Electrical detection of dengue virus (DENV) DNA oligomer using silicon nanowire biosensor with novel molecular gate control.
Identifieur interne : 001589 ( Ncbi/Merge ); précédent : 001588; suivant : 001590Electrical detection of dengue virus (DENV) DNA oligomer using silicon nanowire biosensor with novel molecular gate control.
Auteurs : M. Nuzaihan M N [Malaisie] ; U. Hashim [Malaisie] ; M K Md Arshad [Malaisie] ; S R Kasjoo [Malaisie] ; S F A. Rahman [Malaisie] ; A R Ruslinda [Malaisie] ; M F M. Fathil [Malaisie] ; R. Adzhri [Malaisie] ; M M Shahimin [Malaisie]Source :
- Biosensors & bioelectronics [ 1873-4235 ] ; 2016.
Descripteurs français
- KwdFr :
- ADN viral (analyse), Acides nucléiques immobilisés (), Conception d'appareillage, Dengue (diagnostic), Dengue (virologie), Humains, Laboratoires sur puces, Limite de détection, Nanofils (), Nanofils (ultrastructure), Reproductibilité des résultats, Silicium (), Techniques de biocapteur (instrumentation), Transducteurs, Virus de la dengue (isolement et purification).
- MESH :
- analyse : ADN viral.
- diagnostic : Dengue.
- isolement et purification : Virus de la dengue.
- virologie : Dengue.
- Acides nucléiques immobilisés, Conception d'appareillage, Humains, Laboratoires sur puces, Limite de détection, Nanofils, Reproductibilité des résultats, Silicium, Techniques de biocapteur, Transducteurs.
English descriptors
- KwdEn :
- Biosensing Techniques (instrumentation), DNA, Viral (analysis), Dengue (diagnosis), Dengue (virology), Dengue Virus (isolation & purification), Equipment Design, Humans, Immobilized Nucleic Acids (chemistry), Lab-On-A-Chip Devices, Limit of Detection, Nanowires (chemistry), Nanowires (ultrastructure), Reproducibility of Results, Silicon (chemistry), Transducers.
- MESH :
- chemical , analysis : DNA, Viral.
- chemical , chemistry : Immobilized Nucleic Acids, Silicon.
- chemistry : Nanowires.
- diagnosis : Dengue.
- instrumentation : Biosensing Techniques.
- isolation & purification : Dengue Virus.
- ultrastructure : Nanowires.
- virology : Dengue.
- Equipment Design, Humans, Lab-On-A-Chip Devices, Limit of Detection, Reproducibility of Results, Transducers.
Abstract
In this paper, a silicon nanowire biosensor with novel molecular gate control has been demonstrated for Deoxyribonucleic acid (DNA) detection related to dengue virus (DENV). The silicon nanowire was fabricated using the top-down nanolithography approach, through nanostructuring of silicon-on-insulator (SOI) layers achieved by combination of the electron-beam lithography (EBL), plasma dry etching and size reduction processes. The surface of the fabricated silicon nanowire was functionalized by means of a three-step procedure involving surface modification, DNA immobilization and hybridization. This procedure acts as a molecular gate control to establish the electrical detection for 27-mers base targets DENV DNA oligomer. The electrical detection is based on the changes in current, resistance and conductance of the sensor due to accumulation of negative charges added by the immobilized probe DNA and hybridized target DNA. The sensitivity of the silicon nanowire biosensors attained was 45.0µAM(-1), which shows a wide-range detection capability of the sensor with respect to DNA. The limit of detection (LOD) achieved was approximately 2.0fM. The demonstrated results show that the silicon nanowire has excellent properties for detection of DENV with outstanding repeatability and reproducibility performances.
