ChAdOx1 and MVA based vaccine candidates against MERS-CoV elicit neutralising antibodies and cellular immune responses in mice
Identifieur interne : 001A60 ( Ncbi/Merge ); précédent : 001A59; suivant : 001A61ChAdOx1 and MVA based vaccine candidates against MERS-CoV elicit neutralising antibodies and cellular immune responses in mice
Auteurs : Naif Khalaf Alharbi [Royaume-Uni, Arabie saoudite] ; Eriko Padron-Regalado [Royaume-Uni] ; Craig P. Thompson [Royaume-Uni] ; Alexandra Kupke [Allemagne] ; Daniel Wells [Royaume-Uni] ; Megan A. Sloan [Royaume-Uni] ; Keith Grehan [Royaume-Uni] ; Nigel Temperton [Royaume-Uni] ; Teresa Lambe [Royaume-Uni] ; George Warimwe [Royaume-Uni] ; Stephan Becker [Allemagne] ; Adrian V. S. Hill [Royaume-Uni] ; Sarah C. Gilbert [Royaume-Uni]Source :
- Vaccine [ 0264-410X ] ; 2017.
Descripteurs français
- KwdFr :
- Adenoviridae (génétique), Adenoviridae (immunologie), Animaux, Anticorps antiviraux (biosynthèse), Anticorps antiviraux (immunologie), Anticorps neutralisants (biosynthèse), Anticorps neutralisants (immunologie), Coronavirus du syndrome respiratoire du Moyen-Orient (génétique), Coronavirus du syndrome respiratoire du Moyen-Orient (immunologie), Glycoprotéine de spicule des coronavirus (génétique), Glycoprotéine de spicule des coronavirus (immunologie), Immunité cellulaire, Immunité humorale, Immunogénicité des vaccins, Infections à coronavirus (), Infections à coronavirus (immunologie), Relation dose-réponse (immunologie), Souris, Vaccination, Vaccins antiviraux (génétique), Vaccins antiviraux (immunologie), Vaccins synthétiques (administration et posologie), Vaccins synthétiques (immunologie).
- MESH :
- administration et posologie : Vaccins synthétiques.
- biosynthèse : Anticorps antiviraux, Anticorps neutralisants.
- génétique : Adenoviridae, Coronavirus du syndrome respiratoire du Moyen-Orient, Glycoprotéine de spicule des coronavirus, Vaccins antiviraux.
- immunologie : Adenoviridae, Anticorps antiviraux, Anticorps neutralisants, Coronavirus du syndrome respiratoire du Moyen-Orient, Glycoprotéine de spicule des coronavirus, Infections à coronavirus, Vaccins antiviraux, Vaccins synthétiques.
- Animaux, Immunité cellulaire, Immunité humorale, Immunogénicité des vaccins, Infections à coronavirus, Relation dose-réponse (immunologie), Souris, Vaccination.
English descriptors
- KwdEn :
- Adenoviridae (genetics), Adenoviridae (immunology), Animals, Antibodies, Neutralizing (biosynthesis), Antibodies, Neutralizing (immunology), Antibodies, Viral (biosynthesis), Antibodies, Viral (immunology), Coronavirus Infections (immunology), Coronavirus Infections (prevention & control), Dose-Response Relationship, Immunologic, Immunity, Cellular, Immunity, Humoral, Immunogenicity, Vaccine, Mice, Middle East Respiratory Syndrome Coronavirus (genetics), Middle East Respiratory Syndrome Coronavirus (immunology), Spike Glycoprotein, Coronavirus (genetics), Spike Glycoprotein, Coronavirus (immunology), Vaccination, Vaccines, Synthetic (administration & dosage), Vaccines, Synthetic (immunology), Viral Vaccines (genetics), Viral Vaccines (immunology).
- MESH :
- chemical , administration & dosage : Vaccines, Synthetic.
- chemical , biosynthesis : Antibodies, Neutralizing, Antibodies, Viral.
- genetics : Adenoviridae, Middle East Respiratory Syndrome Coronavirus, Spike Glycoprotein, Coronavirus, Viral Vaccines.
- immunology : Adenoviridae, Antibodies, Neutralizing, Antibodies, Viral, Coronavirus Infections, Middle East Respiratory Syndrome Coronavirus, Spike Glycoprotein, Coronavirus, Vaccines, Synthetic, Viral Vaccines.
- prevention & control : Coronavirus Infections.
- Animals, Dose-Response Relationship, Immunologic, Immunity, Cellular, Immunity, Humoral, Immunogenicity, Vaccine, Mice, Vaccination.
Abstract
Inserting tPA leader sequence enhanced humoral responses of ChAdOx1 MERS. ChAdOx1 MERS elicited cellular immunity and neutralising antibodies. ChAdOx1 MERS responses were boosted by MVA MERS. Immunogenicity of a single dose of ChAdOx1 MERS was equivalent to 2 doses of MVA MERS. In MVA, F11 promoter enhanced cellular, but not humoral, immunogenicity, comparing to mH5 promoter.
Url:
DOI: 10.1016/j.vaccine.2017.05.032
PubMed: 28579232
PubMed Central: 5516308
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 001174
- to stream Pmc, to step Curation: 001174
- to stream Pmc, to step Checkpoint: 000914
- to stream PubMed, to step Corpus: 000C73
- to stream PubMed, to step Curation: 000C73
- to stream PubMed, to step Checkpoint: 000D72
Links to Exploration step
PMC:5516308Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">ChAdOx1 and MVA based vaccine candidates against MERS-CoV elicit neutralising antibodies and cellular immune responses in mice</title>
<author><name sortKey="Alharbi, Naif Khalaf" sort="Alharbi, Naif Khalaf" uniqKey="Alharbi N" first="Naif Khalaf" last="Alharbi">Naif Khalaf Alharbi</name>
<affiliation wicri:level="4"><nlm:aff id="af005">The Jenner Institute, University of Oxford, Oxford OX3 7DQ, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>The Jenner Institute, University of Oxford, Oxford OX3 7DQ</wicri:regionArea>
<orgName type="university">Université d'Oxford</orgName>
<placeName><settlement type="city">Oxford</settlement>
<region type="nation">Angleterre</region>
<region type="région" nuts="1">Oxfordshire</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af010">King Abdullah International Medical Research Center, Riyadh, Saudi Arabia</nlm:aff>
<country xml:lang="fr">Arabie saoudite</country>
<wicri:regionArea>King Abdullah International Medical Research Center, Riyadh</wicri:regionArea>
<wicri:noRegion>Riyadh</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Padron Regalado, Eriko" sort="Padron Regalado, Eriko" uniqKey="Padron Regalado E" first="Eriko" last="Padron-Regalado">Eriko Padron-Regalado</name>
<affiliation wicri:level="4"><nlm:aff id="af005">The Jenner Institute, University of Oxford, Oxford OX3 7DQ, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>The Jenner Institute, University of Oxford, Oxford OX3 7DQ</wicri:regionArea>
<orgName type="university">Université d'Oxford</orgName>
<placeName><settlement type="city">Oxford</settlement>
<region type="nation">Angleterre</region>
<region type="région" nuts="1">Oxfordshire</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Thompson, Craig P" sort="Thompson, Craig P" uniqKey="Thompson C" first="Craig P." last="Thompson">Craig P. Thompson</name>
<affiliation wicri:level="4"><nlm:aff id="af005">The Jenner Institute, University of Oxford, Oxford OX3 7DQ, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>The Jenner Institute, University of Oxford, Oxford OX3 7DQ</wicri:regionArea>
<orgName type="university">Université d'Oxford</orgName>
<placeName><settlement type="city">Oxford</settlement>
<region type="nation">Angleterre</region>
<region type="région" nuts="1">Oxfordshire</region>
</placeName>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="af015">Department of Zoology, University of Oxford, Oxford, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Zoology, University of Oxford, Oxford</wicri:regionArea>
<placeName><settlement type="city">Oxford</settlement>
<region type="country">Angleterre</region>
<region type="comté" nuts="2">Oxfordshire</region>
</placeName>
<orgName type="university">Université d'Oxford</orgName>
</affiliation>
</author>
<author><name sortKey="Kupke, Alexandra" sort="Kupke, Alexandra" uniqKey="Kupke A" first="Alexandra" last="Kupke">Alexandra Kupke</name>
<affiliation wicri:level="3"><nlm:aff id="af020">Institute of Virology, Philipps University of Marburg, Marburg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Virology, Philipps University of Marburg, Marburg</wicri:regionArea>
<placeName><region type="land" nuts="1">Hesse (Land)</region>
<region type="district" nuts="2">District de Giessen</region>
<settlement type="city">Marbourg</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af025">German Center for Infection Research, TTU Emerging Infections, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>German Center for Infection Research, TTU Emerging Infections</wicri:regionArea>
<wicri:noRegion>TTU Emerging Infections</wicri:noRegion>
<wicri:noRegion>TTU Emerging Infections</wicri:noRegion>
<wicri:noRegion>TTU Emerging Infections</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Wells, Daniel" sort="Wells, Daniel" uniqKey="Wells D" first="Daniel" last="Wells">Daniel Wells</name>
<affiliation wicri:level="4"><nlm:aff id="af005">The Jenner Institute, University of Oxford, Oxford OX3 7DQ, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>The Jenner Institute, University of Oxford, Oxford OX3 7DQ</wicri:regionArea>
<orgName type="university">Université d'Oxford</orgName>
<placeName><settlement type="city">Oxford</settlement>
<region type="nation">Angleterre</region>
<region type="région" nuts="1">Oxfordshire</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Sloan, Megan A" sort="Sloan, Megan A" uniqKey="Sloan M" first="Megan A." last="Sloan">Megan A. Sloan</name>
<affiliation wicri:level="4"><nlm:aff id="af005">The Jenner Institute, University of Oxford, Oxford OX3 7DQ, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>The Jenner Institute, University of Oxford, Oxford OX3 7DQ</wicri:regionArea>
<orgName type="university">Université d'Oxford</orgName>
<placeName><settlement type="city">Oxford</settlement>
<region type="nation">Angleterre</region>
<region type="région" nuts="1">Oxfordshire</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Grehan, Keith" sort="Grehan, Keith" uniqKey="Grehan K" first="Keith" last="Grehan">Keith Grehan</name>
<affiliation wicri:level="1"><nlm:aff id="af030">Viral Pseudotype Unit, School of Pharmacy, University of Kent, Chatham Maritime, Kent ME4 4TB, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Viral Pseudotype Unit, School of Pharmacy, University of Kent, Chatham Maritime, Kent ME4 4TB</wicri:regionArea>
<wicri:noRegion>Kent ME4 4TB</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Temperton, Nigel" sort="Temperton, Nigel" uniqKey="Temperton N" first="Nigel" last="Temperton">Nigel Temperton</name>
<affiliation wicri:level="1"><nlm:aff id="af030">Viral Pseudotype Unit, School of Pharmacy, University of Kent, Chatham Maritime, Kent ME4 4TB, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Viral Pseudotype Unit, School of Pharmacy, University of Kent, Chatham Maritime, Kent ME4 4TB</wicri:regionArea>
<wicri:noRegion>Kent ME4 4TB</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lambe, Teresa" sort="Lambe, Teresa" uniqKey="Lambe T" first="Teresa" last="Lambe">Teresa Lambe</name>
<affiliation wicri:level="4"><nlm:aff id="af005">The Jenner Institute, University of Oxford, Oxford OX3 7DQ, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>The Jenner Institute, University of Oxford, Oxford OX3 7DQ</wicri:regionArea>
<orgName type="university">Université d'Oxford</orgName>
<placeName><settlement type="city">Oxford</settlement>
<region type="nation">Angleterre</region>
<region type="région" nuts="1">Oxfordshire</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Warimwe, George" sort="Warimwe, George" uniqKey="Warimwe G" first="George" last="Warimwe">George Warimwe</name>
<affiliation wicri:level="4"><nlm:aff id="af005">The Jenner Institute, University of Oxford, Oxford OX3 7DQ, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>The Jenner Institute, University of Oxford, Oxford OX3 7DQ</wicri:regionArea>
<orgName type="university">Université d'Oxford</orgName>
<placeName><settlement type="city">Oxford</settlement>
<region type="nation">Angleterre</region>
<region type="région" nuts="1">Oxfordshire</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Becker, Stephan" sort="Becker, Stephan" uniqKey="Becker S" first="Stephan" last="Becker">Stephan Becker</name>
<affiliation wicri:level="3"><nlm:aff id="af020">Institute of Virology, Philipps University of Marburg, Marburg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Virology, Philipps University of Marburg, Marburg</wicri:regionArea>
<placeName><region type="land" nuts="1">Hesse (Land)</region>
<region type="district" nuts="2">District de Giessen</region>
<settlement type="city">Marbourg</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af025">German Center for Infection Research, TTU Emerging Infections, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>German Center for Infection Research, TTU Emerging Infections</wicri:regionArea>
<wicri:noRegion>TTU Emerging Infections</wicri:noRegion>
<wicri:noRegion>TTU Emerging Infections</wicri:noRegion>
<wicri:noRegion>TTU Emerging Infections</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hill, Adrian V S" sort="Hill, Adrian V S" uniqKey="Hill A" first="Adrian V. S." last="Hill">Adrian V. S. Hill</name>
<affiliation wicri:level="4"><nlm:aff id="af005">The Jenner Institute, University of Oxford, Oxford OX3 7DQ, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>The Jenner Institute, University of Oxford, Oxford OX3 7DQ</wicri:regionArea>
<orgName type="university">Université d'Oxford</orgName>
<placeName><settlement type="city">Oxford</settlement>
<region type="nation">Angleterre</region>
<region type="région" nuts="1">Oxfordshire</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Gilbert, Sarah C" sort="Gilbert, Sarah C" uniqKey="Gilbert S" first="Sarah C." last="Gilbert">Sarah C. Gilbert</name>
<affiliation wicri:level="4"><nlm:aff id="af005">The Jenner Institute, University of Oxford, Oxford OX3 7DQ, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>The Jenner Institute, University of Oxford, Oxford OX3 7DQ</wicri:regionArea>
<orgName type="university">Université d'Oxford</orgName>
<placeName><settlement type="city">Oxford</settlement>
<region type="nation">Angleterre</region>
<region type="région" nuts="1">Oxfordshire</region>
</placeName>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">28579232</idno>
<idno type="pmc">5516308</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5516308</idno>
<idno type="RBID">PMC:5516308</idno>
<idno type="doi">10.1016/j.vaccine.2017.05.032</idno>
<date when="2017">2017</date>
<idno type="wicri:Area/Pmc/Corpus">001174</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001174</idno>
<idno type="wicri:Area/Pmc/Curation">001174</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">001174</idno>
<idno type="wicri:Area/Pmc/Checkpoint">000914</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000914</idno>
<idno type="wicri:source">PubMed</idno>
<idno type="RBID">pubmed:28579232</idno>
<idno type="wicri:Area/PubMed/Corpus">000C73</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000C73</idno>
<idno type="wicri:Area/PubMed/Curation">000C73</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000C73</idno>
<idno type="wicri:Area/PubMed/Checkpoint">000D72</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000D72</idno>
