Mild encephalitis/encephalopathy with a reversible splenial lesion due to Plasmodium falciparum malaria: a case report
Identifieur interne : 002009 ( Ncbi/Merge ); précédent : 002008; suivant : 002010Mild encephalitis/encephalopathy with a reversible splenial lesion due to Plasmodium falciparum malaria: a case report
Auteurs : Momoko Mawatari [Japon] ; Tetsuro Kobayashi [Japon, États-Unis] ; Shinya Yamamoto [Japon] ; Nozomi Takeshita [Japon] ; Kayoko Hayakawa [Japon] ; Satoshi Kutsuna [Japon] ; Norio Ohmagari [Japon] ; Tomoyuki Noguchi [Japon] ; Yasuyuki Kato [Japon]Source :
- Tropical Medicine and Health [ 1348-8945 ] ; 2018.
Abstract
Neurological complications from malaria cause significant morbidity and mortality. Severe cerebral malaria occurs as a result of intense sequestration of infected erythrocytes in the cerebral capillaries. However, the pathology of the reversible neurological symptoms remains unclear. We report the case of a patient with malaria who also had mild encephalitis/encephalopathy with a reversible splenial lesion (MERS) causing transient neurological symptoms.
A 55-year-old Japanese man was admitted to our hospital with acute fever upon returning from Nigeria. Blood smears and PCR analysis revealed ring forms in the erythrocytes, indicative of
MERS often causes transient headaches, seizures, and/or impaired consciousness. The symptoms are compatible with the reversible symptoms of cerebral malaria.
Url:
DOI: 10.1186/s41182-018-0119-4
PubMed: 30410417
PubMed Central: 6219025
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PMC:6219025Le document en format XML
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<author><name sortKey="Ohmagari, Norio" sort="Ohmagari, Norio" uniqKey="Ohmagari N" first="Norio" last="Ohmagari">Norio Ohmagari</name>
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<author><name sortKey="Noguchi, Tomoyuki" sort="Noguchi, Tomoyuki" uniqKey="Noguchi T" first="Tomoyuki" last="Noguchi">Tomoyuki Noguchi</name>
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Tokyo, Japan</nlm:aff>
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<author><name sortKey="Kato, Yasuyuki" sort="Kato, Yasuyuki" uniqKey="Kato Y" first="Yasuyuki" last="Kato">Yasuyuki Kato</name>
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<series><title level="j">Tropical Medicine and Health</title>
<idno type="ISSN">1348-8945</idno>
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<front><div type="abstract" xml:lang="en"><sec><title>Background</title>
<p id="Par1">Neurological complications from malaria cause significant morbidity and mortality. Severe cerebral malaria occurs as a result of intense sequestration of infected erythrocytes in the cerebral capillaries. However, the pathology of the reversible neurological symptoms remains unclear. We report the case of a patient with malaria who also had mild encephalitis/encephalopathy with a reversible splenial lesion (MERS) causing transient neurological symptoms.</p>
</sec>
<sec><title>Case presentation</title>
<p id="Par2">A 55-year-old Japanese man was admitted to our hospital with acute fever upon returning from Nigeria. Blood smears and PCR analysis revealed ring forms in the erythrocytes, indicative of <italic>Plasmodium falciparum</italic>
infection. He presented with dysarthria, expressive aphasia, and truncal ataxia, all of which were suggestive of cerebellar ataxia. He had no other signs or symptoms of severe malaria. Artemether/lumefantrine was started on the first day of illness. Although the parasites were undetectable on day 3 of illness, his neurological symptoms persisted. Brain magnetic resonance imaging (MRI) demonstrated a high-signal lesion in the splenium of the corpus callosum on diffusion-weighted images along with a decreased apparent diffusion coefficient. The neurological symptoms gradually improved by day 12. Brain MRI on day 16 showed complete regression of the splenic lesion. Therefore, the patient was diagnosed with MERS due to malaria.</p>
</sec>
<sec><title>Conclusions</title>
<p id="Par3">MERS often causes transient headaches, seizures, and/or impaired consciousness. The symptoms are compatible with the reversible symptoms of cerebral malaria.</p>
</sec>
</div>
</front>
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malaria: a case report</title>
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Tokyo, Japan</nlm:aff>
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3-39-15, Showa-machi, Maebashi, Gunma 371-8511 Japan</nlm:aff>
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</author>
<author><name sortKey="Kobayashi, Tetsuro" sort="Kobayashi, Tetsuro" uniqKey="Kobayashi T" first="Tetsuro" last="Kobayashi">Tetsuro Kobayashi</name>
