Comparison of phytochemical profiles and antiproliferative activities of different proanthocyanidins fractions from Choerospondias axillaris fruit peels.
Identifieur interne : 001F57 ( Ncbi/Merge ); précédent : 001F56; suivant : 001F58Comparison of phytochemical profiles and antiproliferative activities of different proanthocyanidins fractions from Choerospondias axillaris fruit peels.
Auteurs : Qian Li [République populaire de Chine] ; Chengmei Liu [République populaire de Chine] ; Ti Li [République populaire de Chine] ; David Julian Mcclements [États-Unis] ; Yinxin Fu [République populaire de Chine] ; Jiyan Liu [République populaire de Chine]Source :
- Food research international (Ottawa, Ont.) [ 1873-7145 ] ; 2018.
Descripteurs français
- KwdFr :
- Anacardiaceae (), Antinéoplasiques (), Antinéoplasiques (analyse), Antinéoplasiques (pharmacologie), Apoptose (), Cellules Caco-2, Composés phytochimiques (), Composés phytochimiques (analyse), Composés phytochimiques (pharmacologie), Extraits de plantes (), Fruit (), Humains, Proanthocyanidines (), Proanthocyanidines (analyse), Proanthocyanidines (pharmacologie), Prolifération cellulaire ().
- MESH :
- analyse : Antinéoplasiques, Composés phytochimiques, Proanthocyanidines.
- pharmacologie : Antinéoplasiques, Composés phytochimiques, Proanthocyanidines.
- Anacardiaceae, Antinéoplasiques, Apoptose, Cellules Caco-2, Composés phytochimiques, Extraits de plantes, Fruit, Humains, Proanthocyanidines, Prolifération cellulaire.
English descriptors
- KwdEn :
- Anacardiaceae (chemistry), Antineoplastic Agents (analysis), Antineoplastic Agents (chemistry), Antineoplastic Agents (pharmacology), Apoptosis (drug effects), Caco-2 Cells, Cell Proliferation (drug effects), Fruit (chemistry), Humans, Phytochemicals (analysis), Phytochemicals (chemistry), Phytochemicals (pharmacology), Plant Extracts (chemistry), Proanthocyanidins (analysis), Proanthocyanidins (chemistry), Proanthocyanidins (pharmacology).
- MESH :
- chemical , analysis : Antineoplastic Agents, Phytochemicals, Proanthocyanidins.
- chemistry : Anacardiaceae, Antineoplastic Agents, Fruit, Phytochemicals, Plant Extracts, Proanthocyanidins.
- drug effects : Apoptosis, Cell Proliferation.
- chemical , pharmacology : Antineoplastic Agents, Phytochemicals, Proanthocyanidins.
- Caco-2 Cells, Humans.
Abstract
Epidemiological studies had indicated that the incidence of colorectal cancer is inversely correlated to the consumption of proanthocyanidins (PAs). In this study, five PAs fractions isolated from Choerospondias axillaris fruit peels with different mean degree of polymerization (mDP) were characterized and their antiproliferative effects on Caco-2 cells were investigated. MALDI-TOF-MS results indicated that PAs fractions were composed of procyanidins with DP up to 13-mers. All PAs fractions induced dose and time-dependent reductions of Caco-2 cell viability. The IC50 values of PAs fractions with increasing mDP were 240 ± 16.0, 143 ± 9.53, 87.0 ± 3.55, 44.3 ± 4.89, and 42.8 ± 2.20 μg/mL after 24 h incubation, respectively. The observed reduction in Caco-2 cell viability was due to apoptosis via the activation of caspase-9, caspase-3, caspase-8 and the elevation of intracellular ROS generation. Moreover, the extent of the reduction in cell viability after exposure to PAs fractions was positively correlated with their mDP and galloylation. These results indicate that Choerospondias axillaris peel is a potential source of natural chemopreventive agents for the treatment of colorectal cancer.
