High fatality rates and associated factors in two hospital outbreaks of MERS in Daejeon, the Republic of Korea
Identifieur interne : 001962 ( Ncbi/Merge ); précédent : 001961; suivant : 001963High fatality rates and associated factors in two hospital outbreaks of MERS in Daejeon, the Republic of Korea
Auteurs : Hae-Sung Nam [Corée du Sud] ; Jung Wan Park [Corée du Sud] ; Moran Ki [Corée du Sud] ; Mi-Yeon Yeon [Corée du Sud] ; Jin Kim [Corée du Sud] ; Seung Woo Kim [Corée du Sud]Source :
- International Journal of Infectious Diseases [ 1201-9712 ] ; 2017.
Descripteurs français
- KwdFr :
- Adulte, Adulte d'âge moyen, Coronavirus du syndrome respiratoire du Moyen-Orient, Facteurs de risque, Femelle, Flambées de maladies, Humains, Infection croisée (mortalité), Infection croisée (épidémiologie), Infections à coronavirus (mortalité), Infections à coronavirus (épidémiologie), Mâle, République de Corée (épidémiologie), Sujet âgé.
- MESH :
English descriptors
- KwdEn :
- MESH :
- epidemiology : Coronavirus Infections, Cross Infection, Republic of Korea.
- mortality : Coronavirus Infections, Cross Infection.
- Adult, Aged, Disease Outbreaks, Female, Humans, Male, Middle Aged, Middle East Respiratory Syndrome Coronavirus, Risk Factors.
Abstract
To explore the epidemiological and clinical factors predictive of the case fatality rate (CFR) of Middle East respiratory syndrome-coronavirus (MERS-CoV) infection in an outbreak in Daejeon, the Republic of Korea.
We reviewed the outbreak investigation reports and medical records of 1 index case and 25 additional MERS cases in hospitals A (14 cases) and B (11 cases), and conducted an in-depth interview with the index case.
The CFR in hospital B was higher than that in hospital A (63.6% vs. 28.6%, respectively). Higher MERS-CoV exposure conditions were also found in hospital B, including aggravated pneumonia in the index case and nebulizer use in a six-bed admission room. The host factors associated with high CFR were pre-existing pneumonia, smoking history, an incubation period of less than 5 days, leukocytosis, abnormal renal function at diagnosis, and respiratory symptoms such as sputum and dyspnea.
The conditions surrounding MERS-CoV exposure and the underlying poor pulmonary function due to a smoking history or pre-existing pneumonia may explain the high CFR in hospital B. The clinical features described above may enable prediction of the prognosis of MERS cases.
Url:
DOI: 10.1016/j.ijid.2017.02.008
PubMed: 28223175
PubMed Central: 7110480
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MERS in Daejeon, the Republic of Korea</title><author><name sortKey="Nam, Hae Sung" sort="Nam, Hae Sung" uniqKey="Nam H" first="Hae-Sung" last="Nam">Hae-Sung Nam</name><affiliation wicri:level="1"><nlm:aff id="aff0005">Department of Preventive Medicine and Public Health, Chungnam National University School of Medicine, Daejeon, Republic of Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Preventive Medicine and Public Health, Chungnam National University School of Medicine, Daejeon</wicri:regionArea><wicri:noRegion>Daejeon</wicri:noRegion></affiliation></author><author><name sortKey="Park, Jung Wan" sort="Park, Jung Wan" uniqKey="Park J" first="Jung Wan" last="Park">Jung Wan Park</name><affiliation wicri:level="1"><nlm:aff id="aff0010">Division of Infectious Disease Surveillance, Korea Centers for Disease Control and Prevention, Cheongju, Republic of Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Division of Infectious Disease Surveillance, Korea Centers for Disease Control and Prevention, Cheongju</wicri:regionArea><wicri:noRegion>Cheongju</wicri:noRegion></affiliation></author><author><name sortKey="Ki, Moran" sort="Ki, Moran" uniqKey="Ki M" first="Moran" last="Ki">Moran Ki</name><affiliation wicri:level="1"><nlm:aff id="aff0015">Department of Cancer Control and Policy, Graduate School of Cancer Science and Policy, National Cancer Center, Goyang, Republic of Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Cancer Control and Policy, Graduate School of Cancer Science and Policy, National Cancer Center, Goyang</wicri:regionArea><wicri:noRegion>Goyang</wicri:noRegion></affiliation></author><author><name sortKey="Yeon, Mi Yeon" sort="Yeon, Mi Yeon" uniqKey="Yeon M" first="Mi-Yeon" last="Yeon">Mi-Yeon Yeon</name><affiliation wicri:level="1"><nlm:aff id="aff0005">Department of Preventive Medicine and Public Health, Chungnam National University School of Medicine, Daejeon, Republic of Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Preventive Medicine and Public Health, Chungnam National University School of Medicine, Daejeon</wicri:regionArea><wicri:noRegion>Daejeon</wicri:noRegion></affiliation></author><author><name sortKey="Kim, Jin" sort="Kim, Jin" uniqKey="Kim J" first="Jin" last="Kim">Jin Kim</name><affiliation wicri:level="1"><nlm:aff id="aff0020">Department of Nursing, Graduate School, Chungnam National University, Daejeon, Republic of Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Nursing, Graduate School, Chungnam National University, Daejeon</wicri:regionArea><wicri:noRegion>Daejeon</wicri:noRegion></affiliation></author><author><name sortKey="Kim, Seung Woo" sort="Kim, Seung Woo" uniqKey="Kim S" first="Seung Woo" last="Kim">Seung Woo Kim</name><affiliation wicri:level="1"><nlm:aff id="aff0010">Division of Infectious Disease Surveillance, Korea Centers for Disease Control and Prevention, Cheongju, Republic of Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Division of Infectious Disease Surveillance, Korea Centers for Disease Control and Prevention, Cheongju</wicri:regionArea><wicri:noRegion>Cheongju</wicri:noRegion></affiliation></author></analytic><series><title level="j">International Journal of Infectious Diseases</title><idno type="ISSN">1201-9712</idno><idno