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<institution-id institution-id-type="GRID">grid.39158.36</institution-id>
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</institution-wrap>
Sapporo, Japan</nlm:aff>
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<wicri:regionArea>Sapporo</wicri:regionArea>
</affiliation>
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<institution-id institution-id-type="GRID">grid.256304.6</institution-id>
<institution>Division of Epidemiology and Biostatistics, School of Public Health,</institution>
<institution>Georgia State University,</institution>
</institution-wrap>
Atlanta, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Atlanta</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Yamamoto, Shinya" sort="Yamamoto, Shinya" uniqKey="Yamamoto S" first="Shinya" last="Yamamoto">Shinya Yamamoto</name>
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<institution>General Internal Medicine,</institution>
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</institution-wrap>
Kamakura, Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Kamakura</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Takeshita, Nozomi" sort="Takeshita, Nozomi" uniqKey="Takeshita N" first="Nozomi" last="Takeshita">Nozomi Takeshita</name>
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Tokyo, Japan</nlm:aff>
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</affiliation>
</author>
<author><name sortKey="Hayakawa, Kayoko" sort="Hayakawa, Kayoko" uniqKey="Hayakawa K" first="Kayoko" last="Hayakawa">Kayoko Hayakawa</name>
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<institution-id institution-id-type="GRID">grid.45203.30</institution-id>
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<institution>National Center for Global Health and Medicine,</institution>
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Tokyo, Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Tokyo</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kutsuna, Satoshi" sort="Kutsuna, Satoshi" uniqKey="Kutsuna S" first="Satoshi" last="Kutsuna">Satoshi Kutsuna</name>
<affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0489 0290</institution-id>
<institution-id institution-id-type="GRID">grid.45203.30</institution-id>
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<institution>National Center for Global Health and Medicine,</institution>
</institution-wrap>
Tokyo, Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Tokyo</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Ohmagari, Norio" sort="Ohmagari, Norio" uniqKey="Ohmagari N" first="Norio" last="Ohmagari">Norio Ohmagari</name>
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<institution-id institution-id-type="GRID">grid.45203.30</institution-id>
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Tokyo, Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Tokyo</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Noguchi, Tomoyuki" sort="Noguchi, Tomoyuki" uniqKey="Noguchi T" first="Tomoyuki" last="Noguchi">Tomoyuki Noguchi</name>
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<institution-id institution-id-type="GRID">grid.45203.30</institution-id>
<institution>Department of Radiology, National Center for Global Health and Medicine,</institution>
</institution-wrap>
Tokyo, Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Tokyo</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kato, Yasuyuki" sort="Kato, Yasuyuki" uniqKey="Kato Y" first="Yasuyuki" last="Kato">Yasuyuki Kato</name>
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<institution-id institution-id-type="GRID">grid.45203.30</institution-id>
<institution>Disease Control and Prevention Center,</institution>
<institution>National Center for Global Health and Medicine,</institution>
</institution-wrap>
Tokyo, Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Tokyo</wicri:regionArea>
</affiliation>
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<idno type="doi">10.1186/s41182-018-0119-4</idno>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Mild encephalitis/encephalopathy with a reversible splenial lesion due to <italic>Plasmodium falciparum</italic>
malaria: a case report</title>
<author><name sortKey="Mawatari, Momoko" sort="Mawatari, Momoko" uniqKey="Mawatari M" first="Momoko" last="Mawatari">Momoko Mawatari</name>
<affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0489 0290</institution-id>
<institution-id institution-id-type="GRID">grid.45203.30</institution-id>
<institution>Disease Control and Prevention Center,</institution>
<institution>National Center for Global Health and Medicine,</institution>
</institution-wrap>
Tokyo, Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Tokyo</wicri:regionArea>
</affiliation>
