Histopathology of Middle East respiratory syndrome coronovirus (MERS-CoV) infection - clinicopathological and ultrastructural study.
Identifieur interne : 001B58 ( Ncbi/Merge ); précédent : 001B57; suivant : 001B59Histopathology of Middle East respiratory syndrome coronovirus (MERS-CoV) infection - clinicopathological and ultrastructural study.
Auteurs : Khaled O. Alsaad [Arabie saoudite] ; Ali H. Hajeer [Arabie saoudite] ; Mohammed Al Balwi [Arabie saoudite] ; Mohammed Al Moaiqel [Arabie saoudite] ; Nourah Al Oudah [Arabie saoudite] ; Abdulaziz Al Ajlan [Arabie saoudite] ; Sameera Aljohani [Arabie saoudite] ; Sami Alsolamy [Arabie saoudite] ; Giamal E. Gmati [Arabie saoudite] ; Hanan Balkhy [Arabie saoudite] ; Hamdan H. Al-Jahdali [Arabie saoudite] ; Salim A. Baharoon [Arabie saoudite] ; Yaseen M. Arabi [Arabie saoudite]Source :
- Histopathology [ 1365-2559 ] ; 2018.
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Abstract
The pathogenesis, viral localization and histopathological features of Middle East respiratory syndrome - coronavirus (MERS-CoV) in humans are not described sufficiently. The aims of this study were to explore and define the spectrum of histological and ultrastructural pathological changes affecting various organs in a patient with MERS-CoV infection and represent a base of MERS-CoV histopathology.
DOI: 10.1111/his.13379
PubMed: 28858401
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Alsaad</name><affiliation wicri:level="1"><nlm:affiliation>Division of Anatomical Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Riyadh, Saudi Arabia.</nlm:affiliation><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Division of Anatomical Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author><author><name sortKey="Hajeer, Ali H" sort="Hajeer, Ali H" uniqKey="Hajeer A" first="Ali H" last="Hajeer">Ali H. 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Gmati</name><affiliation wicri:level="1"><nlm:affiliation>King Abdullah International Medical Research Center, Riyadh, Saudi Arabia.</nlm:affiliation><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>King Abdullah International Medical Research Center, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author><author><name sortKey="Balkhy, Hanan" sort="Balkhy, Hanan" uniqKey="Balkhy H" first="Hanan" last="Balkhy">Hanan Balkhy</name><affiliation wicri:level="1"><nlm:affiliation>King Abdullah International Medical Research Center, Riyadh, Saudi Arabia.</nlm:affiliation><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>King Abdullah International Medical Research Center, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author><author><name sortKey="Al Jahdali, Hamdan H" sort="Al Jahdali, Hamdan H" uniqKey="Al Jahdali H" first="Hamdan H" last="Al-Jahdali">Hamdan H. Al-Jahdali</name><affiliation wicri:level="1"><nlm:affiliation>King Abdullah International Medical Research Center, Riyadh, Saudi Arabia.</nlm:affiliation><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>King Abdullah International Medical Research Center, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author><author><name sortKey="Baharoon, Salim A" sort="Baharoon, Salim A" uniqKey="Baharoon S" first="Salim A" last="Baharoon">Salim A. Baharoon</name><affiliation wicri:level="1"><nlm:affiliation>King Abdullah International Medical Research Center, Riyadh, Saudi Arabia.</nlm:affiliation><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>King Abdullah International Medical Research Center, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author><author><name sortKey="Arabi, Yaseen M" sort="Arabi, Yaseen M" uniqKey="Arabi Y" first="Yaseen M" last="Arabi">Yaseen M. Arabi</name><affiliation wicri:level="1"><nlm:affiliation>King Abdullah International Medical Research Center, Riyadh, Saudi Arabia.</nlm:affiliation><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>King Abdullah International Medical Research Center, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author></analytic><series><title level="j">Histopathology</title><idno type="eISSN">1365-2559</idno><imprint><date when="2018" type="published">2018</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Coronavirus Infections (pathology)</term><term>Humans</term><term>Male</term><term>Microscopy, Electron, Transmission</term><term>Middle East Respiratory Syndrome Coronavirus</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term><term>Coronavirus du syndrome respiratoire du Moyen-Orient</term><term>Humains</term><term>Infections à coronavirus (anatomopathologie)</term><term>Microscopie électronique à transmission</term><term>Mâle</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Infections à coronavirus</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Coronavirus Infections</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Humans</term><term>Male</term><term>Microscopy, Electron, Transmission</term><term>Middle East Respiratory Syndrome Coronavirus</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Coronavirus du syndrome respiratoire du Moyen-Orient</term><term>Humains</term><term>Microscopie électronique à transmission</term><term>Mâle</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The pathogenesis, viral localization and histopathological features of Middle East respiratory syndrome - coronavirus (MERS-CoV) in humans are not described sufficiently. The aims of this study were to explore and define the spectrum of histological and ultrastructural pathological changes affecting various organs in a patient with MERS-CoV infection and represent a base of MERS-CoV histopathology.