<idno type="wicri:Area/Ncbi/Merge">001A60</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">ChAdOx1 and MVA based vaccine candidates against MERS-CoV elicit neutralising antibodies and cellular immune responses in mice</title>
<author><name sortKey="Alharbi, Naif Khalaf" sort="Alharbi, Naif Khalaf" uniqKey="Alharbi N" first="Naif Khalaf" last="Alharbi">Naif Khalaf Alharbi</name>
<affiliation wicri:level="4"><nlm:aff id="af005">The Jenner Institute, University of Oxford, Oxford OX3 7DQ, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>The Jenner Institute, University of Oxford, Oxford OX3 7DQ</wicri:regionArea>
<orgName type="university">Université d'Oxford</orgName>
<placeName><settlement type="city">Oxford</settlement>
<region type="nation">Angleterre</region>
<region type="région" nuts="1">Oxfordshire</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af010">King Abdullah International Medical Research Center, Riyadh, Saudi Arabia</nlm:aff>
<country xml:lang="fr">Arabie saoudite</country>
<wicri:regionArea>King Abdullah International Medical Research Center, Riyadh</wicri:regionArea>
<wicri:noRegion>Riyadh</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Padron Regalado, Eriko" sort="Padron Regalado, Eriko" uniqKey="Padron Regalado E" first="Eriko" last="Padron-Regalado">Eriko Padron-Regalado</name>
<affiliation wicri:level="4"><nlm:aff id="af005">The Jenner Institute, University of Oxford, Oxford OX3 7DQ, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>The Jenner Institute, University of Oxford, Oxford OX3 7DQ</wicri:regionArea>
<orgName type="university">Université d'Oxford</orgName>
<placeName><settlement type="city">Oxford</settlement>
<region type="nation">Angleterre</region>
<region type="région" nuts="1">Oxfordshire</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Thompson, Craig P" sort="Thompson, Craig P" uniqKey="Thompson C" first="Craig P." last="Thompson">Craig P. Thompson</name>
<affiliation wicri:level="4"><nlm:aff id="af005">The Jenner Institute, University of Oxford, Oxford OX3 7DQ, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>The Jenner Institute, University of Oxford, Oxford OX3 7DQ</wicri:regionArea>
<orgName type="university">Université d'Oxford</orgName>
<placeName><settlement type="city">Oxford</settlement>
<region type="nation">Angleterre</region>
<region type="région" nuts="1">Oxfordshire</region>
</placeName>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="af015">Department of Zoology, University of Oxford, Oxford, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Zoology, University of Oxford, Oxford</wicri:regionArea>
<placeName><settlement type="city">Oxford</settlement>
<region type="country">Angleterre</region>
<region type="comté" nuts="2">Oxfordshire</region>
</placeName>
<orgName type="university">Université d'Oxford</orgName>
</affiliation>
</author>
<author><name sortKey="Kupke, Alexandra" sort="Kupke, Alexandra" uniqKey="Kupke A" first="Alexandra" last="Kupke">Alexandra Kupke</name>
<affiliation wicri:level="3"><nlm:aff id="af020">Institute of Virology, Philipps University of Marburg, Marburg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Virology, Philipps University of Marburg, Marburg</wicri:regionArea>
<placeName><region type="land" nuts="1">Hesse (Land)</region>
<region type="district" nuts="2">District de Giessen</region>
<settlement type="city">Marbourg</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af025">German Center for Infection Research, TTU Emerging Infections, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>German Center for Infection Research, TTU Emerging Infections</wicri:regionArea>
<wicri:noRegion>TTU Emerging Infections</wicri:noRegion>
<wicri:noRegion>TTU Emerging Infections</wicri:noRegion>
<wicri:noRegion>TTU Emerging Infections</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Wells, Daniel" sort="Wells, Daniel" uniqKey="Wells D" first="Daniel" last="Wells">Daniel Wells</name>
<affiliation wicri:level="4"><nlm:aff id="af005">The Jenner Institute, University of Oxford, Oxford OX3 7DQ, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>The Jenner Institute, University of Oxford, Oxford OX3 7DQ</wicri:regionArea>
<orgName type="university">Université d'Oxford</orgName>
<placeName><settlement type="city">Oxford</settlement>
<region type="nation">Angleterre</region>
<region type="région" nuts="1">Oxfordshire</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Sloan, Megan A" sort="Sloan, Megan A" uniqKey="Sloan M" first="Megan A." last="Sloan">Megan A. Sloan</name>
<affiliation wicri:level="4"><nlm:aff id="af005">The Jenner Institute, University of Oxford, Oxford OX3 7DQ, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>The Jenner Institute, University of Oxford, Oxford OX3 7DQ</wicri:regionArea>
<orgName type="university">Université d'Oxford</orgName>
<placeName><settlement type="city">Oxford</settlement>
<region type="nation">Angleterre</region>
<region type="région" nuts="1">Oxfordshire</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Grehan, Keith" sort="Grehan, Keith" uniqKey="Grehan K" first="Keith" last="Grehan">Keith Grehan</name>
<affiliation wicri:level="1"><nlm:aff id="af030">Viral Pseudotype Unit, School of Pharmacy, University of Kent, Chatham Maritime, Kent ME4 4TB, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Viral Pseudotype Unit, School of Pharmacy, University of Kent, Chatham Maritime, Kent ME4 4TB</wicri:regionArea>
<wicri:noRegion>Kent ME4 4TB</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Temperton, Nigel" sort="Temperton, Nigel" uniqKey="Temperton N" first="Nigel" last="Temperton">Nigel Temperton</name>
<affiliation wicri:level="1"><nlm:aff id="af030">Viral Pseudotype Unit, School of Pharmacy, University of Kent, Chatham Maritime, Kent ME4 4TB, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Viral Pseudotype Unit, School of Pharmacy, University of Kent, Chatham Maritime, Kent ME4 4TB</wicri:regionArea>
<wicri:noRegion>Kent ME4 4TB</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lambe, Teresa" sort="Lambe, Teresa" uniqKey="Lambe T" first="Teresa" last="Lambe">Teresa Lambe</name>
<affiliation wicri:level="4"><nlm:aff id="af005">The Jenner Institute, University of Oxford, Oxford OX3 7DQ, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>The Jenner Institute, University of Oxford, Oxford OX3 7DQ</wicri:regionArea>
<orgName type="university">Université d'Oxford</orgName>
<placeName><settlement type="city">Oxford</settlement>
<region type="nation">Angleterre</region>
<region type="région" nuts="1">Oxfordshire</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Warimwe, George" sort="Warimwe, George" uniqKey="Warimwe G" first="George" last="Warimwe">George Warimwe</name>
<affiliation wicri:level="4"><nlm:aff id="af005">The Jenner Institute, University of Oxford, Oxford OX3 7DQ, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>The Jenner Institute, University of Oxford, Oxford OX3 7DQ</wicri:regionArea>
<orgName type="university">Université d'Oxford</orgName>
<placeName><settlement type="city">Oxford</settlement>
<region type="nation">Angleterre</region>
<region type="région" nuts="1">Oxfordshire</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Becker, Stephan" sort="Becker, Stephan" uniqKey="Becker S" first="Stephan" last="Becker">Stephan Becker</name>
<affiliation wicri:level="3"><nlm:aff id="af020">Institute of Virology, Philipps University of Marburg, Marburg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Virology, Philipps University of Marburg, Marburg</wicri:regionArea>
<placeName><region type="land" nuts="1">Hesse (Land)</region>
<region type="district" nuts="2">District de Giessen</region>
<settlement type="city">Marbourg</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af025">German Center for Infection Research, TTU Emerging Infections, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>German Center for Infection Research, TTU Emerging Infections</wicri:regionArea>
<wicri:noRegion>TTU Emerging Infections</wicri:noRegion>
<wicri:noRegion>TTU Emerging Infections</wicri:noRegion>
<wicri:noRegion>TTU Emerging Infections</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hill, Adrian V S" sort="Hill, Adrian V S" uniqKey="Hill A" first="Adrian V. S." last="Hill">Adrian V. S. Hill</name>
<affiliation wicri:level="4"><nlm:aff id="af005">The Jenner Institute, University of Oxford, Oxford OX3 7DQ, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>The Jenner Institute, University of Oxford, Oxford OX3 7DQ</wicri:regionArea>
<orgName type="university">Université d'Oxford</orgName>
<placeName><settlement type="city">Oxford</settlement>
<region type="nation">Angleterre</region>
<region type="région" nuts="1">Oxfordshire</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Gilbert, Sarah C" sort="Gilbert, Sarah C" uniqKey="Gilbert S" first="Sarah C." last="Gilbert">Sarah C. Gilbert</name>
<affiliation wicri:level="4"><nlm:aff id="af005">The Jenner Institute, University of Oxford, Oxford OX3 7DQ, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>The Jenner Institute, University of Oxford, Oxford OX3 7DQ</wicri:regionArea>
<orgName type="university">Université d'Oxford</orgName>
<placeName><settlement type="city">Oxford</settlement>
<region type="nation">Angleterre</region>
<region type="région" nuts="1">Oxfordshire</region>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">Vaccine</title>
<idno type="ISSN">0264-410X</idno>
<idno type="eISSN">1873-2518</idno>
<imprint><date when="2017">2017</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adenoviridae (genetics)</term>
<term>Adenoviridae (immunology)</term>
<term>Animals</term>
<term>Antibodies, Neutralizing (biosynthesis)</term>
<term>Antibodies, Neutralizing (immunology)</term>
<term>Antibodies, Viral (biosynthesis)</term>
<term>Antibodies, Viral (immunology)</term>
<term>Coronavirus Infections (immunology)</term>
<term>Coronavirus Infections (prevention & control)</term>
<term>Dose-Response Relationship, Immunologic</term>
<term>Immunity, Cellular</term>
<term>Immunity, Humoral</term>
<term>Immunogenicity, Vaccine</term>
<term>Mice</term>
<term>Middle East Respiratory Syndrome Coronavirus (genetics)</term>
<term>Middle East Respiratory Syndrome Coronavirus (immunology)</term>
<term>Spike Glycoprotein, Coronavirus (genetics)</term>
<term>Spike Glycoprotein, Coronavirus (immunology)</term>
<term>Vaccination</term>
<term>Vaccines, Synthetic (administration & dosage)</term>
<term>Vaccines, Synthetic (immunology)</term>
<term>Viral Vaccines (genetics)</term>
<term>Viral Vaccines (immunology)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Adenoviridae (génétique)</term>
<term>Adenoviridae (immunologie)</term>
<term>Animaux</term>
<term>Anticorps antiviraux (biosynthèse)</term>
<term>Anticorps antiviraux (immunologie)</term>
<term>Anticorps neutralisants (biosynthèse)</term>
<term>Anticorps neutralisants (immunologie)</term>
<term>Coronavirus du syndrome respiratoire du Moyen-Orient (génétique)</term>
<term>Coronavirus du syndrome respiratoire du Moyen-Orient (immunologie)</term>
<term>Glycoprotéine de spicule des coronavirus (génétique)</term>
<term>Glycoprotéine de spicule des coronavirus (immunologie)</term>
<term>Immunité cellulaire</term>
<term>Immunité humorale</term>
<term>Immunogénicité des vaccins</term>
<term>Infections à coronavirus ()</term>
<term>Infections à coronavirus (immunologie)</term>
<term>Relation dose-réponse (immunologie)</term>
<term>Souris</term>
<term>Vaccination</term>
<term>Vaccins antiviraux (génétique)</term>
<term>Vaccins antiviraux (immunologie)</term>
<term>Vaccins synthétiques (administration et posologie)</term>
<term>Vaccins synthétiques (immunologie)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Vaccines, Synthetic</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="biosynthesis" xml:lang="en"><term>Antibodies, Neutralizing</term>
<term>Antibodies, Viral</term>
</keywords>
<keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Vaccins synthétiques</term>
</keywords>
<keywords scheme="MESH" qualifier="biosynthèse" xml:lang="fr"><term>Anticorps antiviraux</term>
<term>Anticorps neutralisants</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Adenoviridae</term>
<term>Middle East Respiratory Syndrome Coronavirus</term>
<term>Spike Glycoprotein, Coronavirus</term>
<term>Viral Vaccines</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Adenoviridae</term>
<term>Coronavirus du syndrome respiratoire du Moyen-Orient</term>
<term>Glycoprotéine de spicule des coronavirus</term>
<term>Vaccins antiviraux</term>
</keywords>
<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Adenoviridae</term>
<term>Anticorps antiviraux</term>
<term>Anticorps neutralisants</term>
<term>Coronavirus du syndrome respiratoire du Moyen-Orient</term>
<term>Glycoprotéine de spicule des coronavirus</term>
<term>Infections à coronavirus</term>
<term>Vaccins antiviraux</term>
<term>Vaccins synthétiques</term>
</keywords>
<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Adenoviridae</term>
<term>Antibodies, Neutralizing</term>
<term>Antibodies, Viral</term>
<term>Coronavirus Infections</term>
<term>Middle East Respiratory Syndrome Coronavirus</term>
<term>Spike Glycoprotein, Coronavirus</term>
<term>Vaccines, Synthetic</term>
<term>Viral Vaccines</term>
</keywords>
<keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Coronavirus Infections</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Dose-Response Relationship, Immunologic</term>
<term>Immunity, Cellular</term>
<term>Immunity, Humoral</term>
<term>Immunogenicity, Vaccine</term>
<term>Mice</term>
<term>Vaccination</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Animaux</term>
<term>Immunité cellulaire</term>
<term>Immunité humorale</term>
<term>Immunogénicité des vaccins</term>
<term>Infections à coronavirus</term>
<term>Relation dose-réponse (immunologie)</term>
<term>Souris</term>
<term>Vaccination</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><title>Highlights</title>
<p><list list-type="simple" id="l0005"><list-item id="o0005"><label>•</label>
<p id="p0005">Inserting tPA leader sequence enhanced humoral responses of ChAdOx1 MERS.</p>
</list-item>
<list-item id="o0010"><label>•</label>
<p id="p0010">ChAdOx1 MERS elicited cellular immunity and neutralising antibodies.</p>
</list-item>
<list-item id="o0015"><label>•</label>
<p id="p0015">ChAdOx1 MERS responses were boosted by MVA MERS.</p>
</list-item>
<list-item id="o0020"><label>•</label>
<p id="p0020">Immunogenicity of a single dose of ChAdOx1 MERS was equivalent to 2 doses of MVA MERS.</p>
</list-item>
<list-item id="o0025"><label>•</label>
<p id="p0025">In MVA, F11 promoter enhanced cellular, but not humoral, immunogenicity, comparing to mH5 promoter.</p>
</list-item>
</list>
</p>
</div>
</front>