<affiliation><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0595 7039</institution-id>
<institution-id institution-id-type="GRID">grid.411887.3</institution-id>
<institution>Infection Control and Prevention Center,</institution>
<institution>Gunma University Hospital,</institution>
</institution-wrap>
3-39-15, Showa-machi, Maebashi, Gunma 371-8511 Japan</nlm:aff>
<wicri:noCountry code="subfield">Gunma 371-8511 Japan</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Kobayashi, Tetsuro" sort="Kobayashi, Tetsuro" uniqKey="Kobayashi T" first="Tetsuro" last="Kobayashi">Tetsuro Kobayashi</name>
<affiliation wicri:level="1"><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2173 7691</institution-id>
<institution-id institution-id-type="GRID">grid.39158.36</institution-id>
<institution>Department of Hygiene, Graduate School of Medicine,</institution>
<institution>Hokkaido University,</institution>
</institution-wrap>
Sapporo, Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Sapporo</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="Aff4"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 7400</institution-id>
<institution-id institution-id-type="GRID">grid.256304.6</institution-id>
<institution>Division of Epidemiology and Biostatistics, School of Public Health,</institution>
<institution>Georgia State University,</institution>
</institution-wrap>
Atlanta, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Atlanta</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Yamamoto, Shinya" sort="Yamamoto, Shinya" uniqKey="Yamamoto S" first="Shinya" last="Yamamoto">Shinya Yamamoto</name>
<affiliation wicri:level="1"><nlm:aff id="Aff5"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0377 3017</institution-id>
<institution-id institution-id-type="GRID">grid.415816.f</institution-id>
<institution>General Internal Medicine,</institution>
<institution>Shonan Kamakura General Hospital,</institution>
</institution-wrap>
Kamakura, Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Kamakura</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Takeshita, Nozomi" sort="Takeshita, Nozomi" uniqKey="Takeshita N" first="Nozomi" last="Takeshita">Nozomi Takeshita</name>
<affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0489 0290</institution-id>
<institution-id institution-id-type="GRID">grid.45203.30</institution-id>
<institution>Disease Control and Prevention Center,</institution>
<institution>National Center for Global Health and Medicine,</institution>
</institution-wrap>
Tokyo, Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Tokyo</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Hayakawa, Kayoko" sort="Hayakawa, Kayoko" uniqKey="Hayakawa K" first="Kayoko" last="Hayakawa">Kayoko Hayakawa</name>
<affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0489 0290</institution-id>
<institution-id institution-id-type="GRID">grid.45203.30</institution-id>
<institution>Disease Control and Prevention Center,</institution>
<institution>National Center for Global Health and Medicine,</institution>
</institution-wrap>
Tokyo, Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Tokyo</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kutsuna, Satoshi" sort="Kutsuna, Satoshi" uniqKey="Kutsuna S" first="Satoshi" last="Kutsuna">Satoshi Kutsuna</name>
<affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0489 0290</institution-id>
<institution-id institution-id-type="GRID">grid.45203.30</institution-id>
<institution>Disease Control and Prevention Center,</institution>
<institution>National Center for Global Health and Medicine,</institution>
</institution-wrap>
Tokyo, Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Tokyo</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Ohmagari, Norio" sort="Ohmagari, Norio" uniqKey="Ohmagari N" first="Norio" last="Ohmagari">Norio Ohmagari</name>
<affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0489 0290</institution-id>
<institution-id institution-id-type="GRID">grid.45203.30</institution-id>
<institution>Disease Control and Prevention Center,</institution>
<institution>National Center for Global Health and Medicine,</institution>
</institution-wrap>
Tokyo, Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Tokyo</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Noguchi, Tomoyuki" sort="Noguchi, Tomoyuki" uniqKey="Noguchi T" first="Tomoyuki" last="Noguchi">Tomoyuki Noguchi</name>
<affiliation wicri:level="1"><nlm:aff id="Aff6"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0489 0290</institution-id>
<institution-id institution-id-type="GRID">grid.45203.30</institution-id>
<institution>Department of Radiology, National Center for Global Health and Medicine,</institution>
</institution-wrap>