DOI: 10.1016/j.foodres.2018.07.006
PubMed: 30195524
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 000787
- to stream PubMed, to step Curation: 000787
- to stream PubMed, to step Checkpoint: 000977
Links to Exploration step
pubmed:30195524Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Comparison of phytochemical profiles and antiproliferative activities of different proanthocyanidins fractions from Choerospondias axillaris fruit peels.</title><author><name sortKey="Li, Qian" sort="Li, Qian" uniqKey="Li Q" first="Qian" last="Li">Qian Li</name><affiliation wicri:level="1"><nlm:affiliation>Key Laboratory of Fermentation Engineering, Ministry of Education, Hubei Key Laboratory of Industrial Microbiology, College of Bioengineering and Food, Hubei University of Technology, Wuhan 430068, Hubei, PR China; State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330047, Jiangxi, PR China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Fermentation Engineering, Ministry of Education, Hubei Key Laboratory of Industrial Microbiology, College of Bioengineering and Food, Hubei University of Technology, Wuhan 430068, Hubei, PR China; State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330047, Jiangxi</wicri:regionArea><wicri:noRegion>Jiangxi</wicri:noRegion></affiliation></author><author><name sortKey="Liu, Chengmei" sort="Liu, Chengmei" uniqKey="Liu C" first="Chengmei" last="Liu">Chengmei Liu</name><affiliation wicri:level="1"><nlm:affiliation>State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330047, Jiangxi, PR China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330047, Jiangxi</wicri:regionArea><wicri:noRegion>Jiangxi</wicri:noRegion></affiliation></author><author><name sortKey="Li, Ti" sort="Li, Ti" uniqKey="Li T" first="Ti" last="Li">Ti Li</name><affiliation wicri:level="1"><nlm:affiliation>State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330047, Jiangxi, PR China. Electronic address: liti@ncu.edu.cn.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330047, Jiangxi</wicri:regionArea><wicri:noRegion>Jiangxi</wicri:noRegion></affiliation></author><author><name sortKey="Mcclements, David Julian" sort="Mcclements, David Julian" uniqKey="Mcclements D" first="David Julian" last="Mcclements">David Julian Mcclements</name><affiliation wicri:level="4"><nlm:affiliation>Department of Food Science, University of Massachusetts, Amherst, MA 01003, USA. Electronic address: mcclements@foodsci.umass.edu.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Food Science, University of Massachusetts, Amherst, MA 01003</wicri:regionArea><placeName><region type="state">Massachusetts</region><settlement type="city">Amherst (Massachusetts)</settlement></placeName><orgName type="university">Université du Massachusetts</orgName></affiliation></author><author><name sortKey="Fu, Yinxin" sort="Fu, Yinxin" uniqKey="Fu Y" first="Yinxin" last="Fu">Yinxin Fu</name><affiliation wicri:level="1"><nlm:affiliation>Wuhan Fourth Hospital, Puai Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430000, Hubei, PR China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Wuhan Fourth Hospital, Puai Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430000, Hubei</wicri:regionArea><wicri:noRegion>Hubei</wicri:noRegion></affiliation></author><author><name sortKey="Liu, Jiyan" sort="Liu, Jiyan" uniqKey="Liu J" first="Jiyan" last="Liu">Jiyan Liu</name><affiliation wicri:level="1"><nlm:affiliation>Jiangxi Qiyunshan Food Co., Ltd, Ganzhou 341000, Jiangxi, PR China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Jiangxi Qiyunshan Food Co., Ltd, Ganzhou 341000, Jiangxi</wicri:regionArea><wicri:noRegion>Jiangxi</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2018">2018</date><idno type="RBID">pubmed:30195524</idno><idno type="pmid">30195524</idno><idno type="doi">10.1016/j.foodres.2018.07.006</idno><idno type="wicri:Area/PubMed/Corpus">000787</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000787</idno><idno type="wicri:Area/PubMed/Curation">000787</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000787</idno><idno type="wicri:Area/PubMed/Checkpoint">000977</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000977</idno><idno type="wicri:Area/Ncbi/Merge">001F57</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Comparison of phytochemical profiles and antiproliferative activities of different proanthocyanidins fractions from Choerospondias axillaris fruit peels.