Trowel: a fast and accurate error correction module for Illumina sequencing reads.
Identifieur interne : 000E53 ( Ncbi/Merge ); précédent : 000E52; suivant : 000E54Trowel: a fast and accurate error correction module for Illumina sequencing reads.
Auteurs : Eun-Cheon Lim [Allemagne] ; Jonas Müller [Allemagne] ; Jörg Hagmann [Allemagne] ; Stefan R. Henz [Allemagne] ; Sang-Tae Kim [Allemagne] ; Detlef Weigel [Allemagne]Source :
- Bioinformatics (Oxford, England) [ 1367-4811 ] ; 2014.
Descripteurs français
- KwdFr :
- MESH :
English descriptors
- KwdEn :
- MESH :
- methods : High-Throughput Nucleotide Sequencing.
- Algorithms, Software.
Abstract
The ability to accurately read the order of nucleotides in DNA and RNA is fundamental for modern biology. Errors in next-generation sequencing can lead to many artifacts, from erroneous genome assemblies to mistaken inferences about RNA editing. Uneven coverage in datasets also contributes to false corrections.
DOI: 10.1093/bioinformatics/btu513
PubMed: 25075116
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pubmed:25075116Le document en format XML
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<front><div type="abstract" xml:lang="en">The ability to accurately read the order of nucleotides in DNA and RNA is fundamental for modern biology. Errors in next-generation sequencing can lead to many artifacts, from erroneous genome assemblies to mistaken inferences about RNA editing. Uneven coverage in datasets also contributes to false corrections.</div>
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<Abstract><AbstractText Label="MOTIVATION" NlmCategory="BACKGROUND">The ability to accurately read the order of nucleotides in DNA and RNA is fundamental for modern biology. Errors in next-generation sequencing can lead to many artifacts, from erroneous genome assemblies to mistaken inferences about RNA editing. Uneven coverage in datasets also contributes to false corrections.</AbstractText>
<AbstractText Label="RESULT" NlmCategory="RESULTS">We introduce Trowel, a massively parallelized and highly efficient error correction module for Illumina read data. Trowel both corrects erroneous base calls and boosts base qualities based on the k-mer spectrum. With high-quality k-mers and relevant base information, Trowel achieves high accuracy for different short read sequencing applications.The latency in the data path has been significantly reduced because of efficient data access and data structures. In performance evaluations, Trowel was highly competitive with other tools regardless of coverage, genome size read length and fragment size.</AbstractText>
<AbstractText Label="AVAILABILITY AND IMPLEMENTATION" NlmCategory="METHODS">Trowel is written in C++ and is provided under the General Public License v3.0 (GPLv3). It is available at http://trowel-ec.sourceforge.net.</AbstractText>
<AbstractText Label="CONTACT" NlmCategory="BACKGROUND">euncheon.lim@tue.mpg.de or weigel@tue.mpg.de</AbstractText>
<AbstractText Label="SUPPLEMENTARY INFORMATION" NlmCategory="BACKGROUND">Supplementary data are available at Bioinformatics online.</AbstractText>
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