Tokyo, Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Tokyo</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kato, Yasuyuki" sort="Kato, Yasuyuki" uniqKey="Kato Y" first="Yasuyuki" last="Kato">Yasuyuki Kato</name>
<affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0489 0290</institution-id>
<institution-id institution-id-type="GRID">grid.45203.30</institution-id>
<institution>Disease Control and Prevention Center,</institution>
<institution>National Center for Global Health and Medicine,</institution>
</institution-wrap>
Tokyo, Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Tokyo</wicri:regionArea>
</affiliation>
</author>
</analytic>
<series><title level="j">Tropical Medicine and Health</title>
<idno type="ISSN">1348-8945</idno>
<idno type="eISSN">1349-4147</idno>
<imprint><date when="2018">2018</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><sec><title>Background</title>
<p id="Par1">Neurological complications from malaria cause significant morbidity and mortality. Severe cerebral malaria occurs as a result of intense sequestration of infected erythrocytes in the cerebral capillaries. However, the pathology of the reversible neurological symptoms remains unclear. We report the case of a patient with malaria who also had mild encephalitis/encephalopathy with a reversible splenial lesion (MERS) causing transient neurological symptoms.</p>
</sec>
<sec><title>Case presentation</title>
<p id="Par2">A 55-year-old Japanese man was admitted to our hospital with acute fever upon returning from Nigeria. Blood smears and PCR analysis revealed ring forms in the erythrocytes, indicative of <italic>Plasmodium falciparum</italic>
infection. He presented with dysarthria, expressive aphasia, and truncal ataxia, all of which were suggestive of cerebellar ataxia. He had no other signs or symptoms of severe malaria. Artemether/lumefantrine was started on the first day of illness. Although the parasites were undetectable on day 3 of illness, his neurological symptoms persisted. Brain magnetic resonance imaging (MRI) demonstrated a high-signal lesion in the splenium of the corpus callosum on diffusion-weighted images along with a decreased apparent diffusion coefficient. The neurological symptoms gradually improved by day 12. Brain MRI on day 16 showed complete regression of the splenic lesion. Therefore, the patient was diagnosed with MERS due to malaria.</p>
</sec>
<sec><title>Conclusions</title>
<p id="Par3">MERS often causes transient headaches, seizures, and/or impaired consciousness. The symptoms are compatible with the reversible symptoms of cerebral malaria.</p>
</sec>
</div>
</front>
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<author><name sortKey="Barkovich, Aj" uniqKey="Barkovich A">AJ Barkovich</name>
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<author><name sortKey="Hernalsteen, D" uniqKey="Hernalsteen D">D Hernalsteen</name>
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<pubmed><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Mild encephalitis/encephalopathy with a reversible splenial lesion due to <i>Plasmodium falciparum</i>
malaria: a case report.</title>
<author><name sortKey="Mawatari, Momoko" sort="Mawatari, Momoko" uniqKey="Mawatari M" first="Momoko" last="Mawatari">Momoko Mawatari</name>
<affiliation wicri:level="3"><nlm:affiliation>1Disease Control and Prevention Center, National Center for Global Health and Medicine, Tokyo, Japan.</nlm:affiliation>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>1Disease Control and Prevention Center, National Center for Global Health and Medicine, Tokyo</wicri:regionArea>
<placeName><settlement type="city">Tokyo</settlement>
<region type="région">Région de Kantō</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kobayashi, Tetsuro" sort="Kobayashi, Tetsuro" uniqKey="Kobayashi T" first="Tetsuro" last="Kobayashi">Tetsuro Kobayashi</name>
<affiliation wicri:level="1"><nlm:affiliation>3Department of Hygiene, Graduate School of Medicine, Hokkaido University, Sapporo, Japan.</nlm:affiliation>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>3Department of Hygiene, Graduate School of Medicine, Hokkaido University, Sapporo</wicri:regionArea>
<wicri:noRegion>Sapporo</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Yamamoto, Shinya" sort="Yamamoto, Shinya" uniqKey="Yamamoto S" first="Shinya" last="Yamamoto">Shinya Yamamoto</name>
<affiliation wicri:level="1"><nlm:affiliation>5General Internal Medicine, Shonan Kamakura General Hospital, Kamakura, Japan.</nlm:affiliation>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>5General Internal Medicine, Shonan Kamakura General Hospital, Kamakura</wicri:regionArea>
<wicri:noRegion>Kamakura</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Takeshita, Nozomi" sort="Takeshita, Nozomi" uniqKey="Takeshita N" first="Nozomi" last="Takeshita">Nozomi Takeshita</name>