</title><author><name sortKey="Li, Qian" sort="Li, Qian" uniqKey="Li Q" first="Qian" last="Li">Qian Li</name><affiliation wicri:level="1"><nlm:affiliation>Key Laboratory of Fermentation Engineering, Ministry of Education, Hubei Key Laboratory of Industrial Microbiology, College of Bioengineering and Food, Hubei University of Technology, Wuhan 430068, Hubei, PR China; State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330047, Jiangxi, PR China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Fermentation Engineering, Ministry of Education, Hubei Key Laboratory of Industrial Microbiology, College of Bioengineering and Food, Hubei University of Technology, Wuhan 430068, Hubei, PR China; State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330047, Jiangxi</wicri:regionArea><wicri:noRegion>Jiangxi</wicri:noRegion></affiliation></author><author><name sortKey="Liu, Chengmei" sort="Liu, Chengmei" uniqKey="Liu C" first="Chengmei" last="Liu">Chengmei Liu</name><affiliation wicri:level="1"><nlm:affiliation>State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330047, Jiangxi, PR China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330047, Jiangxi</wicri:regionArea><wicri:noRegion>Jiangxi</wicri:noRegion></affiliation></author><author><name sortKey="Li, Ti" sort="Li, Ti" uniqKey="Li T" first="Ti" last="Li">Ti Li</name><affiliation wicri:level="1"><nlm:affiliation>State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330047, Jiangxi, PR China. Electronic address: liti@ncu.edu.cn.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330047, Jiangxi</wicri:regionArea><wicri:noRegion>Jiangxi</wicri:noRegion></affiliation></author><author><name sortKey="Mcclements, David Julian" sort="Mcclements, David Julian" uniqKey="Mcclements D" first="David Julian" last="Mcclements">David Julian Mcclements</name><affiliation wicri:level="4"><nlm:affiliation>Department of Food Science, University of Massachusetts, Amherst, MA 01003, USA. Electronic address: mcclements@foodsci.umass.edu.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Food Science, University of Massachusetts, Amherst, MA 01003</wicri:regionArea><placeName><region type="state">Massachusetts</region><settlement type="city">Amherst (Massachusetts)</settlement></placeName><orgName type="university">Université du Massachusetts</orgName></affiliation></author><author><name sortKey="Fu, Yinxin" sort="Fu, Yinxin" uniqKey="Fu Y" first="Yinxin" last="Fu">Yinxin Fu</name><affiliation wicri:level="1"><nlm:affiliation>Wuhan Fourth Hospital, Puai Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430000, Hubei, PR China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Wuhan Fourth Hospital, Puai Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430000, Hubei</wicri:regionArea><wicri:noRegion>Hubei</wicri:noRegion></affiliation></author><author><name sortKey="Liu, Jiyan" sort="Liu, Jiyan" uniqKey="Liu J" first="Jiyan" last="Liu">Jiyan Liu</name><affiliation wicri:level="1"><nlm:affiliation>Jiangxi Qiyunshan Food Co., Ltd, Ganzhou 341000, Jiangxi, PR China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Jiangxi Qiyunshan Food Co., Ltd, Ganzhou 341000, Jiangxi</wicri:regionArea><wicri:noRegion>Jiangxi</wicri:noRegion></affiliation></author></analytic><series><title level="j">Food research international (Ottawa, Ont.)</title><idno type="eISSN">1873-7145</idno><imprint><date when="2018" type="published">2018</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Anacardiaceae (chemistry)</term><term>Antineoplastic Agents (analysis)</term><term>Antineoplastic Agents (chemistry)</term><term>Antineoplastic Agents (pharmacology)</term><term>Apoptosis (drug effects)</term><term>Caco-2 Cells</term><term>Cell Proliferation (drug effects)</term><term>Fruit (chemistry)</term><term>Humans</term><term>Phytochemicals (analysis)</term><term>Phytochemicals (chemistry)</term><term>Phytochemicals (pharmacology)</term><term>Plant Extracts (chemistry)</term><term>Proanthocyanidins (analysis)</term><term>Proanthocyanidins (chemistry)</term><term>Proanthocyanidins (pharmacology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Anacardiaceae ()</term><term>Antinéoplasiques ()</term><term>Antinéoplasiques (analyse)</term><term>Antinéoplasiques (pharmacologie)</term><term>Apoptose ()</term><term>Cellules Caco-2</term><term>Composés phytochimiques ()</term><term>Composés phytochimiques (analyse)</term><term>Composés phytochimiques (pharmacologie)</term><term>Extraits de plantes ()</term><term>Fruit ()</term><term>Humains</term><term>Proanthocyanidines ()</term><term>Proanthocyanidines (analyse)</term><term>Proanthocyanidines (pharmacologie)</term><term>Prolifération cellulaire ()</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Antineoplastic Agents</term><term>Phytochemicals</term><term>Proanthocyanidins</term></keywords><keywords scheme="MESH" qualifier="analyse" xml:lang="fr"><term>Antinéoplasiques</term><term>Composés phytochimiques</term><term>Proanthocyanidines</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Anacardiaceae</term><term>Antineoplastic Agents</term><term>Fruit</term><term>Phytochemicals</term><term>Plant Extracts</term><term>Proanthocyanidins</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Apoptosis</term><term>Cell Proliferation</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Antinéoplasiques</term><term>Composés phytochimiques</term><term>Proanthocyanidines</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Antineoplastic