Immunogenicity of an adenoviral-based Middle East Respiratory Syndrome coronavirus vaccine in BALB/c mice
Identifieur interne : 000E95 ( Ncbi/Merge ); précédent : 000E94; suivant : 000E96Immunogenicity of an adenoviral-based Middle East Respiratory Syndrome coronavirus vaccine in BALB/c mice
Auteurs : Eun Kim [États-Unis] ; Kaori Okada [États-Unis] ; Tom Kenniston [États-Unis] ; V. Stalin Raj [Pays-Bas] ; Mohd M. Alhajri [Qatar] ; Elmoubasher A. B. A. Farag [Qatar] ; Farhoud Alhajri [Qatar] ; Albert D. M. E. Osterhaus [Pays-Bas] ; Bart L. Haagmans [Pays-Bas] ; Andrea Gambotto [États-Unis]Source :
- Vaccine [ 0264-410X ] ; 2014.
Descripteurs français
- KwdFr :
- Adenoviridae, Animaux, Anticorps antiviraux (sang), Anticorps neutralisants (sang), Cellules HEK293, Chameaux, Coronavirus du syndrome respiratoire du Moyen-Orient, Glycoprotéine de spicule des coronavirus (immunologie), Humains, Immunoglobuline G (sang), Infections à coronavirus (), Production d'anticorps, Souris de lignée BALB C, Tests de neutralisation, Vaccins antiviraux (immunologie).
- MESH :
- immunologie : Glycoprotéine de spicule des coronavirus, Vaccins antiviraux.
- sang : Anticorps antiviraux, Anticorps neutralisants, Immunoglobuline G.
- Adenoviridae, Animaux, Cellules HEK293, Chameaux, Coronavirus du syndrome respiratoire du Moyen-Orient, Humains, Infections à coronavirus, Production d'anticorps, Souris de lignée BALB C, Tests de neutralisation.
English descriptors
- KwdEn :
- Adenoviridae, Animals, Antibodies, Neutralizing (blood), Antibodies, Viral (blood), Antibody Formation, Camelus, Coronavirus Infections (prevention & control), HEK293 Cells, Humans, Immunoglobulin G (blood), Mice, Inbred BALB C, Middle East Respiratory Syndrome Coronavirus, Neutralization Tests, Spike Glycoprotein, Coronavirus (immunology), Viral Vaccines (immunology).
- MESH :
- chemical , blood : Antibodies, Neutralizing, Antibodies, Viral, Immunoglobulin G.
- chemical , immunology : Spike Glycoprotein, Coronavirus, Viral Vaccines.
- prevention & control : Coronavirus Infections.
- Adenoviridae, Animals, Antibody Formation, Camelus, HEK293 Cells, Humans, Mice, Inbred BALB C, Middle East Respiratory Syndrome Coronavirus, Neutralization Tests.
Abstract
A new type of coronavirus has been identified as the causative agent underlying Middle East Respiratory Syndrome (MERS). The MERS coronavirus (MERS-CoV) has spread in the Middle East, but cases originating in the Middle East have also occurred in the European Union and the USA. Eight hundred and thirty-seven cases of MERS-CoV infection have been confirmed to date, including 291 deaths. MERS-CoV has infected dromedary camel populations in the Middle East at high rates, representing an immediate source of human infection. The MERS-CoV spike (S) protein, a characteristic structural component of the viral envelope, is considered as a key target of vaccines against coronavirus infection. In an initial attempt to develop a MERS-CoV vaccine to ultimately target dromedary camels, we constructed two recombinant adenoviral vectors encoding the full-length MERS-CoV S protein (Ad5.MERS-S) and the S1 extracellular domain of S protein (Ad5.MERS-S1). BALB/c mice were immunized with both candidate vaccines intramuscularly and boosted three weeks later intranasally. All the vaccinated animals had antibody responses against spike protein, which neutralized MERS-CoV in vitro. These results show that an adenoviral-based vaccine can induce MERS-CoV-specific immune responses in mice and hold promise for the development of a preventive vaccine that targets the animal reservoir, which might be an effective measure to eliminate transmission of MERS-CoV to humans.
