MersV1, Ncbi, Merge, bibRecord, 000E78

An Integrated Genomic and Immunoinformatic Approach to H. pylori Vaccine Design.

Identifieur interne : 000E78 ( Ncbi/Merge ); précédent : 000E77; suivant : 000E79

An Integrated Genomic and Immunoinformatic Approach to H. pylori Vaccine Design.

Auteurs : Matthew Ardito [États-Unis] ; Joanna Fueyo [États-Unis] ; Ryan Tassone [États-Unis] ; Frances Terry [États-Unis] ; Kristen Dasilva [États-Unis] ; Songhua Zhang [États-Unis] ; William Martin [États-Unis] ; Anne S. De Groot [États-Unis] ; Steven F. Moss [États-Unis] ; Leonard Moise [États-Unis]

Source :

Immunome research [ 1745-7580 ] ; 2011.

RBID : pubmed:25152768

Abstract

One useful application of pattern matching algorithms is identification of major histocompatability complex (MHC) ligands and T-cell epitopes. Peptides that bind to MHC molecules and interact with T cell receptors to stimulate the immune system are critical antigens for protection against infectious pathogens. We describe a genomes-to-vaccine approach to H. pylori vaccine design that takes advantage of immunoinformatics algorithms to rapidly identify T-cell epitope sequences from large genomic datasets.

DOI: 10.4172/1745-7580.1000049
PubMed: 25152768

Links toward previous steps (curation, corpus...)

to stream PubMed, to step Corpus: 001F15
to stream PubMed, to step Curation: 001F15
to stream PubMed, to step Checkpoint: 001D99