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">28858401</PMID><DateCompleted><Year>2018</Year><Month>08</Month><Day>06</Day></DateCompleted><DateRevised><Year>2018</Year><Month>08</Month><Day>06</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1365-2559</ISSN><JournalIssue CitedMedium="Internet"><Volume>72</Volume><Issue>3</Issue><PubDate><Year>2018</Year><Month>Feb</Month></PubDate></JournalIssue><Title>Histopathology</Title><ISOAbbreviation>Histopathology</ISOAbbreviation></Journal><ArticleTitle>Histopathology of Middle East respiratory syndrome coronovirus (MERS-CoV) infection - clinicopathological and ultrastructural study.</ArticleTitle><Pagination><MedlinePgn>516-524</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1111/his.13379</ELocationID><Abstract><AbstractText Label="AIMS" NlmCategory="OBJECTIVE">The pathogenesis, viral localization and histopathological features of Middle East respiratory syndrome - coronavirus (MERS-CoV) in humans are not described sufficiently. The aims of this study were to explore and define the spectrum of histological and ultrastructural pathological changes affecting various organs in a patient with MERS-CoV infection and represent a base of MERS-CoV histopathology.</AbstractText><AbstractText Label="METHODS AND RESULTS" NlmCategory="RESULTS">We analysed the post-mortem histopathological findings and investigated localisation of viral particles in the pulmonary and extrapulmonary tissue by transmission electron microscopic examination in a 33-year-old male patient of T cell lymphoma, who acquired MERS-CoV infection. Tissue needle biopsies were obtained from brain, heart, lung, liver, kidney and skeletal muscle. All samples were collected within 45 min from death to reduce tissue decomposition and artefact. Histopathological examination showed necrotising pneumonia, pulmonary diffuse alveolar damage, acute kidney injury, portal and lobular hepatitis and myositis with muscle atrophic changes. The brain and heart were histologically unremarkable. Ultrastructurally, viral particles were localised in the pneumocytes, pulmonary macrophages, renal proximal tubular epithelial cells and macrophages infiltrating the skeletal muscles.</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">The results highlight the pulmonary and extrapulmonary pathological changes of MERS-CoV infection and provide the first evidence of the viral presence in human renal tissue, which suggests tissue trophism for MERS-CoV in kidney.</AbstractText><CopyrightInformation>© 2017 John Wiley & Sons Ltd.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Alsaad</LastName><ForeName>Khaled O</ForeName><Initials>KO</Initials><Identifier Source="ORCID">http://orcid.org/0000-0003-3389-9035</Identifier><AffiliationInfo><Affiliation>Division of Anatomical Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Riyadh, Saudi Arabia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hajeer</LastName><ForeName>Ali H</ForeName><Initials>AH</Initials><AffiliationInfo><Affiliation>King Abdullah International Medical Research Center, Riyadh, Saudi Arabia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Division of Immunopathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Riyadh, Saudi Arabia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Al Balwi</LastName><ForeName>Mohammed</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>King Abdullah International Medical Research Center, Riyadh, Saudi Arabia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Division of Molecular Genetics and Cytogenetics, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Riyadh, Saudi Arabia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Al Moaiqel</LastName><ForeName>Mohammed</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>King Abdullah International Medical Research Center, Riyadh, Saudi Arabia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Medical Imaging, King Abdulaziz Medical City, Riyadh, Saudi Arabia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Al Oudah</LastName><ForeName>Nourah</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Division of Anatomical Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Riyadh, Saudi Arabia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>King Abdullah International Medical Research Center, Riyadh, Saudi Arabia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Al Ajlan</LastName><ForeName>Abdulaziz</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Division of Anatomical Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Riyadh, Saudi Arabia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>King Abdullah International Medical Research Center, Riyadh, Saudi Arabia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>AlJohani</LastName><ForeName>Sameera</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>King Abdullah International Medical Research Center, Riyadh, Saudi Arabia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Division of Microbiology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Riyadh, Saudi Arabia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Alsolamy</LastName><ForeName>Sami</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>King Abdullah International Medical Research