<back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Zaki, A M" uniqKey="Zaki A">A.M. Zaki</name>
</author>
<author><name sortKey="Van Boheemen, S" uniqKey="Van Boheemen S">S. van Boheemen</name>
</author>
<author><name sortKey="Bestebroer, T M" uniqKey="Bestebroer T">T.M. Bestebroer</name>
</author>
<author><name sortKey="Osterhaus, A D" uniqKey="Osterhaus A">A.D. Osterhaus</name>
</author>
<author><name sortKey="Fouchier, R A" uniqKey="Fouchier R">R.A. Fouchier</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Lessler, J" uniqKey="Lessler J">J. Lessler</name>
</author>
<author><name sortKey="Salje, H" uniqKey="Salje H">H. Salje</name>
</author>
<author><name sortKey="Van Kerkhove, M D" uniqKey="Van Kerkhove M">M.D. Van Kerkhove</name>
</author>
<author><name sortKey="Ferguson, N M" uniqKey="Ferguson N">N.M. Ferguson</name>
</author>
<author><name sortKey="Cauchemez, S" uniqKey="Cauchemez S">S. Cauchemez</name>
</author>
<author><name sortKey="Rodriquez Barraquer, I" uniqKey="Rodriquez Barraquer I">I. Rodriquez-Barraquer</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Al Hammadi, Z M" uniqKey="Al Hammadi Z">Z.M. Al Hammadi</name>
</author>
<author><name sortKey="Chu, D K" uniqKey="Chu D">D.K. Chu</name>
</author>
<author><name sortKey="Eltahir, Y M" uniqKey="Eltahir Y">Y.M. Eltahir</name>
</author>
<author><name sortKey="Al Hosani, F" uniqKey="Al Hosani F">F. Al Hosani</name>
</author>
<author><name sortKey="Al Mulla, M" uniqKey="Al Mulla M">M. Al Mulla</name>
</author>
<author><name sortKey="Tarnini, W" uniqKey="Tarnini W">W. Tarnini</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Oboho, I K" uniqKey="Oboho I">I.K. Oboho</name>
</author>
<author><name sortKey="Tomczyk, S M" uniqKey="Tomczyk S">S.M. Tomczyk</name>
</author>
<author><name sortKey="Al Asmari, A M" uniqKey="Al Asmari A">A.M. Al-Asmari</name>
</author>
<author><name sortKey="Banjar, A A" uniqKey="Banjar A">A.A. Banjar</name>
</author>
<author><name sortKey="Al Mugti, H" uniqKey="Al Mugti H">H. Al-Mugti</name>
</author>
<author><name sortKey="Aloraini, M S" uniqKey="Aloraini M">M.S. Aloraini</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Memish, Z A" uniqKey="Memish Z">Z.A. Memish</name>
</author>
<author><name sortKey="Zumla, A I" uniqKey="Zumla A">A.I. Zumla</name>
</author>
<author><name sortKey="Assiri, A" uniqKey="Assiri A">A. Assiri</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Muller, M A" uniqKey="Muller M">M.A. Muller</name>
</author>
<author><name sortKey="Corman, V M" uniqKey="Corman V">V.M. Corman</name>
</author>
<author><name sortKey="Jores, J" uniqKey="Jores J">J. Jores</name>
</author>
<author><name sortKey="Meyer, B" uniqKey="Meyer B">B. Meyer</name>
</author>
<author><name sortKey="Younan, M" uniqKey="Younan M">M. Younan</name>
</author>
<author><name sortKey="Liljander, A" uniqKey="Liljander A">A. Liljander</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Hemida, M G" uniqKey="Hemida M">M.G. Hemida</name>
</author>
<author><name sortKey="Perera, R A" uniqKey="Perera R">R.A. Perera</name>
</author>
<author><name sortKey="Al Jassim, R A" uniqKey="Al Jassim R">R.A. Al Jassim</name>
</author>
<author><name sortKey="Kayali, G" uniqKey="Kayali G">G. Kayali</name>
</author>
<author><name sortKey="Siu, L Y" uniqKey="Siu L">L.Y. Siu</name>
</author>
<author><name sortKey="Wang, P" uniqKey="Wang P">P. Wang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gutierrez, C" uniqKey="Gutierrez C">C. Gutierrez</name>
</author>
<author><name sortKey="Tejedor Junco, M T" uniqKey="Tejedor Junco M">M.T. Tejedor-Junco</name>
</author>
<author><name sortKey="Gonzalez, M" uniqKey="Gonzalez M">M. Gonzalez</name>
</author>
<author><name sortKey="Lattwein, E" uniqKey="Lattwein E">E. Lattwein</name>
</author>
<author><name sortKey="Renneker, S" uniqKey="Renneker S">S. Renneker</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ali, M A" uniqKey="Ali M">M.A. Ali</name>
</author>
<author><name sortKey="Shehata, M M" uniqKey="Shehata M">M.M. Shehata</name>
</author>
<author><name sortKey="Gomaa, M R" uniqKey="Gomaa M">M.R. Gomaa</name>
</author>
<author><name sortKey="Kandeil, A" uniqKey="Kandeil A">A. Kandeil</name>
</author>
<author><name sortKey="El Shesheny, R" uniqKey="El Shesheny R">R. El-Shesheny</name>
</author>
<author><name sortKey="Kayed, A S" uniqKey="Kayed A">A.S. Kayed</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Van Doremalen, N" uniqKey="Van Doremalen N">N. van Doremalen</name>
</author>
<author><name sortKey="Hijazeen, Z S" uniqKey="Hijazeen Z">Z.S. Hijazeen</name>
</author>
<author><name sortKey="Holloway, P" uniqKey="Holloway P">P. Holloway</name>
</author>
<author><name sortKey="Al Omari, B" uniqKey="Al Omari B">B. Al Omari</name>
</author>
<author><name sortKey="Mcdowell, C" uniqKey="Mcdowell C">C. McDowell</name>
</author>
<author><name sortKey="Adney, D" uniqKey="Adney D">D. Adney</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Alraddadi, B M" uniqKey="Alraddadi B">B.M. Alraddadi</name>
</author>
<author><name sortKey="Watson, J T" uniqKey="Watson J">J.T. Watson</name>
</author>
<author><name sortKey="Almarashi, A" uniqKey="Almarashi A">A. Almarashi</name>
</author>
<author><name sortKey="Abedi, G R" uniqKey="Abedi G">G.R. Abedi</name>
</author>
<author><name sortKey="Turkistani, A" uniqKey="Turkistani A">A. Turkistani</name>
</author>
<author><name sortKey="Sadran, M" uniqKey="Sadran M">M. Sadran</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gossner, C" uniqKey="Gossner C">C. Gossner</name>
</author>
<author><name sortKey="Danielson, N" uniqKey="Danielson N">N. Danielson</name>
</author>
<author><name sortKey="Gervelmeyer, A" uniqKey="Gervelmeyer A">A. Gervelmeyer</name>
</author>
<author><name sortKey="Berthe, F" uniqKey="Berthe F">F. Berthe</name>
</author>
<author><name sortKey="Faye, B" uniqKey="Faye B">B. Faye</name>
</author>
<author><name sortKey="Kaasik Aaslav, K" uniqKey="Kaasik Aaslav K">K. Kaasik Aaslav</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Funk, A L" uniqKey="Funk A">A.L. Funk</name>
</author>
<author><name sortKey="Goutard, F L" uniqKey="Goutard F">F.L. Goutard</name>
</author>
<author><name sortKey="Miguel, E" uniqKey="Miguel E">E. Miguel</name>
</author>
<author><name sortKey="Bourgarel, M" uniqKey="Bourgarel M">M. Bourgarel</name>
</author>
<author><name sortKey="Chevalier, V" uniqKey="Chevalier V">V. Chevalier</name>
</author>
<author><name sortKey="Faye, B" uniqKey="Faye B">B. Faye</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Reusken, C B" uniqKey="Reusken C">C.B. Reusken</name>
</author>
<author><name sortKey="Ababneh, M" uniqKey="Ababneh M">M. Ababneh</name>
</author>
<author><name sortKey="Raj, V S" uniqKey="Raj V">V.S. Raj</name>
</author>
<author><name sortKey="Meyer, B" uniqKey="Meyer B">B. Meyer</name>
</author>
<author><name sortKey="Eljarah, A" uniqKey="Eljarah A">A. Eljarah</name>
</author>
<author><name sortKey="Abutarbush, S" uniqKey="Abutarbush S">S. Abutarbush</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hemida, M G" uniqKey="Hemida M">M.G. Hemida</name>
</author>
<author><name sortKey="Perera, R A" uniqKey="Perera R">R.A. Perera</name>
</author>
<author><name sortKey="Wang, P" uniqKey="Wang P">P. Wang</name>
</author>
<author><name sortKey="Alhammadi, M A" uniqKey="Alhammadi M">M.A. Alhammadi</name>
</author>
<author><name sortKey="Siu, L Y" uniqKey="Siu L">L.Y. Siu</name>
</author>
<author><name sortKey="Li, M" uniqKey="Li M">M. Li</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Alagaili, A N" uniqKey="Alagaili A">A.N. Alagaili</name>
</author>
<author><name sortKey="Briese, T" uniqKey="Briese T">T. Briese</name>
</author>
<author><name sortKey="Mishra, N" uniqKey="Mishra N">N. Mishra</name>
</author>
<author><name sortKey="Kapoor, V" uniqKey="Kapoor V">V. Kapoor</name>
</author>
<author><name sortKey="Sameroff, S C" uniqKey="Sameroff S">S.C. Sameroff</name>
</author>
<author><name sortKey="Burbelo, P D" uniqKey="Burbelo P">P.D. Burbelo</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Reusken, C B" uniqKey="Reusken C">C.B. Reusken</name>
</author>
<author><name sortKey="Haagmans, B L" uniqKey="Haagmans B">B.L. Haagmans</name>
</author>
<author><name sortKey="Muller, M A" uniqKey="Muller M">M.A. Muller</name>
</author>
<author><name sortKey="Gutierrez, C" uniqKey="Gutierrez C">C. Gutierrez</name>
</author>
<author><name sortKey="Godeke, G J" uniqKey="Godeke G">G.J. Godeke</name>
</author>
<author><name sortKey="Meyer, B" uniqKey="Meyer B">B. Meyer</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Vergara Alert, J" uniqKey="Vergara Alert J">J. Vergara-Alert</name>
</author>
<author><name sortKey="Van Den Brand, J M" uniqKey="Van Den Brand J">J.M. van den Brand</name>
</author>
<author><name sortKey="Widagdo, W" uniqKey="Widagdo W">W. Widagdo</name>
</author>
<author><name sortKey="Mt, Munoz" uniqKey="Mt M">Munoz Mt</name>
</author>
<author><name sortKey="Raj, S" uniqKey="Raj S">S. Raj</name>
</author>
<author><name sortKey="Schipper, D" uniqKey="Schipper D">D. Schipper</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Adney, D R" uniqKey="Adney D">D.R. Adney</name>
</author>
<author><name sortKey="Brown, V R" uniqKey="Brown V">V.R. Brown</name>
</author>
<author><name sortKey="Porter, S M" uniqKey="Porter S">S.M. Porter</name>
</author>
<author><name sortKey="Bielefeldt Ohmann, H" uniqKey="Bielefeldt Ohmann H">H. Bielefeldt-Ohmann</name>
</author>
<author><name sortKey="Hartwig, A E" uniqKey="Hartwig A">A.E. Hartwig</name>
</author>
<author><name sortKey="Bowen, R A" uniqKey="Bowen R">R.A. Bowen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Alharbi, N K" uniqKey="Alharbi N">N.K. Alharbi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Draper, S J" uniqKey="Draper S">S.J. Draper</name>
</author>
<author><name sortKey="Heeney, J L" uniqKey="Heeney J">J.L. Heeney</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Tao, D" uniqKey="Tao D">D. Tao</name>
</author>
<author><name sortKey="Barba Spaeth, G" uniqKey="Barba Spaeth G">G. Barba-Spaeth</name>
</author>
<author><name sortKey="Rai, U" uniqKey="Rai U">U. Rai</name>
</author>
<author><name sortKey="Nussenzweig, V" uniqKey="Nussenzweig V">V. Nussenzweig</name>
</author>
<author><name sortKey="Rice, C M" uniqKey="Rice C">C.M. Rice</name>
</author>
<author><name sortKey="Nussenzweig, R S" uniqKey="Nussenzweig R">R.S. Nussenzweig</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Dicks, M D" uniqKey="Dicks M">M.D. Dicks</name>
</author>
<author><name sortKey="Spencer, A J" uniqKey="Spencer A">A.J. Spencer</name>
</author>
<author><name sortKey="Edwards, N J" uniqKey="Edwards N">N.J. Edwards</name>
</author>
<author><name sortKey="Wadell, G" uniqKey="Wadell G">G. Wadell</name>
</author>
<author><name sortKey="Bojang, K" uniqKey="Bojang K">K. Bojang</name>
</author>
<author><name sortKey="Gilbert, S C" uniqKey="Gilbert S">S.C. Gilbert</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gomez, C E" uniqKey="Gomez C">C.E. Gomez</name>
</author>
<author><name sortKey="Perdiguero, B" uniqKey="Perdiguero B">B. Perdiguero</name>
</author>
<author><name sortKey="Garcia Arriaza, J" uniqKey="Garcia Arriaza J">J. Garcia-Arriaza</name>
</author>
<author><name sortKey="Esteban, M" uniqKey="Esteban M">M. Esteban</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gilbert, S C" uniqKey="Gilbert S">S.C. Gilbert</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Luo, M" uniqKey="Luo M">M. Luo</name>
</author>
<author><name sortKey="Tao, P" uniqKey="Tao P">P. Tao</name>
</author>
<author><name sortKey="Li, J" uniqKey="Li J">J. Li</name>
</author>
<author><name sortKey="Zhou, S" uniqKey="Zhou S">S. Zhou</name>
</author>
<author><name sortKey="Guo, D" uniqKey="Guo D">D. Guo</name>
</author>
<author><name sortKey="Pan, Z" uniqKey="Pan Z">Z. Pan</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wallace, A" uniqKey="Wallace A">A. Wallace</name>
</author>
<author><name sortKey="West, K" uniqKey="West K">K. West</name>
</author>
<author><name sortKey="Rothman, A L" uniqKey="Rothman A">A.L. Rothman</name>
</author>
<author><name sortKey="Ennis, F A" uniqKey="Ennis F">F.A. Ennis</name>
</author>
<author><name sortKey="Lu, S" uniqKey="Lu S">S. Lu</name>
</author>
<author><name sortKey="Wang, S" uniqKey="Wang S">S. Wang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Alharbi, N K" uniqKey="Alharbi N">N.K. Alharbi</name>
</author>
<author><name sortKey="Spencer, A J" uniqKey="Spencer A">A.J. Spencer</name>
</author>
<author><name sortKey="Salman, A M" uniqKey="Salman A">A.M. Salman</name>
</author>
<author><name sortKey="Tully, C M" uniqKey="Tully C">C.M. Tully</name>
</author>
<author><name sortKey="Chinnakannan, S K" uniqKey="Chinnakannan S">S.K. Chinnakannan</name>
</author>
<author><name sortKey="Lambe, T" uniqKey="Lambe T">T. Lambe</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Warimwe, G M" uniqKey="Warimwe G">G.M. Warimwe</name>
</author>
<author><name sortKey="Gesharisha, J" uniqKey="Gesharisha J">J. Gesharisha</name>
</author>
<author><name sortKey="Carr, B V" uniqKey="Carr B">B.V. Carr</name>
</author>
<author><name sortKey="Otieno, S" uniqKey="Otieno S">S. Otieno</name>
</author>
<author><name sortKey="Otingah, K" uniqKey="Otingah K">K. Otingah</name>
</author>
<author><name sortKey="Wright, D" uniqKey="Wright D">D. Wright</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Antrobus, R D" uniqKey="Antrobus R">R.D. Antrobus</name>
</author>
<author><name sortKey="Coughlan, L" uniqKey="Coughlan L">L. Coughlan</name>
</author>
<author><name sortKey="Berthoud, T K" uniqKey="Berthoud T">T.K. Berthoud</name>
</author>
<author><name sortKey="Dicks, M D" uniqKey="Dicks M">M.D. Dicks</name>
</author>
<author><name sortKey="Hill, A V" uniqKey="Hill A">A.V. Hill</name>
</author>
<author><name sortKey="Lambe, T" uniqKey="Lambe T">T. Lambe</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Cottingham, M G" uniqKey="Cottingham M">M.G. Cottingham</name>
</author>
<author><name sortKey="Carroll, F" uniqKey="Carroll F">F. Carroll</name>
</author>
<author><name sortKey="Morris, S J" uniqKey="Morris S">S.J. Morris</name>
</author>
<author><name sortKey="Turner, A V" uniqKey="Turner A">A.V. Turner</name>
</author>
<author><name sortKey="Vaughan, A M" uniqKey="Vaughan A">A.M. Vaughan</name>
</author>
<author><name sortKey="Kapulu, M C" uniqKey="Kapulu M">M.C. Kapulu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Sridhar, S" uniqKey="Sridhar S">S. Sridhar</name>
</author>
<author><name sortKey="Reyes Sandoval, A" uniqKey="Reyes Sandoval A">A. Reyes-Sandoval</name>
</author>
<author><name sortKey="Draper, S J" uniqKey="Draper S">S.J. Draper</name>
</author>
<author><name sortKey="Moore, A C" uniqKey="Moore A">A.C. Moore</name>
</author>
<author><name sortKey="Gilbert, S C" uniqKey="Gilbert S">S.C. Gilbert</name>
</author>
