Inactivation of Ebola virus and Middle East respiratory syndrome coronavirus in platelet concentrates and plasma by ultraviolet C light and methylene blue plus visible light, respectively.
Identifieur interne : 001E19 ( Ncbi/Merge ); précédent : 001E18; suivant : 001E20Inactivation of Ebola virus and Middle East respiratory syndrome coronavirus in platelet concentrates and plasma by ultraviolet C light and methylene blue plus visible light, respectively.
Auteurs : Markus Eickmann [Allemagne] ; Ute Gravemann [Allemagne] ; Wiebke Handke [Allemagne] ; Frank Tolksdorf [Allemagne] ; Stefan Reichenberg [Allemagne] ; Thomas H. Müller [Allemagne] ; Axel Seltsam [Allemagne]Source :
- Transfusion [ 1537-2995 ] ; 2018.
Descripteurs français
- KwdFr :
- Animaux, Bleu de méthylène (pharmacologie), Cellules Vero, Coronavirus du syndrome respiratoire du Moyen-Orient (), Coronavirus du syndrome respiratoire du Moyen-Orient (effets des radiations), Coronavirus du syndrome respiratoire du Moyen-Orient (isolement et purification), Ebolavirus (), Ebolavirus (effets des radiations), Ebolavirus (isolement et purification), Fièvre hémorragique à virus Ebola (), Fièvre hémorragique à virus Ebola (sang), Fièvre hémorragique à virus Ebola (virologie), Humains, Inactivation virale (), Inactivation virale (effets des radiations), Infections à coronavirus (), Infections à coronavirus (sang), Infections à coronavirus (virologie), Lumière, Plaquettes (virologie), Plasma sanguin (virologie), Rayons ultraviolets, Virémie (virologie).
- MESH :
- effets des radiations : Coronavirus du syndrome respiratoire du Moyen-Orient, Ebolavirus, Inactivation virale.
- isolement et purification : Coronavirus du syndrome respiratoire du Moyen-Orient, Ebolavirus.
- pharmacologie : Bleu de méthylène.
- sang : Fièvre hémorragique à virus Ebola, Infections à coronavirus.
- virologie : Fièvre hémorragique à virus Ebola, Infections à coronavirus, Plaquettes, Plasma sanguin, Virémie.
- Animaux, Cellules Vero, Coronavirus du syndrome respiratoire du Moyen-Orient, Ebolavirus, Fièvre hémorragique à virus Ebola, Humains, Inactivation virale, Infections à coronavirus, Lumière, Rayons ultraviolets.
English descriptors
- KwdEn :
- Animals, Blood Platelets (virology), Chlorocebus aethiops, Coronavirus Infections (blood), Coronavirus Infections (prevention & control), Coronavirus Infections (virology), Ebolavirus (drug effects), Ebolavirus (isolation & purification), Ebolavirus (radiation effects), Hemorrhagic Fever, Ebola (blood), Hemorrhagic Fever, Ebola (prevention & control), Hemorrhagic Fever, Ebola (virology), Humans, Light, Methylene Blue (pharmacology), Middle East Respiratory Syndrome Coronavirus (drug effects), Middle East Respiratory Syndrome Coronavirus (isolation & purification), Middle East Respiratory Syndrome Coronavirus (radiation effects), Plasma (virology), Ultraviolet Rays, Vero Cells, Viremia (virology), Virus Inactivation (drug effects), Virus Inactivation (radiation effects).
- MESH :
- chemical , pharmacology : Methylene Blue.
- blood : Coronavirus Infections, Hemorrhagic Fever, Ebola.
- drug effects : Ebolavirus, Middle East Respiratory Syndrome Coronavirus, Virus Inactivation.
- isolation & purification : Ebolavirus, Middle East Respiratory Syndrome Coronavirus.
- prevention & control : Coronavirus Infections, Hemorrhagic Fever, Ebola.
- radiation effects : Ebolavirus, Middle East Respiratory Syndrome Coronavirus, Virus Inactivation.
- virology : Blood Platelets, Coronavirus Infections, Hemorrhagic Fever, Ebola, Plasma, Viremia.
- Animals, Chlorocebus aethiops, Humans, Light, Ultraviolet Rays, Vero Cells.
Abstract
Ebola virus (EBOV) and Middle East respiratory syndrome coronavirus (MERS-CoV) have been identified as potential threats to blood safety. This study investigated the efficacy of the THERAFLEX UV-Platelets and THERAFLEX MB-Plasma pathogen inactivation systems to inactivate EBOV and MERS-CoV in platelet concentrates (PCs) and plasma, respectively.