type="eISSN">1878-3511</idno><imprint><date when="2017">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Coronavirus Infections (epidemiology)</term><term>Coronavirus Infections (mortality)</term><term>Cross Infection (epidemiology)</term><term>Cross Infection (mortality)</term><term>Disease Outbreaks</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Middle East Respiratory Syndrome Coronavirus</term><term>Republic of Korea (epidemiology)</term><term>Risk Factors</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Coronavirus du syndrome respiratoire du Moyen-Orient</term><term>Facteurs de risque</term><term>Femelle</term><term>Flambées de maladies</term><term>Humains</term><term>Infection croisée (mortalité)</term><term>Infection croisée (épidémiologie)</term><term>Infections à coronavirus (mortalité)</term><term>Infections à coronavirus (épidémiologie)</term><term>Mâle</term><term>République de Corée (épidémiologie)</term><term>Sujet âgé</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Coronavirus Infections</term><term>Cross Infection</term><term>Republic of Korea</term></keywords><keywords scheme="MESH" qualifier="mortality" xml:lang="en"><term>Coronavirus Infections</term><term>Cross Infection</term></keywords><keywords scheme="MESH" qualifier="mortalité" xml:lang="fr"><term>Infection croisée</term><term>Infections à coronavirus</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Infection croisée</term><term>Infections à coronavirus</term><term>République de Corée</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Disease Outbreaks</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Middle East Respiratory Syndrome Coronavirus</term><term>Risk Factors</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Coronavirus du syndrome respiratoire du Moyen-Orient</term><term>Facteurs de risque</term><term>Femelle</term><term>Flambées de maladies</term><term>Humains</term><term>Mâle</term><term>Sujet âgé</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Objectives</title><p>To explore the epidemiological and clinical factors predictive of the case fatality rate (CFR) of Middle East respiratory syndrome-coronavirus (MERS-CoV) infection in an outbreak in Daejeon, the Republic of Korea.</p></sec><sec><title>Methods</title><p>We reviewed the outbreak investigation reports and medical records of 1 index case and 25 additional MERS cases in hospitals A (14 cases) and B (11 cases), and conducted an in-depth interview with the index case.</p></sec><sec><title>Results</title><p>The CFR in hospital B was higher than that in hospital A (63.6% vs. 28.6%, respectively). Higher MERS-CoV exposure conditions were also found in hospital B, including aggravated pneumonia in the index case and nebulizer use in a six-bed admission room. The host factors associated with high CFR were pre-existing pneumonia, smoking history, an incubation period of less than 5 days, leukocytosis, abnormal renal function at diagnosis, and respiratory symptoms such as sputum and dyspnea.</p></sec><sec><title>Conclusions</title><p>The conditions surrounding MERS-CoV exposure and the underlying poor pulmonary function due to a smoking history or pre-existing pneumonia may explain the high CFR in hospital B. The clinical features described above may enable prediction of the prognosis of MERS cases.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Korea Centers For Disease Control And Prevention" uniqKey="Korea Centers For Disease Control And Prevention">Korea Centers for Disease Control and Prevention</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ki, M" uniqKey="Ki M">M. Ki</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zumla, A" uniqKey="Zumla A">A. Zumla</name></author><author><name sortKey="Hui, D S" uniqKey="Hui D">D.S. Hui</name></author><author><name sortKey="Perlman, S" uniqKey="Perlman S">S. Perlman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kim, K M" uniqKey="Kim K">K.M. Kim</name></author><author><name sortKey="Ki, M" uniqKey="Ki M">M. Ki</name></author><author><name sortKey="Cho, S I" uniqKey="Cho S">S.I. Cho</name></author><author><name sortKey="Sung, M" uniqKey="Sung M">M. Sung</name></author><author><name sortKey="Hong, J K" uniqKey="Hong J">J.K. Hong</name></author><author><name sortKey="Cheong, H K" uniqKey="Cheong H">H.K. Cheong</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Feikin, D R" uniqKey="Feikin D">D.R. Feikin</name></author><author><name sortKey="Alraddadi, B" uniqKey="Alraddadi B">B. Alraddadi</name></author><author><name sortKey="Qutub, M" uniqKey="Qutub M">M. Qutub</name></author><author><name sortKey="Shabouni, O" uniqKey="Shabouni O">O. Shabouni</name></author><author><name sortKey="Curns, A" uniqKey="Curns A">A. Curns</name></author><author><name sortKey="Oboho, I K" uniqKey="Oboho I">I.K. Oboho</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shehata, M M" uniqKey="Shehata M">M.M. Shehata</name></author><author><name sortKey="Gomaa, M R" uniqKey="Gomaa M">M.R. Gomaa</name></author><author><name sortKey="Ali, M A" uniqKey="Ali M">M.A. Ali</name></author><author><name sortKey="Kayali, G" uniqKey="Kayali G">G. Kayali</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Assiri, A" uniqKey="Assiri A">A. Assiri</name></author><author><name sortKey="Mcgeer, A" uniqKey="Mcgeer A">A. McGeer</name></author><author><name sortKey="Perl, T M" uniqKey="Perl T">T.M. Perl</name></author><author><name sortKey="Price, C S" uniqKey="Price C">C.S. Price</name></author><author><name sortKey="Al Rabeeah, A A" uniqKey="Al Rabeeah A">A.A. Al Rabeeah</name></author><author><name sortKey="Cummings, D A" uniqKey="Cummings D">D.A. Cummings</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Maltezou, H C" uniqKey="Maltezou H">H.C. Maltezou</name></author><author><name