<author><name sortKey="Gao, G P" uniqKey="Gao G">G.P. Gao</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Cottingham, M G" uniqKey="Cottingham M">M.G. Cottingham</name>
</author>
<author><name sortKey="Andersen, R F" uniqKey="Andersen R">R.F. Andersen</name>
</author>
<author><name sortKey="Spencer, A J" uniqKey="Spencer A">A.J. Spencer</name>
</author>
<author><name sortKey="Saurya, S" uniqKey="Saurya S">S. Saurya</name>
</author>
<author><name sortKey="Furze, J" uniqKey="Furze J">J. Furze</name>
</author>
<author><name sortKey="Hill, A V" uniqKey="Hill A">A.V. Hill</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Volz, A" uniqKey="Volz A">A. Volz</name>
</author>
<author><name sortKey="Kupke, A" uniqKey="Kupke A">A. Kupke</name>
</author>
<author><name sortKey="Song, F" uniqKey="Song F">F. Song</name>
</author>
<author><name sortKey="Jany, S" uniqKey="Jany S">S. Jany</name>
</author>
<author><name sortKey="Fux, R" uniqKey="Fux R">R. Fux</name>
</author>
<author><name sortKey="Shams Eldin, H" uniqKey="Shams Eldin H">H. Shams-Eldin</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Tscharke, D C" uniqKey="Tscharke D">D.C. Tscharke</name>
</author>
<author><name sortKey="Woo, W P" uniqKey="Woo W">W.P. Woo</name>
</author>
<author><name sortKey="Sakala, I G" uniqKey="Sakala I">I.G. Sakala</name>
</author>
<author><name sortKey="Sidney, J" uniqKey="Sidney J">J. Sidney</name>
</author>
<author><name sortKey="Sette, A" uniqKey="Sette A">A. Sette</name>
</author>
<author><name sortKey="Moss, D J" uniqKey="Moss D">D.J. Moss</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Draper, S J" uniqKey="Draper S">S.J. Draper</name>
</author>
<author><name sortKey="Moore, A C" uniqKey="Moore A">A.C. Moore</name>
</author>
<author><name sortKey="Goodman, A L" uniqKey="Goodman A">A.L. Goodman</name>
</author>
<author><name sortKey="Long, C A" uniqKey="Long C">C.A. Long</name>
</author>
<author><name sortKey="Holder, A A" uniqKey="Holder A">A.A. Holder</name>
</author>
<author><name sortKey="Gilbert, S C" uniqKey="Gilbert S">S.C. Gilbert</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Grehan, K" uniqKey="Grehan K">K. Grehan</name>
</author>
<author><name sortKey="Ferrara, F" uniqKey="Ferrara F">F. Ferrara</name>
</author>
<author><name sortKey="Temperton, N" uniqKey="Temperton N">N. Temperton</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Song, F" uniqKey="Song F">F. Song</name>
</author>
<author><name sortKey="Fux, R" uniqKey="Fux R">R. Fux</name>
</author>
<author><name sortKey="Provacia, L B" uniqKey="Provacia L">L.B. Provacia</name>
</author>
<author><name sortKey="Volz, A" uniqKey="Volz A">A. Volz</name>
</author>
<author><name sortKey="Eickmann, M" uniqKey="Eickmann M">M. Eickmann</name>
</author>
<author><name sortKey="Becker, S" uniqKey="Becker S">S. Becker</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Muthumani, K" uniqKey="Muthumani K">K. Muthumani</name>
</author>
<author><name sortKey="Falzarano, D" uniqKey="Falzarano D">D. Falzarano</name>
</author>
<author><name sortKey="Reuschel, E L" uniqKey="Reuschel E">E.L. Reuschel</name>
</author>
<author><name sortKey="Tingey, C" uniqKey="Tingey C">C. Tingey</name>
</author>
<author><name sortKey="Flingai, S" uniqKey="Flingai S">S. Flingai</name>
</author>
<author><name sortKey="Villarreal, D O" uniqKey="Villarreal D">D.O. Villarreal</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lan, J" uniqKey="Lan J">J. Lan</name>
</author>
<author><name sortKey="Yao, Y" uniqKey="Yao Y">Y. Yao</name>
</author>
<author><name sortKey="Deng, Y" uniqKey="Deng Y">Y. Deng</name>
</author>
<author><name sortKey="Chen, H" uniqKey="Chen H">H. Chen</name>
</author>
<author><name sortKey="Lu, G" uniqKey="Lu G">G. Lu</name>
</author>
<author><name sortKey="Wang, W" uniqKey="Wang W">W. Wang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wang, L" uniqKey="Wang L">L. Wang</name>
</author>
<author><name sortKey="Shi, W" uniqKey="Shi W">W. Shi</name>
</author>
<author><name sortKey="Joyce, M G" uniqKey="Joyce M">M.G. Joyce</name>
</author>
<author><name sortKey="Modjarrad, K" uniqKey="Modjarrad K">K. Modjarrad</name>
</author>
<author><name sortKey="Zhang, Y" uniqKey="Zhang Y">Y. Zhang</name>
</author>
<author><name sortKey="Leung, K" uniqKey="Leung K">K. Leung</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Haagmans, B L" uniqKey="Haagmans B">B.L. Haagmans</name>
</author>
<author><name sortKey="Van Den Brand, J M" uniqKey="Van Den Brand J">J.M. van den Brand</name>
</author>
<author><name sortKey="Raj, V S" uniqKey="Raj V">V.S. Raj</name>
</author>
<author><name sortKey="Volz, A" uniqKey="Volz A">A. Volz</name>
</author>
<author><name sortKey="Wohlsein, P" uniqKey="Wohlsein P">P. Wohlsein</name>
</author>
<author><name sortKey="Smits, S L" uniqKey="Smits S">S.L. Smits</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Warimwe, G M" uniqKey="Warimwe G">G.M. Warimwe</name>
</author>
<author><name sortKey="Lorenzo, G" uniqKey="Lorenzo G">G. Lorenzo</name>
</author>
<author><name sortKey="Lopez Gil, E" uniqKey="Lopez Gil E">E. Lopez-Gil</name>
</author>
<author><name sortKey="Reyes Sandoval, A" uniqKey="Reyes Sandoval A">A. Reyes-Sandoval</name>
</author>
<author><name sortKey="Cottingham, M G" uniqKey="Cottingham M">M.G. Cottingham</name>
</author>
<author><name sortKey="Spencer, A J" uniqKey="Spencer A">A.J. Spencer</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wang, W" uniqKey="Wang W">W. Wang</name>
</author>
<author><name sortKey="Wang, H" uniqKey="Wang H">H. Wang</name>
</author>
<author><name sortKey="Deng, Y" uniqKey="Deng Y">Y. Deng</name>
</author>
<author><name sortKey="Song, T" uniqKey="Song T">T. Song</name>
</author>
<author><name sortKey="Lan, J" uniqKey="Lan J">J. Lan</name>
</author>
<author><name sortKey="Wu, G" uniqKey="Wu G">G. Wu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Min, C K" uniqKey="Min C">C.K. Min</name>
</author>
<author><name sortKey="Cheon, S" uniqKey="Cheon S">S. Cheon</name>
</author>
<author><name sortKey="Ha, N Y" uniqKey="Ha N">N.Y. Ha</name>
</author>
<author><name sortKey="Sohn, K M" uniqKey="Sohn K">K.M. Sohn</name>
</author>
<author><name sortKey="Kim, Y" uniqKey="Kim Y">Y. Kim</name>
</author>
<author><name sortKey="Aigerim, A" uniqKey="Aigerim A">A. Aigerim</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Park, W B" uniqKey="Park W">W.B. Park</name>
</author>
<author><name sortKey="Perera, R A" uniqKey="Perera R">R.A. Perera</name>
</author>
<author><name sortKey="Choe, P G" uniqKey="Choe P">P.G. Choe</name>
</author>
<author><name sortKey="Lau, E H" uniqKey="Lau E">E.H. Lau</name>
</author>
<author><name sortKey="Choi, S J" uniqKey="Choi S">S.J. Choi</name>
</author>
<author><name sortKey="Chun, J Y" uniqKey="Chun J">J.Y. Chun</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Corman, V M" uniqKey="Corman V">V.M. Corman</name>
</author>
<author><name sortKey="Albarrak, A M" uniqKey="Albarrak A">A.M. Albarrak</name>
</author>
<author><name sortKey="Omrani, A S" uniqKey="Omrani A">A.S. Omrani</name>
</author>
<author><name sortKey="Albarrak, M M" uniqKey="Albarrak M">M.M. Albarrak</name>
</author>
<author><name sortKey="Farah, M E" uniqKey="Farah M">M.E. Farah</name>
</author>
<author><name sortKey="Almasri, M" uniqKey="Almasri M">M. Almasri</name>
</author>
</analytic>
</biblStruct>
</listBibl>
</div1>
</back>
</TEI>
<double pmid="28579232"><pmc><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">ChAdOx1 and MVA based vaccine candidates against MERS-CoV elicit neutralising antibodies and cellular immune responses in mice</title>
<author><name sortKey="Alharbi, Naif Khalaf" sort="Alharbi, Naif Khalaf" uniqKey="Alharbi N" first="Naif Khalaf" last="Alharbi">Naif Khalaf Alharbi</name>
<affiliation wicri:level="4"><nlm:aff id="af005">The Jenner Institute, University of Oxford, Oxford OX3 7DQ, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>The Jenner Institute, University of Oxford, Oxford OX3 7DQ</wicri:regionArea>
<orgName type="university">Université d'Oxford</orgName>
<placeName><settlement type="city">Oxford</settlement>
<region type="nation">Angleterre</region>
<region type="région" nuts="1">Oxfordshire</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af010">King Abdullah International Medical Research Center, Riyadh, Saudi Arabia</nlm:aff>
<country xml:lang="fr">Arabie saoudite</country>
<wicri:regionArea>King Abdullah International Medical Research Center, Riyadh</wicri:regionArea>
<wicri:noRegion>Riyadh</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Padron Regalado, Eriko" sort="Padron Regalado, Eriko" uniqKey="Padron Regalado E" first="Eriko" last="Padron-Regalado">Eriko Padron-Regalado</name>
<affiliation wicri:level="4"><nlm:aff id="af005">The Jenner Institute, University of Oxford, Oxford OX3 7DQ, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>The Jenner Institute, University of Oxford, Oxford OX3 7DQ</wicri:regionArea>
<orgName type="university">Université d'Oxford</orgName>
<placeName><settlement type="city">Oxford</settlement>
<region type="nation">Angleterre</region>
<region type="région" nuts="1">Oxfordshire</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Thompson, Craig P" sort="Thompson, Craig P" uniqKey="Thompson C" first="Craig P." last="Thompson">Craig P. Thompson</name>
<affiliation wicri:level="4"><nlm:aff id="af005">The Jenner Institute, University of Oxford, Oxford OX3 7DQ, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>The Jenner Institute, University of Oxford, Oxford OX3 7DQ</wicri:regionArea>
<orgName type="university">Université d'Oxford</orgName>
<placeName><settlement type="city">Oxford</settlement>
<region type="nation">Angleterre</region>
<region type="région" nuts="1">Oxfordshire</region>
</placeName>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="af015">Department of Zoology, University of Oxford, Oxford, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Zoology, University of Oxford, Oxford</wicri:regionArea>
<placeName><settlement type="city">Oxford</settlement>
<region type="country">Angleterre</region>
<region type="comté" nuts="2">Oxfordshire</region>
</placeName>
<orgName type="university">Université d'Oxford</orgName>
</affiliation>
</author>
<author><name sortKey="Kupke, Alexandra" sort="Kupke, Alexandra" uniqKey="Kupke A" first="Alexandra" last="Kupke">Alexandra Kupke</name>
<affiliation wicri:level="3"><nlm:aff id="af020">Institute of Virology, Philipps University of Marburg, Marburg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Virology, Philipps University of Marburg, Marburg</wicri:regionArea>
<placeName><region type="land" nuts="1">Hesse (Land)</region>
<region type="district" nuts="2">District de Giessen</region>
<settlement type="city">Marbourg</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af025">German Center for Infection Research, TTU Emerging Infections, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>German Center for Infection Research, TTU Emerging Infections</wicri:regionArea>
<wicri:noRegion>TTU Emerging Infections</wicri:noRegion>
<wicri:noRegion>TTU Emerging Infections</wicri:noRegion>
<wicri:noRegion>TTU Emerging Infections</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Wells, Daniel" sort="Wells, Daniel" uniqKey="Wells D" first="Daniel" last="Wells">Daniel Wells</name>
<affiliation wicri:level="4"><nlm:aff id="af005">The Jenner Institute, University of Oxford, Oxford OX3 7DQ, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>The Jenner Institute, University of Oxford, Oxford OX3 7DQ</wicri:regionArea>
<orgName type="university">Université d'Oxford</orgName>
<placeName><settlement type="city">Oxford</settlement>
<region type="nation">Angleterre</region>
<region type="région" nuts="1">Oxfordshire</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Sloan, Megan A" sort="Sloan, Megan A" uniqKey="Sloan M" first="Megan A." last="Sloan">Megan A. Sloan</name>
<affiliation wicri:level="4"><nlm:aff id="af005">The Jenner Institute, University of Oxford, Oxford OX3 7DQ, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>The Jenner Institute, University of Oxford, Oxford OX3 7DQ</wicri:regionArea>
<orgName type="university">Université d'Oxford</orgName>
<placeName><settlement type="city">Oxford</settlement>
<region type="nation">Angleterre</region>
<region type="région" nuts="1">Oxfordshire</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Grehan, Keith" sort="Grehan, Keith" uniqKey="Grehan K" first="Keith" last="Grehan">Keith Grehan</name>
<affiliation wicri:level="1"><nlm:aff id="af030">Viral Pseudotype Unit, School of Pharmacy, University of Kent, Chatham Maritime, Kent ME4 4TB, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Viral Pseudotype Unit, School of Pharmacy, University of Kent, Chatham Maritime, Kent ME4 4TB</wicri:regionArea>
<wicri:noRegion>Kent ME4 4TB</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Temperton, Nigel" sort="Temperton, Nigel" uniqKey="Temperton N" first="Nigel" last="Temperton">Nigel Temperton</name>
<affiliation wicri:level="1"><nlm:aff id="af030">Viral Pseudotype Unit, School of Pharmacy, University of Kent, Chatham Maritime, Kent ME4 4TB, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Viral Pseudotype Unit, School of Pharmacy, University of Kent, Chatham Maritime, Kent ME4 4TB</wicri:regionArea>
<wicri:noRegion>Kent ME4 4TB</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lambe, Teresa" sort="Lambe, Teresa" uniqKey="Lambe T" first="Teresa" last="Lambe">Teresa Lambe</name>
<affiliation wicri:level="4"><nlm:aff id="af005">The Jenner Institute, University of Oxford, Oxford OX3 7DQ, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>The Jenner Institute, University of Oxford, Oxford OX3 7DQ</wicri:regionArea>
<orgName type="university">Université d'Oxford</orgName>
<placeName><settlement type="city">Oxford</settlement>
<region type="nation">Angleterre</region>
<region type="région" nuts="1">Oxfordshire</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Warimwe, George" sort="Warimwe, George" uniqKey="Warimwe G" first="George" last="Warimwe">George Warimwe</name>
<affiliation wicri:level="4"><nlm:aff id="af005">The Jenner Institute, University of Oxford, Oxford OX3 7DQ, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>The Jenner Institute, University of Oxford, Oxford OX3 7DQ</wicri:regionArea>
<orgName type="university">Université d'Oxford</orgName>
<placeName><settlement type="city">Oxford</settlement>
<region type="nation">Angleterre</region>
<region type="région" nuts="1">Oxfordshire</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Becker, Stephan" sort="Becker, Stephan" uniqKey="Becker S" first="Stephan" last="Becker">Stephan Becker</name>
<affiliation wicri:level="3"><nlm:aff id="af020">Institute of Virology, Philipps University of Marburg, Marburg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Virology, Philipps University of Marburg, Marburg</wicri:regionArea>