DOI: 10.1016/j.bios.2016.04.033
PubMed: 27107147
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pubmed:27107147Le document en format XML
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Nuzaihan M N</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Nano Electronic Engineering, Universiti Malaysia Perlis (UniMAP), 01000 Kangar, Perlis, Malaysia. Electronic address: m.nuzaihan@unimap.edu.my.</nlm:affiliation><country xml:lang="fr">Malaisie</country><wicri:regionArea>Institute of Nano Electronic Engineering, Universiti Malaysia Perlis (UniMAP), 01000 Kangar, Perlis</wicri:regionArea><wicri:noRegion>Perlis</wicri:noRegion></affiliation></author><author><name sortKey="Hashim, U" sort="Hashim, U" uniqKey="Hashim U" first="U" last="Hashim">U. Hashim</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Nano Electronic Engineering, Universiti Malaysia Perlis (UniMAP), 01000 Kangar, Perlis, Malaysia; School of Microelectronic Engineering, Universiti Malaysia Perlis (UniMAP), 02600 Pauh, Perlis, Malaysia.</nlm:affiliation><country xml:lang="fr">Malaisie</country><wicri:regionArea>Institute of Nano Electronic Engineering, Universiti Malaysia Perlis (UniMAP), 01000 Kangar, Perlis, Malaysia; School of Microelectronic Engineering, Universiti Malaysia Perlis (UniMAP), 02600 Pauh, Perlis</wicri:regionArea><wicri:noRegion>Perlis</wicri:noRegion></affiliation></author><author><name sortKey="Md Arshad, M K" sort="Md Arshad, M K" uniqKey="Md Arshad M" first="M K" last="Md Arshad">M K Md Arshad</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Nano Electronic Engineering, Universiti Malaysia Perlis (UniMAP), 01000 Kangar, Perlis, Malaysia; School of Microelectronic Engineering, Universiti Malaysia Perlis (UniMAP), 02600 Pauh, Perlis, Malaysia.</nlm:affiliation><country xml:lang="fr">Malaisie</country><wicri:regionArea>Institute of Nano Electronic Engineering, Universiti Malaysia Perlis (UniMAP), 01000 Kangar, Perlis, Malaysia; School of Microelectronic Engineering, Universiti Malaysia Perlis (UniMAP), 02600 Pauh, Perlis</wicri:regionArea><wicri:noRegion>Perlis</wicri:noRegion></affiliation></author><author><name sortKey="Kasjoo, S R" sort="Kasjoo, S R" uniqKey="Kasjoo S" first="S R" last="Kasjoo">S R Kasjoo</name><affiliation wicri:level="1"><nlm:affiliation>School of Microelectronic Engineering, Universiti Malaysia Perlis (UniMAP), 02600 Pauh, Perlis, Malaysia.</nlm:affiliation><country xml:lang="fr">Malaisie</country><wicri:regionArea>School of Microelectronic Engineering, Universiti Malaysia Perlis (UniMAP), 02600 Pauh, Perlis</wicri:regionArea><wicri:noRegion>Perlis</wicri:noRegion></affiliation></author><author><name sortKey="Rahman, S F A" sort="Rahman, S F A" uniqKey="Rahman S" first="S F A" last="Rahman">S F A. Rahman</name><affiliation wicri:level="1"><nlm:affiliation>Chemistry Department, Faculty of Science, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia.</nlm:affiliation><country xml:lang="fr">Malaisie</country><wicri:regionArea>Chemistry Department, Faculty of Science, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor</wicri:regionArea><wicri:noRegion>Selangor</wicri:noRegion></affiliation></author><author><name sortKey="Ruslinda, A R" sort="Ruslinda, A R" uniqKey="Ruslinda A" first="A R" last="Ruslinda">A R Ruslinda</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Nano Electronic Engineering, Universiti Malaysia Perlis (UniMAP), 01000 Kangar, Perlis, Malaysia.</nlm:affiliation><country xml:lang="fr">Malaisie</country><wicri:regionArea>Institute of Nano Electronic Engineering, Universiti Malaysia Perlis (UniMAP), 01000 Kangar, Perlis</wicri:regionArea><wicri:noRegion>Perlis</wicri:noRegion></affiliation></author><author><name sortKey="Fathil, M F M" sort="Fathil, M F M" uniqKey="Fathil M" first="M F M" last="Fathil">M F M. Fathil</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Nano Electronic Engineering, Universiti Malaysia Perlis (UniMAP), 01000 Kangar, Perlis, Malaysia.</nlm:affiliation><country xml:lang="fr">Malaisie</country><wicri:regionArea>Institute of Nano Electronic Engineering, Universiti Malaysia Perlis (UniMAP), 01000 Kangar, Perlis</wicri:regionArea><wicri:noRegion>Perlis</wicri:noRegion></affiliation></author><author><name sortKey="Adzhri, R" sort="Adzhri, R" uniqKey="Adzhri R" first="R" last="Adzhri">R. Adzhri</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Nano Electronic Engineering, Universiti Malaysia Perlis (UniMAP), 01000 Kangar, Perlis, Malaysia.