Url:
DOI: 10.1016/j.vaccine.2014.08.058
PubMed: 25192975
PubMed Central: 7115510
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PMC:7115510Le document en format XML
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<term>Antibodies, Viral (blood)</term>
<term>Antibody Formation</term>
<term>Camelus</term>
<term>Coronavirus Infections (prevention & control)</term>
<term>HEK293 Cells</term>
<term>Humans</term>
<term>Immunoglobulin G (blood)</term>
<term>Mice, Inbred BALB C</term>
<term>Middle East Respiratory Syndrome Coronavirus</term>
<term>Neutralization Tests</term>
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<term>Viral Vaccines (immunology)</term>
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<term>Cellules HEK293</term>
<term>Chameaux</term>
<term>Coronavirus du syndrome respiratoire du Moyen-Orient</term>
<term>Glycoprotéine de spicule des coronavirus (immunologie)</term>
<term>Humains</term>
<term>Immunoglobuline G (sang)</term>
<term>Infections à coronavirus ()</term>
<term>Production d'anticorps</term>
<term>Souris de lignée BALB C</term>
<term>Tests de neutralisation</term>
<term>Vaccins antiviraux (immunologie)</term>
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<term>Antibodies, Viral</term>
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<term>Antibody Formation</term>
<term>Camelus</term>
<term>HEK293 Cells</term>
<term>Humans</term>
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<term>Infections à coronavirus</term>
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<front><div type="abstract" xml:lang="en"><p>A new type of coronavirus has been identified as the causative agent underlying Middle East Respiratory Syndrome (MERS). The MERS coronavirus (MERS-CoV) has spread in the Middle East, but cases originating in the Middle East have also occurred in the European Union and the USA. Eight hundred and thirty-seven cases of MERS-CoV infection have been confirmed to date, including 291 deaths. MERS-CoV has infected dromedary camel populations in the Middle East at high rates, representing an immediate source of human infection. The MERS-CoV spike (S) protein, a characteristic structural component of the viral envelope, is considered as a key target of vaccines against coronavirus infection. In an initial attempt to develop a MERS-CoV vaccine to ultimately target dromedary camels, we constructed two recombinant adenoviral vectors encoding the full-length MERS-CoV S protein (Ad5.MERS-S) and the S1 extracellular domain of S protein (Ad5.MERS-S1). BALB/c mice were immunized with both candidate vaccines intramuscularly and boosted three weeks later intranasally. All the vaccinated animals had antibody responses against spike protein, which neutralized MERS-CoV in vitro. These results show that an adenoviral-based vaccine can induce MERS-CoV-specific immune responses in mice and hold promise for the development of a preventive vaccine that targets the animal reservoir, which might be an effective measure to eliminate transmission of MERS-CoV to humans.</p>
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<author><name sortKey="Okada, Kaori" sort="Okada, Kaori" uniqKey="Okada K" first="Kaori" last="Okada">Kaori Okada</name>
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<author><name sortKey="Kenniston, Tom" sort="Kenniston, Tom" uniqKey="Kenniston T" first="Tom" last="Kenniston">Tom Kenniston</name>
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<country xml:lang="fr">États-Unis</country>
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</affiliation>
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<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Viroscience, Erasmus Medical Center Rotterdam, Rotterdam</wicri:regionArea>
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<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Alhajri, Mohd M" sort="Alhajri, Mohd M" uniqKey="Alhajri M" first="Mohd M." last="Alhajri">Mohd M. Alhajri</name>
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<country xml:lang="fr">Qatar</country>
<wicri:regionArea>Supreme Council of Health, Doha</wicri:regionArea>
<wicri:noRegion>Doha</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Farag, Elmoubasher A B A" sort="Farag, Elmoubasher A B A" uniqKey="Farag E" first="Elmoubasher A. B. A." last="Farag">Elmoubasher A. B. A. Farag</name>
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<country xml:lang="fr">Qatar</country>
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</author>
<author><name sortKey="Alhajri, Farhoud" sort="Alhajri, Farhoud" uniqKey="Alhajri F" first="Farhoud" last="Alhajri">Farhoud Alhajri</name>
