MersV1, Ncbi, Merge, bibRecord, 001A94

Optimisation of peptides that actively cross the tympanic membrane by random amino acid extension: a phage display study.

Identifieur interne : 001A94 ( Ncbi/Merge ); précédent : 001A93; suivant : 001A95

Optimisation of peptides that actively cross the tympanic membrane by random amino acid extension: a phage display study.

Auteurs : Arwa Kurabi [États-Unis] ; Daniel Schaerer [États-Unis] ; Lisa Chang [États-Unis] ; Kwang Pak [États-Unis] ; Allen F. Ryan [États-Unis]

Source :

Journal of drug targeting [ 1029-2330 ] ; 2018.

RBID : pubmed:28658990

Descripteurs français

KwdFr :
- Animaux, Banque de peptides, Haemophilus influenzae, Infections à Haemophilus (anatomopathologie), Membrane du tympan (physiologie), Otite moyenne (microbiologie), Otite moyenne (métabolisme), Peptides (), Peptides (métabolisme), Rat Sprague-Dawley, Rats, Séquence d'acides aminés, Transport biologique.
MESH :
- anatomopathologie : Infections à Haemophilus.
- microbiologie : Otite moyenne.
- métabolisme : Otite moyenne, Peptides.
- physiologie : Membrane du tympan.
- Animaux, Banque de peptides, Haemophilus influenzae, Peptides, Rat Sprague-Dawley, Rats, Séquence d'acides aminés, Transport biologique.

English descriptors

KwdEn :
- Amino Acid Sequence, Animals, Biological Transport, Haemophilus Infections (pathology), Haemophilus influenzae, Otitis Media (metabolism), Otitis Media (microbiology), Peptide Library, Peptides (chemistry), Peptides (metabolism), Rats, Rats, Sprague-Dawley, Tympanic Membrane (physiology).
MESH :
- chemical , chemistry : Peptides.
- chemical , metabolism : Peptides.
- chemical : Peptide Library.
- metabolism : Otitis Media.
- microbiology : Otitis Media.
- pathology : Haemophilus Infections.
- physiology : Tympanic Membrane.
- Amino Acid Sequence, Animals, Biological Transport, Haemophilus influenzae, Rats, Rats, Sprague-Dawley.

Abstract

Local treatment of middle ear (ME) disease currently requires surgical penetration of the tympanic membrane (TM). We previously discovered 12-mer peptides that are actively transported across the intact TM, a process that could be used for non-invasive drug delivery into the ME. To optimise transport and provide further understanding of the peptides transport mechanism, we extended two of the candidate peptides by six additional amino acids at random, and screened the resulting 18-mers libraries on TMs of rats with active bacterial otitis media (OM) for transport efficiency using phage display. Six identified peptides were individually tested in vivo for trans-TM transport to verify the tissue specificity. Three exhibited enhanced transport compared to their parent 12-mer scaffold, with the best showing an approximately nine-fold increase. Sequence analysis revealed anchor residues and structural features associated with enhanced transport. This included the prominent display of conserved sequence motifs at the extended free ends of the predicted peptide structures.

DOI: 10.1080/1061186X.2017.1347791
PubMed: 28658990

Links toward previous steps (curation, corpus...)

to stream PubMed, to step Corpus: 000C40
to stream PubMed, to step Curation: 000C40
to stream PubMed, to step Checkpoint: 000818