</nlm:affiliation><country xml:lang="fr">Malaisie</country><wicri:regionArea>Institute of Nano Electronic Engineering, Universiti Malaysia Perlis (UniMAP), 01000 Kangar, Perlis</wicri:regionArea><wicri:noRegion>Perlis</wicri:noRegion></affiliation></author><author><name sortKey="Shahimin, M M" sort="Shahimin, M M" uniqKey="Shahimin M" first="M M" last="Shahimin">M M Shahimin</name><affiliation wicri:level="1"><nlm:affiliation>School of Microelectronic Engineering, Universiti Malaysia Perlis (UniMAP), 02600 Pauh, Perlis, Malaysia.</nlm:affiliation><country xml:lang="fr">Malaisie</country><wicri:regionArea>School of Microelectronic Engineering, Universiti Malaysia Perlis (UniMAP), 02600 Pauh, Perlis</wicri:regionArea><wicri:noRegion>Perlis</wicri:noRegion></affiliation></author></analytic><series><title level="j">Biosensors & bioelectronics</title><idno type="eISSN">1873-4235</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Biosensing Techniques (instrumentation)</term><term>DNA, Viral (analysis)</term><term>Dengue (diagnosis)</term><term>Dengue (virology)</term><term>Dengue Virus (isolation & purification)</term><term>Equipment Design</term><term>Humans</term><term>Immobilized Nucleic Acids (chemistry)</term><term>Lab-On-A-Chip Devices</term><term>Limit of Detection</term><term>Nanowires (chemistry)</term><term>Nanowires (ultrastructure)</term><term>Reproducibility of Results</term><term>Silicon (chemistry)</term><term>Transducers</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>ADN viral (analyse)</term><term>Acides nucléiques immobilisés ()</term><term>Conception d'appareillage</term><term>Dengue (diagnostic)</term><term>Dengue (virologie)</term><term>Humains</term><term>Laboratoires sur puces</term><term>Limite de détection</term><term>Nanofils ()</term><term>Nanofils (ultrastructure)</term><term>Reproductibilité des résultats</term><term>Silicium ()</term><term>Techniques de biocapteur (instrumentation)</term><term>Transducteurs</term><term>Virus de la dengue (isolement et purification)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>DNA, Viral</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Immobilized Nucleic Acids</term><term>Silicon</term></keywords><keywords scheme="MESH" qualifier="analyse" xml:lang="fr"><term>ADN viral</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Nanowires</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Dengue</term></keywords><keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Dengue</term></keywords><keywords scheme="MESH" qualifier="instrumentation" xml:lang="en"><term>Biosensing Techniques</term></keywords><keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>Dengue Virus</term></keywords><keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Virus de la dengue</term></keywords><keywords scheme="MESH" qualifier="ultrastructure" xml:lang="en"><term>Nanowires</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Dengue</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Dengue</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Equipment Design</term><term>Humans</term><term>Lab-On-A-Chip Devices</term><term>Limit of Detection</term><term>Reproducibility of Results</term><term>Transducers</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Acides nucléiques immobilisés</term><term>Conception d'appareillage</term><term>Humains</term><term>Laboratoires sur puces</term><term>Limite de détection</term><term>Nanofils</term><term>Reproductibilité des résultats</term><term>Silicium</term><term>Techniques de biocapteur</term><term>Transducteurs</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">In this paper, a silicon nanowire biosensor with novel molecular gate control has been demonstrated for Deoxyribonucleic acid (DNA) detection related to dengue virus (DENV). The silicon nanowire was fabricated using the top-down nanolithography approach, through nanostructuring of silicon-on-insulator (SOI) layers achieved by combination of the electron-beam lithography (EBL), plasma dry etching and size reduction processes. The surface of the fabricated silicon nanowire was functionalized by means of a three-step procedure involving surface modification, DNA immobilization and hybridization. This procedure acts as a molecular gate control to establish the electrical detection for 27-mers base targets DENV DNA oligomer. The electrical detection is based on the changes in current, resistance and conductance of the sensor due to accumulation of negative charges added by the immobilized probe DNA and hybridized target DNA. The sensitivity of the silicon nanowire biosensors attained was 45.0µAM(-1), which shows a wide-range detection capability of the sensor with respect to DNA. The limit of detection (LOD) achieved was approximately 2.0fM. The demonstrated results show that the silicon nanowire has excellent properties for detection of