sortKey="Tsiodras, S" uniqKey="Tsiodras S">S. Tsiodras</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wong, R S" uniqKey="Wong R">R.S. Wong</name></author><author><name sortKey="Hui, D S" uniqKey="Hui D">D.S. Hui</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cho, S Y" uniqKey="Cho S">S.Y. Cho</name></author><author><name sortKey="Kang, J M" uniqKey="Kang J">J.M. Kang</name></author><author><name sortKey="Ha, Y E" uniqKey="Ha Y">Y.E. Ha</name></author><author><name sortKey="Park, G E" uniqKey="Park G">G.E. Park</name></author><author><name sortKey="Lee, J Y" uniqKey="Lee J">J.Y. Lee</name></author><author><name sortKey="Ko, J H" uniqKey="Ko J">J.H. Ko</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Virlogeux, V" uniqKey="Virlogeux V">V. Virlogeux</name></author><author><name sortKey="Fang, V J" uniqKey="Fang V">V.J. Fang</name></author><author><name sortKey="Wu, J T" uniqKey="Wu J">J.T. Wu</name></author><author><name sortKey="Ho, L M" uniqKey="Ho L">L.M. Ho</name></author><author><name sortKey="Peiris, J S" uniqKey="Peiris J">J.S. Peiris</name></author><author><name sortKey="Leung, G M" uniqKey="Leung G">G.M. Leung</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Virlogeux, V" uniqKey="Virlogeux V">V. Virlogeux</name></author><author><name sortKey="Park, M" uniqKey="Park M">M. Park</name></author><author><name sortKey="Wu, J T" uniqKey="Wu J">J.T. Wu</name></author><author><name sortKey="Cowling, B J" uniqKey="Cowling B">B.J. Cowling</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Saad, M" uniqKey="Saad M">M. Saad</name></author><author><name sortKey="Omrani, A S" uniqKey="Omrani A">A.S. Omrani</name></author><author><name sortKey="Baig, K" uniqKey="Baig K">K. Baig</name></author><author><name sortKey="Bahloul, A" uniqKey="Bahloul A">A. Bahloul</name></author><author><name sortKey="Elzein, F" uniqKey="Elzein F">F. Elzein</name></author><author><name sortKey="Matin, M A" uniqKey="Matin M">M.A. Matin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cilloniz, C" uniqKey="Cilloniz C">C. Cilloniz</name></author><author><name sortKey="Ewig, S" uniqKey="Ewig S">S. Ewig</name></author><author><name sortKey="Menendez, R" uniqKey="Menendez R">R. Menendez</name></author><author><name sortKey="Ferrer, M" uniqKey="Ferrer M">M. Ferrer</name></author><author><name sortKey="Polverino, E" uniqKey="Polverino E">E. Polverino</name></author><author><name sortKey="Reyes, S" uniqKey="Reyes S">S. Reyes</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ware, L B" uniqKey="Ware L">L.B. Ware</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jones, J G" uniqKey="Jones J">J.G. Jones</name></author><author><name sortKey="Minty, B D" uniqKey="Minty B">B.D. Minty</name></author><author><name sortKey="Lawler, P" uniqKey="Lawler P">P. Lawler</name></author><author><name sortKey="Hulands, G" uniqKey="Hulands G">G. Hulands</name></author><author><name sortKey="Crawley, J C" uniqKey="Crawley J">J.C. Crawley</name></author><author><name sortKey="Veall, N" uniqKey="Veall N">N. Veall</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kang, M J" uniqKey="Kang M">M.J. Kang</name></author><author><name sortKey="Lee, C G" uniqKey="Lee C">C.G. Lee</name></author><author><name sortKey="Lee, J Y" uniqKey="Lee J">J.Y. Lee</name></author><author><name sortKey="Dela Cruz, C S" uniqKey="Dela Cruz C">C.S. Dela Cruz</name></author><author><name sortKey="Chen, Z J" uniqKey="Chen Z">Z.J. Chen</name></author><author><name sortKey="Enelow, R" uniqKey="Enelow R">R. Enelow</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Peiris, J S" uniqKey="Peiris J">J.S. Peiris</name></author><author><name sortKey="Chu, C M" uniqKey="Chu C">C.M. Chu</name></author><author><name sortKey="Cheng, V C" uniqKey="Cheng V">V.C. Cheng</name></author><author><name sortKey="Chan, K S" uniqKey="Chan K">K.S. Chan</name></author><author><name sortKey="Hung, I F" uniqKey="Hung I">I.F. Hung</name></author><author><name sortKey="Poon, L L" uniqKey="Poon L">L.L. Poon</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ho, M S" uniqKey="Ho M">M.S. Ho</name></author><author><name sortKey="Chen, W J" uniqKey="Chen W">W.J. Chen</name></author><author><name sortKey="Chen, H Y" uniqKey="Chen H">H.Y. Chen</name></author><author><name sortKey="Lin, S F" uniqKey="Lin S">S.F. Lin</name></author><author><name sortKey="Wang, M C" uniqKey="Wang M">M.C. Wang</name></author><author><name sortKey="Di, J" uniqKey="Di J">J. Di</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tsui, P T" uniqKey="Tsui P">P.T. Tsui</name></author><author><name sortKey="Kwok, M L" uniqKey="Kwok M">M.L. Kwok</name></author><author><name sortKey="Yuen, H" uniqKey="Yuen H">H. Yuen</name></author><author><name sortKey="Lai, S T" uniqKey="Lai S">S.T. Lai</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cha, R H" uniqKey="Cha R">R.H. Cha</name></author><author><name sortKey="Joh, J S" uniqKey="Joh J">J.S. Joh</name></author><author><name sortKey="Jeong, I" uniqKey="Jeong I">I. Jeong</name></author><author><name sortKey="Lee, J Y" uniqKey="Lee J">J.Y. Lee</name></author><author><name sortKey="Shin, H S" uniqKey="Shin H">H.S. Shin</name></author><author><name sortKey="Kim, G" uniqKey="Kim G">G. Kim</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chu, K H" uniqKey="Chu K">K.H. Chu</name></author><author><name sortKey="Tsang, W K" uniqKey="Tsang W">W.K. Tsang</name></author><author><name sortKey="Tang, C S" uniqKey="Tang C">C.S. Tang</name></author><author><name sortKey="Lam, M F" uniqKey="Lam M">M.F. Lam</name></author><author><name sortKey="Lai, F M" uniqKey="Lai F">F.M. Lai</name></author><author><name sortKey="To, K F" uniqKey="To K">K.F. To</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kim, S Y" uniqKey="Kim S">S.Y. Kim</name></author><author><name