<affiliation wicri:level="1"><nlm:aff id="aff0020">Animal Resources Department – Ministry of Environment, Doha, Qatar</nlm:aff>
<country xml:lang="fr">Qatar</country>
<wicri:regionArea>Animal Resources Department – Ministry of Environment, Doha</wicri:regionArea>
<wicri:noRegion>Doha</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Osterhaus, Albert D M E" sort="Osterhaus, Albert D M E" uniqKey="Osterhaus A" first="Albert D. M. E." last="Osterhaus">Albert D. M. E. Osterhaus</name>
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<author><name sortKey="Haagmans, Bart L" sort="Haagmans, Bart L" uniqKey="Haagmans B" first="Bart L." last="Haagmans">Bart L. Haagmans</name>
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<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Viroscience, Erasmus Medical Center Rotterdam, Rotterdam</wicri:regionArea>
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<author><name sortKey="Gambotto, Andrea" sort="Gambotto, Andrea" uniqKey="Gambotto A" first="Andrea" last="Gambotto">Andrea Gambotto</name>
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<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15224</wicri:regionArea>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Immunogenicity of an adenoviral-based Middle East Respiratory Syndrome coronavirus vaccine in BALB/c mice</title>
<author><name sortKey="Kim, Eun" sort="Kim, Eun" uniqKey="Kim E" first="Eun" last="Kim">Eun Kim</name>
<affiliation wicri:level="2"><nlm:aff id="aff0005">Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15224, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15224</wicri:regionArea>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Okada, Kaori" sort="Okada, Kaori" uniqKey="Okada K" first="Kaori" last="Okada">Kaori Okada</name>
<affiliation wicri:level="2"><nlm:aff id="aff0005">Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15224, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15224</wicri:regionArea>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kenniston, Tom" sort="Kenniston, Tom" uniqKey="Kenniston T" first="Tom" last="Kenniston">Tom Kenniston</name>
<affiliation wicri:level="2"><nlm:aff id="aff0005">Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15224, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15224</wicri:regionArea>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Raj, V Stalin" sort="Raj, V Stalin" uniqKey="Raj V" first="V. Stalin" last="Raj">V. Stalin Raj</name>
<affiliation wicri:level="3"><nlm:aff id="aff0010">Department of Viroscience, Erasmus Medical Center Rotterdam, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Viroscience, Erasmus Medical Center Rotterdam, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Alhajri, Mohd M" sort="Alhajri, Mohd M" uniqKey="Alhajri M" first="Mohd M." last="Alhajri">Mohd M. Alhajri</name>
<affiliation wicri:level="1"><nlm:aff id="aff0015">Supreme Council of Health, Doha, Qatar</nlm:aff>
<country xml:lang="fr">Qatar</country>
<wicri:regionArea>Supreme Council of Health, Doha</wicri:regionArea>
<wicri:noRegion>Doha</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Farag, Elmoubasher A B A" sort="Farag, Elmoubasher A B A" uniqKey="Farag E" first="Elmoubasher A. B. A." last="Farag">Elmoubasher A. B. A. Farag</name>
<affiliation wicri:level="1"><nlm:aff id="aff0015">Supreme Council of Health, Doha, Qatar</nlm:aff>
<country xml:lang="fr">Qatar</country>
<wicri:regionArea>Supreme Council of Health, Doha</wicri:regionArea>
<wicri:noRegion>Doha</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Alhajri, Farhoud" sort="Alhajri, Farhoud" uniqKey="Alhajri F" first="Farhoud" last="Alhajri">Farhoud Alhajri</name>
<affiliation wicri:level="1"><nlm:aff id="aff0020">Animal Resources Department – Ministry of Environment, Doha, Qatar</nlm:aff>
<country xml:lang="fr">Qatar</country>
<wicri:regionArea>Animal Resources Department – Ministry of Environment, Doha</wicri:regionArea>
<wicri:noRegion>Doha</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Osterhaus, Albert D M E" sort="Osterhaus, Albert D M E" uniqKey="Osterhaus A" first="Albert D. M. E." last="Osterhaus">Albert D. M. E. Osterhaus</name>
<affiliation wicri:level="3"><nlm:aff id="aff0010">Department of Viroscience, Erasmus Medical Center Rotterdam, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Viroscience, Erasmus Medical Center Rotterdam, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Haagmans, Bart L" sort="Haagmans, Bart L" uniqKey="Haagmans B" first="Bart L." last="Haagmans">Bart L. Haagmans</name>