DENV with outstanding repeatability and reproducibility performances. </div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">27107147</PMID><DateCompleted><Year>2017</Year><Month>02</Month><Day>07</Day></DateCompleted><DateRevised><Year>2019</Year><Month>12</Month><Day>10</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1873-4235</ISSN><JournalIssue CitedMedium="Internet"><Volume>83</Volume><PubDate><Year>2016</Year><Month>Sep</Month><Day>15</Day></PubDate></JournalIssue><Title>Biosensors & bioelectronics</Title><ISOAbbreviation>Biosens Bioelectron</ISOAbbreviation></Journal><ArticleTitle>Electrical detection of dengue virus (DENV) DNA oligomer using silicon nanowire biosensor with novel molecular gate control.</ArticleTitle><Pagination><MedlinePgn>106-14</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.bios.2016.04.033</ELocationID><ELocationID EIdType="pii" ValidYN="Y">S0956-5663(16)30311-6</ELocationID><Abstract><AbstractText>In this paper, a silicon nanowire biosensor with novel molecular gate control has been demonstrated for Deoxyribonucleic acid (DNA) detection related to dengue virus (DENV). The silicon nanowire was fabricated using the top-down nanolithography approach, through nanostructuring of silicon-on-insulator (SOI) layers achieved by combination of the electron-beam lithography (EBL), plasma dry etching and size reduction processes. The surface of the fabricated silicon nanowire was functionalized by means of a three-step procedure involving surface modification, DNA immobilization and hybridization. This procedure acts as a molecular gate control to establish the electrical detection for 27-mers base targets DENV DNA oligomer. The electrical detection is based on the changes in current, resistance and conductance of the sensor due to accumulation of negative charges added by the immobilized probe DNA and hybridized target DNA. The sensitivity of the silicon nanowire biosensors attained was 45.0µAM(-1), which shows a wide-range detection capability of the sensor with respect to DNA. The limit of detection (LOD) achieved was approximately 2.0fM. The demonstrated results show that the silicon nanowire has excellent properties for detection of DENV with outstanding repeatability and reproducibility performances. </AbstractText><CopyrightInformation>Copyright © 2016 Elsevier B.V. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Nuzaihan M N</LastName><ForeName>M</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Institute of Nano Electronic Engineering, Universiti Malaysia Perlis (UniMAP), 01000 Kangar, Perlis, Malaysia. Electronic address: m.nuzaihan@unimap.edu.my.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hashim</LastName><ForeName>U</ForeName><Initials>U</Initials><AffiliationInfo><Affiliation>Institute of Nano Electronic Engineering, Universiti Malaysia Perlis (UniMAP), 01000 Kangar, Perlis, Malaysia; School of Microelectronic Engineering, Universiti Malaysia Perlis (UniMAP), 02600 Pauh, Perlis, Malaysia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Md Arshad</LastName><ForeName>M K</ForeName><Initials>MK</Initials><AffiliationInfo><Affiliation>Institute of Nano Electronic Engineering, Universiti Malaysia Perlis (UniMAP), 01000 Kangar, Perlis, Malaysia; School of Microelectronic Engineering, Universiti Malaysia Perlis (UniMAP), 02600 Pauh, Perlis, Malaysia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kasjoo</LastName><ForeName>S R</ForeName><Initials>SR</Initials><AffiliationInfo><Affiliation>School of Microelectronic Engineering, Universiti Malaysia Perlis (UniMAP), 02600 Pauh, Perlis, Malaysia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rahman</LastName><ForeName>S F A</ForeName><Initials>SF</Initials><AffiliationInfo><Affiliation>Chemistry Department, Faculty of Science, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ruslinda</LastName><ForeName>A R</ForeName><Initials>AR</Initials><AffiliationInfo><Affiliation>Institute of Nano Electronic Engineering, Universiti Malaysia Perlis (UniMAP), 01000 Kangar, Perlis, Malaysia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fathil</LastName><ForeName>M F M</ForeName><Initials>MF</Initials><AffiliationInfo><Affiliation>Institute of Nano Electronic Engineering, Universiti Malaysia Perlis (UniMAP), 01000 Kangar, Perlis, Malaysia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Adzhri</LastName><ForeName>R</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Institute of Nano Electronic Engineering, Universiti Malaysia Perlis (UniMAP), 01000 Kangar, Perlis, Malaysia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Shahimin</LastName><ForeName>M M</ForeName><Initials>MM</Initials><AffiliationInfo><Affiliation>School of Microelectronic Engineering, Universiti Malaysia Perlis (UniMAP), 02600 Pauh, Perlis, Malaysia.