CEPI: Driving Progress Toward Epidemic Preparedness and Response.
Identifieur interne : 002383 ( Ncbi/Merge ); précédent : 002382; suivant : 002384CEPI: Driving Progress Toward Epidemic Preparedness and Response.
Auteurs : Dimitrios Gouglas ; Mario Christodoulou ; Stanley A. Plotkin ; Richard HatchettSource :
- Epidemiologic reviews [ 1478-6729 ] ; 2019.
Abstract
The Coalition for Epidemic Preparedness Innovations (CEPI) was formed in the aftermath of the 2014-2015 Ebola outbreak in west Africa to support the development of vaccines that could improve the world's preparedness against outbreaks of epidemic infectious diseases. Since its launch in 2017, CEPI has mobilized more than US$750 million to support its mission to develop vaccines against agents such as Lassa virus, Middle East respiratory syndrome coronavirus, and Nipah virus, as well as several rapid-response vaccine platforms to accelerate response times to unexpected epidemic threats. CEPI has also played a leading role in fostering institutional partnerships between public- and private-sector organizations to optimize allocation of resources for vaccine development against its priority pathogens. CEPI's priorities include diversification of its current vaccine research and development investment portfolio to include additional pathogens, such as Rift Valley fever and chikungunya; establishment of technical and regulatory pathways for vaccine development across CEPI's portfolio; development of sustainable manufacturing solutions for vaccine candidates nearing completion of safety and immunogenicity testing in humans; and creation of investigational stockpiles of its vaccine candidates for use in emergency situations. This commentary provides an overview of the global health challenges CEPI was established to address and its achievements to date, and indicates priorities for funding and coordination in the coming years.
DOI: 10.1093/epirev/mxz012
PubMed: 31673694
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Plotkin</name></author><author><name sortKey="Hatchett, Richard" sort="Hatchett, Richard" uniqKey="Hatchett R" first="Richard" last="Hatchett">Richard Hatchett</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2019">2019</date><idno type="RBID">pubmed:31673694</idno><idno type="pmid">31673694</idno><idno type="doi">10.1093/epirev/mxz012</idno><idno type="wicri:Area/PubMed/Corpus">000380</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000380</idno><idno type="wicri:Area/PubMed/Curation">000380</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000380</idno><idno type="wicri:Area/PubMed/Checkpoint">000646</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000646</idno><idno type="wicri:Area/Ncbi/Merge">002383</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">CEPI: Driving Progress Toward Epidemic Preparedness and Response.</title><author><name sortKey="Gouglas, Dimitrios" sort="Gouglas, Dimitrios" uniqKey="Gouglas D" first="Dimitrios" last="Gouglas">Dimitrios Gouglas</name></author><author><name sortKey="Christodoulou, Mario" sort="Christodoulou, Mario" uniqKey="Christodoulou M" first="Mario" last="Christodoulou">Mario Christodoulou</name></author><author><name sortKey="Plotkin, Stanley A" sort="Plotkin, Stanley A" uniqKey="Plotkin S" first="Stanley A" last="Plotkin">Stanley A. Plotkin</name></author><author><name sortKey="Hatchett, Richard" sort="Hatchett, Richard" uniqKey="Hatchett R" first="Richard" last="Hatchett">Richard Hatchett</name></author></analytic><series><title level="j">Epidemiologic reviews</title><idno type="eISSN">1478-6729</idno><imprint><date when="2019" type="published">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The Coalition for Epidemic Preparedness Innovations (CEPI) was formed in the aftermath of the 2014-2015 Ebola outbreak in west Africa to support the development of vaccines that could improve the world's preparedness against outbreaks of epidemic infectious diseases. Since its launch in 2017, CEPI has mobilized more than US$750 million to support its mission to develop vaccines against agents such as Lassa virus, Middle East respiratory syndrome coronavirus, and Nipah virus, as well as several rapid-response vaccine platforms to accelerate response times to unexpected epidemic threats. CEPI has also played a leading role in fostering institutional partnerships between public- and private-sector organizations to optimize allocation of resources for vaccine development against its priority pathogens. CEPI's priorities include diversification of its current vaccine research and development investment portfolio to include additional pathogens, such as Rift Valley fever and chikungunya; establishment of technical and regulatory pathways for vaccine development across CEPI's portfolio; development of sustainable manufacturing solutions for vaccine candidates nearing completion of safety and immunogenicity testing in humans; and creation of investigational stockpiles of its vaccine candidates for use in emergency situations. This commentary provides an overview of the global health challenges CEPI was established to address and its achievements to date, and indicates priorities for funding and coordination in the coming years.