Links to Exploration step

pubmed:25152768

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">An Integrated Genomic and Immunoinformatic Approach to <i>H. pylori</i>
 Vaccine Design.</title>
<author><name sortKey="Ardito, Matthew" sort="Ardito, Matthew" uniqKey="Ardito M" first="Matthew" last="Ardito">Matthew Ardito</name>
<affiliation wicri:level="1"><nlm:affiliation>EpiVax, Inc., Providence, Rhode Island 02903, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>EpiVax, Inc., Providence, Rhode Island 02903</wicri:regionArea>
<wicri:noRegion>Rhode Island 02903</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Fueyo, Joanna" sort="Fueyo, Joanna" uniqKey="Fueyo J" first="Joanna" last="Fueyo">Joanna Fueyo</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Biomedical and Pharmaceutical Sciences, INBRE Program, College of Pharmacy, University of Rhode Island, Kingston, Rhode Island 02871, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Biomedical and Pharmaceutical Sciences, INBRE Program, College of Pharmacy, University of Rhode Island, Kingston, Rhode Island 02871</wicri:regionArea>
<wicri:noRegion>Rhode Island 02871</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Tassone, Ryan" sort="Tassone, Ryan" uniqKey="Tassone R" first="Ryan" last="Tassone">Ryan Tassone</name>
<affiliation wicri:level="1"><nlm:affiliation>EpiVax, Inc., Providence, Rhode Island 02903, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>EpiVax, Inc., Providence, Rhode Island 02903</wicri:regionArea>
<wicri:noRegion>Rhode Island 02903</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Terry, Frances" sort="Terry, Frances" uniqKey="Terry F" first="Frances" last="Terry">Frances Terry</name>
<affiliation wicri:level="1"><nlm:affiliation>EpiVax, Inc., Providence, Rhode Island 02903, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>EpiVax, Inc., Providence, Rhode Island 02903</wicri:regionArea>
<wicri:noRegion>Rhode Island 02903</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Dasilva, Kristen" sort="Dasilva, Kristen" uniqKey="Dasilva K" first="Kristen" last="Dasilva">Kristen Dasilva</name>
<affiliation wicri:level="1"><nlm:affiliation>Institute for Immunology and Informatics, University of Rhode Island, Providence, Rhode Island 02903, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Institute for Immunology and Informatics, University of Rhode Island, Providence, Rhode Island 02903</wicri:regionArea>
<wicri:noRegion>Rhode Island 02903</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Zhang, Songhua" sort="Zhang, Songhua" uniqKey="Zhang S" first="Songhua" last="Zhang">Songhua Zhang</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Gastroenterology, Brown University Warren Alpert Medical School, Providence, Rhode Island 02903, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Gastroenterology, Brown University Warren Alpert Medical School, Providence, Rhode Island 02903</wicri:regionArea>
<wicri:noRegion>Rhode Island 02903</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Martin, William" sort="Martin, William" uniqKey="Martin W" first="William" last="Martin">William Martin</name>
<affiliation wicri:level="1"><nlm:affiliation>EpiVax, Inc., Providence, Rhode Island 02903, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>EpiVax, Inc., Providence, Rhode Island 02903</wicri:regionArea>
<wicri:noRegion>Rhode Island 02903</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="De Groot, Anne S" sort="De Groot, Anne S" uniqKey="De Groot A" first="Anne S" last="De Groot">Anne S. De Groot</name>
<affiliation wicri:level="1"><nlm:affiliation>EpiVax, Inc., Providence, Rhode Island 02903, USA ; Institute for Immunology and Informatics, University of Rhode Island, Providence, Rhode Island 02903, USA ; Department of Pediatric Infectious Disease, Brown University Warren Alpert Medical School, Providence, Rhode Island 02912, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>EpiVax, Inc., Providence, Rhode Island 02903, USA ; Institute for Immunology and Informatics, University of Rhode Island, Providence, Rhode Island 02903, USA ; Department of Pediatric Infectious Disease, Brown University Warren Alpert Medical School, Providence, Rhode Island 02912</wicri:regionArea>
<wicri:noRegion>Rhode Island 02912</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Moss, Steven F" sort="Moss, Steven F" uniqKey="Moss S" first="Steven F" last="Moss">Steven F. Moss</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Gastroenterology, Brown University Warren Alpert Medical School, Providence, Rhode Island 02903, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Gastroenterology, Brown University Warren Alpert Medical School, Providence, Rhode Island 02903</wicri:regionArea>
<wicri:noRegion>Rhode Island 02903</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Moise, Leonard" sort="Moise, Leonard" uniqKey="Moise L" first="Leonard" last="Moise">Leonard Moise</name>