<affiliation wicri:level="3"><nlm:affiliation>1Disease Control and Prevention Center, National Center for Global Health and Medicine, Tokyo, Japan.</nlm:affiliation>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>1Disease Control and Prevention Center, National Center for Global Health and Medicine, Tokyo</wicri:regionArea>
<placeName><settlement type="city">Tokyo</settlement>
<region type="région">Région de Kantō</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hayakawa, Kayoko" sort="Hayakawa, Kayoko" uniqKey="Hayakawa K" first="Kayoko" last="Hayakawa">Kayoko Hayakawa</name>
<affiliation wicri:level="3"><nlm:affiliation>1Disease Control and Prevention Center, National Center for Global Health and Medicine, Tokyo, Japan.</nlm:affiliation>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>1Disease Control and Prevention Center, National Center for Global Health and Medicine, Tokyo</wicri:regionArea>
<placeName><settlement type="city">Tokyo</settlement>
<region type="région">Région de Kantō</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kutsuna, Satoshi" sort="Kutsuna, Satoshi" uniqKey="Kutsuna S" first="Satoshi" last="Kutsuna">Satoshi Kutsuna</name>
<affiliation wicri:level="3"><nlm:affiliation>1Disease Control and Prevention Center, National Center for Global Health and Medicine, Tokyo, Japan.</nlm:affiliation>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>1Disease Control and Prevention Center, National Center for Global Health and Medicine, Tokyo</wicri:regionArea>
<placeName><settlement type="city">Tokyo</settlement>
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</placeName>
</affiliation>
</author>
<author><name sortKey="Ohmagari, Norio" sort="Ohmagari, Norio" uniqKey="Ohmagari N" first="Norio" last="Ohmagari">Norio Ohmagari</name>
<affiliation wicri:level="3"><nlm:affiliation>1Disease Control and Prevention Center, National Center for Global Health and Medicine, Tokyo, Japan.</nlm:affiliation>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>1Disease Control and Prevention Center, National Center for Global Health and Medicine, Tokyo</wicri:regionArea>
<placeName><settlement type="city">Tokyo</settlement>
<region type="région">Région de Kantō</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Noguchi, Tomoyuki" sort="Noguchi, Tomoyuki" uniqKey="Noguchi T" first="Tomoyuki" last="Noguchi">Tomoyuki Noguchi</name>
<affiliation wicri:level="3"><nlm:affiliation>6Department of Radiology, National Center for Global Health and Medicine, Tokyo, Japan.</nlm:affiliation>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>6Department of Radiology, National Center for Global Health and Medicine, Tokyo</wicri:regionArea>
<placeName><settlement type="city">Tokyo</settlement>
<region type="région">Région de Kantō</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kato, Yasuyuki" sort="Kato, Yasuyuki" uniqKey="Kato Y" first="Yasuyuki" last="Kato">Yasuyuki Kato</name>
<affiliation wicri:level="3"><nlm:affiliation>1Disease Control and Prevention Center, National Center for Global Health and Medicine, Tokyo, Japan.</nlm:affiliation>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>1Disease Control and Prevention Center, National Center for Global Health and Medicine, Tokyo</wicri:regionArea>
<placeName><settlement type="city">Tokyo</settlement>
<region type="région">Région de Kantō</region>
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<date when="2018">2018</date>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Mild encephalitis/encephalopathy with a reversible splenial lesion due to <i>Plasmodium falciparum</i>
malaria: a case report.</title>
<author><name sortKey="Mawatari, Momoko" sort="Mawatari, Momoko" uniqKey="Mawatari M" first="Momoko" last="Mawatari">Momoko Mawatari</name>
<affiliation wicri:level="3"><nlm:affiliation>1Disease Control and Prevention Center, National Center for Global Health and Medicine, Tokyo, Japan.</nlm:affiliation>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>1Disease Control and Prevention Center, National Center for Global Health and Medicine, Tokyo</wicri:regionArea>
<placeName><settlement type="city">Tokyo</settlement>
<region type="région">Région de Kantō</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kobayashi, Tetsuro" sort="Kobayashi, Tetsuro" uniqKey="Kobayashi T" first="Tetsuro" last="Kobayashi">Tetsuro Kobayashi</name>
<affiliation wicri:level="1"><nlm:affiliation>3Department of Hygiene, Graduate School of Medicine, Hokkaido University, Sapporo, Japan.</nlm:affiliation>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>3Department of Hygiene, Graduate School of Medicine, Hokkaido University, Sapporo</wicri:regionArea>