sortKey="Park, S J" uniqKey="Park S">S.J. Park</name></author><author><name sortKey="Cho, S Y" uniqKey="Cho S">S.Y. Cho</name></author><author><name sortKey="Cha, R H" uniqKey="Cha R">R.H. Cha</name></author><author><name sortKey="Jee, H G" uniqKey="Jee H">H.G. Jee</name></author><author><name sortKey="Kim, G" uniqKey="Kim G">G. Kim</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Peduzzi, P" uniqKey="Peduzzi P">P. Peduzzi</name></author><author><name sortKey="Concato, J" uniqKey="Concato J">J. Concato</name></author><author><name sortKey="Kemper, E" uniqKey="Kemper E">E. Kemper</name></author><author><name sortKey="Holford, T R" uniqKey="Holford T">T.R. Holford</name></author><author><name sortKey="Feinstein, A R" uniqKey="Feinstein A">A.R. Feinstein</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Courvoisier, D S" uniqKey="Courvoisier D">D.S. Courvoisier</name></author><author><name sortKey="Combescure, C" uniqKey="Combescure C">C. Combescure</name></author><author><name sortKey="Agoritsas, T" uniqKey="Agoritsas T">T. Agoritsas</name></author><author><name sortKey="Gayet Ageron, A" uniqKey="Gayet Ageron A">A. Gayet-Ageron</name></author><author><name sortKey="Perneger, T V" uniqKey="Perneger T">T.V. Perneger</name></author></analytic></biblStruct></listBibl></div1></back></TEI><double pmid="28223175"><pmc><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">High fatality rates and associated factors in two hospital outbreaks of MERS in Daejeon, the Republic of Korea</title><author><name sortKey="Nam, Hae Sung" sort="Nam, Hae Sung" uniqKey="Nam H" first="Hae-Sung" last="Nam">Hae-Sung Nam</name><affiliation wicri:level="1"><nlm:aff id="aff0005">Department of Preventive Medicine and Public Health, Chungnam National University School of Medicine, Daejeon, Republic of Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Preventive Medicine and Public Health, Chungnam National University School of Medicine, Daejeon</wicri:regionArea><wicri:noRegion>Daejeon</wicri:noRegion></affiliation></author><author><name sortKey="Park, Jung Wan" sort="Park, Jung Wan" uniqKey="Park J" first="Jung Wan" last="Park">Jung Wan Park</name><affiliation wicri:level="1"><nlm:aff id="aff0010">Division of Infectious Disease Surveillance, Korea Centers for Disease Control and Prevention, Cheongju, Republic of Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Division of Infectious Disease Surveillance, Korea Centers for Disease Control and Prevention, Cheongju</wicri:regionArea><wicri:noRegion>Cheongju</wicri:noRegion></affiliation></author><author><name sortKey="Ki, Moran" sort="Ki, Moran" uniqKey="Ki M" first="Moran" last="Ki">Moran Ki</name><affiliation wicri:level="1"><nlm:aff id="aff0015">Department of Cancer Control and Policy, Graduate School of Cancer Science and Policy, National Cancer Center, Goyang, Republic of Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Cancer Control and Policy, Graduate School of Cancer Science and Policy, National Cancer Center, Goyang</wicri:regionArea><wicri:noRegion>Goyang</wicri:noRegion></affiliation></author><author><name sortKey="Yeon, Mi Yeon" sort="Yeon, Mi Yeon" uniqKey="Yeon M" first="Mi-Yeon" last="Yeon">Mi-Yeon Yeon</name><affiliation wicri:level="1"><nlm:aff id="aff0005">Department of Preventive Medicine and Public Health, Chungnam National University School of Medicine, Daejeon, Republic of Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Preventive Medicine and Public Health, Chungnam National University School of Medicine, Daejeon</wicri:regionArea><wicri:noRegion>Daejeon</wicri:noRegion></affiliation></author><author><name sortKey="Kim, Jin" sort="Kim, Jin" uniqKey="Kim J" first="Jin" last="Kim">Jin Kim</name><affiliation wicri:level="1"><nlm:aff id="aff0020">Department of Nursing, Graduate School, Chungnam National University, Daejeon, Republic of Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Nursing, Graduate School, Chungnam National University, Daejeon</wicri:regionArea><wicri:noRegion>Daejeon</wicri:noRegion></affiliation></author><author><name sortKey="Kim, Seung Woo" sort="Kim, Seung Woo" uniqKey="Kim S" first="Seung Woo" last="Kim">Seung Woo Kim</name><affiliation wicri:level="1"><nlm:aff id="aff0010">Division of Infectious Disease Surveillance, Korea Centers for Disease Control and Prevention, Cheongju, Republic of Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Division of Infectious Disease Surveillance, Korea Centers for Disease Control and Prevention, Cheongju</wicri:regionArea><wicri:noRegion>Cheongju</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">28223175</idno><idno type="pmc">7110480</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7110480</idno><idno type="RBID">PMC:7110480</idno><idno type="doi">10.1016/j.ijid.2017.02.008</idno><date when="2017">2017</date><idno type="wicri:Area/Pmc/Corpus">000D52</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000D52</idno><idno type="wicri:Area/Pmc/Curation">000D52</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000D52</idno><idno type="wicri:Area/Pmc/Checkpoint">000844</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000844</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">High fatality rates and associated factors in two hospital outbreaks of MERS in Daejeon, the Republic of Korea</title><author><name sortKey="Nam, Hae Sung" sort="Nam, Hae Sung" uniqKey="Nam H" first="Hae-Sung" last="Nam">Hae-Sung Nam</name><affiliation wicri:level="1"><nlm:aff id="aff0005">Department of Preventive Medicine and Public Health, Chungnam National University School of Medicine, Daejeon, Republic of Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Preventive Medicine and Public Health, Chungnam National University School of