<affiliation wicri:level="3"><nlm:aff id="aff0010">Department of Viroscience, Erasmus Medical Center Rotterdam, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Viroscience, Erasmus Medical Center Rotterdam, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Gambotto, Andrea" sort="Gambotto, Andrea" uniqKey="Gambotto A" first="Andrea" last="Gambotto">Andrea Gambotto</name>
<affiliation wicri:level="2"><nlm:aff id="aff0005">Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15224, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15224</wicri:regionArea>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
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</analytic>
<series><title level="j">Vaccine</title>
<idno type="ISSN">0264-410X</idno>
<idno type="eISSN">1873-2518</idno>
<imprint><date when="2014">2014</date>
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</series>
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<front><div type="abstract" xml:lang="en"><p>A new type of coronavirus has been identified as the causative agent underlying Middle East Respiratory Syndrome (MERS). The MERS coronavirus (MERS-CoV) has spread in the Middle East, but cases originating in the Middle East have also occurred in the European Union and the USA. Eight hundred and thirty-seven cases of MERS-CoV infection have been confirmed to date, including 291 deaths. MERS-CoV has infected dromedary camel populations in the Middle East at high rates, representing an immediate source of human infection. The MERS-CoV spike (S) protein, a characteristic structural component of the viral envelope, is considered as a key target of vaccines against coronavirus infection. In an initial attempt to develop a MERS-CoV vaccine to ultimately target dromedary camels, we constructed two recombinant adenoviral vectors encoding the full-length MERS-CoV S protein (Ad5.MERS-S) and the S1 extracellular domain of S protein (Ad5.MERS-S1). BALB/c mice were immunized with both candidate vaccines intramuscularly and boosted three weeks later intranasally. All the vaccinated animals had antibody responses against spike protein, which neutralized MERS-CoV in vitro. These results show that an adenoviral-based vaccine can induce MERS-CoV-specific immune responses in mice and hold promise for the development of a preventive vaccine that targets the animal reservoir, which might be an effective measure to eliminate transmission of MERS-CoV to humans.</p>
</div>
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<pubmed><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Immunogenicity of an adenoviral-based Middle East Respiratory Syndrome coronavirus vaccine in BALB/c mice.</title>
<author><name sortKey="Kim, Eun" sort="Kim, Eun" uniqKey="Kim E" first="Eun" last="Kim">Eun Kim</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15224, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15224</wicri:regionArea>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Okada, Kaori" sort="Okada, Kaori" uniqKey="Okada K" first="Kaori" last="Okada">Kaori Okada</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15224, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15224</wicri:regionArea>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kenniston, Tom" sort="Kenniston, Tom" uniqKey="Kenniston T" first="Tom" last="Kenniston">Tom Kenniston</name>
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<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15224</wicri:regionArea>
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</placeName>
</affiliation>
</author>
<author><name sortKey="Raj, V Stalin" sort="Raj, V Stalin" uniqKey="Raj V" first="V Stalin" last="Raj">V Stalin Raj</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Viroscience, Erasmus Medical Center Rotterdam, Rotterdam, The Netherlands.</nlm:affiliation>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Viroscience, Erasmus Medical Center Rotterdam, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Alhajri, Mohd M" sort="Alhajri, Mohd M" uniqKey="Alhajri M" first="Mohd M" last="Alhajri">Mohd M. Alhajri</name>
<affiliation wicri:level="1"><nlm:affiliation>Supreme Council of Health, Doha, Qatar.</nlm:affiliation>
<country xml:lang="fr">Qatar</country>
<wicri:regionArea>Supreme Council of Health, Doha</wicri:regionArea>
<wicri:noRegion>Doha</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Farag, Elmoubasher A B A" sort="Farag, Elmoubasher A B A" uniqKey="Farag E" first="Elmoubasher A B A" last="Farag">Elmoubasher A B A. Farag</name>
<affiliation wicri:level="1"><nlm:affiliation>Supreme Council of Health, Doha, Qatar.</nlm:affiliation>
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<author><name sortKey="Alhajri, Farhoud" sort="Alhajri, Farhoud" uniqKey="Alhajri F" first="Farhoud" last="Alhajri">Farhoud Alhajri</name>
<affiliation wicri:level="1"><nlm:affiliation>Animal Resources Department - Ministry of Environment, Doha, Qatar.</nlm:affiliation>
<country xml:lang="fr">Qatar</country>
<wicri:regionArea>Animal Resources Department - Ministry of Environment, Doha</wicri:regionArea>
<wicri:noRegion>Doha</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Osterhaus, Albert D M E" sort="Osterhaus, Albert D M E" uniqKey="Osterhaus A" first="Albert D M E" last="Osterhaus">Albert D M E. Osterhaus</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Viroscience, Erasmus Medical Center Rotterdam, Rotterdam, The Netherlands.</nlm:affiliation>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Viroscience, Erasmus Medical Center Rotterdam, Rotterdam</wicri:regionArea>
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<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Haagmans, Bart L" sort="Haagmans, Bart L" uniqKey="Haagmans B" first="Bart L" last="Haagmans">Bart L. Haagmans</name>
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<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Viroscience, Erasmus Medical Center Rotterdam, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Gambotto, Andrea" sort="Gambotto, Andrea" uniqKey="Gambotto A" first="Andrea" last="Gambotto">Andrea Gambotto</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15224, USA. Electronic address: gambottoa@upmc.edu.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15224</wicri:regionArea>
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<author><name sortKey="Kim, Eun" sort="Kim, Eun" uniqKey="Kim E" first="Eun" last="Kim">Eun Kim</name>
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<author><name sortKey="Okada, Kaori" sort="Okada, Kaori" uniqKey="Okada K" first="Kaori" last="Okada">Kaori Okada</name>
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<country xml:lang="fr">États-Unis</country>
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<author><name sortKey="Kenniston, Tom" sort="Kenniston, Tom" uniqKey="Kenniston T" first="Tom" last="Kenniston">Tom Kenniston</name>
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<country xml:lang="fr">États-Unis</country>
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</placeName>
</affiliation>
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<author><name sortKey="Raj, V Stalin" sort="Raj, V Stalin" uniqKey="Raj V" first="V Stalin" last="Raj">V Stalin Raj</name>
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<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Viroscience, Erasmus Medical Center Rotterdam, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
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<author><name sortKey="Alhajri, Mohd M" sort="Alhajri, Mohd M" uniqKey="Alhajri M" first="Mohd M" last="Alhajri">Mohd M. Alhajri</name>
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<author><name sortKey="Farag, Elmoubasher A B A" sort="Farag, Elmoubasher A B A" uniqKey="Farag E" first="Elmoubasher A B A" last="Farag">Elmoubasher A B A. Farag</name>
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<wicri:regionArea>Supreme Council of Health, Doha</wicri:regionArea>
<wicri:noRegion>Doha</wicri:noRegion>
</affiliation>
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<author><name sortKey="Alhajri, Farhoud" sort="Alhajri, Farhoud" uniqKey="Alhajri F" first="Farhoud" last="Alhajri">Farhoud Alhajri</name>
<affiliation wicri:level="1"><nlm:affiliation>Animal Resources Department - Ministry of Environment, Doha, Qatar.</nlm:affiliation>
<country xml:lang="fr">Qatar</country>
<wicri:regionArea>Animal Resources Department - Ministry of Environment, Doha</wicri:regionArea>
<wicri:noRegion>Doha</wicri:noRegion>
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<author><name sortKey="Osterhaus, Albert D M E" sort="Osterhaus, Albert D M E" uniqKey="Osterhaus A" first="Albert D M E" last="Osterhaus">Albert D M E. Osterhaus</name>
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<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Viroscience, Erasmus Medical Center Rotterdam, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Haagmans, Bart L" sort="Haagmans, Bart L" uniqKey="Haagmans B" first="Bart L" last="Haagmans">Bart L. Haagmans</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Viroscience, Erasmus Medical Center Rotterdam, Rotterdam, The Netherlands.</nlm:affiliation>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Viroscience, Erasmus Medical Center Rotterdam, Rotterdam</wicri:regionArea>
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<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