<wicri:noRegion>Sapporo</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Yamamoto, Shinya" sort="Yamamoto, Shinya" uniqKey="Yamamoto S" first="Shinya" last="Yamamoto">Shinya Yamamoto</name>
<affiliation wicri:level="1"><nlm:affiliation>5General Internal Medicine, Shonan Kamakura General Hospital, Kamakura, Japan.</nlm:affiliation>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>5General Internal Medicine, Shonan Kamakura General Hospital, Kamakura</wicri:regionArea>
<wicri:noRegion>Kamakura</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Takeshita, Nozomi" sort="Takeshita, Nozomi" uniqKey="Takeshita N" first="Nozomi" last="Takeshita">Nozomi Takeshita</name>
<affiliation wicri:level="3"><nlm:affiliation>1Disease Control and Prevention Center, National Center for Global Health and Medicine, Tokyo, Japan.</nlm:affiliation>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>1Disease Control and Prevention Center, National Center for Global Health and Medicine, Tokyo</wicri:regionArea>
<placeName><settlement type="city">Tokyo</settlement>
<region type="région">Région de Kantō</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hayakawa, Kayoko" sort="Hayakawa, Kayoko" uniqKey="Hayakawa K" first="Kayoko" last="Hayakawa">Kayoko Hayakawa</name>
<affiliation wicri:level="3"><nlm:affiliation>1Disease Control and Prevention Center, National Center for Global Health and Medicine, Tokyo, Japan.</nlm:affiliation>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>1Disease Control and Prevention Center, National Center for Global Health and Medicine, Tokyo</wicri:regionArea>
<placeName><settlement type="city">Tokyo</settlement>
<region type="région">Région de Kantō</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kutsuna, Satoshi" sort="Kutsuna, Satoshi" uniqKey="Kutsuna S" first="Satoshi" last="Kutsuna">Satoshi Kutsuna</name>
<affiliation wicri:level="3"><nlm:affiliation>1Disease Control and Prevention Center, National Center for Global Health and Medicine, Tokyo, Japan.</nlm:affiliation>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>1Disease Control and Prevention Center, National Center for Global Health and Medicine, Tokyo</wicri:regionArea>
<placeName><settlement type="city">Tokyo</settlement>
<region type="région">Région de Kantō</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ohmagari, Norio" sort="Ohmagari, Norio" uniqKey="Ohmagari N" first="Norio" last="Ohmagari">Norio Ohmagari</name>
<affiliation wicri:level="3"><nlm:affiliation>1Disease Control and Prevention Center, National Center for Global Health and Medicine, Tokyo, Japan.</nlm:affiliation>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>1Disease Control and Prevention Center, National Center for Global Health and Medicine, Tokyo</wicri:regionArea>
<placeName><settlement type="city">Tokyo</settlement>
<region type="région">Région de Kantō</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Noguchi, Tomoyuki" sort="Noguchi, Tomoyuki" uniqKey="Noguchi T" first="Tomoyuki" last="Noguchi">Tomoyuki Noguchi</name>
<affiliation wicri:level="3"><nlm:affiliation>6Department of Radiology, National Center for Global Health and Medicine, Tokyo, Japan.</nlm:affiliation>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>6Department of Radiology, National Center for Global Health and Medicine, Tokyo</wicri:regionArea>
<placeName><settlement type="city">Tokyo</settlement>
<region type="région">Région de Kantō</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kato, Yasuyuki" sort="Kato, Yasuyuki" uniqKey="Kato Y" first="Yasuyuki" last="Kato">Yasuyuki Kato</name>
<affiliation wicri:level="3"><nlm:affiliation>1Disease Control and Prevention Center, National Center for Global Health and Medicine, Tokyo, Japan.</nlm:affiliation>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>1Disease Control and Prevention Center, National Center for Global Health and Medicine, Tokyo</wicri:regionArea>
<placeName><settlement type="city">Tokyo</settlement>
<region type="région">Région de Kantō</region>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">Tropical medicine and health</title>
<idno type="ISSN">1348-8945</idno>
<imprint><date when="2018" type="published">2018</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Neurological complications from malaria cause significant morbidity and mortality. Severe cerebral malaria occurs as a result of intense sequestration of infected erythrocytes in the cerebral capillaries. However, the pathology of the reversible neurological symptoms remains unclear. We report the case of a patient with malaria who also had mild encephalitis/encephalopathy with a reversible splenial lesion (MERS) causing transient neurological symptoms.</div>
</front>
</TEI>
</pubmed>
</double>
</record>
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