Agents</term><term>Phytochemicals</term><term>Proanthocyanidins</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Caco-2 Cells</term><term>Humans</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Anacardiaceae</term><term>Antinéoplasiques</term><term>Apoptose</term><term>Cellules Caco-2</term><term>Composés phytochimiques</term><term>Extraits de plantes</term><term>Fruit</term><term>Humains</term><term>Proanthocyanidines</term><term>Prolifération cellulaire</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Epidemiological studies had indicated that the incidence of colorectal cancer is inversely correlated to the consumption of proanthocyanidins (PAs). In this study, five PAs fractions isolated from Choerospondias axillaris fruit peels with different mean degree of polymerization (mDP) were characterized and their antiproliferative effects on Caco-2 cells were investigated. MALDI-TOF-MS results indicated that PAs fractions were composed of procyanidins with DP up to 13-mers. All PAs fractions induced dose and time-dependent reductions of Caco-2 cell viability. The IC<sub>50</sub> values of PAs fractions with increasing mDP were 240 ± 16.0, 143 ± 9.53, 87.0 ± 3.55, 44.3 ± 4.89, and 42.8 ± 2.20 μg/mL after 24 h incubation, respectively. The observed reduction in Caco-2 cell viability was due to apoptosis via the activation of caspase-9, caspase-3, caspase-8 and the elevation of intracellular ROS generation. Moreover, the extent of the reduction in cell viability after exposure to PAs fractions was positively correlated with their mDP and galloylation. These results indicate that Choerospondias axillaris peel is a potential source of natural chemopreventive agents for the treatment of colorectal cancer.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">30195524</PMID><DateCompleted><Year>2019</Year><Month>10</Month><Day>14</Day></DateCompleted><DateRevised><Year>2019</Year><Month>10</Month><Day>14</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1873-7145</ISSN><JournalIssue CitedMedium="Internet"><Volume>113</Volume><PubDate><Year>2018</Year><Month>11</Month></PubDate></JournalIssue><Title>Food research international (Ottawa, Ont.)</Title><ISOAbbreviation>Food Res. Int.</ISOAbbreviation></Journal><ArticleTitle>Comparison of phytochemical profiles and antiproliferative activities of different proanthocyanidins fractions from Choerospondias axillaris fruit peels.</ArticleTitle><Pagination><MedlinePgn>298-308</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">S0963-9969(18)30534-9</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.foodres.2018.07.006</ELocationID><Abstract><AbstractText>Epidemiological studies had indicated that the incidence of colorectal cancer is inversely correlated to the consumption of proanthocyanidins (PAs). In this study, five PAs fractions isolated from Choerospondias axillaris fruit peels with different mean degree of polymerization (mDP) were characterized and their antiproliferative effects on Caco-2 cells were investigated. MALDI-TOF-MS results indicated that PAs fractions were composed of procyanidins with DP up to 13-mers. All PAs fractions induced dose and time-dependent reductions of Caco-2 cell viability. The IC<sub>50</sub> values of PAs fractions with increasing mDP were 240 ± 16.0, 143 ± 9.53, 87.0 ± 3.55, 44.3 ± 4.89, and 42.8 ± 2.20 μg/mL after 24 h incubation, respectively. The observed reduction in Caco-2 cell viability was due to apoptosis via the activation of caspase-9, caspase-3, caspase-8 and the elevation of intracellular ROS generation. Moreover, the extent of the reduction in cell viability after exposure to PAs fractions was positively correlated with their mDP and galloylation. These results indicate that Choerospondias axillaris peel is a potential source of natural chemopreventive agents for the treatment of colorectal cancer.</AbstractText><CopyrightInformation>Copyright © 2018 Elsevier Ltd. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Li</LastName><ForeName>Qian</ForeName><Initials>Q</Initials><AffiliationInfo><Affiliation>Key Laboratory of Fermentation Engineering, Ministry of Education, Hubei Key Laboratory of Industrial Microbiology, College of Bioengineering and Food, Hubei University of Technology, Wuhan 430068, Hubei, PR China; State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330047, Jiangxi, PR China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Liu</LastName><ForeName>Chengmei</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330047, Jiangxi, PR China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Li</LastName><ForeName>Ti</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330047, Jiangxi, PR China. Electronic address: liti@ncu.edu.cn.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>McClements</LastName><ForeName>David Julian</ForeName><Initials>DJ</Initials><AffiliationInfo><Affiliation>Department of Food Science, University of Massachusetts, Amherst, MA 01003, USA. Electronic address: mcclements@foodsci.umass.edu.