MersV1, Ncbi, Merge, bibRecord, 001620

MERS versus Standard Surgical Approaches for Porcine Vocal Fold Scarring with Adipose Stem Cell Constructs.

Identifieur interne : 001620 ( Ncbi/Merge ); précédent : 001619; suivant : 001621

MERS versus Standard Surgical Approaches for Porcine Vocal Fold Scarring with Adipose Stem Cell Constructs.

Auteurs : Joo Hyun Woo [Corée du Sud] ; Suzanne N. King [États-Unis] ; Henry Hoffman [États-Unis] ; Seth Dailey [États-Unis] ; Sarah Wang [États-Unis] ; Michael B. Christensen [États-Unis] ; Susan L. Thibeault [États-Unis]

Source :

Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery [ 1097-6817 ] ; 2016.

RBID : pubmed:27165681

Descripteurs français

KwdFr :
- Animaux, Cellules cultivées, Cicatrice (), Cicatrice (anatomopathologie), Colle de fibrine, Femelle, Hydrogels (administration et posologie), Hydrogels (pharmacologie), Laryngoscopie, Marqueurs biologiques (analyse), Modèles animaux de maladie humaine, Plis vocaux (), Plis vocaux (anatomopathologie), Réaction de polymérisation en chaine en temps réel, Suidae, Techniques immunoenzymatiques, Transplantation de cellules souches.
MESH :
- administration et posologie : Hydrogels.
- analyse : Marqueurs biologiques.
- anatomopathologie : Cicatrice, Plis vocaux.
- pharmacologie : Hydrogels.
- Animaux, Cellules cultivées, Cicatrice, Colle de fibrine, Femelle, Laryngoscopie, Modèles animaux de maladie humaine, Plis vocaux, Réaction de polymérisation en chaine en temps réel, Suidae, Techniques immunoenzymatiques, Transplantation de cellules souches.

English descriptors

KwdEn :
- Animals, Biomarkers (analysis), Cells, Cultured, Cicatrix (pathology), Cicatrix (surgery), Disease Models, Animal, Female, Fibrin Tissue Adhesive, Hydrogels (administration & dosage), Hydrogels (pharmacology), Immunoenzyme Techniques, Laryngoscopy, Real-Time Polymerase Chain Reaction, Stem Cell Transplantation, Swine, Vocal Cords (pathology), Vocal Cords (surgery).
MESH :
- chemical , administration & dosage : Hydrogels.
- chemical , analysis : Biomarkers.
- pathology : Cicatrix, Vocal Cords.
- chemical , pharmacology : Hydrogels.
- surgery : Cicatrix, Vocal Cords.
- Animals, Cells, Cultured, Disease Models, Animal, Female, Fibrin Tissue Adhesive, Immunoenzyme Techniques, Laryngoscopy, Real-Time Polymerase Chain Reaction, Stem Cell Transplantation, Swine.

Abstract

Cells, scaffold, and surgical approaches are important for regeneration of the lamina propria of the scarred vocal fold (VF). Microendoscopy of Reinke's space (MERS) is a surgical approach used to access the lamina propria. The present study evaluated MERS in the treatment of VF scarring as compared with standardized approaches for the treatment of VF scarring with adipose stem cell constructs.

DOI: 10.1177/0194599816645772
PubMed: 27165681

Links toward previous steps (curation, corpus...)

to stream PubMed, to step Corpus: 001125
to stream PubMed, to step Curation: 001125
to stream PubMed, to step Checkpoint: 001025