<affiliation wicri:level="1"><nlm:affiliation>EpiVax, Inc., Providence, Rhode Island 02903, USA ; Institute for Immunology and Informatics, University of Rhode Island, Providence, Rhode Island 02903, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>EpiVax, Inc., Providence, Rhode Island 02903, USA ; Institute for Immunology and Informatics, University of Rhode Island, Providence, Rhode Island 02903</wicri:regionArea>
<wicri:noRegion>Rhode Island 02903</wicri:noRegion>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2011">2011</date>
<idno type="RBID">pubmed:25152768</idno>
<idno type="pmid">25152768</idno>
<idno type="doi">10.4172/1745-7580.1000049</idno>
<idno type="wicri:Area/PubMed/Corpus">001F15</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001F15</idno>
<idno type="wicri:Area/PubMed/Curation">001F15</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001F15</idno>
<idno type="wicri:Area/PubMed/Checkpoint">001D99</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001D99</idno>
<idno type="wicri:Area/Ncbi/Merge">000E78</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">An Integrated Genomic and Immunoinformatic Approach to <i>H. pylori</i>
 Vaccine Design.</title>
<author><name sortKey="Ardito, Matthew" sort="Ardito, Matthew" uniqKey="Ardito M" first="Matthew" last="Ardito">Matthew Ardito</name>
<affiliation wicri:level="1"><nlm:affiliation>EpiVax, Inc., Providence, Rhode Island 02903, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>EpiVax, Inc., Providence, Rhode Island 02903</wicri:regionArea>
<wicri:noRegion>Rhode Island 02903</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Fueyo, Joanna" sort="Fueyo, Joanna" uniqKey="Fueyo J" first="Joanna" last="Fueyo">Joanna Fueyo</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Biomedical and Pharmaceutical Sciences, INBRE Program, College of Pharmacy, University of Rhode Island, Kingston, Rhode Island 02871, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Biomedical and Pharmaceutical Sciences, INBRE Program, College of Pharmacy, University of Rhode Island, Kingston, Rhode Island 02871</wicri:regionArea>
<wicri:noRegion>Rhode Island 02871</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Tassone, Ryan" sort="Tassone, Ryan" uniqKey="Tassone R" first="Ryan" last="Tassone">Ryan Tassone</name>
<affiliation wicri:level="1"><nlm:affiliation>EpiVax, Inc., Providence, Rhode Island 02903, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>EpiVax, Inc., Providence, Rhode Island 02903</wicri:regionArea>
<wicri:noRegion>Rhode Island 02903</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Terry, Frances" sort="Terry, Frances" uniqKey="Terry F" first="Frances" last="Terry">Frances Terry</name>
<affiliation wicri:level="1"><nlm:affiliation>EpiVax, Inc., Providence, Rhode Island 02903, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>EpiVax, Inc., Providence, Rhode Island 02903</wicri:regionArea>
<wicri:noRegion>Rhode Island 02903</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Dasilva, Kristen" sort="Dasilva, Kristen" uniqKey="Dasilva K" first="Kristen" last="Dasilva">Kristen Dasilva</name>
<affiliation wicri:level="1"><nlm:affiliation>Institute for Immunology and Informatics, University of Rhode Island, Providence, Rhode Island 02903, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Institute for Immunology and Informatics, University of Rhode Island, Providence, Rhode Island 02903</wicri:regionArea>
<wicri:noRegion>Rhode Island 02903</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Zhang, Songhua" sort="Zhang, Songhua" uniqKey="Zhang S" first="Songhua" last="Zhang">Songhua Zhang</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Gastroenterology, Brown University Warren Alpert Medical School, Providence, Rhode Island 02903, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Gastroenterology, Brown University Warren Alpert Medical School, Providence, Rhode Island 02903</wicri:regionArea>
<wicri:noRegion>Rhode Island 02903</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Martin, William" sort="Martin, William" uniqKey="Martin W" first="William" last="Martin">William Martin</name>
<affiliation wicri:level="1"><nlm:affiliation>EpiVax, Inc., Providence, Rhode Island 02903, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>EpiVax, Inc., Providence, Rhode Island 02903</wicri:regionArea>
<wicri:noRegion>Rhode Island 02903</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="De Groot, Anne S" sort="De Groot, Anne S" uniqKey="De Groot A" first="Anne S" last="De Groot">Anne S. De Groot</name>
<affiliation wicri:level="1"><nlm:affiliation>EpiVax, Inc., Providence, Rhode Island 02903, USA ; Institute for Immunology and Informatics, University of Rhode Island, Providence, Rhode Island 02903, USA ; Department of Pediatric Infectious Disease, Brown University Warren Alpert Medical School, Providence, Rhode Island 02912, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>EpiVax, Inc., Providence, Rhode Island 02903, USA ; Institute for Immunology and Informatics, University of Rhode Island, Providence, Rhode Island 02903, USA ; Department of Pediatric Infectious Disease, Brown University Warren Alpert Medical School, Providence, Rhode Island 02912</wicri:regionArea>
