Passive immunotherapy with dromedary immune serum in an experimental animal model for Middle East respiratory syndrome coronavirus infection.
Identifieur interne : 001068 ( Ncbi/Merge ); précédent : 001067; suivant : 001069Passive immunotherapy with dromedary immune serum in an experimental animal model for Middle East respiratory syndrome coronavirus infection.
Auteurs : Jincun Zhao [République populaire de Chine] ; Ranawaka A P M. Perera [République populaire de Chine] ; Ghazi Kayali [États-Unis] ; David Meyerholz [États-Unis] ; Stanley Perlman [États-Unis] ; Malik Peiris [États-Unis]Source :
- Journal of virology [ 1098-5514 ] ; 2015.
Descripteurs français
- KwdFr :
- Animaux, Chameaux, Coronavirus du syndrome respiratoire du Moyen-Orient (immunologie), Femelle, Immunisation passive (), Infections à coronavirus (anatomopathologie), Infections à coronavirus (traitement médicamenteux), Modèles animaux de maladie humaine, Poumon (anatomopathologie), Résultat thérapeutique, Souris de lignée BALB C, Sérums immuns (administration et posologie).
- MESH :
- administration et posologie : Sérums immuns.
- anatomopathologie : Infections à coronavirus, Poumon.
- immunologie : Coronavirus du syndrome respiratoire du Moyen-Orient.
- traitement médicamenteux : Infections à coronavirus.
- Animaux, Chameaux, Femelle, Immunisation passive, Modèles animaux de maladie humaine, Résultat thérapeutique, Souris de lignée BALB C.
English descriptors
- KwdEn :
- Animals, Camelus, Coronavirus Infections (drug therapy), Coronavirus Infections (pathology), Disease Models, Animal, Female, Immune Sera (administration & dosage), Immunization, Passive (methods), Lung (pathology), Mice, Inbred BALB C, Middle East Respiratory Syndrome Coronavirus (immunology), Treatment Outcome.
- MESH :
- chemical , administration & dosage : Immune Sera.
- drug therapy : Coronavirus Infections.
- immunology : Middle East Respiratory Syndrome Coronavirus.
- methods : Immunization, Passive.
- pathology : Coronavirus Infections, Lung.
- Animals, Camelus, Disease Models, Animal, Female, Mice, Inbred BALB C, Treatment Outcome.
Abstract
Middle East respiratory syndrome (MERS) is a highly lethal pulmonary infection. Serum from convalescent MERS patients may provide some benefit but is not readily available. In contrast, nearly all camels in the Middle East have been infected with MERS-CoV. Here, we show that sera obtained from MERS-immune camels augment the kinetics of MERS-CoV clearance and reduce the severity of pathological changes in infected lungs, with efficacy proportional to the titer of MERS-CoV-neutralizing serum antibody.
DOI: 10.1128/JVI.00446-15
PubMed: 25787284
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 001673
- to stream PubMed, to step Curation: 001673
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pubmed:25787284Le document en format XML
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<front><div type="abstract" xml:lang="en">Middle East respiratory syndrome (MERS) is a highly lethal pulmonary infection. Serum from convalescent MERS patients may provide some benefit but is not readily available. In contrast, nearly all camels in the Middle East have been infected with MERS-CoV. Here, we show that sera obtained from MERS-immune camels augment the kinetics of MERS-CoV clearance and reduce the severity of pathological changes in infected lungs, with efficacy proportional to the titer of MERS-CoV-neutralizing serum antibody.</div>
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<Abstract><AbstractText Label="UNLABELLED">Middle East respiratory syndrome (MERS) is a highly lethal pulmonary infection. Serum from convalescent MERS patients may provide some benefit but is not readily available. In contrast, nearly all camels in the Middle East have been infected with MERS-CoV. Here, we show that sera obtained from MERS-immune camels augment the kinetics of MERS-CoV clearance and reduce the severity of pathological changes in infected lungs, with efficacy proportional to the titer of MERS-CoV-neutralizing serum antibody.</AbstractText>
<AbstractText Label="IMPORTANCE" NlmCategory="OBJECTIVE">Middle East respiratory syndrome, caused by a coronavirus, is highly lethal, with a case fatality rate of 35 to 40%. No specific therapy is available, and care is generally supportive. One promising approach is passive administration of sera from convalescent human MERS patients or other animals to exposed or infected patients. The vast majority of, if not all, camels in the Middle East have been infected with MERS-CoV, and some contain high titers of antibody to the virus. Here, we show that this antibody is protective if delivered either prophylactically or therapeutically to mice infected with MERS-CoV, indicating that this may be a useful intervention in infected patients.</AbstractText>
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<ForeName>Jincun</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Department of Microbiology, University of Iowa, Iowa City, Iowa, USA State Key Laboratory of Respiratory Diseases, Guangzhou Institute of Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.</Affiliation>
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<affiliations><list><country><li>République populaire de Chine</li>
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<li>Iowa</li>
<li>Tennessee</li>
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