Links to Exploration step

pubmed:27165681

Le document en format XML

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<idno type="eISSN">1097-6817</idno>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term>
<term>Biomarkers (analysis)</term>
<term>Cells, Cultured</term>
<term>Cicatrix (pathology)</term>
<term>Cicatrix (surgery)</term>
<term>Disease Models, Animal</term>
<term>Female</term>
<term>Fibrin Tissue Adhesive</term>
<term>Hydrogels (administration & dosage)</term>
<term>Hydrogels (pharmacology)</term>
<term>Immunoenzyme Techniques</term>
<term>Laryngoscopy</term>
<term>Real-Time Polymerase Chain Reaction</term>
<term>Stem Cell Transplantation</term>
<term>Swine</term>
<term>Vocal Cords (pathology)</term>
<term>Vocal Cords (surgery)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term>
<term>Cellules cultivées</term>
<term>Cicatrice ()</term>
<term>Cicatrice (anatomopathologie)</term>
<term>Colle de fibrine</term>
<term>Femelle</term>
<term>Hydrogels (administration et posologie)</term>
<term>Hydrogels (pharmacologie)</term>
<term>Laryngoscopie</term>
<term>Marqueurs biologiques (analyse)</term>
<term>Modèles animaux de maladie humaine</term>
<term>Plis vocaux ()</term>
<term>Plis vocaux (anatomopathologie)</term>
<term>Réaction de polymérisation en chaine en temps réel</term>
<term>Suidae</term>
<term>Techniques immunoenzymatiques</term>
<term>Transplantation de cellules souches</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Hydrogels</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Biomarkers</term>
</keywords>
<keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Hydrogels</term>
</keywords>
<keywords scheme="MESH" qualifier="analyse" xml:lang="fr"><term>Marqueurs biologiques</term>
</keywords>
<keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Cicatrice</term>
<term>Plis vocaux</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Cicatrix</term>
<term>Vocal Cords</term>
</keywords>
<keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Hydrogels</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Hydrogels</term>
</keywords>
<keywords scheme="MESH" qualifier="surgery" xml:lang="en"><term>Cicatrix</term>
<term>Vocal Cords</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Cells, Cultured</term>
<term>Disease Models, Animal</term>
<term>Female</term>
<term>Fibrin Tissue Adhesive</term>
<term>Immunoenzyme Techniques</term>
<term>Laryngoscopy</term>
<term>Real-Time Polymerase Chain Reaction</term>
<term>Stem Cell Transplantation</term>
<term>Swine</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Animaux</term>
<term>Cellules cultivées</term>
<term>Cicatrice</term>
<term>Colle de fibrine</term>
<term>Femelle</term>
<term>Laryngoscopie</term>
<term>Modèles animaux de maladie humaine</term>
<term>Plis vocaux</term>
<term>Réaction de polymérisation en chaine en temps réel</term>
<term>Suidae</term>
<term>Techniques immunoenzymatiques</term>
<term>Transplantation de cellules souches</term>
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<front><div type="abstract" xml:lang="en">Cells, scaffold, and surgical approaches are important for regeneration of the lamina propria of the scarred vocal fold (VF). Microendoscopy of Reinke's space (MERS) is a surgical approach used to access the lamina propria. The present study evaluated MERS in the treatment of VF scarring as compared with standardized approaches for the treatment of VF scarring with adipose stem cell constructs.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">27165681</PMID>
<DateCompleted><Year>2017</Year>
<Month>07</Month>
<Day>18</Day>
</DateCompleted>
<DateRevised><Year>2020</Year>
<Month>04</Month>
<Day>02</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1097-6817</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>155</Volume>
<Issue>4</Issue>
<PubDate><Year>2016</Year>
<Month>10</Month>
</PubDate>
</JournalIssue>
<Title>Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery</Title>
<ISOAbbreviation>Otolaryngol Head Neck Surg</ISOAbbreviation>
</Journal>
<ArticleTitle>MERS versus Standard Surgical Approaches for Porcine Vocal Fold Scarring with Adipose Stem Cell Constructs.</ArticleTitle>
<Pagination><MedlinePgn>612-23</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1177/0194599816645772</ELocationID>
<Abstract><AbstractText Label="OBJECTIVE">Cells, scaffold, and surgical approaches are important for regeneration of the lamina propria of the scarred vocal fold (VF). Microendoscopy of Reinke's space (MERS) is a surgical approach used to access the lamina propria. The present study evaluated MERS in the treatment of VF scarring as compared with standardized approaches for the treatment of VF scarring with adipose stem cell constructs.</AbstractText>
<AbstractText Label="STUDY DESIGN">Animal study.</AbstractText>
<AbstractText Label="SETTING">Academic center.</AbstractText>
<AbstractText Label="SUBJECTS AND METHODS">VF injury was performed bilaterally to induce scarring in 20 pigs. Eight weeks after injury, pigs were classified into no treatment, minithyrotomy, VF injection, VF incision/dissection, and MERS. All groups (except control) were implanted with adipose stem cell and hyaluronan. Four weeks after treatment, histology for collagen, hyaluronan, and fibronectin; mRNA expression for α-smooth muscle actin, tumor growth factor β1, collagen 1α1, collagen 3α1, matrix metalloproteinase 2, basic fibroblast growth factor, and hepatocyte growth factor; and tissue rheology were evaluated.</AbstractText>
