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Differential diagnosis of delirious behavior in children with influenza.

Identifieur interne : 000F19 ( Ncbi/Merge ); précédent : 000F18; suivant : 000F20

Differential diagnosis of delirious behavior in children with influenza.

Auteurs : Mitsuru Kashiwagi [Japon] ; Takuya Tanabe [Japon] ; Chizu Ooba [Japon] ; Midori Masuda [Japon] ; Seiji Shigehara [Japon] ; Shinya Murata [Japon] ; Atsuko Ashida [Japon] ; Akihiko Shirasu [Japon] ; Keisuke Inoue [Japon] ; Keisuke Okasora [Japon] ; Hiroshi Tamai [Japon]

Source :

RBID : pubmed:25277296

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English descriptors

Abstract

Delirious behavior (DB) in children infected with influenza virus is an important symptom associated with encephalopathy. As children with influenza-associated DB with encephalopathy may require therapy whereas children with influenza-associated DB without encephalopathy do not, distinguishing between these conditions is essential. To clarify these differences and identify the most common features of acute encephalopathy, we retrospectively reviewed the clinical course, laboratory data, magnetic resonance imaging (MRI) and electroencephalography (EEG) findings, therapy, and prognosis of 48 children with influenza exhibiting DB. Of the 48 children, 37 and 11 were diagnosed with influenza A and B, respectively. Moreover, 40 were diagnosed with DB without encephalopathy (DBNE group) and 8, with DB with encephalopathy (DBE group). Reversible splenial lesion (RESLE) was detected in 7 patients in the DBNE group, mild encephalitis/encephalopathy with a reversible splenial lesion (MERS) in 2 patients, and a mild form of acute encephalopathy with biphasic seizures and late reduced diffusion in 1 patient in the DBE group. Serum sodium levels <136mEq/L were observed in 28 cases. Disturbance of consciousness was observed in 25 cases, seizure in 20, and slow waves on EEG in 22. Methylprednisolone pulse therapy was administered in 8 cases. No cases of neurological sequelae were observed. Although most of the clinico-radiological features of the DBNE and DBE groups did not differ substantially, marked differences were observed in the age at onset, initial neurological symptoms, duration of DB, rate of seizure, and slowing of background activity on EEG. These differences should be considered when distinguishing between DBNE and DBE in children.

DOI: 10.1016/j.braindev.2014.09.003
PubMed: 25277296

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Le document en format XML

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<div type="abstract" xml:lang="en">Delirious behavior (DB) in children infected with influenza virus is an important symptom associated with encephalopathy. As children with influenza-associated DB with encephalopathy may require therapy whereas children with influenza-associated DB without encephalopathy do not, distinguishing between these conditions is essential. To clarify these differences and identify the most common features of acute encephalopathy, we retrospectively reviewed the clinical course, laboratory data, magnetic resonance imaging (MRI) and electroencephalography (EEG) findings, therapy, and prognosis of 48 children with influenza exhibiting DB. Of the 48 children, 37 and 11 were diagnosed with influenza A and B, respectively. Moreover, 40 were diagnosed with DB without encephalopathy (DBNE group) and 8, with DB with encephalopathy (DBE group). Reversible splenial lesion (RESLE) was detected in 7 patients in the DBNE group, mild encephalitis/encephalopathy with a reversible splenial lesion (MERS) in 2 patients, and a mild form of acute encephalopathy with biphasic seizures and late reduced diffusion in 1 patient in the DBE group. Serum sodium levels <136mEq/L were observed in 28 cases. Disturbance of consciousness was observed in 25 cases, seizure in 20, and slow waves on EEG in 22. Methylprednisolone pulse therapy was administered in 8 cases. No cases of neurological sequelae were observed. Although most of the clinico-radiological features of the DBNE and DBE groups did not differ substantially, marked differences were observed in the age at onset, initial neurological symptoms, duration of DB, rate of seizure, and slowing of background activity on EEG. These differences should be considered when distinguishing between DBNE and DBE in children. </div>
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<AbstractText>Delirious behavior (DB) in children infected with influenza virus is an important symptom associated with encephalopathy. As children with influenza-associated DB with encephalopathy may require therapy whereas children with influenza-associated DB without encephalopathy do not, distinguishing between these conditions is essential. To clarify these differences and identify the most common features of acute encephalopathy, we retrospectively reviewed the clinical course, laboratory data, magnetic resonance imaging (MRI) and electroencephalography (EEG) findings, therapy, and prognosis of 48 children with influenza exhibiting DB. Of the 48 children, 37 and 11 were diagnosed with influenza A and B, respectively. Moreover, 40 were diagnosed with DB without encephalopathy (DBNE group) and 8, with DB with encephalopathy (DBE group). Reversible splenial lesion (RESLE) was detected in 7 patients in the DBNE group, mild encephalitis/encephalopathy with a reversible splenial lesion (MERS) in 2 patients, and a mild form of acute encephalopathy with biphasic seizures and late reduced diffusion in 1 patient in the DBE group. Serum sodium levels <136mEq/L were observed in 28 cases. Disturbance of consciousness was observed in 25 cases, seizure in 20, and slow waves on EEG in 22. Methylprednisolone pulse therapy was administered in 8 cases. No cases of neurological sequelae were observed. Although most of the clinico-radiological features of the DBNE and DBE groups did not differ substantially, marked differences were observed in the age at onset, initial neurological symptoms, duration of DB, rate of seizure, and slowing of background activity on EEG. These differences should be considered when distinguishing between DBNE and DBE in children. </AbstractText>
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<Initials>K</Initials>
<AffiliationInfo>
<Affiliation>Department of Pediatrics, Hirakata City Hospital, Japan.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Okasora</LastName>
<ForeName>Keisuke</ForeName>
<Initials>K</Initials>
<AffiliationInfo>
<Affiliation>Department of Pediatrics, Hirakata City Hospital, Japan.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Tamai</LastName>
<ForeName>Hiroshi</ForeName>
<Initials>H</Initials>
<AffiliationInfo>
<Affiliation>Department of Pediatrics, Osaka Medical College, Japan.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
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<PublicationType UI="D016428">Journal Article</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic">
<Year>2014</Year>
<Month>09</Month>
<Day>29</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo>
<Country>Netherlands</Country>
<MedlineTA>Brain Dev</MedlineTA>
<NlmUniqueID>7909235</NlmUniqueID>
<ISSNLinking>0387-7604</ISSNLinking>
</MedlineJournalInfo>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList>
<MeshHeading>
<DescriptorName UI="D000293" MajorTopicYN="N">Adolescent</DescriptorName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D001921" MajorTopicYN="N">Brain</DescriptorName>
<QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D001927" MajorTopicYN="N">Brain Diseases</DescriptorName>
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<QualifierName UI="Q000175" MajorTopicYN="Y">diagnosis</QualifierName>
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<MeshHeading>
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<QualifierName UI="Q000175" MajorTopicYN="Y">diagnosis</QualifierName>
<QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D003937" MajorTopicYN="N">Diagnosis, Differential</DescriptorName>
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<MeshHeading>
<DescriptorName UI="D004569" MajorTopicYN="N">Electroencephalography</DescriptorName>
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<MeshHeading>
<DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName>
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<MeshHeading>
<DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D007251" MajorTopicYN="N">Influenza, Human</DescriptorName>
<QualifierName UI="Q000150" MajorTopicYN="N">complications</QualifierName>
<QualifierName UI="Q000175" MajorTopicYN="Y">diagnosis</QualifierName>
<QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D008279" MajorTopicYN="N">Magnetic Resonance Imaging</DescriptorName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
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</MeshHeadingList>
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<Keyword MajorTopicYN="N">Age</Keyword>
<Keyword MajorTopicYN="N">Delirious behavior</Keyword>
<Keyword MajorTopicYN="N">Differential diagnosis</Keyword>
<Keyword MajorTopicYN="N">Disturbance of consciousness</Keyword>
<Keyword MajorTopicYN="N">Encephalopathy</Keyword>
<Keyword MajorTopicYN="N">Influenza</Keyword>
<Keyword MajorTopicYN="N">Reversible splenial lesion during febrile illness</Keyword>
<Keyword MajorTopicYN="N">Seizure</Keyword>
</KeywordList>
</MedlineCitation>
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<History>
<PubMedPubDate PubStatus="received">
<Year>2014</Year>
<Month>02</Month>
<Day>22</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="revised">
<Year>2014</Year>
<Month>09</Month>
<Day>05</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="accepted">
<Year>2014</Year>
<Month>09</Month>
<Day>10</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="entrez">
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<Month>10</Month>
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<PubMedPubDate PubStatus="pubmed">
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<Month>10</Month>
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<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline">
<Year>2016</Year>
<Month>1</Month>
<Day>14</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList>
<ArticleId IdType="pubmed">25277296</ArticleId>
<ArticleId IdType="pii">S0387-7604(14)00215-0</ArticleId>
<ArticleId IdType="doi">10.1016/j.braindev.2014.09.003</ArticleId>
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</PubmedData>
</pubmed>
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<list>
<country>
<li>Japon</li>
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<country name="Japon">
<noRegion>
<name sortKey="Kashiwagi, Mitsuru" sort="Kashiwagi, Mitsuru" uniqKey="Kashiwagi M" first="Mitsuru" last="Kashiwagi">Mitsuru Kashiwagi</name>
</noRegion>
<name sortKey="Ashida, Atsuko" sort="Ashida, Atsuko" uniqKey="Ashida A" first="Atsuko" last="Ashida">Atsuko Ashida</name>
<name sortKey="Inoue, Keisuke" sort="Inoue, Keisuke" uniqKey="Inoue K" first="Keisuke" last="Inoue">Keisuke Inoue</name>
<name sortKey="Masuda, Midori" sort="Masuda, Midori" uniqKey="Masuda M" first="Midori" last="Masuda">Midori Masuda</name>
<name sortKey="Murata, Shinya" sort="Murata, Shinya" uniqKey="Murata S" first="Shinya" last="Murata">Shinya Murata</name>
<name sortKey="Okasora, Keisuke" sort="Okasora, Keisuke" uniqKey="Okasora K" first="Keisuke" last="Okasora">Keisuke Okasora</name>
<name sortKey="Ooba, Chizu" sort="Ooba, Chizu" uniqKey="Ooba C" first="Chizu" last="Ooba">Chizu Ooba</name>
<name sortKey="Shigehara, Seiji" sort="Shigehara, Seiji" uniqKey="Shigehara S" first="Seiji" last="Shigehara">Seiji Shigehara</name>
<name sortKey="Shirasu, Akihiko" sort="Shirasu, Akihiko" uniqKey="Shirasu A" first="Akihiko" last="Shirasu">Akihiko Shirasu</name>
<name sortKey="Tamai, Hiroshi" sort="Tamai, Hiroshi" uniqKey="Tamai H" first="Hiroshi" last="Tamai">Hiroshi Tamai</name>
<name sortKey="Tanabe, Takuya" sort="Tanabe, Takuya" uniqKey="Tanabe T" first="Takuya" last="Tanabe">Takuya Tanabe</name>
</country>
</tree>
</affiliations>
</record>

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