<placeName><region type="land" nuts="1">Hesse (Land)</region>
<region type="district" nuts="2">District de Giessen</region>
<settlement type="city">Marbourg</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af025">German Center for Infection Research, TTU Emerging Infections, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>German Center for Infection Research, TTU Emerging Infections</wicri:regionArea>
<wicri:noRegion>TTU Emerging Infections</wicri:noRegion>
<wicri:noRegion>TTU Emerging Infections</wicri:noRegion>
<wicri:noRegion>TTU Emerging Infections</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hill, Adrian V S" sort="Hill, Adrian V S" uniqKey="Hill A" first="Adrian V. S." last="Hill">Adrian V. S. Hill</name>
<affiliation wicri:level="4"><nlm:aff id="af005">The Jenner Institute, University of Oxford, Oxford OX3 7DQ, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>The Jenner Institute, University of Oxford, Oxford OX3 7DQ</wicri:regionArea>
<orgName type="university">Université d'Oxford</orgName>
<placeName><settlement type="city">Oxford</settlement>
<region type="nation">Angleterre</region>
<region type="région" nuts="1">Oxfordshire</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Gilbert, Sarah C" sort="Gilbert, Sarah C" uniqKey="Gilbert S" first="Sarah C." last="Gilbert">Sarah C. Gilbert</name>
<affiliation wicri:level="4"><nlm:aff id="af005">The Jenner Institute, University of Oxford, Oxford OX3 7DQ, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>The Jenner Institute, University of Oxford, Oxford OX3 7DQ</wicri:regionArea>
<orgName type="university">Université d'Oxford</orgName>
<placeName><settlement type="city">Oxford</settlement>
<region type="nation">Angleterre</region>
<region type="région" nuts="1">Oxfordshire</region>
</placeName>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">28579232</idno>
<idno type="pmc">5516308</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5516308</idno>
<idno type="RBID">PMC:5516308</idno>
<idno type="doi">10.1016/j.vaccine.2017.05.032</idno>
<date when="2017">2017</date>
<idno type="wicri:Area/Pmc/Corpus">001174</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001174</idno>
<idno type="wicri:Area/Pmc/Curation">001174</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">001174</idno>
<idno type="wicri:Area/Pmc/Checkpoint">000914</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000914</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">ChAdOx1 and MVA based vaccine candidates against MERS-CoV elicit neutralising antibodies and cellular immune responses in mice</title>
<author><name sortKey="Alharbi, Naif Khalaf" sort="Alharbi, Naif Khalaf" uniqKey="Alharbi N" first="Naif Khalaf" last="Alharbi">Naif Khalaf Alharbi</name>
<affiliation wicri:level="4"><nlm:aff id="af005">The Jenner Institute, University of Oxford, Oxford OX3 7DQ, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>The Jenner Institute, University of Oxford, Oxford OX3 7DQ</wicri:regionArea>
<orgName type="university">Université d'Oxford</orgName>
<placeName><settlement type="city">Oxford</settlement>
<region type="nation">Angleterre</region>
<region type="région" nuts="1">Oxfordshire</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af010">King Abdullah International Medical Research Center, Riyadh, Saudi Arabia</nlm:aff>
<country xml:lang="fr">Arabie saoudite</country>
<wicri:regionArea>King Abdullah International Medical Research Center, Riyadh</wicri:regionArea>
<wicri:noRegion>Riyadh</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Padron Regalado, Eriko" sort="Padron Regalado, Eriko" uniqKey="Padron Regalado E" first="Eriko" last="Padron-Regalado">Eriko Padron-Regalado</name>
<affiliation wicri:level="4"><nlm:aff id="af005">The Jenner Institute, University of Oxford, Oxford OX3 7DQ, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>The Jenner Institute, University of Oxford, Oxford OX3 7DQ</wicri:regionArea>
<orgName type="university">Université d'Oxford</orgName>
<placeName><settlement type="city">Oxford</settlement>
<region type="nation">Angleterre</region>
<region type="région" nuts="1">Oxfordshire</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Thompson, Craig P" sort="Thompson, Craig P" uniqKey="Thompson C" first="Craig P." last="Thompson">Craig P. Thompson</name>
<affiliation wicri:level="4"><nlm:aff id="af005">The Jenner Institute, University of Oxford, Oxford OX3 7DQ, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>The Jenner Institute, University of Oxford, Oxford OX3 7DQ</wicri:regionArea>
<orgName type="university">Université d'Oxford</orgName>
<placeName><settlement type="city">Oxford</settlement>
<region type="nation">Angleterre</region>
<region type="région" nuts="1">Oxfordshire</region>
</placeName>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="af015">Department of Zoology, University of Oxford, Oxford, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Zoology, University of Oxford, Oxford</wicri:regionArea>
<placeName><settlement type="city">Oxford</settlement>
<region type="country">Angleterre</region>
<region type="comté" nuts="2">Oxfordshire</region>
</placeName>
<orgName type="university">Université d'Oxford</orgName>
</affiliation>
</author>
<author><name sortKey="Kupke, Alexandra" sort="Kupke, Alexandra" uniqKey="Kupke A" first="Alexandra" last="Kupke">Alexandra Kupke</name>
<affiliation wicri:level="3"><nlm:aff id="af020">Institute of Virology, Philipps University of Marburg, Marburg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Virology, Philipps University of Marburg, Marburg</wicri:regionArea>
<placeName><region type="land" nuts="1">Hesse (Land)</region>
<region type="district" nuts="2">District de Giessen</region>
<settlement type="city">Marbourg</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af025">German Center for Infection Research, TTU Emerging Infections, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>German Center for Infection Research, TTU Emerging Infections</wicri:regionArea>
<wicri:noRegion>TTU Emerging Infections</wicri:noRegion>
<wicri:noRegion>TTU Emerging Infections</wicri:noRegion>
<wicri:noRegion>TTU Emerging Infections</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Wells, Daniel" sort="Wells, Daniel" uniqKey="Wells D" first="Daniel" last="Wells">Daniel Wells</name>
<affiliation wicri:level="4"><nlm:aff id="af005">The Jenner Institute, University of Oxford, Oxford OX3 7DQ, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>The Jenner Institute, University of Oxford, Oxford OX3 7DQ</wicri:regionArea>
<orgName type="university">Université d'Oxford</orgName>
<placeName><settlement type="city">Oxford</settlement>
<region type="nation">Angleterre</region>
<region type="région" nuts="1">Oxfordshire</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Sloan, Megan A" sort="Sloan, Megan A" uniqKey="Sloan M" first="Megan A." last="Sloan">Megan A. Sloan</name>
<affiliation wicri:level="4"><nlm:aff id="af005">The Jenner Institute, University of Oxford, Oxford OX3 7DQ, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>The Jenner Institute, University of Oxford, Oxford OX3 7DQ</wicri:regionArea>
<orgName type="university">Université d'Oxford</orgName>
<placeName><settlement type="city">Oxford</settlement>
<region type="nation">Angleterre</region>
<region type="région" nuts="1">Oxfordshire</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Grehan, Keith" sort="Grehan, Keith" uniqKey="Grehan K" first="Keith" last="Grehan">Keith Grehan</name>
<affiliation wicri:level="1"><nlm:aff id="af030">Viral Pseudotype Unit, School of Pharmacy, University of Kent, Chatham Maritime, Kent ME4 4TB, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Viral Pseudotype Unit, School of Pharmacy, University of Kent, Chatham Maritime, Kent ME4 4TB</wicri:regionArea>
<wicri:noRegion>Kent ME4 4TB</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Temperton, Nigel" sort="Temperton, Nigel" uniqKey="Temperton N" first="Nigel" last="Temperton">Nigel Temperton</name>
<affiliation wicri:level="1"><nlm:aff id="af030">Viral Pseudotype Unit, School of Pharmacy, University of Kent, Chatham Maritime, Kent ME4 4TB, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Viral Pseudotype Unit, School of Pharmacy, University of Kent, Chatham Maritime, Kent ME4 4TB</wicri:regionArea>
<wicri:noRegion>Kent ME4 4TB</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lambe, Teresa" sort="Lambe, Teresa" uniqKey="Lambe T" first="Teresa" last="Lambe">Teresa Lambe</name>
<affiliation wicri:level="4"><nlm:aff id="af005">The Jenner Institute, University of Oxford, Oxford OX3 7DQ, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>The Jenner Institute, University of Oxford, Oxford OX3 7DQ</wicri:regionArea>
<orgName type="university">Université d'Oxford</orgName>
<placeName><settlement type="city">Oxford</settlement>
<region type="nation">Angleterre</region>
<region type="région" nuts="1">Oxfordshire</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Warimwe, George" sort="Warimwe, George" uniqKey="Warimwe G" first="George" last="Warimwe">George Warimwe</name>
<affiliation wicri:level="4"><nlm:aff id="af005">The Jenner Institute, University of Oxford, Oxford OX3 7DQ, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>The Jenner Institute, University of Oxford, Oxford OX3 7DQ</wicri:regionArea>
<orgName type="university">Université d'Oxford</orgName>
<placeName><settlement type="city">Oxford</settlement>
<region type="nation">Angleterre</region>
<region type="région" nuts="1">Oxfordshire</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Becker, Stephan" sort="Becker, Stephan" uniqKey="Becker S" first="Stephan" last="Becker">Stephan Becker</name>
<affiliation wicri:level="3"><nlm:aff id="af020">Institute of Virology, Philipps University of Marburg, Marburg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Virology, Philipps University of Marburg, Marburg</wicri:regionArea>
<placeName><region type="land" nuts="1">Hesse (Land)</region>
<region type="district" nuts="2">District de Giessen</region>
<settlement type="city">Marbourg</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af025">German Center for Infection Research, TTU Emerging Infections, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>German Center for Infection Research, TTU Emerging Infections</wicri:regionArea>
<wicri:noRegion>TTU Emerging Infections</wicri:noRegion>
<wicri:noRegion>TTU Emerging Infections</wicri:noRegion>
<wicri:noRegion>TTU Emerging Infections</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hill, Adrian V S" sort="Hill, Adrian V S" uniqKey="Hill A" first="Adrian V. S." last="Hill">Adrian V. S. Hill</name>
<affiliation wicri:level="4"><nlm:aff id="af005">The Jenner Institute, University of Oxford, Oxford OX3 7DQ, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>The Jenner Institute, University of Oxford, Oxford OX3 7DQ</wicri:regionArea>
<orgName type="university">Université d'Oxford</orgName>
<placeName><settlement type="city">Oxford</settlement>
<region type="nation">Angleterre</region>
<region type="région" nuts="1">Oxfordshire</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Gilbert, Sarah C" sort="Gilbert, Sarah C" uniqKey="Gilbert S" first="Sarah C." last="Gilbert">Sarah C. Gilbert</name>
<affiliation wicri:level="4"><nlm:aff id="af005">The Jenner Institute, University of Oxford, Oxford OX3 7DQ, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>The Jenner Institute, University of Oxford, Oxford OX3 7DQ</wicri:regionArea>
<orgName type="university">Université d'Oxford</orgName>
<placeName><settlement type="city">Oxford</settlement>
<region type="nation">Angleterre</region>
<region type="région" nuts="1">Oxfordshire</region>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">Vaccine</title>
<idno type="ISSN">0264-410X</idno>
<idno type="eISSN">1873-2518</idno>
<imprint><date when="2017">2017</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><title>Highlights</title>
<p><list list-type="simple" id="l0005"><list-item id="o0005"><label>•</label>
<p id="p0005">Inserting tPA leader sequence enhanced humoral responses of ChAdOx1 MERS.</p>
</list-item>
<list-item id="o0010"><label>•</label>
<p id="p0010">ChAdOx1 MERS elicited cellular immunity and neutralising antibodies.</p>
</list-item>
<list-item id="o0015"><label>•</label>
<p id="p0015">ChAdOx1 MERS responses were boosted by MVA MERS.</p>
</list-item>
<list-item id="o0020"><label>•</label>
<p id="p0020">Immunogenicity of a single dose of ChAdOx1 MERS was equivalent to 2 doses of MVA MERS.</p>
</list-item>
<list-item id="o0025"><label>•</label>
<p id="p0025">In MVA, F11 promoter enhanced cellular, but not humoral, immunogenicity, comparing to mH5 promoter.</p>
</list-item>
</list>
</p>
</div>
</front>
<back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Zaki, A M" uniqKey="Zaki A">A.M. Zaki</name>
</author>
<author><name sortKey="Van Boheemen, S" uniqKey="Van Boheemen S">S. van Boheemen</name>
</author>
<author><name sortKey="Bestebroer, T M" uniqKey="Bestebroer T">T.M. Bestebroer</name>
</author>
<author><name sortKey="Osterhaus, A D" uniqKey="Osterhaus A">A.D. Osterhaus</name>
</author>
<author><name sortKey="Fouchier, R A" uniqKey="Fouchier R">R.A. Fouchier</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Lessler, J" uniqKey="Lessler J">J. Lessler</name>
</author>
<author><name sortKey="Salje, H" uniqKey="Salje H">H. Salje</name>
</author>
<author><name sortKey="Van Kerkhove, M D" uniqKey="Van Kerkhove M">M.D. Van Kerkhove</name>
</author>
<author><name sortKey="Ferguson, N M" uniqKey="Ferguson N">N.M. Ferguson</name>
</author>
<author><name sortKey="Cauchemez, S" uniqKey="Cauchemez S">S. Cauchemez</name>
</author>
<author><name sortKey="Rodriquez Barraquer, I" uniqKey="Rodriquez Barraquer I">I. Rodriquez-Barraquer</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Al Hammadi, Z M" uniqKey="Al Hammadi Z">Z.M. Al Hammadi</name>
</author>
<author><name sortKey="Chu, D K" uniqKey="Chu D">D.K. Chu</name>
</author>
<author><name sortKey="Eltahir, Y M" uniqKey="Eltahir Y">Y.M. Eltahir</name>
</author>
<author><name sortKey="Al Hosani, F" uniqKey="Al Hosani F">F. Al Hosani</name>
</author>
<author><name sortKey="Al Mulla, M" uniqKey="Al Mulla M">M. Al Mulla</name>
</author>
<author><name sortKey="Tarnini, W" uniqKey="Tarnini W">W. Tarnini</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Oboho, I K" uniqKey="Oboho I">I.K. Oboho</name>
</author>
<author><name sortKey="Tomczyk, S M" uniqKey="Tomczyk S">S.M. Tomczyk</name>
</author>
<author><name sortKey="Al Asmari, A M" uniqKey="Al Asmari A">A.M. Al-Asmari</name>
</author>
<author><name sortKey="Banjar, A A" uniqKey="Banjar A">A.A. Banjar</name>
</author>
<author><name sortKey="Al Mugti, H" uniqKey="Al Mugti H">H. Al-Mugti</name>
</author>