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fu</LastName><ForeName>Yinxin</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Wuhan Fourth Hospital, Puai Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430000, Hubei, PR China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Liu</LastName><ForeName>Jiyan</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Jiangxi Qiyunshan Food Co., Ltd, Ganzhou 341000, Jiangxi, PR China.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2018</Year><Month>07</Month><Day>05</Day></ArticleDate></Article><MedlineJournalInfo><Country>Canada</Country><MedlineTA>Food Res Int</MedlineTA><NlmUniqueID>9210143</NlmUniqueID><ISSNLinking>0963-9969</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000970">Antineoplastic Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D064209">Phytochemicals</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D010936">Plant Extracts</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D044945">Proanthocyanidins</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D027926" MajorTopicYN="N">Anacardiaceae</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000970" MajorTopicYN="Y">Antineoplastic Agents</DescriptorName><QualifierName UI="Q000032" MajorTopicYN="N">analysis</QualifierName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D017209" MajorTopicYN="N">Apoptosis</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D018938" MajorTopicYN="N">Caco-2 Cells</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D049109" MajorTopicYN="N">Cell Proliferation</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005638" MajorTopicYN="N">Fruit</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D064209" MajorTopicYN="Y">Phytochemicals</DescriptorName><QualifierName UI="Q000032" MajorTopicYN="N">analysis</QualifierName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010936" MajorTopicYN="N">Plant Extracts</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D044945" MajorTopicYN="Y">Proanthocyanidins</DescriptorName><QualifierName UI="Q000032" MajorTopicYN="N">analysis</QualifierName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">Antiproliferative</Keyword><Keyword MajorTopicYN="Y">Apoptosis</Keyword><Keyword MajorTopicYN="Y">Choerospondias axillaris</Keyword><Keyword MajorTopicYN="Y">Human colorectal cancer</Keyword><Keyword MajorTopicYN="Y">Proanthocyanidins</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2018</Year><Month>04</Month><Day>02</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2018</Year><Month>06</Month><Day>23</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2018</Year><Month>07</Month><Day>04</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2018</Year><Month>9</Month><Day>10</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2018</Year><Month>9</Month><Day>10</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2019</Year><Month>10</Month><Day>15</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">30195524</ArticleId><ArticleId IdType="pii">S0963-9969(18)30534-9</ArticleId><ArticleId IdType="doi">10.1016/j.foodres.2018.07.006</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>République populaire de Chine</li><li>États-Unis</li></country><region><li>Massachusetts</li></region><settlement><li>Amherst (Massachusetts)</li></settlement><orgName><li>Université du Massachusetts</li></orgName></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Li, Qian" sort="Li, Qian" uniqKey="Li Q" first="Qian" last="Li">Qian Li</name></noRegion><name sortKey="Fu, Yinxin" sort="Fu, Yinxin" uniqKey="Fu Y" first="Yinxin" last="Fu">Yinxin Fu</name><name sortKey="Li, Ti" sort="Li, Ti" uniqKey="Li T" first="Ti" last="Li">Ti Li</name><name sortKey="Liu, Chengmei" sort="Liu, Chengmei" uniqKey="Liu C" first="Chengmei" last="Liu">Chengmei Liu</name><name sortKey="Liu, Jiyan" sort="Liu, Jiyan" uniqKey="Liu J" first="Jiyan" last="Liu">Jiyan Liu</name></country><country name="États-Unis"><region name="Massachusetts"><name sortKey="Mcclements, David Julian" sort="Mcclements, David Julian" uniqKey="Mcclements D" first="David Julian" last="Mcclements">David Julian Mcclements</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/MersV1/Data/Ncbi/Merge
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001F57 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Ncbi/Merge/biblio.hfd -nk 001F57 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= MersV1
|flux= Ncbi
|étape= Merge
|type= RBID
|clé= pubmed:30195524
|texte= Comparison of phytochemical profiles and antiproliferative activities of different proanthocyanidins fractions from Choerospondias axillaris fruit peels.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Ncbi/Merge/RBID.i -Sk "pubmed:30195524" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Ncbi/Merge/biblio.hfd \
| NlmPubMed2Wicri -a MersV1
| This area was generated with Dilib version V0.6.33. |  |