<AbstractText Label="RESULTS">Differences were measured among surgical approaches for protein levels of collagen, hyaluronan, and fibronectin (P = .0133, P < .0001, and P = .0025, respectively). Fibroblast growth factor, collagen 1α1, and matrix metalloproteinase 2 transcript levels were different among treatment groups (P = .003, P = .0086, and P = .014, respectively), while no differences were measured for α-smooth muscle actin, tumor growth factor β1, hepatocyte growth factor, and collagen 3α1. Rheologically, significant differences were not measured between groups.</AbstractText>
<AbstractText Label="CONCLUSION">MERS is a promising surgical approach for the treatment of VF scarring, optimizing the placement of implanted biomaterials.</AbstractText>
<CopyrightInformation>© American Academy of Otolaryngology—Head and Neck Surgery Foundation 2016.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Woo</LastName>
<ForeName>Joo Hyun</ForeName>
<Initials>JH</Initials>
<AffiliationInfo><Affiliation>Department of Otorhinolaryngology-Head and Neck Surgery, Gil Medical Center, Gachon University, Incheon, Korea.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>King</LastName>
<ForeName>Suzanne N</ForeName>
<Initials>SN</Initials>
<AffiliationInfo><Affiliation>Department of Neurological Surgery, University of Louisville, Louisville, Kentucky, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Hoffman</LastName>
<ForeName>Henry</ForeName>
<Initials>H</Initials>
<AffiliationInfo><Affiliation>Department of Otolaryngology-Head and Neck Surgery, University of Iowa, Iowa City, Iowa, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Dailey</LastName>
<ForeName>Seth</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>Division of Otolaryngology-Head and Neck Surgery, Department of Surgery, University of Wisconsin-Madison, Madison, Wisconsin, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Wang</LastName>
<ForeName>Sarah</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>Division of Otolaryngology-Head and Neck Surgery, Department of Surgery, University of Wisconsin-Madison, Madison, Wisconsin, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Christensen</LastName>
<ForeName>Michael B</ForeName>
<Initials>MB</Initials>
<AffiliationInfo><Affiliation>National Center for Voice and Speech, University of Utah, Salt Lake City, Utah, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Thibeault</LastName>
<ForeName>Susan L</ForeName>
<Initials>SL</Initials>
<AffiliationInfo><Affiliation>Division of Otolaryngology-Head and Neck Surgery, Department of Surgery, University of Wisconsin-Madison, Madison, Wisconsin, USA thibeaul@surgery.wisc.edu.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<GrantList CompleteYN="Y"><Grant><GrantID>R01 DC004336</GrantID>
<Acronym>DC</Acronym>
<Agency>NIDCD NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>R01 DC013508</GrantID>
<Acronym>DC</Acronym>
<Agency>NIDCD NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>T32 DC009401</GrantID>
<Acronym>DC</Acronym>
<Agency>NIDCD NIH HHS</Agency>
<Country>United States</Country>
</Grant>
</GrantList>
<PublicationTypeList><PublicationType UI="D003160">Comparative Study</PublicationType>
<PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D052061">Research Support, N.I.H., Extramural</PublicationType>
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<ArticleDate DateType="Electronic"><Year>2016</Year>
<Month>05</Month>
<Day>10</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>England</Country>
<MedlineTA>Otolaryngol Head Neck Surg</MedlineTA>
<NlmUniqueID>8508176</NlmUniqueID>
<ISSNLinking>0194-5998</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D015415">Biomarkers</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D015718">Fibrin Tissue Adhesive</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D020100">Hydrogels</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D015415" MajorTopicYN="N">Biomarkers</DescriptorName>
<QualifierName UI="Q000032" MajorTopicYN="N">analysis</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002478" MajorTopicYN="N">Cells, Cultured</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002921" MajorTopicYN="N">Cicatrix</DescriptorName>
<QualifierName UI="Q000473" MajorTopicYN="Y">pathology</QualifierName>
<QualifierName UI="Q000601" MajorTopicYN="Y">surgery</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D004195" MajorTopicYN="N">Disease Models, Animal</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D015718" MajorTopicYN="N">Fibrin Tissue Adhesive</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D020100" MajorTopicYN="N">Hydrogels</DescriptorName>
<QualifierName UI="Q000008" MajorTopicYN="N">administration & dosage</QualifierName>
<QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D007124" MajorTopicYN="N">Immunoenzyme Techniques</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D007828" MajorTopicYN="N">Laryngoscopy</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D060888" MajorTopicYN="N">Real-Time Polymerase Chain Reaction</DescriptorName>
</MeshHeading>
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Serveur d'exploration MERS

MERS versus Standard Surgical Approaches for Porcine Vocal Fold Scarring with Adipose Stem Cell Constructs.

MERS versus Standard Surgical Approaches for Porcine Vocal Fold Scarring with Adipose Stem Cell Constructs.

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