Medicine, Daejeon</wicri:regionArea><wicri:noRegion>Daejeon</wicri:noRegion></affiliation></author><author><name sortKey="Park, Jung Wan" sort="Park, Jung Wan" uniqKey="Park J" first="Jung Wan" last="Park">Jung Wan Park</name><affiliation wicri:level="1"><nlm:aff id="aff0010">Division of Infectious Disease Surveillance, Korea Centers for Disease Control and Prevention, Cheongju, Republic of Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Division of Infectious Disease Surveillance, Korea Centers for Disease Control and Prevention, Cheongju</wicri:regionArea><wicri:noRegion>Cheongju</wicri:noRegion></affiliation></author><author><name sortKey="Ki, Moran" sort="Ki, Moran" uniqKey="Ki M" first="Moran" last="Ki">Moran Ki</name><affiliation wicri:level="1"><nlm:aff id="aff0015">Department of Cancer Control and Policy, Graduate School of Cancer Science and Policy, National Cancer Center, Goyang, Republic of Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Cancer Control and Policy, Graduate School of Cancer Science and Policy, National Cancer Center, Goyang</wicri:regionArea><wicri:noRegion>Goyang</wicri:noRegion></affiliation></author><author><name sortKey="Yeon, Mi Yeon" sort="Yeon, Mi Yeon" uniqKey="Yeon M" first="Mi-Yeon" last="Yeon">Mi-Yeon Yeon</name><affiliation wicri:level="1"><nlm:aff id="aff0005">Department of Preventive Medicine and Public Health, Chungnam National University School of Medicine, Daejeon, Republic of Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Preventive Medicine and Public Health, Chungnam National University School of Medicine, Daejeon</wicri:regionArea><wicri:noRegion>Daejeon</wicri:noRegion></affiliation></author><author><name sortKey="Kim, Jin" sort="Kim, Jin" uniqKey="Kim J" first="Jin" last="Kim">Jin Kim</name><affiliation wicri:level="1"><nlm:aff id="aff0020">Department of Nursing, Graduate School, Chungnam National University, Daejeon, Republic of Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Nursing, Graduate School, Chungnam National University, Daejeon</wicri:regionArea><wicri:noRegion>Daejeon</wicri:noRegion></affiliation></author><author><name sortKey="Kim, Seung Woo" sort="Kim, Seung Woo" uniqKey="Kim S" first="Seung Woo" last="Kim">Seung Woo Kim</name><affiliation wicri:level="1"><nlm:aff id="aff0010">Division of Infectious Disease Surveillance, Korea Centers for Disease Control and Prevention, Cheongju, Republic of Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Division of Infectious Disease Surveillance, Korea Centers for Disease Control and Prevention, Cheongju</wicri:regionArea><wicri:noRegion>Cheongju</wicri:noRegion></affiliation></author></analytic><series><title level="j">International Journal of Infectious Diseases</title><idno type="ISSN">1201-9712</idno><idno type="eISSN">1878-3511</idno><imprint><date when="2017">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Objectives</title><p>To explore the epidemiological and clinical factors predictive of the case fatality rate (CFR) of Middle East respiratory syndrome-coronavirus (MERS-CoV) infection in an outbreak in Daejeon, the Republic of Korea.</p></sec><sec><title>Methods</title><p>We reviewed the outbreak investigation reports and medical records of 1 index case and 25 additional MERS cases in hospitals A (14 cases) and B (11 cases), and conducted an in-depth interview with the index case.</p></sec><sec><title>Results</title><p>The CFR in hospital B was higher than that in hospital A (63.6% vs. 28.6%, respectively). Higher MERS-CoV exposure conditions were also found in hospital B, including aggravated pneumonia in the index case and nebulizer use in a six-bed admission room. The host factors associated with high CFR were pre-existing pneumonia, smoking history, an incubation period of less than 5 days, leukocytosis, abnormal renal function at diagnosis, and respiratory symptoms such as sputum and dyspnea.</p></sec><sec><title>Conclusions</title><p>The conditions surrounding MERS-CoV exposure and the underlying poor pulmonary function due to a smoking history or pre-existing pneumonia may explain the high CFR in hospital B. The clinical features described above may enable prediction of the prognosis of MERS cases.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Korea Centers For Disease Control And Prevention" uniqKey="Korea Centers For Disease Control And Prevention">Korea Centers for Disease Control and Prevention</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ki, M" uniqKey="Ki M">M. Ki</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zumla, A" uniqKey="Zumla A">A. Zumla</name></author><author><name sortKey="Hui, D S" uniqKey="Hui D">D.S. Hui</name></author><author><name sortKey="Perlman, S" uniqKey="Perlman S">S. Perlman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kim, K M" uniqKey="Kim K">K.M. Kim</name></author><author><name sortKey="Ki, M" uniqKey="Ki M">M. Ki</name></author><author><name sortKey="Cho, S I" uniqKey="Cho S">S.I. Cho</name></author><author><name sortKey="Sung, M" uniqKey="Sung M">M. Sung</name></author><author><name sortKey="Hong, J K" uniqKey="Hong J">J.K. Hong</name></author><author><name sortKey="Cheong, H K" uniqKey="Cheong H">H.K. Cheong</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Feikin, D R" uniqKey="Feikin D">D.R. Feikin</name></author><author><name sortKey="Alraddadi, B" uniqKey="Alraddadi B">B. Alraddadi</name></author><author><name sortKey="Qutub, M" uniqKey="Qutub M">M. Qutub</name></author><author><name sortKey="Shabouni, O" uniqKey="Shabouni O">O. Shabouni</name></author><author><name sortKey="Curns, A" uniqKey="Curns A">A. Curns</name></author><author><name sortKey="Oboho, I K" uniqKey="Oboho I">I.K. Oboho</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shehata, M M" uniqKey="Shehata M">M.M. Shehata</name></author><author><name sortKey="Gomaa, M