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D023362">Evaluation Study</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2016</Year><Month>04</Month><Day>14</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Biosens Bioelectron</MedlineTA><NlmUniqueID>9001289</NlmUniqueID><ISSNLinking>0956-5663</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D004279">DNA, Viral</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D061925">Immobilized Nucleic Acids</NameOfSubstance></Chemical><Chemical><RegistryNumber>Z4152N8IUI</RegistryNumber><NameOfSubstance UI="D012825">Silicon</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D015374" MajorTopicYN="N">Biosensing Techniques</DescriptorName><QualifierName UI="Q000295" MajorTopicYN="Y">instrumentation</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004279" MajorTopicYN="N">DNA, Viral</DescriptorName><QualifierName UI="Q000032" MajorTopicYN="Y">analysis</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D003715" MajorTopicYN="N">Dengue</DescriptorName><QualifierName UI="Q000175" MajorTopicYN="N">diagnosis</QualifierName><QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D003716" MajorTopicYN="N">Dengue Virus</DescriptorName><QualifierName UI="Q000302" MajorTopicYN="Y">isolation & purification</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004867" MajorTopicYN="N">Equipment Design</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D061925" MajorTopicYN="N">Immobilized Nucleic Acids</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D056656" MajorTopicYN="N">Lab-On-A-Chip Devices</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D057230" MajorTopicYN="N">Limit of Detection</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D053770" MajorTopicYN="N">Nanowires</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName><QualifierName UI="Q000648" MajorTopicYN="N">ultrastructure</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015203" MajorTopicYN="N">Reproducibility of Results</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012825" MajorTopicYN="N">Silicon</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014159" MajorTopicYN="N">Transducers</DescriptorName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Dengue fever (DF)</Keyword><Keyword MajorTopicYN="N">Deoxyribonucleic acid (DNA)</Keyword><Keyword MajorTopicYN="N">Electrical detection</Keyword><Keyword MajorTopicYN="N">Molecular gate control</Keyword><Keyword MajorTopicYN="N">Nanolithography</Keyword><Keyword MajorTopicYN="N">Silicon nanowire biosensor</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2016</Year><Month>02</Month><Day>26</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2016</Year><Month>04</Month><Day>11</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2016</Year><Month>04</Month><Day>12</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2016</Year><Month>4</Month><Day>24</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2016</Year><Month>4</Month><Day>24</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2017</Year><Month>2</Month><Day>9</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">27107147</ArticleId><ArticleId IdType="pii">S0956-5663(16)30311-6</ArticleId><ArticleId IdType="doi">10.1016/j.bios.2016.04.033</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Malaisie</li></country></list><tree><country name="Malaisie"><noRegion><name sortKey="Nuzaihan M N, M" sort="Nuzaihan M N, M" uniqKey="Nuzaihan M N M" first="M" last="Nuzaihan M N">M. Nuzaihan M N</name></noRegion><name sortKey="Adzhri, R" sort="Adzhri, R" uniqKey="Adzhri R" first="R" last="Adzhri">R. Adzhri</name><name sortKey="Fathil, M F M" sort="Fathil, M F M" uniqKey="Fathil M" first="M F M" last="Fathil">M F M. Fathil</name><name sortKey="Hashim, U" sort="Hashim, U" uniqKey="Hashim U" first="U" last="Hashim">U. Hashim</name><name sortKey="Kasjoo, S R" sort="Kasjoo, S R" uniqKey="Kasjoo S" first="S R" last="Kasjoo">S R Kasjoo</name><name sortKey="Md Arshad, M K" sort="Md Arshad, M K" uniqKey="Md Arshad M" first="M K" last="Md Arshad">M K Md Arshad</name><name sortKey="Rahman, S F A" sort="Rahman, S F A" uniqKey="Rahman S" first="S F A" last="Rahman">S F A. Rahman</name><name sortKey="Ruslinda, A R" sort="Ruslinda, A R" uniqKey="Ruslinda A" first="A R" last="Ruslinda">A R Ruslinda</name><name sortKey="Shahimin, M M" sort="Shahimin, M M" uniqKey="Shahimin M" first="M M" last="Shahimin">M M Shahimin</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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