Links to Exploration step

pubmed:28658990

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Optimisation of peptides that actively cross the tympanic membrane by random amino acid extension: a phage display study.</title>
<author><name sortKey="Kurabi, Arwa" sort="Kurabi, Arwa" uniqKey="Kurabi A" first="Arwa" last="Kurabi">Arwa Kurabi</name>
<affiliation wicri:level="2"><nlm:affiliation>a Department of Surgery, Division of Otolaryngology , School of Medicine, University of California , La Jolla , CA , USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>a Department of Surgery, Division of Otolaryngology , School of Medicine, University of California , La Jolla , CA </wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Schaerer, Daniel" sort="Schaerer, Daniel" uniqKey="Schaerer D" first="Daniel" last="Schaerer">Daniel Schaerer</name>
<affiliation wicri:level="2"><nlm:affiliation>a Department of Surgery, Division of Otolaryngology , School of Medicine, University of California , La Jolla , CA , USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>a Department of Surgery, Division of Otolaryngology , School of Medicine, University of California , La Jolla , CA </wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Chang, Lisa" sort="Chang, Lisa" uniqKey="Chang L" first="Lisa" last="Chang">Lisa Chang</name>
<affiliation wicri:level="2"><nlm:affiliation>a Department of Surgery, Division of Otolaryngology , School of Medicine, University of California , La Jolla , CA , USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>a Department of Surgery, Division of Otolaryngology , School of Medicine, University of California , La Jolla , CA </wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Pak, Kwang" sort="Pak, Kwang" uniqKey="Pak K" first="Kwang" last="Pak">Kwang Pak</name>
<affiliation wicri:level="2"><nlm:affiliation>a Department of Surgery, Division of Otolaryngology , School of Medicine, University of California , La Jolla , CA , USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>a Department of Surgery, Division of Otolaryngology , School of Medicine, University of California , La Jolla , CA </wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ryan, Allen F" sort="Ryan, Allen F" uniqKey="Ryan A" first="Allen F" last="Ryan">Allen F. Ryan</name>
<affiliation wicri:level="2"><nlm:affiliation>a Department of Surgery, Division of Otolaryngology , School of Medicine, University of California , La Jolla , CA , USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>a Department of Surgery, Division of Otolaryngology , School of Medicine, University of California , La Jolla , CA </wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2018">2018</date>
<idno type="RBID">pubmed:28658990</idno>
<idno type="pmid">28658990</idno>
<idno type="doi">10.1080/1061186X.2017.1347791</idno>
<idno type="wicri:Area/PubMed/Corpus">000C40</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000C40</idno>
<idno type="wicri:Area/PubMed/Curation">000C40</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000C40</idno>
<idno type="wicri:Area/PubMed/Checkpoint">000818</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000818</idno>
<idno type="wicri:Area/Ncbi/Merge">001A94</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Optimisation of peptides that actively cross the tympanic membrane by random amino acid extension: a phage display study.</title>
<author><name sortKey="Kurabi, Arwa" sort="Kurabi, Arwa" uniqKey="Kurabi A" first="Arwa" last="Kurabi">Arwa Kurabi</name>
<affiliation wicri:level="2"><nlm:affiliation>a Department of Surgery, Division of Otolaryngology , School of Medicine, University of California , La Jolla , CA , USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>a Department of Surgery, Division of Otolaryngology , School of Medicine, University of California , La Jolla , CA </wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Schaerer, Daniel" sort="Schaerer, Daniel" uniqKey="Schaerer D" first="Daniel" last="Schaerer">Daniel Schaerer</name>
<affiliation wicri:level="2"><nlm:affiliation>a Department of Surgery, Division of Otolaryngology , School of Medicine, University of California , La Jolla , CA , USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>a Department of Surgery, Division of Otolaryngology , School of Medicine, University of California , La Jolla , CA </wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Chang, Lisa" sort="Chang, Lisa" uniqKey="Chang L" first="Lisa" last="Chang">Lisa Chang</name>
<affiliation wicri:level="2"><nlm:affiliation>a Department of Surgery, Division of Otolaryngology , School of Medicine, University of California , La Jolla , CA , USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>a Department of Surgery, Division of Otolaryngology , School of Medicine, University of California , La Jolla , CA </wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Pak, Kwang" sort="Pak, Kwang" uniqKey="Pak K" first="Kwang" last="Pak">Kwang Pak</name>
<affiliation wicri:level="2"><nlm:affiliation>a Department of Surgery, Division of Otolaryngology , School of Medicine, University of California , La Jolla , CA , USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>a Department of Surgery, Division of Otolaryngology , School of Medicine, University of California , La Jolla , CA </wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ryan, Allen F" sort="Ryan, Allen F" uniqKey="Ryan A" first="Allen F" last="Ryan">Allen F. Ryan</name>
<affiliation wicri:level="2"><nlm:affiliation>a Department of Surgery, Division of Otolaryngology , School of Medicine, University of California , La Jolla , CA , USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>a Department of Surgery, Division of Otolaryngology , School of Medicine, University of California , La Jolla , CA </wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">Journal of drug targeting</title>
<idno type="eISSN">1029-2330</idno>
<imprint><date when="2018" type="published">2018</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Amino Acid Sequence</term>