R" uniqKey="Gomaa M">M.R. Gomaa</name></author><author><name sortKey="Ali, M A" uniqKey="Ali M">M.A. Ali</name></author><author><name sortKey="Kayali, G" uniqKey="Kayali G">G. Kayali</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Assiri, A" uniqKey="Assiri A">A. Assiri</name></author><author><name sortKey="Mcgeer, A" uniqKey="Mcgeer A">A. McGeer</name></author><author><name sortKey="Perl, T M" uniqKey="Perl T">T.M. Perl</name></author><author><name sortKey="Price, C S" uniqKey="Price C">C.S. Price</name></author><author><name sortKey="Al Rabeeah, A A" uniqKey="Al Rabeeah A">A.A. Al Rabeeah</name></author><author><name sortKey="Cummings, D A" uniqKey="Cummings D">D.A. Cummings</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Maltezou, H C" uniqKey="Maltezou H">H.C. Maltezou</name></author><author><name sortKey="Tsiodras, S" uniqKey="Tsiodras S">S. Tsiodras</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wong, R S" uniqKey="Wong R">R.S. Wong</name></author><author><name sortKey="Hui, D S" uniqKey="Hui D">D.S. Hui</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cho, S Y" uniqKey="Cho S">S.Y. Cho</name></author><author><name sortKey="Kang, J M" uniqKey="Kang J">J.M. Kang</name></author><author><name sortKey="Ha, Y E" uniqKey="Ha Y">Y.E. Ha</name></author><author><name sortKey="Park, G E" uniqKey="Park G">G.E. Park</name></author><author><name sortKey="Lee, J Y" uniqKey="Lee J">J.Y. Lee</name></author><author><name sortKey="Ko, J H" uniqKey="Ko J">J.H. Ko</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Virlogeux, V" uniqKey="Virlogeux V">V. Virlogeux</name></author><author><name sortKey="Fang, V J" uniqKey="Fang V">V.J. Fang</name></author><author><name sortKey="Wu, J T" uniqKey="Wu J">J.T. Wu</name></author><author><name sortKey="Ho, L M" uniqKey="Ho L">L.M. Ho</name></author><author><name sortKey="Peiris, J S" uniqKey="Peiris J">J.S. Peiris</name></author><author><name sortKey="Leung, G M" uniqKey="Leung G">G.M. Leung</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Virlogeux, V" uniqKey="Virlogeux V">V. Virlogeux</name></author><author><name sortKey="Park, M" uniqKey="Park M">M. Park</name></author><author><name sortKey="Wu, J T" uniqKey="Wu J">J.T. Wu</name></author><author><name sortKey="Cowling, B J" uniqKey="Cowling B">B.J. Cowling</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Saad, M" uniqKey="Saad M">M. Saad</name></author><author><name sortKey="Omrani, A S" uniqKey="Omrani A">A.S. Omrani</name></author><author><name sortKey="Baig, K" uniqKey="Baig K">K. Baig</name></author><author><name sortKey="Bahloul, A" uniqKey="Bahloul A">A. Bahloul</name></author><author><name sortKey="Elzein, F" uniqKey="Elzein F">F. Elzein</name></author><author><name sortKey="Matin, M A" uniqKey="Matin M">M.A. Matin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cilloniz, C" uniqKey="Cilloniz C">C. Cilloniz</name></author><author><name sortKey="Ewig, S" uniqKey="Ewig S">S. Ewig</name></author><author><name sortKey="Menendez, R" uniqKey="Menendez R">R. Menendez</name></author><author><name sortKey="Ferrer, M" uniqKey="Ferrer M">M. Ferrer</name></author><author><name sortKey="Polverino, E" uniqKey="Polverino E">E. Polverino</name></author><author><name sortKey="Reyes, S" uniqKey="Reyes S">S. Reyes</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ware, L B" uniqKey="Ware L">L.B. Ware</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jones, J G" uniqKey="Jones J">J.G. Jones</name></author><author><name sortKey="Minty, B D" uniqKey="Minty B">B.D. Minty</name></author><author><name sortKey="Lawler, P" uniqKey="Lawler P">P. Lawler</name></author><author><name sortKey="Hulands, G" uniqKey="Hulands G">G. Hulands</name></author><author><name sortKey="Crawley, J C" uniqKey="Crawley J">J.C. Crawley</name></author><author><name sortKey="Veall, N" uniqKey="Veall N">N. Veall</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kang, M J" uniqKey="Kang M">M.J. Kang</name></author><author><name sortKey="Lee, C G" uniqKey="Lee C">C.G. Lee</name></author><author><name sortKey="Lee, J Y" uniqKey="Lee J">J.Y. Lee</name></author><author><name sortKey="Dela Cruz, C S" uniqKey="Dela Cruz C">C.S. Dela Cruz</name></author><author><name sortKey="Chen, Z J" uniqKey="Chen Z">Z.J. Chen</name></author><author><name sortKey="Enelow, R" uniqKey="Enelow R">R. Enelow</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Peiris, J S" uniqKey="Peiris J">J.S. Peiris</name></author><author><name sortKey="Chu, C M" uniqKey="Chu C">C.M. Chu</name></author><author><name sortKey="Cheng, V C" uniqKey="Cheng V">V.C. Cheng</name></author><author><name sortKey="Chan, K S" uniqKey="Chan K">K.S. Chan</name></author><author><name sortKey="Hung, I F" uniqKey="Hung I">I.F. Hung</name></author><author><name sortKey="Poon, L L" uniqKey="Poon L">L.L. Poon</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ho, M S" uniqKey="Ho M">M.S. Ho</name></author><author><name sortKey="Chen, W J" uniqKey="Chen W">W.J. Chen</name></author><author><name sortKey="Chen, H Y" uniqKey="Chen H">H.Y. Chen</name></author><author><name sortKey="Lin, S F" uniqKey="Lin S">S.F. Lin</name></author><author><name sortKey="Wang, M C" uniqKey="Wang M">M.C. Wang</name></author><author><name sortKey="Di, J" uniqKey="Di J">J. Di</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tsui, P T" uniqKey="Tsui P">P.T. Tsui</name></author><author><name sortKey="Kwok, M L" uniqKey="Kwok M">M.L. Kwok</name></author><author><name sortKey="Yuen, H" uniqKey="Yuen H">H. Yuen</name></author><author><name sortKey="Lai, S T" uniqKey="Lai S">S.T. Lai</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cha, R H" uniqKey="Cha R">R.H. Cha</name></author><author><name sortKey="Joh, J S" uniqKey="Joh J">J.S. Joh</name></author><author><name sortKey="Jeong, I" uniqKey="Jeong