Center, Riyadh, Saudi Arabia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Intensive Care, King Abdulaziz Medical City, Riyadh, Saudi Arabia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gmati</LastName><ForeName>Giamal E</ForeName><Initials>GE</Initials><AffiliationInfo><Affiliation>King Abdullah International Medical Research Center, Riyadh, Saudi Arabia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Division of Hematology, Department of Oncology, King Abdulaziz Medical City, Riyadh, Saudi Arabia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Balkhy</LastName><ForeName>Hanan</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>King Abdullah International Medical Research Center, Riyadh, Saudi Arabia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Infection Prevention and Control and Division of Infectious Diseases, Department of Pediatrics, King Abdulaziz Medical City, Riyadh, Saudi Arabia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Al-Jahdali</LastName><ForeName>Hamdan H</ForeName><Initials>HH</Initials><AffiliationInfo><Affiliation>King Abdullah International Medical Research Center, Riyadh, Saudi Arabia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Division of Pulmonology, Department of Medicine, King Abdulaziz Medical City, Riyadh, Saudi Arabia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Baharoon</LastName><ForeName>Salim A</ForeName><Initials>SA</Initials><AffiliationInfo><Affiliation>King Abdullah International Medical Research Center, Riyadh, Saudi Arabia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Intensive Care, King Abdulaziz Medical City, Riyadh, Saudi Arabia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Arabi</LastName><ForeName>Yaseen M</ForeName><Initials>YM</Initials><AffiliationInfo><Affiliation>King Abdullah International Medical Research Center, Riyadh, Saudi Arabia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Intensive Care, King Abdulaziz Medical City, Riyadh, Saudi Arabia.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D002363">Case Reports</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2017</Year><Month>11</Month><Day>21</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Histopathology</MedlineTA><NlmUniqueID>7704136</NlmUniqueID><ISSNLinking>0309-0167</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018352" MajorTopicYN="N">Coronavirus Infections</DescriptorName><QualifierName UI="Q000473" MajorTopicYN="Y">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D046529" MajorTopicYN="N">Microscopy, Electron, Transmission</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D065207" MajorTopicYN="N">Middle East Respiratory Syndrome Coronavirus</DescriptorName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">MERS-CoV</Keyword><Keyword MajorTopicYN="N">Middle East respiratory syndrome coronavirus</Keyword><Keyword MajorTopicYN="N">electron microscopy</Keyword><Keyword MajorTopicYN="N">extra pulmonary</Keyword><Keyword MajorTopicYN="N">histopathology</Keyword><Keyword MajorTopicYN="N">pulmonary</Keyword><Keyword MajorTopicYN="N">renal</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2017</Year><Month>9</Month><Day>1</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2018</Year><Month>8</Month><Day>7</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2017</Year><Month>9</Month><Day>1</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">28858401</ArticleId><ArticleId IdType="doi">10.1111/his.13379</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Arabie saoudite</li></country></list><tree><country name="Arabie saoudite"><noRegion><name sortKey="Alsaad, Khaled O" sort="Alsaad, Khaled O" uniqKey="Alsaad K" first="Khaled O" last="Alsaad">Khaled O. Alsaad</name></noRegion><name sortKey="Al Ajlan, Abdulaziz" sort="Al Ajlan, Abdulaziz" uniqKey="Al Ajlan A" first="Abdulaziz" last="Al Ajlan">Abdulaziz Al Ajlan</name><name sortKey="Al Balwi, Mohammed" sort="Al Balwi, Mohammed" uniqKey="Al Balwi M" first="Mohammed" last="Al Balwi">Mohammed Al Balwi</name><name sortKey="Al Jahdali, Hamdan H" sort="Al Jahdali, Hamdan H" uniqKey="Al Jahdali H" first="Hamdan H" last="Al-Jahdali">Hamdan H. Al-Jahdali</name><name sortKey="Al Moaiqel, Mohammed" sort="Al Moaiqel, Mohammed" uniqKey="Al Moaiqel M" first="Mohammed" last="Al Moaiqel">Mohammed Al Moaiqel</name><name sortKey="Al Oudah, Nourah" sort="Al Oudah, Nourah" uniqKey="Al Oudah N" first="Nourah" last="Al Oudah">Nourah Al Oudah</name><name sortKey="Aljohani, Sameera" sort="Aljohani, Sameera" uniqKey="Aljohani S" first="Sameera" last="Aljohani">Sameera Aljohani</name><name sortKey="Alsolamy, Sami" sort="Alsolamy, Sami" uniqKey="Alsolamy S" first="Sami" last="Alsolamy">Sami Alsolamy</name><name sortKey="Arabi, Yaseen M" sort="Arabi, Yaseen M" uniqKey="Arabi Y" first="Yaseen M" last="Arabi">Yaseen M. Arabi</name><name sortKey="Baharoon, Salim A" sort="Baharoon, Salim A" uniqKey="Baharoon S" first="Salim A" last="Baharoon">Salim A. Baharoon</name><name sortKey="Balkhy, Hanan" sort="Balkhy, Hanan" uniqKey="Balkhy H" first="Hanan" last="Balkhy">Hanan Balkhy</name><name sortKey="Gmati, Giamal E" sort="Gmati, Giamal E" uniqKey="Gmati G" first="Giamal E" last="Gmati">Giamal E. Gmati</name><name sortKey="Hajeer, Ali H" sort="Hajeer, Ali H" uniqKey="Hajeer A" first="Ali H" last="Hajeer">Ali H. Hajeer</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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