<term>Animals</term>
<term>Biological Transport</term>
<term>Haemophilus Infections (pathology)</term>
<term>Haemophilus influenzae</term>
<term>Otitis Media (metabolism)</term>
<term>Otitis Media (microbiology)</term>
<term>Peptide Library</term>
<term>Peptides (chemistry)</term>
<term>Peptides (metabolism)</term>
<term>Rats</term>
<term>Rats, Sprague-Dawley</term>
<term>Tympanic Membrane (physiology)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term>
<term>Banque de peptides</term>
<term>Haemophilus influenzae</term>
<term>Infections à Haemophilus (anatomopathologie)</term>
<term>Membrane du tympan (physiologie)</term>
<term>Otite moyenne (microbiologie)</term>
<term>Otite moyenne (métabolisme)</term>
<term>Peptides ()</term>
<term>Peptides (métabolisme)</term>
<term>Rat Sprague-Dawley</term>
<term>Rats</term>
<term>Séquence d'acides aminés</term>
<term>Transport biologique</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Peptides</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Peptides</term>
</keywords>
<keywords scheme="MESH" type="chemical" xml:lang="en"><term>Peptide Library</term>
</keywords>
<keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Infections à Haemophilus</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Otitis Media</term>
</keywords>
<keywords scheme="MESH" qualifier="microbiologie" xml:lang="fr"><term>Otite moyenne</term>
</keywords>
<keywords scheme="MESH" qualifier="microbiology" xml:lang="en"><term>Otitis Media</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Otite moyenne</term>
<term>Peptides</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Haemophilus Infections</term>
</keywords>
<keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Membrane du tympan</term>
</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Tympanic Membrane</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Amino Acid Sequence</term>
<term>Animals</term>
<term>Biological Transport</term>
<term>Haemophilus influenzae</term>
<term>Rats</term>
<term>Rats, Sprague-Dawley</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Animaux</term>
<term>Banque de peptides</term>
<term>Haemophilus influenzae</term>
<term>Peptides</term>
<term>Rat Sprague-Dawley</term>
<term>Rats</term>
<term>Séquence d'acides aminés</term>
<term>Transport biologique</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Local treatment of middle ear (ME) disease currently requires surgical penetration of the tympanic membrane (TM). We previously discovered 12-mer peptides that are actively transported across the intact TM, a process that could be used for non-invasive drug delivery into the ME. To optimise transport and provide further understanding of the peptides transport mechanism, we extended two of the candidate peptides by six additional amino acids at random, and screened the resulting 18-mers libraries on TMs of rats with active bacterial otitis media (OM) for transport efficiency using phage display. Six identified peptides were individually tested in vivo for trans-TM transport to verify the tissue specificity. Three exhibited enhanced transport compared to their parent 12-mer scaffold, with the best showing an approximately nine-fold increase. Sequence analysis revealed anchor residues and structural features associated with enhanced transport. This included the prominent display of conserved sequence motifs at the extended free ends of the predicted peptide structures.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">28658990</PMID>
<DateCompleted><Year>2019</Year>
<Month>05</Month>
<Day>01</Day>
</DateCompleted>
<DateRevised><Year>2020</Year>
<Month>03</Month>
<Day>11</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1029-2330</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>26</Volume>
<Issue>2</Issue>
<PubDate><Year>2018</Year>
<Month>02</Month>
</PubDate>
</JournalIssue>
<Title>Journal of drug targeting</Title>
<ISOAbbreviation>J Drug Target</ISOAbbreviation>
</Journal>
<ArticleTitle>Optimisation of peptides that actively cross the tympanic membrane by random amino acid extension: a phage display study.</ArticleTitle>
<Pagination><MedlinePgn>127-134</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1080/1061186X.2017.1347791</ELocationID>
<Abstract><AbstractText>Local treatment of middle ear (ME) disease currently requires surgical penetration of the tympanic membrane (TM). We previously discovered 12-mer peptides that are actively transported across the intact TM, a process that could be used for non-invasive drug delivery into the ME. To optimise transport and provide further understanding of the peptides transport mechanism, we extended two of the candidate peptides by six additional amino acids at random, and screened the resulting 18-mers libraries on TMs of rats with active bacterial otitis media (OM) for transport efficiency using phage display. Six identified peptides were individually tested in vivo for trans-TM transport to verify the tissue specificity. Three exhibited enhanced transport compared to their parent 12-mer scaffold, with the best showing an approximately nine-fold increase. Sequence analysis revealed anchor residues and structural features associated with enhanced transport. This included the prominent display of conserved sequence motifs at the extended free ends of the predicted peptide structures.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Kurabi</LastName>
<ForeName>Arwa</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>a Department of Surgery, Division of Otolaryngology , School of Medicine, University of California , La Jolla , CA , USA.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>b San Diego VA Healthcare System , San Diego , CA , USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Schaerer</LastName>
<ForeName>Daniel</ForeName>
<Initials>D</Initials>
<AffiliationInfo><Affiliation>a Department of Surgery, Division of Otolaryngology , School of Medicine, University of California , La Jolla , CA , USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Chang</LastName>