I">I. Jeong</name></author><author><name sortKey="Lee, J Y" uniqKey="Lee J">J.Y. Lee</name></author><author><name sortKey="Shin, H S" uniqKey="Shin H">H.S. Shin</name></author><author><name sortKey="Kim, G" uniqKey="Kim G">G. Kim</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chu, K H" uniqKey="Chu K">K.H. Chu</name></author><author><name sortKey="Tsang, W K" uniqKey="Tsang W">W.K. Tsang</name></author><author><name sortKey="Tang, C S" uniqKey="Tang C">C.S. Tang</name></author><author><name sortKey="Lam, M F" uniqKey="Lam M">M.F. Lam</name></author><author><name sortKey="Lai, F M" uniqKey="Lai F">F.M. Lai</name></author><author><name sortKey="To, K F" uniqKey="To K">K.F. To</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kim, S Y" uniqKey="Kim S">S.Y. Kim</name></author><author><name sortKey="Park, S J" uniqKey="Park S">S.J. Park</name></author><author><name sortKey="Cho, S Y" uniqKey="Cho S">S.Y. Cho</name></author><author><name sortKey="Cha, R H" uniqKey="Cha R">R.H. Cha</name></author><author><name sortKey="Jee, H G" uniqKey="Jee H">H.G. Jee</name></author><author><name sortKey="Kim, G" uniqKey="Kim G">G. Kim</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Peduzzi, P" uniqKey="Peduzzi P">P. Peduzzi</name></author><author><name sortKey="Concato, J" uniqKey="Concato J">J. Concato</name></author><author><name sortKey="Kemper, E" uniqKey="Kemper E">E. Kemper</name></author><author><name sortKey="Holford, T R" uniqKey="Holford T">T.R. Holford</name></author><author><name sortKey="Feinstein, A R" uniqKey="Feinstein A">A.R. Feinstein</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Courvoisier, D S" uniqKey="Courvoisier D">D.S. Courvoisier</name></author><author><name sortKey="Combescure, C" uniqKey="Combescure C">C. Combescure</name></author><author><name sortKey="Agoritsas, T" uniqKey="Agoritsas T">T. Agoritsas</name></author><author><name sortKey="Gayet Ageron, A" uniqKey="Gayet Ageron A">A. Gayet-Ageron</name></author><author><name sortKey="Perneger, T V" uniqKey="Perneger T">T.V. Perneger</name></author></analytic></biblStruct></listBibl></div1></back></TEI></pmc><pubmed><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">High fatality rates and associated factors in two hospital outbreaks of MERS in Daejeon, the Republic of Korea.</title><author><name sortKey="Nam, Hae Sung" sort="Nam, Hae Sung" uniqKey="Nam H" first="Hae-Sung" last="Nam">Hae-Sung Nam</name><affiliation wicri:level="1"><nlm:affiliation>Department of Preventive Medicine and Public Health, Chungnam National University School of Medicine, Daejeon, Republic of Korea. Electronic address: hsnam@cnu.ac.kr.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Preventive Medicine and Public Health, Chungnam National University School of Medicine, Daejeon</wicri:regionArea><wicri:noRegion>Daejeon</wicri:noRegion></affiliation></author><author><name sortKey="Park, Jung Wan" sort="Park, Jung Wan" uniqKey="Park J" first="Jung Wan" last="Park">Jung Wan Park</name><affiliation wicri:level="1"><nlm:affiliation>Division of Infectious Disease Surveillance, Korea Centers for Disease Control and Prevention, Cheongju, Republic of Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Division of Infectious Disease Surveillance, Korea Centers for Disease Control and Prevention, Cheongju</wicri:regionArea><wicri:noRegion>Cheongju</wicri:noRegion></affiliation></author><author><name sortKey="Ki, Moran" sort="Ki, Moran" uniqKey="Ki M" first="Moran" last="Ki">Moran Ki</name><affiliation wicri:level="1"><nlm:affiliation>Department of Cancer Control and Policy, Graduate School of Cancer Science and Policy, National Cancer Center, Goyang, Republic of Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Cancer Control and Policy, Graduate School of Cancer Science and Policy, National Cancer Center, Goyang</wicri:regionArea><wicri:noRegion>Goyang</wicri:noRegion></affiliation></author><author><name sortKey="Yeon, Mi Yeon" sort="Yeon, Mi Yeon" uniqKey="Yeon M" first="Mi-Yeon" last="Yeon">Mi-Yeon Yeon</name><affiliation wicri:level="1"><nlm:affiliation>Department of Preventive Medicine and Public Health, Chungnam National University School of Medicine, Daejeon, Republic of Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Preventive Medicine and Public Health, Chungnam National University School of Medicine, Daejeon</wicri:regionArea><wicri:noRegion>Daejeon</wicri:noRegion></affiliation></author><author><name sortKey="Kim, Jin" sort="Kim, Jin" uniqKey="Kim J" first="Jin" last="Kim">Jin Kim</name><affiliation wicri:level="1"><nlm:affiliation>Department of Nursing, Graduate School, Chungnam National University, Daejeon, Republic of Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Nursing, Graduate School, Chungnam National University, Daejeon</wicri:regionArea><wicri:noRegion>Daejeon</wicri:noRegion></affiliation></author><author><name sortKey="Kim, Seung Woo" sort="Kim, Seung Woo" uniqKey="Kim S" first="Seung Woo" last="Kim">Seung Woo Kim</name><affiliation wicri:level="1"><nlm:affiliation>Division of Infectious Disease Surveillance, Korea Centers for Disease Control and Prevention, Cheongju, Republic of Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Division of Infectious Disease Surveillance, Korea Centers for Disease Control and Prevention, Cheongju</wicri:regionArea><wicri:noRegion>Cheongju</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2017">2017</date><idno type="RBID">pubmed:28223175</idno><idno type="pmid">28223175</idno><idno type="doi">10.1016/j.ijid.2017.02.008</idno><idno type="wicri:Area/PubMed/Corpus">000D69</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000D69</idno><idno type="wicri:Area/PubMed/Curation">000D69</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000D69</idno><idno type="wicri:Area/PubMed/Checkpoint">000C85</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000C85</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">High fatality rates and associated factors in two hospital outbreaks of MERS in Daejeon, the Republic of Korea.