DOI: 10.1111/trf.14652
PubMed: 29732571
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 000913
- to stream PubMed, to step Curation: 000913
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Links to Exploration step
pubmed:29732571Le document en format XML
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Coronavirus (radiation effects)</term><term>Plasma (virology)</term><term>Ultraviolet Rays</term><term>Vero Cells</term><term>Viremia (virology)</term><term>Virus Inactivation (drug effects)</term><term>Virus Inactivation (radiation effects)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Bleu de méthylène (pharmacologie)</term><term>Cellules Vero</term><term>Coronavirus du syndrome respiratoire du Moyen-Orient ()</term><term>Coronavirus du syndrome respiratoire du Moyen-Orient (effets des radiations)</term><term>Coronavirus du syndrome respiratoire du Moyen-Orient (isolement et purification)</term><term>Ebolavirus ()</term><term>Ebolavirus (effets des radiations)</term><term>Ebolavirus (isolement et purification)</term><term>Fièvre hémorragique à virus Ebola ()</term><term>Fièvre hémorragique à virus Ebola (sang)</term><term>Fièvre hémorragique à virus Ebola (virologie)</term><term>Humains</term><term>Inactivation virale ()</term><term>Inactivation virale (effets des radiations)</term><term>Infections à coronavirus ()</term><term>Infections à coronavirus (sang)</term><term>Infections à coronavirus (virologie)</term><term>Lumière</term><term>Plaquettes (virologie)</term><term>Plasma sanguin (virologie)</term><term>Rayons ultraviolets</term><term>Virémie (virologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Methylene Blue</term></keywords><keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Coronavirus Infections</term><term>Hemorrhagic Fever, Ebola</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Ebolavirus</term><term>Middle East Respiratory Syndrome Coronavirus</term><term>Virus Inactivation</term></keywords><keywords scheme="MESH" qualifier="effets des radiations" xml:lang="fr"><term>Coronavirus du syndrome respiratoire du Moyen-Orient</term><term>Ebolavirus</term><term>Inactivation virale</term></keywords><keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>Ebolavirus</term><term>Middle East Respiratory Syndrome Coronavirus</term></keywords><keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Coronavirus du syndrome respiratoire du Moyen-Orient</term><term>Ebolavirus</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Bleu de méthylène</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Coronavirus Infections</term><term>Hemorrhagic Fever, Ebola</term></keywords><keywords scheme="MESH" qualifier="radiation effects" xml:lang="en"><term>Ebolavirus</term><term>Middle East Respiratory Syndrome Coronavirus</term><term>Virus Inactivation</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Fièvre hémorragique à virus Ebola</term><term>Infections à coronavirus</term></keywords><keywords scheme="MESH" qualifier="virologie" 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type="abstract" xml:lang="en">Ebola virus (EBOV) and Middle East respiratory syndrome coronavirus (MERS-CoV) have been identified as potential threats to blood safety. This study investigated the efficacy of the THERAFLEX UV-Platelets and THERAFLEX MB-Plasma pathogen inactivation systems to inactivate EBOV and MERS-CoV in platelet concentrates (PCs) and plasma, respectively.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">29732571</PMID><DateCompleted><Year>2019</Year><Month>02</Month><Day>13</Day></DateCompleted><DateRevised><Year>2019</Year><Month>12</Month><Day>10</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1537-2995</ISSN><JournalIssue CitedMedium="Internet"><Volume>58</Volume><Issue>9</Issue><PubDate><Year>2018</Year><Month>09</Month></PubDate></JournalIssue><Title>Transfusion</Title><ISOAbbreviation>Transfusion</ISOAbbreviation></Journal><ArticleTitle>Inactivation of Ebola virus and Middle East respiratory syndrome coronavirus in platelet concentrates and plasma by ultraviolet C light and methylene blue plus visible light, respectively.</ArticleTitle><Pagination><MedlinePgn>2202-2207</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1111/trf.14652</ELocationID><Abstract><AbstractText Label="BACKGROUND">Ebola virus (EBOV) and Middle East respiratory syndrome coronavirus (MERS-CoV) have been identified as potential threats to blood safety. This study investigated the efficacy of the THERAFLEX UV-Platelets and THERAFLEX MB-Plasma pathogen inactivation systems to inactivate EBOV and MERS-CoV in platelet concentrates (PCs) and plasma, respectively.</AbstractText><AbstractText Label="STUDY DESIGN AND METHODS">PCs and plasma were spiked with high titers of cell culture-derived EBOV and MERS-CoV, treated with various light doses of ultraviolet C (UVC; THERAFLEX UV-Platelets) or methylene blue (MB) plus visible light (MB/light; THERAFLEX MB-Plasma), and assessed for residual viral infectivity.</AbstractText><AbstractText Label="RESULTS">UVC reduced EBOV (≥4.5 log) and MERS-CoV (≥3.7 log) infectivity in PCs to the limit of detection, and MB/light decreased EBOV (≥4.6 log) and MERS-CoV (≥3.3 log) titers in plasma to nondetectable levels.</AbstractText><AbstractText Label="CONCLUSIONS">Both THERAFLEX UV-Platelets (UVC) and THERAFLEX MB-Plasma (MB/light) effectively reduce EBOV and MERS-CoV infectivity in platelets and plasma, respectively.</AbstractText><CopyrightInformation>© 2018 AABB.