<ForeName>Lisa</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>a Department of Surgery, Division of Otolaryngology , School of Medicine, University of California , La Jolla , CA , USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Pak</LastName>
<ForeName>Kwang</ForeName>
<Initials>K</Initials>
<AffiliationInfo><Affiliation>a Department of Surgery, Division of Otolaryngology , School of Medicine, University of California , La Jolla , CA , USA.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>b San Diego VA Healthcare System , San Diego , CA , USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Ryan</LastName>
<ForeName>Allen F</ForeName>
<Initials>AF</Initials>
<AffiliationInfo><Affiliation>a Department of Surgery, Division of Otolaryngology , School of Medicine, University of California , La Jolla , CA , USA.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>b San Diego VA Healthcare System , San Diego , CA , USA.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<GrantList CompleteYN="Y"><Grant><GrantID>I01 BX001205</GrantID>
<Acronym>BX</Acronym>
<Agency>BLRD VA</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>R01 DC012595</GrantID>
<Acronym>DC</Acronym>
<Agency>NIDCD NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>T1</GrantID>
<Acronym>ACT_</Acronym>
<Agency>Action on Hearing Loss</Agency>
<Country>United Kingdom</Country>
</Grant>
<Grant><GrantID>R01 DC000129</GrantID>
<Acronym>DC</Acronym>
<Agency>NIDCD NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>T32 DC000028</GrantID>
<Acronym>DC</Acronym>
<Agency>NIDCD NIH HHS</Agency>
<Country>United States</Country>
</Grant>
</GrantList>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D052061">Research Support, N.I.H., Extramural</PublicationType>
<PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
<PublicationType UI="D013486">Research Support, U.S. Gov't, Non-P.H.S.</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2017</Year>
<Month>08</Month>
<Day>16</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>England</Country>
<MedlineTA>J Drug Target</MedlineTA>
<NlmUniqueID>9312476</NlmUniqueID>
<ISSNLinking>1026-7158</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D019151">Peptide Library</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D010455">Peptides</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000595" MajorTopicYN="N">Amino Acid Sequence</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D001692" MajorTopicYN="N">Biological Transport</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006192" MajorTopicYN="N">Haemophilus Infections</DescriptorName>
<QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006193" MajorTopicYN="N">Haemophilus influenzae</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D010033" MajorTopicYN="N">Otitis Media</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
<QualifierName UI="Q000382" MajorTopicYN="N">microbiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D019151" MajorTopicYN="N">Peptide Library</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D010455" MajorTopicYN="N">Peptides</DescriptorName>
<QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D051381" MajorTopicYN="N">Rats</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D017207" MajorTopicYN="N">Rats, Sprague-Dawley</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D014432" MajorTopicYN="N">Tympanic Membrane</DescriptorName>
<QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName>
</MeshHeading>
</MeshHeadingList>
<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">Drug delivery</Keyword>
<Keyword MajorTopicYN="Y">active transport</Keyword>
<Keyword MajorTopicYN="Y">conserved motifs</Keyword>
<Keyword MajorTopicYN="Y">otitis media</Keyword>
<Keyword MajorTopicYN="Y">peptide structure</Keyword>
</KeywordList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2017</Year>
<Month>7</Month>
<Day>1</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2019</Year>
<Month>5</Month>
<Day>2</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="entrez"><Year>2017</Year>
<Month>6</Month>
<Day>30</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">28658990</ArticleId>
<ArticleId IdType="doi">10.1080/1061186X.2017.1347791</ArticleId>
<ArticleId IdType="pmc">PMC6223256</ArticleId>
<ArticleId IdType="mid">NIHMS1505139</ArticleId>
</ArticleIdList>
<ReferenceList><Reference><Citation>Ann Otol Rhinol Laryngol. 2004 Jun;113(6):438-44</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15224825</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Int J Pediatr Otorhinolaryngol. 2015 Dec;79(12):2129-33</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26454530</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Natl Health Stat Report. 2009 Jan 28;(11):1-25</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19294964</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Int J Pediatr Otorhinolaryngol. 2016 Aug;87:154-63</Citation>
<ArticleIdList><ArticleId IdType="pubmed">27368465</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Vaccine. 2000 Dec 8;19 Suppl 1:S2-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11163456</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Harefuah. 2004 Apr;143(4):277-82, 318, 317</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15116585</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Sci Rep. 2015 Mar 25;5:9388</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25807192</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Acta Otolaryngol Suppl. 2000;543:73-6</Citation>
<ArticleIdList><ArticleId IdType="pubmed">10908983</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Dig Dis. 1998 Sep-Oct;16(5):292-307</Citation>
<ArticleIdList><ArticleId IdType="pubmed">9892789</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Infect Dis. 1989 Jul;160(1):83-94</Citation>