<wicri:noRegion>Rhode Island 02912</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Moss, Steven F" sort="Moss, Steven F" uniqKey="Moss S" first="Steven F" last="Moss">Steven F. Moss</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Gastroenterology, Brown University Warren Alpert Medical School, Providence, Rhode Island 02903, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Gastroenterology, Brown University Warren Alpert Medical School, Providence, Rhode Island 02903</wicri:regionArea>
<wicri:noRegion>Rhode Island 02903</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Moise, Leonard" sort="Moise, Leonard" uniqKey="Moise L" first="Leonard" last="Moise">Leonard Moise</name>
<affiliation wicri:level="1"><nlm:affiliation>EpiVax, Inc., Providence, Rhode Island 02903, USA ; Institute for Immunology and Informatics, University of Rhode Island, Providence, Rhode Island 02903, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>EpiVax, Inc., Providence, Rhode Island 02903, USA ; Institute for Immunology and Informatics, University of Rhode Island, Providence, Rhode Island 02903</wicri:regionArea>
<wicri:noRegion>Rhode Island 02903</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j">Immunome research</title>
<idno type="ISSN">1745-7580</idno>
<imprint><date when="2011" type="published">2011</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">One useful application of pattern matching algorithms is identification of major histocompatability complex (MHC) ligands and T-cell epitopes. Peptides that bind to MHC molecules and interact with T cell receptors to stimulate the immune system are critical antigens for protection against infectious pathogens. We describe a genomes-to-vaccine approach to <i>H. pylori</i>
 vaccine design that takes advantage of immunoinformatics algorithms to rapidly identify T-cell epitope sequences from large genomic datasets.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="Publisher" Owner="NLM"><PMID Version="1">25152768</PMID>
<DateRevised><Year>2019</Year>
<Month>11</Month>
<Day>20</Day>
</DateRevised>
<Article PubModel="Print"><Journal><ISSN IssnType="Print">1745-7580</ISSN>
<JournalIssue CitedMedium="Print"><Volume>7</Volume>
<Issue>2</Issue>
<PubDate><Year>2011</Year>
</PubDate>
</JournalIssue>
<Title>Immunome research</Title>
<ISOAbbreviation>Immunome Res</ISOAbbreviation>
</Journal>
<ArticleTitle>An Integrated Genomic and Immunoinformatic Approach to <i>H. pylori</i>
 Vaccine Design.</ArticleTitle>
<ELocationID EIdType="pii" ValidYN="Y">http://omicsonline.org/search-related-journal-articles.php</ELocationID>
<Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">One useful application of pattern matching algorithms is identification of major histocompatability complex (MHC) ligands and T-cell epitopes. Peptides that bind to MHC molecules and interact with T cell receptors to stimulate the immune system are critical antigens for protection against infectious pathogens. We describe a genomes-to-vaccine approach to <i>H. pylori</i>
 vaccine design that takes advantage of immunoinformatics algorithms to rapidly identify T-cell epitope sequences from large genomic datasets.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">To design a globally relevant vaccine, we used computational methods to identify a core genome comprised of 676 open reading frames (ORFs) from amongst seven genetically and phenotypically diverse <i>H. pylori</i>
 strains from around the world. Of the 1,241,153 9-mer sequences encoded by these ORFs, 106,791 were identical amongst all seven genomes and 23,654 scored in the top 5% of predicted HLA ligands for at least one of eight archetypal Class II HLA alleles when evaluated by EpiMatrix. To maximize the number of epitopes that can be assessed experimentally, we used a computational algorithm to increase epitope density in 20-25 amino acid stretches by assembling potentially immunogenic 9-mers to be identically positioned as they are in the native protein antigen. 1,805 immunogenic consensus sequences (ICS) were generated. 79% of selected ICS epitopes bound to a panel of 6 HLA Class II haplotypes, representing >90% of the global human population.</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">The breadth of <i>H. pylori</i>
 genome datasets was computationally assessed to rapidly and carefully determine a core set of genes. Application of immunoinformatics tools to this gene set accurately predicted epitopes with promising properties for T cell-based vaccine development.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Ardito</LastName>
<ForeName>Matthew</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>EpiVax, Inc., Providence, Rhode Island 02903, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Fueyo</LastName>