</title><author><name sortKey="Nam, Hae Sung" sort="Nam, Hae Sung" uniqKey="Nam H" first="Hae-Sung" last="Nam">Hae-Sung Nam</name><affiliation wicri:level="1"><nlm:affiliation>Department of Preventive Medicine and Public Health, Chungnam National University School of Medicine, Daejeon, Republic of Korea. Electronic address: hsnam@cnu.ac.kr.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Preventive Medicine and Public Health, Chungnam National University School of Medicine, Daejeon</wicri:regionArea><wicri:noRegion>Daejeon</wicri:noRegion></affiliation></author><author><name sortKey="Park, Jung Wan" sort="Park, Jung Wan" uniqKey="Park J" first="Jung Wan" last="Park">Jung Wan Park</name><affiliation wicri:level="1"><nlm:affiliation>Division of Infectious Disease Surveillance, Korea Centers for Disease Control and Prevention, Cheongju, Republic of Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Division of Infectious Disease Surveillance, Korea Centers for Disease Control and Prevention, Cheongju</wicri:regionArea><wicri:noRegion>Cheongju</wicri:noRegion></affiliation></author><author><name sortKey="Ki, Moran" sort="Ki, Moran" uniqKey="Ki M" first="Moran" last="Ki">Moran Ki</name><affiliation wicri:level="1"><nlm:affiliation>Department of Cancer Control and Policy, Graduate School of Cancer Science and Policy, National Cancer Center, Goyang, Republic of Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Cancer Control and Policy, Graduate School of Cancer Science and Policy, National Cancer Center, Goyang</wicri:regionArea><wicri:noRegion>Goyang</wicri:noRegion></affiliation></author><author><name sortKey="Yeon, Mi Yeon" sort="Yeon, Mi Yeon" uniqKey="Yeon M" first="Mi-Yeon" last="Yeon">Mi-Yeon Yeon</name><affiliation wicri:level="1"><nlm:affiliation>Department of Preventive Medicine and Public Health, Chungnam National University School of Medicine, Daejeon, Republic of Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Preventive Medicine and Public Health, Chungnam National University School of Medicine, Daejeon</wicri:regionArea><wicri:noRegion>Daejeon</wicri:noRegion></affiliation></author><author><name sortKey="Kim, Jin" sort="Kim, Jin" uniqKey="Kim J" first="Jin" last="Kim">Jin Kim</name><affiliation wicri:level="1"><nlm:affiliation>Department of Nursing, Graduate School, Chungnam National University, Daejeon, Republic of Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Nursing, Graduate School, Chungnam National University, Daejeon</wicri:regionArea><wicri:noRegion>Daejeon</wicri:noRegion></affiliation></author><author><name sortKey="Kim, Seung Woo" sort="Kim, Seung Woo" uniqKey="Kim S" first="Seung Woo" last="Kim">Seung Woo Kim</name><affiliation wicri:level="1"><nlm:affiliation>Division of Infectious Disease Surveillance, Korea Centers for Disease Control and Prevention, Cheongju, Republic of Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Division of Infectious Disease Surveillance, Korea Centers for Disease Control and Prevention, Cheongju</wicri:regionArea><wicri:noRegion>Cheongju</wicri:noRegion></affiliation></author></analytic><series><title level="j">International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases</title><idno type="eISSN">1878-3511</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Coronavirus Infections (epidemiology)</term><term>Coronavirus Infections (mortality)</term><term>Cross Infection (epidemiology)</term><term>Cross Infection (mortality)</term><term>Disease Outbreaks</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Middle East Respiratory Syndrome Coronavirus</term><term>Republic of Korea (epidemiology)</term><term>Risk Factors</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Coronavirus du syndrome respiratoire du Moyen-Orient</term><term>Facteurs de risque</term><term>Femelle</term><term>Flambées de maladies</term><term>Humains</term><term>Infection croisée (mortalité)</term><term>Infection croisée (épidémiologie)</term><term>Infections à coronavirus (mortalité)</term><term>Infections à coronavirus (épidémiologie)</term><term>Mâle</term><term>République de Corée (épidémiologie)</term><term>Sujet âgé</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Coronavirus Infections</term><term>Cross Infection</term><term>Republic of Korea</term></keywords><keywords scheme="MESH" qualifier="mortality" xml:lang="en"><term>Coronavirus Infections</term><term>Cross Infection</term></keywords><keywords scheme="MESH" qualifier="mortalité" xml:lang="fr"><term>Infection croisée</term><term>Infections à coronavirus</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Infection croisée</term><term>Infections à coronavirus</term><term>République de Corée</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Disease Outbreaks</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Middle East Respiratory Syndrome Coronavirus</term><term>Risk Factors</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Coronavirus du syndrome respiratoire du Moyen-Orient</term><term>Facteurs de risque</term><term>Femelle</term><term>Flambées de maladies</term><term>Humains</term><term>Mâle</term><term>Sujet âgé</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">To explore the epidemiological and clinical factors predictive of the case fatality rate (CFR) of Middle East respiratory syndrome-coronavirus (MERS-CoV) infection in an outbreak in Daejeon, the Republic of Korea.</div></front></TEI></pubmed></double></record>Pour manipuler ce document sous Unix (Dilib)
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