<ArticleIdList><ArticleId IdType="pubmed">2732519</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Postgrad Med. 2015 May;127(4):391-5</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25913599</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Vaccine. 2008 Dec 23;26 Suppl 7:G2-4</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19094933</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Pediatr Infect Dis J. 2010 Apr;29(4):304-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19935445</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Laryngoscope. 2014 Jan;124(1):301-5</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23649905</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Infect Dis. 2008 Dec 15;198(12):1862-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18986247</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Ann Fam Med. 2007 Jan-Feb;5(1):29-38</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17261862</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Pediatrics. 2004 Jul;114(1):e58-67</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15231974</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Pediatr Infect Dis J. 2016 Sep;35(9):1027-32</Citation>
<ArticleIdList><ArticleId IdType="pubmed">27182898</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Paediatr Drugs. 2009;11(4):243-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19566108</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Comput Aided Mol Des. 2016 Mar;30(3):271-7</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26909892</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Mol Biol. 1990 Oct 5;215(3):403-10</Citation>
<ArticleIdList><ArticleId IdType="pubmed">2231712</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Immunol. 2010 Mar 15;184(6):3087-97</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20164426</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Sci Rep. 2016 Mar 07;6:22663</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26946957</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Pharmaceutics. 2017 Mar 27;9(2):</Citation>
<ArticleIdList><ArticleId IdType="pubmed">28346375</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Vaccine. 2008 Dec 23;26 Suppl 7:G5-10</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19094935</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Pediatrics. 2010 Feb;125(2):214-20</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20100746</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Curr Opin Otolaryngol Head Neck Surg. 2008 Oct;16(5):406-11</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18797280</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nucleic Acids Res. 2009 Jul;37(Web Server issue):W498-503</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19433514</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Pediatr Infect Dis. 1982 Mar-Apr;1(2):104-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">7177899</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Arch Otolaryngol Head Neck Surg. 2003 May;129(5):517-22</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12759263</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Int J Pediatr Otorhinolaryngol. 2010 Dec;74(12):1419-24</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20965578</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Acta Otolaryngol. 2010 Apr;130(4):472-6</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19895333</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Pediatrics. 2004 May;113(5):1412-29</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15121966</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Biomed Sci. 2016 Jan 19;23:8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26786672</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>PLoS One. 2017 Feb 24;12(2):e0172158</Citation>
<ArticleIdList><ArticleId IdType="pubmed">28234923</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Eur Arch Otorhinolaryngol. 1994;251(7):399-403</Citation>
<ArticleIdList><ArticleId IdType="pubmed">7857627</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
</PubmedData>
</pubmed>
<affiliations><list><country><li>États-Unis</li>
</country>
<region><li>Californie</li>
</region>
</list>
<tree><country name="États-Unis"><region name="Californie"><name sortKey="Kurabi, Arwa" sort="Kurabi, Arwa" uniqKey="Kurabi A" first="Arwa" last="Kurabi">Arwa Kurabi</name>
</region>
<name sortKey="Chang, Lisa" sort="Chang, Lisa" uniqKey="Chang L" first="Lisa" last="Chang">Lisa Chang</name>
<name sortKey="Pak, Kwang" sort="Pak, Kwang" uniqKey="Pak K" first="Kwang" last="Pak">Kwang Pak</name>
<name sortKey="Ryan, Allen F" sort="Ryan, Allen F" uniqKey="Ryan A" first="Allen F" last="Ryan">Allen F. Ryan</name>
<name sortKey="Schaerer, Daniel" sort="Schaerer, Daniel" uniqKey="Schaerer D" first="Daniel" last="Schaerer">Daniel Schaerer</name>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Sante/explor/MersV1/Data/Ncbi/Merge

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001A94 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Ncbi/Merge/biblio.hfd -nk 001A94 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Sante
   |area=    MersV1
   |flux=    Ncbi
   |étape=   Merge
   |type=    RBID
   |clé=     pubmed:28658990
   |texte=   Optimisation of peptides that actively cross the tympanic membrane by random amino acid extension: a phage display study.
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/Ncbi/Merge/RBID.i   -Sk "pubmed:28658990" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Ncbi/Merge/biblio.hfd   \
       | NlmPubMed2Wicri -a MersV1

This area was generated with Dilib version V0.6.33.
Data generation: Mon Apr 20 23:26:43 2020. Site generation: Sat Mar 27 09:06:09 2021

	Serveur d'exploration MERS
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Serveur d'exploration MERS

Optimisation of peptides that actively cross the tympanic membrane by random amino acid extension: a phage display study.

Optimisation of peptides that actively cross the tympanic membrane by random amino acid extension: a phage display study.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki