine, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Furukawa</LastName><ForeName>Rieko</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Department of Pediatric Medical Imaging, Jichi Medical University School of Medicine, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wakabayashi</LastName><ForeName>Kei</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Department of Pediatrics, Jichi Medical University School of Medicine, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Monden</LastName><ForeName>Yukifumi</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Department of Pediatrics, Jichi Medical University School of Medicine, Japan; Department of Pediatrics, International University of Health and Welfare, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Osaka</LastName><ForeName>Hitoshi</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Department of Pediatrics, Jichi Medical University School of Medicine, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yamagata</LastName><ForeName>Takanori</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Department of Pediatrics, Jichi Medical University School of Medicine, Japan.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2019</Year><Month>11</Month><Day>29</Day></ArticleDate></Article><MedlineJournalInfo><Country>Netherlands</Country><MedlineTA>Brain Dev</MedlineTA><NlmUniqueID>7909235</NlmUniqueID><ISSNLinking>0387-7604</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Acute encephalopathy</Keyword><Keyword MajorTopicYN="N">Chemokine</Keyword><Keyword MajorTopicYN="N">Children</Keyword><Keyword MajorTopicYN="N">Cytokine</Keyword><Keyword MajorTopicYN="N">Microglia</Keyword><Keyword MajorTopicYN="N">Osteopontin</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2019</Year><Month>05</Month><Day>09</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2019</Year><Month>10</Month><Day>24</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2019</Year><Month>11</Month><Day>08</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2019</Year><Month>12</Month><Day>4</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2019</Year><Month>12</Month><Day>4</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2019</Year><Month>12</Month><Day>3</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">31787380</ArticleId><ArticleId IdType="pii">S0387-7604(19)30289-X</ArticleId><ArticleId IdType="doi">10.1016/j.braindev.2019.11.002</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Japon</li></country></list><tree><country name="Japon"><noRegion><name sortKey="Kawahara, Yuta" sort="Kawahara, Yuta" uniqKey="Kawahara Y" first="Yuta" last="Kawahara">Yuta Kawahara</name></noRegion><name sortKey="Furukawa, Rieko" sort="Furukawa, Rieko" uniqKey="Furukawa R" first="Rieko" last="Furukawa">Rieko Furukawa</name><name sortKey="Monden, Yukifumi" sort="Monden, Yukifumi" uniqKey="Monden Y" first="Yukifumi" last="Monden">Yukifumi Monden</name><name sortKey="Morimoto, Akira" sort="Morimoto, Akira" uniqKey="Morimoto A" first="Akira" last="Morimoto">Akira Morimoto</name><name sortKey="Oh, Yukiko" sort="Oh, Yukiko" uniqKey="Oh Y" first="Yukiko" last="Oh">Yukiko Oh</name><name sortKey="Osaka, Hitoshi" sort="Osaka, Hitoshi" uniqKey="Osaka H" first="Hitoshi" last="Osaka">Hitoshi Osaka</name><name sortKey="Wakabayashi, Kei" sort="Wakabayashi, Kei" uniqKey="Wakabayashi K" first="Kei" last="Wakabayashi">Kei Wakabayashi</name><name sortKey="Yamagata, Takanori" sort="Yamagata, Takanori" uniqKey="Yamagata T" first="Takanori" last="Yamagata">Takanori Yamagata</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/MersV1/Data/Ncbi/Merge
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002416 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Ncbi/Merge/biblio.hfd -nk 002416 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= MersV1
|flux= Ncbi
|étape= Merge
|type= RBID
|clé= pubmed:31787380
|texte= Serum and cerebrospinal fluid cytokines in children with acute encephalopathy.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Ncbi/Merge/RBID.i -Sk "pubmed:31787380" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Ncbi/Merge/biblio.hfd \
| NlmPubMed2Wicri -a MersV1
| This area was generated with Dilib version V0.6.33. |  |