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<author><name sortKey="Gambotto, Andrea" sort="Gambotto, Andrea" uniqKey="Gambotto A" first="Andrea" last="Gambotto">Andrea Gambotto</name>
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<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15224</wicri:regionArea>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">Vaccine</title>
<idno type="eISSN">1873-2518</idno>
<imprint><date when="2014" type="published">2014</date>
</imprint>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adenoviridae</term>
<term>Animals</term>
<term>Antibodies, Neutralizing (blood)</term>
<term>Antibodies, Viral (blood)</term>
<term>Antibody Formation</term>
<term>Camelus</term>
<term>Coronavirus Infections (prevention & control)</term>
<term>HEK293 Cells</term>
<term>Humans</term>
<term>Immunoglobulin G (blood)</term>
<term>Mice, Inbred BALB C</term>
<term>Middle East Respiratory Syndrome Coronavirus</term>
<term>Neutralization Tests</term>
<term>Spike Glycoprotein, Coronavirus (immunology)</term>
<term>Viral Vaccines (immunology)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Adenoviridae</term>
<term>Animaux</term>
<term>Anticorps antiviraux (sang)</term>
<term>Anticorps neutralisants (sang)</term>
<term>Cellules HEK293</term>
<term>Chameaux</term>
<term>Coronavirus du syndrome respiratoire du Moyen-Orient</term>
<term>Glycoprotéine de spicule des coronavirus (immunologie)</term>
<term>Humains</term>
<term>Immunoglobuline G (sang)</term>
<term>Infections à coronavirus ()</term>
<term>Production d'anticorps</term>
<term>Souris de lignée BALB C</term>
<term>Tests de neutralisation</term>
<term>Vaccins antiviraux (immunologie)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Antibodies, Neutralizing</term>
<term>Antibodies, Viral</term>
<term>Immunoglobulin G</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Spike Glycoprotein, Coronavirus</term>
<term>Viral Vaccines</term>
</keywords>
<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Glycoprotéine de spicule des coronavirus</term>
<term>Vaccins antiviraux</term>
</keywords>
<keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Coronavirus Infections</term>
</keywords>
<keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Anticorps antiviraux</term>
<term>Anticorps neutralisants</term>
<term>Immunoglobuline G</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adenoviridae</term>
<term>Animals</term>
<term>Antibody Formation</term>
<term>Camelus</term>
<term>HEK293 Cells</term>
<term>Humans</term>
<term>Mice, Inbred BALB C</term>
<term>Middle East Respiratory Syndrome Coronavirus</term>
<term>Neutralization Tests</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Adenoviridae</term>
<term>Animaux</term>
<term>Cellules HEK293</term>
<term>Chameaux</term>
<term>Coronavirus du syndrome respiratoire du Moyen-Orient</term>
<term>Humains</term>
<term>Infections à coronavirus</term>
<term>Production d'anticorps</term>
<term>Souris de lignée BALB C</term>
<term>Tests de neutralisation</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">A new type of coronavirus has been identified as the causative agent underlying Middle East Respiratory Syndrome (MERS). The MERS coronavirus (MERS-CoV) has spread in the Middle East, but cases originating in the Middle East have also occurred in the European Union and the USA. Eight hundred and thirty-seven cases of MERS-CoV infection have been confirmed to date, including 291 deaths. MERS-CoV has infected dromedary camel populations in the Middle East at high rates, representing an immediate source of human infection. The MERS-CoV spike (S) protein, a characteristic structural component of the viral envelope, is considered as a key target of vaccines against coronavirus infection. In an initial attempt to develop a MERS-CoV vaccine to ultimately target dromedary camels, we constructed two recombinant adenoviral vectors encoding the full-length MERS-CoV S protein (Ad5.MERS-S) and the S1 extracellular domain of S protein (Ad5.MERS-S1). BALB/c mice were immunized with both candidate vaccines intramuscularly and boosted three weeks later intranasally. All the vaccinated animals had antibody responses against spike protein, which neutralized MERS-CoV in vitro. These results show that an adenoviral-based vaccine can induce MERS-CoV-specific immune responses in mice and hold promise for the development of a preventive vaccine that targets the animal reservoir, which might be an effective measure to eliminate transmission of MERS-CoV to humans. </div>
</front>
</TEI>
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