<author><name sortKey="Aloraini, M S" uniqKey="Aloraini M">M.S. Aloraini</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Memish, Z A" uniqKey="Memish Z">Z.A. Memish</name>
</author>
<author><name sortKey="Zumla, A I" uniqKey="Zumla A">A.I. Zumla</name>
</author>
<author><name sortKey="Assiri, A" uniqKey="Assiri A">A. Assiri</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Muller, M A" uniqKey="Muller M">M.A. Muller</name>
</author>
<author><name sortKey="Corman, V M" uniqKey="Corman V">V.M. Corman</name>
</author>
<author><name sortKey="Jores, J" uniqKey="Jores J">J. Jores</name>
</author>
<author><name sortKey="Meyer, B" uniqKey="Meyer B">B. Meyer</name>
</author>
<author><name sortKey="Younan, M" uniqKey="Younan M">M. Younan</name>
</author>
<author><name sortKey="Liljander, A" uniqKey="Liljander A">A. Liljander</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Hemida, M G" uniqKey="Hemida M">M.G. Hemida</name>
</author>
<author><name sortKey="Perera, R A" uniqKey="Perera R">R.A. Perera</name>
</author>
<author><name sortKey="Al Jassim, R A" uniqKey="Al Jassim R">R.A. Al Jassim</name>
</author>
<author><name sortKey="Kayali, G" uniqKey="Kayali G">G. Kayali</name>
</author>
<author><name sortKey="Siu, L Y" uniqKey="Siu L">L.Y. Siu</name>
</author>
<author><name sortKey="Wang, P" uniqKey="Wang P">P. Wang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gutierrez, C" uniqKey="Gutierrez C">C. Gutierrez</name>
</author>
<author><name sortKey="Tejedor Junco, M T" uniqKey="Tejedor Junco M">M.T. Tejedor-Junco</name>
</author>
<author><name sortKey="Gonzalez, M" uniqKey="Gonzalez M">M. Gonzalez</name>
</author>
<author><name sortKey="Lattwein, E" uniqKey="Lattwein E">E. Lattwein</name>
</author>
<author><name sortKey="Renneker, S" uniqKey="Renneker S">S. Renneker</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ali, M A" uniqKey="Ali M">M.A. Ali</name>
</author>
<author><name sortKey="Shehata, M M" uniqKey="Shehata M">M.M. Shehata</name>
</author>
<author><name sortKey="Gomaa, M R" uniqKey="Gomaa M">M.R. Gomaa</name>
</author>
<author><name sortKey="Kandeil, A" uniqKey="Kandeil A">A. Kandeil</name>
</author>
<author><name sortKey="El Shesheny, R" uniqKey="El Shesheny R">R. El-Shesheny</name>
</author>
<author><name sortKey="Kayed, A S" uniqKey="Kayed A">A.S. Kayed</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Van Doremalen, N" uniqKey="Van Doremalen N">N. van Doremalen</name>
</author>
<author><name sortKey="Hijazeen, Z S" uniqKey="Hijazeen Z">Z.S. Hijazeen</name>
</author>
<author><name sortKey="Holloway, P" uniqKey="Holloway P">P. Holloway</name>
</author>
<author><name sortKey="Al Omari, B" uniqKey="Al Omari B">B. Al Omari</name>
</author>
<author><name sortKey="Mcdowell, C" uniqKey="Mcdowell C">C. McDowell</name>
</author>
<author><name sortKey="Adney, D" uniqKey="Adney D">D. Adney</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Alraddadi, B M" uniqKey="Alraddadi B">B.M. Alraddadi</name>
</author>
<author><name sortKey="Watson, J T" uniqKey="Watson J">J.T. Watson</name>
</author>
<author><name sortKey="Almarashi, A" uniqKey="Almarashi A">A. Almarashi</name>
</author>
<author><name sortKey="Abedi, G R" uniqKey="Abedi G">G.R. Abedi</name>
</author>
<author><name sortKey="Turkistani, A" uniqKey="Turkistani A">A. Turkistani</name>
</author>
<author><name sortKey="Sadran, M" uniqKey="Sadran M">M. Sadran</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gossner, C" uniqKey="Gossner C">C. Gossner</name>
</author>
<author><name sortKey="Danielson, N" uniqKey="Danielson N">N. Danielson</name>
</author>
<author><name sortKey="Gervelmeyer, A" uniqKey="Gervelmeyer A">A. Gervelmeyer</name>
</author>
<author><name sortKey="Berthe, F" uniqKey="Berthe F">F. Berthe</name>
</author>
<author><name sortKey="Faye, B" uniqKey="Faye B">B. Faye</name>
</author>
<author><name sortKey="Kaasik Aaslav, K" uniqKey="Kaasik Aaslav K">K. Kaasik Aaslav</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Funk, A L" uniqKey="Funk A">A.L. Funk</name>
</author>
<author><name sortKey="Goutard, F L" uniqKey="Goutard F">F.L. Goutard</name>
</author>
<author><name sortKey="Miguel, E" uniqKey="Miguel E">E. Miguel</name>
</author>
<author><name sortKey="Bourgarel, M" uniqKey="Bourgarel M">M. Bourgarel</name>
</author>
<author><name sortKey="Chevalier, V" uniqKey="Chevalier V">V. Chevalier</name>
</author>
<author><name sortKey="Faye, B" uniqKey="Faye B">B. Faye</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Reusken, C B" uniqKey="Reusken C">C.B. Reusken</name>
</author>
<author><name sortKey="Ababneh, M" uniqKey="Ababneh M">M. Ababneh</name>
</author>
<author><name sortKey="Raj, V S" uniqKey="Raj V">V.S. Raj</name>
</author>
<author><name sortKey="Meyer, B" uniqKey="Meyer B">B. Meyer</name>
</author>
<author><name sortKey="Eljarah, A" uniqKey="Eljarah A">A. Eljarah</name>
</author>
<author><name sortKey="Abutarbush, S" uniqKey="Abutarbush S">S. Abutarbush</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hemida, M G" uniqKey="Hemida M">M.G. Hemida</name>
</author>
<author><name sortKey="Perera, R A" uniqKey="Perera R">R.A. Perera</name>
</author>
<author><name sortKey="Wang, P" uniqKey="Wang P">P. Wang</name>
</author>
<author><name sortKey="Alhammadi, M A" uniqKey="Alhammadi M">M.A. Alhammadi</name>
</author>
<author><name sortKey="Siu, L Y" uniqKey="Siu L">L.Y. Siu</name>
</author>
<author><name sortKey="Li, M" uniqKey="Li M">M. Li</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Alagaili, A N" uniqKey="Alagaili A">A.N. Alagaili</name>
</author>
<author><name sortKey="Briese, T" uniqKey="Briese T">T. Briese</name>
</author>
<author><name sortKey="Mishra, N" uniqKey="Mishra N">N. Mishra</name>
</author>
<author><name sortKey="Kapoor, V" uniqKey="Kapoor V">V. Kapoor</name>
</author>
<author><name sortKey="Sameroff, S C" uniqKey="Sameroff S">S.C. Sameroff</name>
</author>
<author><name sortKey="Burbelo, P D" uniqKey="Burbelo P">P.D. Burbelo</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Reusken, C B" uniqKey="Reusken C">C.B. Reusken</name>
</author>
<author><name sortKey="Haagmans, B L" uniqKey="Haagmans B">B.L. Haagmans</name>
</author>
<author><name sortKey="Muller, M A" uniqKey="Muller M">M.A. Muller</name>
</author>
<author><name sortKey="Gutierrez, C" uniqKey="Gutierrez C">C. Gutierrez</name>
</author>
<author><name sortKey="Godeke, G J" uniqKey="Godeke G">G.J. Godeke</name>
</author>
<author><name sortKey="Meyer, B" uniqKey="Meyer B">B. Meyer</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Vergara Alert, J" uniqKey="Vergara Alert J">J. Vergara-Alert</name>
</author>
<author><name sortKey="Van Den Brand, J M" uniqKey="Van Den Brand J">J.M. van den Brand</name>
</author>
<author><name sortKey="Widagdo, W" uniqKey="Widagdo W">W. Widagdo</name>
</author>
<author><name sortKey="Mt, Munoz" uniqKey="Mt M">Munoz Mt</name>
</author>
<author><name sortKey="Raj, S" uniqKey="Raj S">S. Raj</name>
</author>
<author><name sortKey="Schipper, D" uniqKey="Schipper D">D. Schipper</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Adney, D R" uniqKey="Adney D">D.R. Adney</name>
</author>
<author><name sortKey="Brown, V R" uniqKey="Brown V">V.R. Brown</name>
</author>
<author><name sortKey="Porter, S M" uniqKey="Porter S">S.M. Porter</name>
</author>
<author><name sortKey="Bielefeldt Ohmann, H" uniqKey="Bielefeldt Ohmann H">H. Bielefeldt-Ohmann</name>
</author>
<author><name sortKey="Hartwig, A E" uniqKey="Hartwig A">A.E. Hartwig</name>
</author>
<author><name sortKey="Bowen, R A" uniqKey="Bowen R">R.A. Bowen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Alharbi, N K" uniqKey="Alharbi N">N.K. Alharbi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Draper, S J" uniqKey="Draper S">S.J. Draper</name>
</author>
<author><name sortKey="Heeney, J L" uniqKey="Heeney J">J.L. Heeney</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Tao, D" uniqKey="Tao D">D. Tao</name>
</author>
<author><name sortKey="Barba Spaeth, G" uniqKey="Barba Spaeth G">G. Barba-Spaeth</name>
</author>
<author><name sortKey="Rai, U" uniqKey="Rai U">U. Rai</name>
</author>
<author><name sortKey="Nussenzweig, V" uniqKey="Nussenzweig V">V. Nussenzweig</name>
</author>
<author><name sortKey="Rice, C M" uniqKey="Rice C">C.M. Rice</name>
</author>
<author><name sortKey="Nussenzweig, R S" uniqKey="Nussenzweig R">R.S. Nussenzweig</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Dicks, M D" uniqKey="Dicks M">M.D. Dicks</name>
</author>
<author><name sortKey="Spencer, A J" uniqKey="Spencer A">A.J. Spencer</name>
</author>
<author><name sortKey="Edwards, N J" uniqKey="Edwards N">N.J. Edwards</name>
</author>
<author><name sortKey="Wadell, G" uniqKey="Wadell G">G. Wadell</name>
</author>
<author><name sortKey="Bojang, K" uniqKey="Bojang K">K. Bojang</name>
</author>
<author><name sortKey="Gilbert, S C" uniqKey="Gilbert S">S.C. Gilbert</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gomez, C E" uniqKey="Gomez C">C.E. Gomez</name>
</author>
<author><name sortKey="Perdiguero, B" uniqKey="Perdiguero B">B. Perdiguero</name>
</author>
<author><name sortKey="Garcia Arriaza, J" uniqKey="Garcia Arriaza J">J. Garcia-Arriaza</name>
</author>
<author><name sortKey="Esteban, M" uniqKey="Esteban M">M. Esteban</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gilbert, S C" uniqKey="Gilbert S">S.C. Gilbert</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Luo, M" uniqKey="Luo M">M. Luo</name>
</author>
<author><name sortKey="Tao, P" uniqKey="Tao P">P. Tao</name>
</author>
<author><name sortKey="Li, J" uniqKey="Li J">J. Li</name>
</author>
<author><name sortKey="Zhou, S" uniqKey="Zhou S">S. Zhou</name>
</author>
<author><name sortKey="Guo, D" uniqKey="Guo D">D. Guo</name>
</author>
<author><name sortKey="Pan, Z" uniqKey="Pan Z">Z. Pan</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wallace, A" uniqKey="Wallace A">A. Wallace</name>
</author>
<author><name sortKey="West, K" uniqKey="West K">K. West</name>
</author>
<author><name sortKey="Rothman, A L" uniqKey="Rothman A">A.L. Rothman</name>
</author>
<author><name sortKey="Ennis, F A" uniqKey="Ennis F">F.A. Ennis</name>
</author>
<author><name sortKey="Lu, S" uniqKey="Lu S">S. Lu</name>
</author>
<author><name sortKey="Wang, S" uniqKey="Wang S">S. Wang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Alharbi, N K" uniqKey="Alharbi N">N.K. Alharbi</name>
</author>
<author><name sortKey="Spencer, A J" uniqKey="Spencer A">A.J. Spencer</name>
</author>
<author><name sortKey="Salman, A M" uniqKey="Salman A">A.M. Salman</name>
</author>
<author><name sortKey="Tully, C M" uniqKey="Tully C">C.M. Tully</name>
</author>
<author><name sortKey="Chinnakannan, S K" uniqKey="Chinnakannan S">S.K. Chinnakannan</name>
</author>
<author><name sortKey="Lambe, T" uniqKey="Lambe T">T. Lambe</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Warimwe, G M" uniqKey="Warimwe G">G.M. Warimwe</name>
</author>
<author><name sortKey="Gesharisha, J" uniqKey="Gesharisha J">J. Gesharisha</name>
</author>
<author><name sortKey="Carr, B V" uniqKey="Carr B">B.V. Carr</name>
</author>
<author><name sortKey="Otieno, S" uniqKey="Otieno S">S. Otieno</name>
</author>
<author><name sortKey="Otingah, K" uniqKey="Otingah K">K. Otingah</name>
</author>
<author><name sortKey="Wright, D" uniqKey="Wright D">D. Wright</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Antrobus, R D" uniqKey="Antrobus R">R.D. Antrobus</name>
</author>
<author><name sortKey="Coughlan, L" uniqKey="Coughlan L">L. Coughlan</name>
</author>
<author><name sortKey="Berthoud, T K" uniqKey="Berthoud T">T.K. Berthoud</name>
</author>
<author><name sortKey="Dicks, M D" uniqKey="Dicks M">M.D. Dicks</name>
</author>
<author><name sortKey="Hill, A V" uniqKey="Hill A">A.V. Hill</name>
</author>
<author><name sortKey="Lambe, T" uniqKey="Lambe T">T. Lambe</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Cottingham, M G" uniqKey="Cottingham M">M.G. Cottingham</name>
</author>
<author><name sortKey="Carroll, F" uniqKey="Carroll F">F. Carroll</name>
</author>
<author><name sortKey="Morris, S J" uniqKey="Morris S">S.J. Morris</name>
</author>
<author><name sortKey="Turner, A V" uniqKey="Turner A">A.V. Turner</name>
</author>
<author><name sortKey="Vaughan, A M" uniqKey="Vaughan A">A.M. Vaughan</name>
</author>
<author><name sortKey="Kapulu, M C" uniqKey="Kapulu M">M.C. Kapulu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Sridhar, S" uniqKey="Sridhar S">S. Sridhar</name>
</author>
<author><name sortKey="Reyes Sandoval, A" uniqKey="Reyes Sandoval A">A. Reyes-Sandoval</name>
</author>
<author><name sortKey="Draper, S J" uniqKey="Draper S">S.J. Draper</name>
</author>
<author><name sortKey="Moore, A C" uniqKey="Moore A">A.C. Moore</name>
</author>
<author><name sortKey="Gilbert, S C" uniqKey="Gilbert S">S.C. Gilbert</name>
</author>
<author><name sortKey="Gao, G P" uniqKey="Gao G">G.P. Gao</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Cottingham, M G" uniqKey="Cottingham M">M.G. Cottingham</name>
</author>
<author><name sortKey="Andersen, R F" uniqKey="Andersen R">R.F. Andersen</name>
</author>
<author><name sortKey="Spencer, A J" uniqKey="Spencer A">A.J. Spencer</name>
</author>
<author><name sortKey="Saurya, S" uniqKey="Saurya S">S. Saurya</name>
</author>
<author><name sortKey="Furze, J" uniqKey="Furze J">J. Furze</name>
</author>
<author><name sortKey="Hill, A V" uniqKey="Hill A">A.V. Hill</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Volz, A" uniqKey="Volz A">A. Volz</name>
</author>
<author><name sortKey="Kupke, A" uniqKey="Kupke A">A. Kupke</name>
</author>
<author><name sortKey="Song, F" uniqKey="Song F">F. Song</name>
</author>
<author><name sortKey="Jany, S" uniqKey="Jany S">S. Jany</name>
</author>
<author><name sortKey="Fux, R" uniqKey="Fux R">R. Fux</name>
</author>
<author><name sortKey="Shams Eldin, H" uniqKey="Shams Eldin H">H. Shams-Eldin</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Tscharke, D C" uniqKey="Tscharke D">D.C. Tscharke</name>
</author>
<author><name sortKey="Woo, W P" uniqKey="Woo W">W.P. Woo</name>
</author>
<author><name sortKey="Sakala, I G" uniqKey="Sakala I">I.G. Sakala</name>
</author>
<author><name sortKey="Sidney, J" uniqKey="Sidney J">J. Sidney</name>
</author>
<author><name sortKey="Sette, A" uniqKey="Sette A">A. Sette</name>
</author>
<author><name sortKey="Moss, D J" uniqKey="Moss D">D.J. Moss</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Draper, S J" uniqKey="Draper S">S.J. Draper</name>
</author>
<author><name sortKey="Moore, A C" uniqKey="Moore A">A.C. Moore</name>
</author>
<author><name sortKey="Goodman, A L" uniqKey="Goodman A">A.L. Goodman</name>
</author>
<author><name sortKey="Long, C A" uniqKey="Long C">C.A. Long</name>
</author>
<author><name sortKey="Holder, A A" uniqKey="Holder A">A.A. Holder</name>
</author>
<author><name sortKey="Gilbert, S C" uniqKey="Gilbert S">S.C. Gilbert</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Grehan, K" uniqKey="Grehan K">K. Grehan</name>
</author>