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Eickmann</LastName><ForeName>Markus</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Institute for Virology, Philipps University Marburg, Marburg, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gravemann</LastName><ForeName>Ute</ForeName><Initials>U</Initials><AffiliationInfo><Affiliation>German Red Cross Blood Service NSTOB, Springe, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Handke</LastName><ForeName>Wiebke</ForeName><Initials>W</Initials><AffiliationInfo><Affiliation>German Red Cross Blood Service NSTOB, Springe, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tolksdorf</LastName><ForeName>Frank</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Macopharma International GmbH, Langen, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Reichenberg</LastName><ForeName>Stefan</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Macopharma International GmbH, Langen, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Müller</LastName><ForeName>Thomas H</ForeName><Initials>TH</Initials><AffiliationInfo><Affiliation>German Red Cross Blood Service NSTOB, Springe, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Seltsam</LastName><ForeName>Axel</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>German Red Cross Blood Service NSTOB, Springe, Germany.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D003160">Comparative Study</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2018</Year><Month>05</Month><Day>06</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Transfusion</MedlineTA><NlmUniqueID>0417360</NlmUniqueID><ISSNLinking>0041-1132</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>T42P99266K</RegistryNumber><NameOfSubstance UI="D008751">Methylene Blue</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001792" MajorTopicYN="N">Blood Platelets</DescriptorName><QualifierName UI="Q000821" MajorTopicYN="Y">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002522" MajorTopicYN="N">Chlorocebus aethiops</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018352" MajorTopicYN="N">Coronavirus Infections</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName><QualifierName UI="Q000517" MajorTopicYN="N">prevention & control</QualifierName><QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D029043" MajorTopicYN="N">Ebolavirus</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName><QualifierName UI="Q000302" MajorTopicYN="N">isolation & purification</QualifierName><QualifierName UI="Q000528" MajorTopicYN="Y">radiation effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D019142" MajorTopicYN="N">Hemorrhagic Fever, Ebola</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName><QualifierName UI="Q000517" MajorTopicYN="N">prevention & control</QualifierName><QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008027" MajorTopicYN="Y">Light</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008751" MajorTopicYN="N">Methylene Blue</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D065207" MajorTopicYN="N">Middle East Respiratory Syndrome Coronavirus</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName><QualifierName UI="Q000302" MajorTopicYN="N">isolation & purification</QualifierName><QualifierName UI="Q000528" MajorTopicYN="Y">radiation effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010949" MajorTopicYN="N">Plasma</DescriptorName><QualifierName UI="Q000821" MajorTopicYN="Y">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014466" MajorTopicYN="Y">Ultraviolet Rays</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D014709" MajorTopicYN="N">Vero Cells</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D014766" MajorTopicYN="N">Viremia</DescriptorName><QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D038301" MajorTopicYN="N">Virus Inactivation</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName><QualifierName UI="Q000528" MajorTopicYN="Y">radiation effects</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2018</Year><Month>03</Month><Day>01</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2018</Year><Month>03</Month><Day>22</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2018</Year><Month>03</Month><Day>23</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2018</Year><Month>5</Month><Day>8</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2019</Year><Month>2</Month><Day>14</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2018</Year><Month>5</Month><Day>8</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">29732571</ArticleId><ArticleId IdType="doi">10.1111/trf.14652</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Allemagne</li></country><region><li>District de Giessen</li><li>Hesse (Land)</li></region><settlement><li>Marbourg</li></settlement></list><tree><country name="Allemagne"><region name="Hesse (Land)"><name sortKey="Eickmann, Markus" sort="Eickmann, Markus" uniqKey="Eickmann M" first="Markus" last="Eickmann">Markus Eickmann</name></region><name sortKey="Gravemann, Ute" sort="Gravemann, Ute" uniqKey="Gravemann U" first="Ute" last="Gravemann">Ute Gravemann</name><name sortKey="Handke, Wiebke" sort="Handke, Wiebke" uniqKey="Handke W" first="Wiebke" last="Handke">Wiebke Handke</name><name sortKey="Muller, Thomas H" sort="Muller, Thomas H" uniqKey="Muller T" first="Thomas H" last="Müller">Thomas H. Müller</name><name sortKey="Reichenberg, Stefan" sort="Reichenberg, Stefan" uniqKey="Reichenberg S" first="Stefan" last="Reichenberg">Stefan Reichenberg</name><name sortKey="Seltsam, Axel" sort="Seltsam, Axel" uniqKey="Seltsam A" first="Axel" last="Seltsam">Axel Seltsam</name><name sortKey="Tolksdorf, Frank" sort="Tolksdorf, Frank" uniqKey="Tolksdorf F" first="Frank" last="Tolksdorf">Frank Tolksdorf</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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