</div></front></TEI><pubmed><MedlineCitation Status="In-Data-Review" Owner="NLM"><PMID Version="1">31673694</PMID><DateRevised><Year>2020</Year><Month>04</Month><Day>16</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1478-6729</ISSN><JournalIssue CitedMedium="Internet"><Volume>41</Volume><Issue>1</Issue><PubDate><Year>2019</Year><Month>Jan</Month><Day>31</Day></PubDate></JournalIssue><Title>Epidemiologic reviews</Title><ISOAbbreviation>Epidemiol Rev</ISOAbbreviation></Journal><ArticleTitle>CEPI: Driving Progress Toward Epidemic Preparedness and Response.</ArticleTitle><Pagination><MedlinePgn>28-33</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1093/epirev/mxz012</ELocationID><Abstract><AbstractText>The Coalition for Epidemic Preparedness Innovations (CEPI) was formed in the aftermath of the 2014-2015 Ebola outbreak in west Africa to support the development of vaccines that could improve the world's preparedness against outbreaks of epidemic infectious diseases. Since its launch in 2017, CEPI has mobilized more than US$750 million to support its mission to develop vaccines against agents such as Lassa virus, Middle East respiratory syndrome coronavirus, and Nipah virus, as well as several rapid-response vaccine platforms to accelerate response times to unexpected epidemic threats. CEPI has also played a leading role in fostering institutional partnerships between public- and private-sector organizations to optimize allocation of resources for vaccine development against its priority pathogens. CEPI's priorities include diversification of its current vaccine research and development investment portfolio to include additional pathogens, such as Rift Valley fever and chikungunya; establishment of technical and regulatory pathways for vaccine development across CEPI's portfolio; development of sustainable manufacturing solutions for vaccine candidates nearing completion of safety and immunogenicity testing in humans; and creation of investigational stockpiles of its vaccine candidates for use in emergency situations. This commentary provides an overview of the global health challenges CEPI was established to address and its achievements to date, and indicates priorities for funding and coordination in the coming years.</AbstractText><CopyrightInformation>© The Author(s) 2019. Published by Oxford University Press on behalf of the Johns Hopkins Bloomberg School of Public Health.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Gouglas</LastName><ForeName>Dimitrios</ForeName><Initials>D</Initials></Author><Author ValidYN="Y"><LastName>Christodoulou</LastName><ForeName>Mario</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Plotkin</LastName><ForeName>Stanley A</ForeName><Initials>SA</Initials></Author><Author ValidYN="Y"><LastName>Hatchett</LastName><ForeName>Richard</ForeName><Initials>R</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Epidemiol Rev</MedlineTA><NlmUniqueID>7910703</NlmUniqueID><ISSNLinking>0193-936X</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">CEPI</Keyword><Keyword MajorTopicYN="N">Lassa</Keyword><Keyword MajorTopicYN="N">MERS-CoV</Keyword><Keyword MajorTopicYN="N">Nipah</Keyword><Keyword MajorTopicYN="N">Rift Valley fever</Keyword><Keyword MajorTopicYN="N">chikungunya</Keyword><Keyword MajorTopicYN="N">epidemic infectious diseases</Keyword><Keyword MajorTopicYN="N">epidemic preparedness</Keyword><Keyword MajorTopicYN="N">global health research and development priorities</Keyword><Keyword MajorTopicYN="N">vaccines</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2018</Year><Month>12</Month><Day>04</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2019</Year><Month>09</Month><Day>23</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2019</Year><Month>09</Month><Day>24</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2019</Year><Month>11</Month><Day>2</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2019</Year><Month>11</Month><Day>2</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2019</Year><Month>11</Month><Day>2</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">31673694</ArticleId><ArticleId IdType="pii">5588068</ArticleId><ArticleId IdType="doi">10.1093/epirev/mxz012</ArticleId><ArticleId IdType="pmc">PMC7108492</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list></list><tree><noCountry><name sortKey="Christodoulou, Mario" sort="Christodoulou, Mario" uniqKey="Christodoulou M" first="Mario" last="Christodoulou">Mario Christodoulou</name><name sortKey="Gouglas, Dimitrios" sort="Gouglas, Dimitrios" uniqKey="Gouglas D" first="Dimitrios" last="Gouglas">Dimitrios Gouglas</name><name sortKey="Hatchett, Richard" sort="Hatchett, Richard" uniqKey="Hatchett R" first="Richard" last="Hatchett">Richard Hatchett</name><name sortKey="Plotkin, Stanley A" sort="Plotkin, Stanley A" uniqKey="Plotkin S" first="Stanley A" last="Plotkin">Stanley A. 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