<author><name sortKey="Ferrara, F" uniqKey="Ferrara F">F. Ferrara</name>
</author>
<author><name sortKey="Temperton, N" uniqKey="Temperton N">N. Temperton</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Song, F" uniqKey="Song F">F. Song</name>
</author>
<author><name sortKey="Fux, R" uniqKey="Fux R">R. Fux</name>
</author>
<author><name sortKey="Provacia, L B" uniqKey="Provacia L">L.B. Provacia</name>
</author>
<author><name sortKey="Volz, A" uniqKey="Volz A">A. Volz</name>
</author>
<author><name sortKey="Eickmann, M" uniqKey="Eickmann M">M. Eickmann</name>
</author>
<author><name sortKey="Becker, S" uniqKey="Becker S">S. Becker</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Muthumani, K" uniqKey="Muthumani K">K. Muthumani</name>
</author>
<author><name sortKey="Falzarano, D" uniqKey="Falzarano D">D. Falzarano</name>
</author>
<author><name sortKey="Reuschel, E L" uniqKey="Reuschel E">E.L. Reuschel</name>
</author>
<author><name sortKey="Tingey, C" uniqKey="Tingey C">C. Tingey</name>
</author>
<author><name sortKey="Flingai, S" uniqKey="Flingai S">S. Flingai</name>
</author>
<author><name sortKey="Villarreal, D O" uniqKey="Villarreal D">D.O. Villarreal</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lan, J" uniqKey="Lan J">J. Lan</name>
</author>
<author><name sortKey="Yao, Y" uniqKey="Yao Y">Y. Yao</name>
</author>
<author><name sortKey="Deng, Y" uniqKey="Deng Y">Y. Deng</name>
</author>
<author><name sortKey="Chen, H" uniqKey="Chen H">H. Chen</name>
</author>
<author><name sortKey="Lu, G" uniqKey="Lu G">G. Lu</name>
</author>
<author><name sortKey="Wang, W" uniqKey="Wang W">W. Wang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wang, L" uniqKey="Wang L">L. Wang</name>
</author>
<author><name sortKey="Shi, W" uniqKey="Shi W">W. Shi</name>
</author>
<author><name sortKey="Joyce, M G" uniqKey="Joyce M">M.G. Joyce</name>
</author>
<author><name sortKey="Modjarrad, K" uniqKey="Modjarrad K">K. Modjarrad</name>
</author>
<author><name sortKey="Zhang, Y" uniqKey="Zhang Y">Y. Zhang</name>
</author>
<author><name sortKey="Leung, K" uniqKey="Leung K">K. Leung</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Haagmans, B L" uniqKey="Haagmans B">B.L. Haagmans</name>
</author>
<author><name sortKey="Van Den Brand, J M" uniqKey="Van Den Brand J">J.M. van den Brand</name>
</author>
<author><name sortKey="Raj, V S" uniqKey="Raj V">V.S. Raj</name>
</author>
<author><name sortKey="Volz, A" uniqKey="Volz A">A. Volz</name>
</author>
<author><name sortKey="Wohlsein, P" uniqKey="Wohlsein P">P. Wohlsein</name>
</author>
<author><name sortKey="Smits, S L" uniqKey="Smits S">S.L. Smits</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Warimwe, G M" uniqKey="Warimwe G">G.M. Warimwe</name>
</author>
<author><name sortKey="Lorenzo, G" uniqKey="Lorenzo G">G. Lorenzo</name>
</author>
<author><name sortKey="Lopez Gil, E" uniqKey="Lopez Gil E">E. Lopez-Gil</name>
</author>
<author><name sortKey="Reyes Sandoval, A" uniqKey="Reyes Sandoval A">A. Reyes-Sandoval</name>
</author>
<author><name sortKey="Cottingham, M G" uniqKey="Cottingham M">M.G. Cottingham</name>
</author>
<author><name sortKey="Spencer, A J" uniqKey="Spencer A">A.J. Spencer</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wang, W" uniqKey="Wang W">W. Wang</name>
</author>
<author><name sortKey="Wang, H" uniqKey="Wang H">H. Wang</name>
</author>
<author><name sortKey="Deng, Y" uniqKey="Deng Y">Y. Deng</name>
</author>
<author><name sortKey="Song, T" uniqKey="Song T">T. Song</name>
</author>
<author><name sortKey="Lan, J" uniqKey="Lan J">J. Lan</name>
</author>
<author><name sortKey="Wu, G" uniqKey="Wu G">G. Wu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Min, C K" uniqKey="Min C">C.K. Min</name>
</author>
<author><name sortKey="Cheon, S" uniqKey="Cheon S">S. Cheon</name>
</author>
<author><name sortKey="Ha, N Y" uniqKey="Ha N">N.Y. Ha</name>
</author>
<author><name sortKey="Sohn, K M" uniqKey="Sohn K">K.M. Sohn</name>
</author>
<author><name sortKey="Kim, Y" uniqKey="Kim Y">Y. Kim</name>
</author>
<author><name sortKey="Aigerim, A" uniqKey="Aigerim A">A. Aigerim</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Park, W B" uniqKey="Park W">W.B. Park</name>
</author>
<author><name sortKey="Perera, R A" uniqKey="Perera R">R.A. Perera</name>
</author>
<author><name sortKey="Choe, P G" uniqKey="Choe P">P.G. Choe</name>
</author>
<author><name sortKey="Lau, E H" uniqKey="Lau E">E.H. Lau</name>
</author>
<author><name sortKey="Choi, S J" uniqKey="Choi S">S.J. Choi</name>
</author>
<author><name sortKey="Chun, J Y" uniqKey="Chun J">J.Y. Chun</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Corman, V M" uniqKey="Corman V">V.M. Corman</name>
</author>
<author><name sortKey="Albarrak, A M" uniqKey="Albarrak A">A.M. Albarrak</name>
</author>
<author><name sortKey="Omrani, A S" uniqKey="Omrani A">A.S. Omrani</name>
</author>
<author><name sortKey="Albarrak, M M" uniqKey="Albarrak M">M.M. Albarrak</name>
</author>
<author><name sortKey="Farah, M E" uniqKey="Farah M">M.E. Farah</name>
</author>
<author><name sortKey="Almasri, M" uniqKey="Almasri M">M. Almasri</name>
</author>
</analytic>
</biblStruct>
</listBibl>
</div1>
</back>
</TEI>
</pmc>
<pubmed><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">ChAdOx1 and MVA based vaccine candidates against MERS-CoV elicit neutralising antibodies and cellular immune responses in mice.</title>
<author><name sortKey="Alharbi, Naif Khalaf" sort="Alharbi, Naif Khalaf" uniqKey="Alharbi N" first="Naif Khalaf" last="Alharbi">Naif Khalaf Alharbi</name>
<affiliation wicri:level="4"><nlm:affiliation>The Jenner Institute, University of Oxford, Oxford OX3 7DQ, UK; King Abdullah International Medical Research Center, Riyadh, Saudi Arabia. Electronic address: harbina2@ngha.med.sa.</nlm:affiliation>
<country xml:lang="fr">Arabie saoudite</country>
<wicri:regionArea>The Jenner Institute, University of Oxford, Oxford OX3 7DQ, UK; King Abdullah International Medical Research Center, Riyadh</wicri:regionArea>
<orgName type="university">Université d'Oxford</orgName>
<placeName><settlement type="city">Oxford</settlement>
<region type="nation">Angleterre</region>
<region type="région" nuts="1">Oxfordshire</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Padron Regalado, Eriko" sort="Padron Regalado, Eriko" uniqKey="Padron Regalado E" first="Eriko" last="Padron-Regalado">Eriko Padron-Regalado</name>
<affiliation wicri:level="4"><nlm:affiliation>The Jenner Institute, University of Oxford, Oxford OX3 7DQ, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>The Jenner Institute, University of Oxford, Oxford OX3 7DQ</wicri:regionArea>
<orgName type="university">Université d'Oxford</orgName>
<placeName><settlement type="city">Oxford</settlement>
<region type="nation">Angleterre</region>
<region type="région" nuts="1">Oxfordshire</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Thompson, Craig P" sort="Thompson, Craig P" uniqKey="Thompson C" first="Craig P" last="Thompson">Craig P. Thompson</name>
<affiliation wicri:level="4"><nlm:affiliation>The Jenner Institute, University of Oxford, Oxford OX3 7DQ, UK; Department of Zoology, University of Oxford, Oxford, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>The Jenner Institute, University of Oxford, Oxford OX3 7DQ, UK; Department of Zoology, University of Oxford, Oxford</wicri:regionArea>
<placeName><settlement type="city">Oxford</settlement>
<region type="country">Angleterre</region>
<region type="comté" nuts="2">Oxfordshire</region>
</placeName>
<orgName type="university">Université d'Oxford</orgName>
</affiliation>
</author>
<author><name sortKey="Kupke, Alexandra" sort="Kupke, Alexandra" uniqKey="Kupke A" first="Alexandra" last="Kupke">Alexandra Kupke</name>
<affiliation wicri:level="1"><nlm:affiliation>Institute of Virology, Philipps University of Marburg, Marburg, Germany; German Center for Infection Research, TTU Emerging Infections, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Virology, Philipps University of Marburg, Marburg, Germany; German Center for Infection Research, TTU Emerging Infections</wicri:regionArea>
<wicri:noRegion>TTU Emerging Infections</wicri:noRegion>
<wicri:noRegion>TTU Emerging Infections</wicri:noRegion>
<wicri:noRegion>TTU Emerging Infections</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Wells, Daniel" sort="Wells, Daniel" uniqKey="Wells D" first="Daniel" last="Wells">Daniel Wells</name>
<affiliation wicri:level="4"><nlm:affiliation>The Jenner Institute, University of Oxford, Oxford OX3 7DQ, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>The Jenner Institute, University of Oxford, Oxford OX3 7DQ</wicri:regionArea>
<orgName type="university">Université d'Oxford</orgName>
<placeName><settlement type="city">Oxford</settlement>
<region type="nation">Angleterre</region>
<region type="région" nuts="1">Oxfordshire</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Sloan, Megan A" sort="Sloan, Megan A" uniqKey="Sloan M" first="Megan A" last="Sloan">Megan A. Sloan</name>
<affiliation wicri:level="4"><nlm:affiliation>The Jenner Institute, University of Oxford, Oxford OX3 7DQ, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>The Jenner Institute, University of Oxford, Oxford OX3 7DQ</wicri:regionArea>
<orgName type="university">Université d'Oxford</orgName>
<placeName><settlement type="city">Oxford</settlement>
<region type="nation">Angleterre</region>
<region type="région" nuts="1">Oxfordshire</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Grehan, Keith" sort="Grehan, Keith" uniqKey="Grehan K" first="Keith" last="Grehan">Keith Grehan</name>
<affiliation wicri:level="1"><nlm:affiliation>Viral Pseudotype Unit, School of Pharmacy, University of Kent, Chatham Maritime, Kent ME4 4TB, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Viral Pseudotype Unit, School of Pharmacy, University of Kent, Chatham Maritime, Kent ME4 4TB</wicri:regionArea>
<wicri:noRegion>Kent ME4 4TB</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Temperton, Nigel" sort="Temperton, Nigel" uniqKey="Temperton N" first="Nigel" last="Temperton">Nigel Temperton</name>
<affiliation wicri:level="1"><nlm:affiliation>Viral Pseudotype Unit, School of Pharmacy, University of Kent, Chatham Maritime, Kent ME4 4TB, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Viral Pseudotype Unit, School of Pharmacy, University of Kent, Chatham Maritime, Kent ME4 4TB</wicri:regionArea>
<wicri:noRegion>Kent ME4 4TB</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lambe, Teresa" sort="Lambe, Teresa" uniqKey="Lambe T" first="Teresa" last="Lambe">Teresa Lambe</name>
<affiliation wicri:level="4"><nlm:affiliation>The Jenner Institute, University of Oxford, Oxford OX3 7DQ, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>The Jenner Institute, University of Oxford, Oxford OX3 7DQ</wicri:regionArea>
<orgName type="university">Université d'Oxford</orgName>
<placeName><settlement type="city">Oxford</settlement>
<region type="nation">Angleterre</region>
<region type="région" nuts="1">Oxfordshire</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Warimwe, George" sort="Warimwe, George" uniqKey="Warimwe G" first="George" last="Warimwe">George Warimwe</name>
<affiliation wicri:level="4"><nlm:affiliation>The Jenner Institute, University of Oxford, Oxford OX3 7DQ, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>The Jenner Institute, University of Oxford, Oxford OX3 7DQ</wicri:regionArea>
<orgName type="university">Université d'Oxford</orgName>
<placeName><settlement type="city">Oxford</settlement>
<region type="nation">Angleterre</region>
<region type="région" nuts="1">Oxfordshire</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Becker, Stephan" sort="Becker, Stephan" uniqKey="Becker S" first="Stephan" last="Becker">Stephan Becker</name>
<affiliation wicri:level="1"><nlm:affiliation>Institute of Virology, Philipps University of Marburg, Marburg, Germany; German Center for Infection Research, TTU Emerging Infections, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Virology, Philipps University of Marburg, Marburg, Germany; German Center for Infection Research, TTU Emerging Infections</wicri:regionArea>
<wicri:noRegion>TTU Emerging Infections</wicri:noRegion>
<wicri:noRegion>TTU Emerging Infections</wicri:noRegion>
<wicri:noRegion>TTU Emerging Infections</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hill, Adrian V S" sort="Hill, Adrian V S" uniqKey="Hill A" first="Adrian V S" last="Hill">Adrian V S. Hill</name>
<affiliation wicri:level="4"><nlm:affiliation>The Jenner Institute, University of Oxford, Oxford OX3 7DQ, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>The Jenner Institute, University of Oxford, Oxford OX3 7DQ</wicri:regionArea>
<orgName type="university">Université d'Oxford</orgName>
<placeName><settlement type="city">Oxford</settlement>
<region type="nation">Angleterre</region>
<region type="région" nuts="1">Oxfordshire</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Gilbert, Sarah C" sort="Gilbert, Sarah C" uniqKey="Gilbert S" first="Sarah C" last="Gilbert">Sarah C. Gilbert</name>
<affiliation wicri:level="4"><nlm:affiliation>The Jenner Institute, University of Oxford, Oxford OX3 7DQ, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>The Jenner Institute, University of Oxford, Oxford OX3 7DQ</wicri:regionArea>
<orgName type="university">Université d'Oxford</orgName>
<placeName><settlement type="city">Oxford</settlement>
<region type="nation">Angleterre</region>
<region type="région" nuts="1">Oxfordshire</region>
</placeName>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2017">2017</date>
<idno type="RBID">pubmed:28579232</idno>
<idno type="pmid">28579232</idno>
<idno type="doi">10.1016/j.vaccine.2017.05.032</idno>
<idno type="wicri:Area/PubMed/Corpus">000C73</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000C73</idno>
<idno type="wicri:Area/PubMed/Curation">000C73</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000C73</idno>
<idno type="wicri:Area/PubMed/Checkpoint">000D72</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000D72</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">ChAdOx1 and MVA based vaccine candidates against MERS-CoV elicit neutralising antibodies and cellular immune responses in mice.</title>
<author><name sortKey="Alharbi, Naif Khalaf" sort="Alharbi, Naif Khalaf" uniqKey="Alharbi N" first="Naif Khalaf" last="Alharbi">Naif Khalaf Alharbi</name>
<affiliation wicri:level="4"><nlm:affiliation>The Jenner Institute, University of Oxford, Oxford OX3 7DQ, UK; King Abdullah International Medical Research Center, Riyadh, Saudi Arabia. Electronic address: harbina2@ngha.med.sa.</nlm:affiliation>
<country xml:lang="fr">Arabie saoudite</country>
<wicri:regionArea>The Jenner Institute, University of Oxford, Oxford OX3 7DQ, UK; King Abdullah International Medical Research Center, Riyadh</wicri:regionArea>