<ForeName>Joanna</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Department of Biomedical and Pharmaceutical Sciences, INBRE Program, College of Pharmacy, University of Rhode Island, Kingston, Rhode Island 02871, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Tassone</LastName>
<ForeName>Ryan</ForeName>
<Initials>R</Initials>
<AffiliationInfo><Affiliation>EpiVax, Inc., Providence, Rhode Island 02903, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Terry</LastName>
<ForeName>Frances</ForeName>
<Initials>F</Initials>
<AffiliationInfo><Affiliation>EpiVax, Inc., Providence, Rhode Island 02903, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>DaSilva</LastName>
<ForeName>Kristen</ForeName>
<Initials>K</Initials>
<AffiliationInfo><Affiliation>Institute for Immunology and Informatics, University of Rhode Island, Providence, Rhode Island 02903, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Zhang</LastName>
<ForeName>Songhua</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>Department of Gastroenterology, Brown University Warren Alpert Medical School, Providence, Rhode Island 02903, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Martin</LastName>
<ForeName>William</ForeName>
<Initials>W</Initials>
<AffiliationInfo><Affiliation>EpiVax, Inc., Providence, Rhode Island 02903, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>De Groot</LastName>
<ForeName>Anne S</ForeName>
<Initials>AS</Initials>
<AffiliationInfo><Affiliation>EpiVax, Inc., Providence, Rhode Island 02903, USA ; Institute for Immunology and Informatics, University of Rhode Island, Providence, Rhode Island 02903, USA ; Department of Pediatric Infectious Disease, Brown University Warren Alpert Medical School, Providence, Rhode Island 02912, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Moss</LastName>
<ForeName>Steven F</ForeName>
<Initials>SF</Initials>
<AffiliationInfo><Affiliation>Department of Gastroenterology, Brown University Warren Alpert Medical School, Providence, Rhode Island 02903, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Moise</LastName>
<ForeName>Leonard</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>EpiVax, Inc., Providence, Rhode Island 02903, USA ; Institute for Immunology and Informatics, University of Rhode Island, Providence, Rhode Island 02903, USA.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<GrantList CompleteYN="Y"><Grant><GrantID>U19 AI082642</GrantID>
<Acronym>AI</Acronym>
<Agency>NIAID NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>U19 AI082642-03</GrantID>
<Acronym>AI</Acronym>
<Agency>NIAID NIH HHS</Agency>
<Country>United States</Country>
</Grant>
</GrantList>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
</PublicationTypeList>
</Article>
<MedlineJournalInfo><Country>England</Country>
<MedlineTA>Immunome Res</MedlineTA>
<NlmUniqueID>101245791</NlmUniqueID>
<ISSNLinking>1745-7580</ISSNLinking>
</MedlineJournalInfo>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2014</Year>
<Month>8</Month>
<Day>26</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="pubmed"><Year>2011</Year>
<Month>1</Month>
<Day>1</Day>
<Hour>0</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2011</Year>
<Month>1</Month>
<Day>1</Day>
<Hour>0</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">25152768</ArticleId>
<ArticleId IdType="doi">10.4172/1745-7580.1000049</ArticleId>
<ArticleId IdType="pmc">PMC4138956</ArticleId>
<ArticleId IdType="mid">NIHMS587245</ArticleId>
</ArticleIdList>
<pmc-dir>nihms</pmc-dir>
        <ReferenceList><Reference><Citation>J Mol Biol. 1982 Dec 15;162(3):705-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">7166760</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nature. 1997 Aug 7;388(6642):539-47</Citation>
<ArticleIdList><ArticleId IdType="pubmed">9252185</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Mol Biol. 1982 May 5;157(1):105-32</Citation>
<ArticleIdList><ArticleId IdType="pubmed">7108955</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Int J Med Microbiol. 2005 Sep;295(5):343-53</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16173501</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nature. 1999 Jan 14;397(6715):176-80</Citation>
<ArticleIdList><ArticleId IdType="pubmed">9923682</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Bacteriol. 2009 Jan;191(1):447-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18952803</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Med Health R I. 2007 Oct;90(10):311-4</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18019188</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>AIDS Res Hum Retroviruses. 1997 May 1;13(7):529-31</Citation>