<orgName type="university">Université d'Oxford</orgName>
<placeName><settlement type="city">Oxford</settlement>
<region type="nation">Angleterre</region>
<region type="région" nuts="1">Oxfordshire</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Padron Regalado, Eriko" sort="Padron Regalado, Eriko" uniqKey="Padron Regalado E" first="Eriko" last="Padron-Regalado">Eriko Padron-Regalado</name>
<affiliation wicri:level="4"><nlm:affiliation>The Jenner Institute, University of Oxford, Oxford OX3 7DQ, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>The Jenner Institute, University of Oxford, Oxford OX3 7DQ</wicri:regionArea>
<orgName type="university">Université d'Oxford</orgName>
<placeName><settlement type="city">Oxford</settlement>
<region type="nation">Angleterre</region>
<region type="région" nuts="1">Oxfordshire</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Thompson, Craig P" sort="Thompson, Craig P" uniqKey="Thompson C" first="Craig P" last="Thompson">Craig P. Thompson</name>
<affiliation wicri:level="4"><nlm:affiliation>The Jenner Institute, University of Oxford, Oxford OX3 7DQ, UK; Department of Zoology, University of Oxford, Oxford, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>The Jenner Institute, University of Oxford, Oxford OX3 7DQ, UK; Department of Zoology, University of Oxford, Oxford</wicri:regionArea>
<placeName><settlement type="city">Oxford</settlement>
<region type="country">Angleterre</region>
<region type="comté" nuts="2">Oxfordshire</region>
</placeName>
<orgName type="university">Université d'Oxford</orgName>
</affiliation>
</author>
<author><name sortKey="Kupke, Alexandra" sort="Kupke, Alexandra" uniqKey="Kupke A" first="Alexandra" last="Kupke">Alexandra Kupke</name>
<affiliation wicri:level="1"><nlm:affiliation>Institute of Virology, Philipps University of Marburg, Marburg, Germany; German Center for Infection Research, TTU Emerging Infections, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Virology, Philipps University of Marburg, Marburg, Germany; German Center for Infection Research, TTU Emerging Infections</wicri:regionArea>
<wicri:noRegion>TTU Emerging Infections</wicri:noRegion>
<wicri:noRegion>TTU Emerging Infections</wicri:noRegion>
<wicri:noRegion>TTU Emerging Infections</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Wells, Daniel" sort="Wells, Daniel" uniqKey="Wells D" first="Daniel" last="Wells">Daniel Wells</name>
<affiliation wicri:level="4"><nlm:affiliation>The Jenner Institute, University of Oxford, Oxford OX3 7DQ, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>The Jenner Institute, University of Oxford, Oxford OX3 7DQ</wicri:regionArea>
<orgName type="university">Université d'Oxford</orgName>
<placeName><settlement type="city">Oxford</settlement>
<region type="nation">Angleterre</region>
<region type="région" nuts="1">Oxfordshire</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Sloan, Megan A" sort="Sloan, Megan A" uniqKey="Sloan M" first="Megan A" last="Sloan">Megan A. Sloan</name>
<affiliation wicri:level="4"><nlm:affiliation>The Jenner Institute, University of Oxford, Oxford OX3 7DQ, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>The Jenner Institute, University of Oxford, Oxford OX3 7DQ</wicri:regionArea>
<orgName type="university">Université d'Oxford</orgName>
<placeName><settlement type="city">Oxford</settlement>
<region type="nation">Angleterre</region>
<region type="région" nuts="1">Oxfordshire</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Grehan, Keith" sort="Grehan, Keith" uniqKey="Grehan K" first="Keith" last="Grehan">Keith Grehan</name>
<affiliation wicri:level="1"><nlm:affiliation>Viral Pseudotype Unit, School of Pharmacy, University of Kent, Chatham Maritime, Kent ME4 4TB, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Viral Pseudotype Unit, School of Pharmacy, University of Kent, Chatham Maritime, Kent ME4 4TB</wicri:regionArea>
<wicri:noRegion>Kent ME4 4TB</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Temperton, Nigel" sort="Temperton, Nigel" uniqKey="Temperton N" first="Nigel" last="Temperton">Nigel Temperton</name>
<affiliation wicri:level="1"><nlm:affiliation>Viral Pseudotype Unit, School of Pharmacy, University of Kent, Chatham Maritime, Kent ME4 4TB, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Viral Pseudotype Unit, School of Pharmacy, University of Kent, Chatham Maritime, Kent ME4 4TB</wicri:regionArea>
<wicri:noRegion>Kent ME4 4TB</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lambe, Teresa" sort="Lambe, Teresa" uniqKey="Lambe T" first="Teresa" last="Lambe">Teresa Lambe</name>
<affiliation wicri:level="4"><nlm:affiliation>The Jenner Institute, University of Oxford, Oxford OX3 7DQ, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>The Jenner Institute, University of Oxford, Oxford OX3 7DQ</wicri:regionArea>
<orgName type="university">Université d'Oxford</orgName>
<placeName><settlement type="city">Oxford</settlement>
<region type="nation">Angleterre</region>
<region type="région" nuts="1">Oxfordshire</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Warimwe, George" sort="Warimwe, George" uniqKey="Warimwe G" first="George" last="Warimwe">George Warimwe</name>
<affiliation wicri:level="4"><nlm:affiliation>The Jenner Institute, University of Oxford, Oxford OX3 7DQ, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>The Jenner Institute, University of Oxford, Oxford OX3 7DQ</wicri:regionArea>
<orgName type="university">Université d'Oxford</orgName>
<placeName><settlement type="city">Oxford</settlement>
<region type="nation">Angleterre</region>
<region type="région" nuts="1">Oxfordshire</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Becker, Stephan" sort="Becker, Stephan" uniqKey="Becker S" first="Stephan" last="Becker">Stephan Becker</name>
<affiliation wicri:level="1"><nlm:affiliation>Institute of Virology, Philipps University of Marburg, Marburg, Germany; German Center for Infection Research, TTU Emerging Infections, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Virology, Philipps University of Marburg, Marburg, Germany; German Center for Infection Research, TTU Emerging Infections</wicri:regionArea>
<wicri:noRegion>TTU Emerging Infections</wicri:noRegion>
<wicri:noRegion>TTU Emerging Infections</wicri:noRegion>
<wicri:noRegion>TTU Emerging Infections</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hill, Adrian V S" sort="Hill, Adrian V S" uniqKey="Hill A" first="Adrian V S" last="Hill">Adrian V S. Hill</name>
<affiliation wicri:level="4"><nlm:affiliation>The Jenner Institute, University of Oxford, Oxford OX3 7DQ, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>The Jenner Institute, University of Oxford, Oxford OX3 7DQ</wicri:regionArea>
<orgName type="university">Université d'Oxford</orgName>
<placeName><settlement type="city">Oxford</settlement>
<region type="nation">Angleterre</region>
<region type="région" nuts="1">Oxfordshire</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Gilbert, Sarah C" sort="Gilbert, Sarah C" uniqKey="Gilbert S" first="Sarah C" last="Gilbert">Sarah C. Gilbert</name>
<affiliation wicri:level="4"><nlm:affiliation>The Jenner Institute, University of Oxford, Oxford OX3 7DQ, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>The Jenner Institute, University of Oxford, Oxford OX3 7DQ</wicri:regionArea>
<orgName type="university">Université d'Oxford</orgName>
<placeName><settlement type="city">Oxford</settlement>
<region type="nation">Angleterre</region>
<region type="région" nuts="1">Oxfordshire</region>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">Vaccine</title>
<idno type="eISSN">1873-2518</idno>
<imprint><date when="2017" type="published">2017</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adenoviridae (genetics)</term>
<term>Adenoviridae (immunology)</term>
<term>Animals</term>
<term>Antibodies, Neutralizing (biosynthesis)</term>
<term>Antibodies, Neutralizing (immunology)</term>
<term>Antibodies, Viral (biosynthesis)</term>
<term>Antibodies, Viral (immunology)</term>
<term>Coronavirus Infections (immunology)</term>
<term>Coronavirus Infections (prevention & control)</term>
<term>Dose-Response Relationship, Immunologic</term>
<term>Immunity, Cellular</term>
<term>Immunity, Humoral</term>
<term>Immunogenicity, Vaccine</term>
<term>Mice</term>
<term>Middle East Respiratory Syndrome Coronavirus (genetics)</term>
<term>Middle East Respiratory Syndrome Coronavirus (immunology)</term>
<term>Spike Glycoprotein, Coronavirus (genetics)</term>
<term>Spike Glycoprotein, Coronavirus (immunology)</term>
<term>Vaccination</term>
<term>Vaccines, Synthetic (administration & dosage)</term>
<term>Vaccines, Synthetic (immunology)</term>
<term>Viral Vaccines (genetics)</term>
<term>Viral Vaccines (immunology)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Adenoviridae (génétique)</term>
<term>Adenoviridae (immunologie)</term>
<term>Animaux</term>
<term>Anticorps antiviraux (biosynthèse)</term>
<term>Anticorps antiviraux (immunologie)</term>
<term>Anticorps neutralisants (biosynthèse)</term>
<term>Anticorps neutralisants (immunologie)</term>
<term>Coronavirus du syndrome respiratoire du Moyen-Orient (génétique)</term>
<term>Coronavirus du syndrome respiratoire du Moyen-Orient (immunologie)</term>
<term>Glycoprotéine de spicule des coronavirus (génétique)</term>
<term>Glycoprotéine de spicule des coronavirus (immunologie)</term>
<term>Immunité cellulaire</term>
<term>Immunité humorale</term>
<term>Immunogénicité des vaccins</term>
<term>Infections à coronavirus ()</term>
<term>Infections à coronavirus (immunologie)</term>
<term>Relation dose-réponse (immunologie)</term>
<term>Souris</term>
<term>Vaccination</term>
<term>Vaccins antiviraux (génétique)</term>
<term>Vaccins antiviraux (immunologie)</term>
<term>Vaccins synthétiques (administration et posologie)</term>
<term>Vaccins synthétiques (immunologie)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Vaccines, Synthetic</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="biosynthesis" xml:lang="en"><term>Antibodies, Neutralizing</term>
<term>Antibodies, Viral</term>
</keywords>
<keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Vaccins synthétiques</term>
</keywords>
<keywords scheme="MESH" qualifier="biosynthèse" xml:lang="fr"><term>Anticorps antiviraux</term>
<term>Anticorps neutralisants</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Adenoviridae</term>
<term>Middle East Respiratory Syndrome Coronavirus</term>
<term>Spike Glycoprotein, Coronavirus</term>
<term>Viral Vaccines</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Adenoviridae</term>
<term>Coronavirus du syndrome respiratoire du Moyen-Orient</term>
<term>Glycoprotéine de spicule des coronavirus</term>
<term>Vaccins antiviraux</term>
</keywords>
<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Adenoviridae</term>
<term>Anticorps antiviraux</term>
<term>Anticorps neutralisants</term>
<term>Coronavirus du syndrome respiratoire du Moyen-Orient</term>
<term>Glycoprotéine de spicule des coronavirus</term>
<term>Infections à coronavirus</term>
<term>Vaccins antiviraux</term>
<term>Vaccins synthétiques</term>
</keywords>
<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Adenoviridae</term>
<term>Antibodies, Neutralizing</term>
<term>Antibodies, Viral</term>
<term>Coronavirus Infections</term>
<term>Middle East Respiratory Syndrome Coronavirus</term>
<term>Spike Glycoprotein, Coronavirus</term>
<term>Vaccines, Synthetic</term>
<term>Viral Vaccines</term>
</keywords>
<keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Coronavirus Infections</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Dose-Response Relationship, Immunologic</term>
<term>Immunity, Cellular</term>
<term>Immunity, Humoral</term>
<term>Immunogenicity, Vaccine</term>
<term>Mice</term>
<term>Vaccination</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Animaux</term>
<term>Immunité cellulaire</term>
<term>Immunité humorale</term>
<term>Immunogénicité des vaccins</term>
<term>Infections à coronavirus</term>
<term>Relation dose-réponse (immunologie)</term>
<term>Souris</term>
<term>Vaccination</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">The Middle East respiratory syndrome coronavirus (MERS-CoV) has infected more than 1900 humans, since 2012. The syndrome ranges from asymptomatic and mild cases to severe pneumonia and death. The virus is believed to be circulating in dromedary camels without notable symptoms since the 1980s. Therefore, dromedary camels are considered the only animal source of infection. Neither antiviral drugs nor vaccines are approved for veterinary or medical use despite active research on this area. Here, we developed four vaccine candidates against MERS-CoV based on ChAdOx1 and MVA viral vectors, two candidates per vector. All vaccines contained the full-length spike gene of MERS-CoV; ChAdOx1 MERS vaccines were produced with or without the leader sequence of the human tissue plasminogen activator gene (tPA) where MVA MERS vaccines were produced with tPA, but either the mH5 or F11 promoter driving expression of the spike gene. All vaccine candidates were evaluated in a mouse model in prime only or prime-boost regimens. ChAdOx1 MERS with tPA induced higher neutralising antibodies than ChAdOx1 MERS without tPA. A single dose of ChAdOx1 MERS with tPA elicited cellular immune responses as well as neutralising antibodies that were boosted to a significantly higher level by MVA MERS. The humoral immunogenicity of a single dose of ChAdOx1 MERS with tPA was equivalent to two doses of MVA MERS (also with tPA). MVA MERS with mH5 or F11 promoter induced similar antibody levels; however, F11 promoter enhanced the cellular immunogenicity of MVA MERS to significantly higher magnitudes. In conclusion, our study showed that MERS-CoV vaccine candidates could be optimized by utilising different viral vectors, various genetic designs of the vectors, or different regimens to increase immunogenicity. ChAdOx1 and MVA vectored vaccines have been safely evaluated in camels and humans and these MERS vaccine candidates should now be tested in camels and in clinical trials.</div>
</front>
</TEI>
</pubmed>
</double>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/MersV1/Data/Ncbi/Merge
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001A60 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Ncbi/Merge/biblio.hfd -nk 001A60 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Sante |area= MersV1 |flux= Ncbi |étape= Merge |type= RBID |clé= PMC:5516308 |texte= ChAdOx1 and MVA based vaccine candidates against MERS-CoV elicit neutralising antibodies and cellular immune responses in mice }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Ncbi/Merge/RBID.i -Sk "pubmed:28579232" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Ncbi/Merge/biblio.hfd \ | NlmPubMed2Wicri -a MersV1
![]() | This area was generated with Dilib version V0.6.33. | ![]() |