<ArticleIdList><ArticleId IdType="pubmed">9135870</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Proc Natl Acad Sci U S A. 2000 Dec 19;97(26):14668-73</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11121067</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Proc Natl Acad Sci U S A. 1992 Nov 15;89(22):10915-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">1438297</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>PLoS Genet. 2005 Oct;1(4):e43</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16217547</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>BMC Genomics. 2009 Jan 05;10:3</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19123947</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Exp Med. 2006 Apr 17;203(4):961-71</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16585267</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Immunol. 1998 Apr 1;160(7):3363-73</Citation>
<ArticleIdList><ArticleId IdType="pubmed">9531296</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Gastroenterology. 2007 Jul;133(1):288-308</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17631150</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Clin Immunol. 2009 May;131(2):189-201</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19269256</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Methods Enzymol. 1983;91:60-75</Citation>
<ArticleIdList><ArticleId IdType="pubmed">6855604</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>PLoS One. 2010 Nov 29;5(11):e15076</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21124785</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nucleic Acids Res. 2010 Oct;38(18):6089-101</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20478826</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Proc Natl Acad Sci U S A. 2006 Jun 27;103(26):9999-10004</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16788065</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Infect Disord Drug Targets. 2009 Jun;9(3):248-56</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19519479</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Hum Vaccin. 2008 May-Jun;4(3):219-23</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18376134</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Science. 1997 Oct 24;278(5338):631-7</Citation>
<ArticleIdList><ArticleId IdType="pubmed">9381173</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Vaccine. 2011 Mar 3;29(11):2085-91</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21236233</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Methods. 2004 Dec;34(4):476-87</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15542374</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
</PubmedData>
</pubmed>
<affiliations><list><country><li>États-Unis</li>
</country>
</list>
<tree><country name="États-Unis"><noRegion><name sortKey="Ardito, Matthew" sort="Ardito, Matthew" uniqKey="Ardito M" first="Matthew" last="Ardito">Matthew Ardito</name>
</noRegion>
<name sortKey="Dasilva, Kristen" sort="Dasilva, Kristen" uniqKey="Dasilva K" first="Kristen" last="Dasilva">Kristen Dasilva</name>
<name sortKey="De Groot, Anne S" sort="De Groot, Anne S" uniqKey="De Groot A" first="Anne S" last="De Groot">Anne S. De Groot</name>
<name sortKey="Fueyo, Joanna" sort="Fueyo, Joanna" uniqKey="Fueyo J" first="Joanna" last="Fueyo">Joanna Fueyo</name>
<name sortKey="Martin, William" sort="Martin, William" uniqKey="Martin W" first="William" last="Martin">William Martin</name>
<name sortKey="Moise, Leonard" sort="Moise, Leonard" uniqKey="Moise L" first="Leonard" last="Moise">Leonard Moise</name>
<name sortKey="Moss, Steven F" sort="Moss, Steven F" uniqKey="Moss S" first="Steven F" last="Moss">Steven F. Moss</name>
<name sortKey="Tassone, Ryan" sort="Tassone, Ryan" uniqKey="Tassone R" first="Ryan" last="Tassone">Ryan Tassone</name>
<name sortKey="Terry, Frances" sort="Terry, Frances" uniqKey="Terry F" first="Frances" last="Terry">Frances Terry</name>
<name sortKey="Zhang, Songhua" sort="Zhang, Songhua" uniqKey="Zhang S" first="Songhua" last="Zhang">Songhua Zhang</name>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Sante/explor/MersV1/Data/Ncbi/Merge

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000E78 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Ncbi/Merge/biblio.hfd -nk 000E78 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Sante
   |area=    MersV1
   |flux=    Ncbi
   |étape=   Merge
   |type=    RBID
   |clé=     pubmed:25152768
   |texte=   An Integrated Genomic and Immunoinformatic Approach to H. pylori Vaccine Design.
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/Ncbi/Merge/RBID.i   -Sk "pubmed:25152768" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Ncbi/Merge/biblio.hfd   \
       | NlmPubMed2Wicri -a MersV1

This area was generated with Dilib version V0.6.33.
Data generation: Mon Apr 20 23:26:43 2020. Site generation: Sat Mar 27 09:06:09 2021

	Serveur d'exploration MERS
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Serveur d'exploration MERS

An Integrated Genomic and Immunoinformatic Approach to H. pylori Vaccine Design.

An Integrated Genomic and Immunoinformatic Approach to H. pylori Vaccine Design.

Source :

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki