Middle east respiratory syndrome coronavirus 4a protein is a double-stranded RNA-binding protein that suppresses PACT-induced activation of RIG-I and MDA5 in the innate antiviral response.
Identifieur interne : 000C86 ( Ncbi/Merge ); précédent : 000C85; suivant : 000C87Middle east respiratory syndrome coronavirus 4a protein is a double-stranded RNA-binding protein that suppresses PACT-induced activation of RIG-I and MDA5 in the innate antiviral response.
Auteurs : Kam-Leung Siu [Hong Kong] ; Man Lung Yeung ; Kin-Hang Kok ; Kit-San Yuen ; Chun Kew ; Pak-Yin Lui ; Chi-Ping Chan ; Herman Tse ; Patrick C Y. Woo ; Kwok-Yung Yuen ; Dong-Yan JinSource :
- Journal of virology [ 1098-5514 ] ; 2014.
Descripteurs français
- KwdFr :
- Cartographie d'interactions entre protéines, Coronavirus (immunologie), DEAD-box RNA helicases (antagonistes et inhibiteurs), Humains, Hélicase IFIH1 inductrice de l'interféron, Interactions hôte-pathogène, Interférons (antagonistes et inhibiteurs), Liaison aux protéines, Lignée cellulaire, Protéine-58 à domaine DEAD, Protéines de liaison à l'ARN (métabolisme), Protéines virales (métabolisme), Échappement immunitaire.
- MESH :
- antagonistes et inhibiteurs : DEAD-box RNA helicases, Interférons.
- immunologie : Coronavirus.
- métabolisme : Protéines de liaison à l'ARN, Protéines virales.
- Cartographie d'interactions entre protéines, Humains, Hélicase IFIH1 inductrice de l'interféron, Interactions hôte-pathogène, Liaison aux protéines, Lignée cellulaire, Protéine-58 à domaine DEAD, Échappement immunitaire.
English descriptors
- KwdEn :
- Cell Line, Coronavirus (immunology), DEAD Box Protein 58, DEAD-box RNA Helicases (antagonists & inhibitors), Host-Pathogen Interactions, Humans, Immune Evasion, Interferon-Induced Helicase, IFIH1, Interferons (antagonists & inhibitors), Protein Binding, Protein Interaction Mapping, RNA-Binding Proteins (metabolism), Viral Proteins (metabolism).
- MESH :
- chemical , antagonists & inhibitors : DEAD-box RNA Helicases, Interferons.
- chemical , metabolism : RNA-Binding Proteins, Viral Proteins.
- chemical : DEAD Box Protein 58, Interferon-Induced Helicase, IFIH1.
- immunology : Coronavirus.
- Cell Line, Host-Pathogen Interactions, Humans, Immune Evasion, Protein Binding, Protein Interaction Mapping.
Abstract
Middle East respiratory syndrome coronavirus (MERS-CoV) is an emerging pathogen that causes severe disease in human. MERS-CoV is closely related to bat coronaviruses HKU4 and HKU5. Evasion of the innate antiviral response might contribute significantly to MERS-CoV pathogenesis, but the mechanism is poorly understood. In this study, we characterized MERS-CoV 4a protein as a novel immunosuppressive factor that antagonizes type I interferon production. MERS-CoV 4a protein contains a double-stranded RNA-binding domain capable of interacting with poly(I · C). Expression of MERS-CoV 4a protein suppressed the interferon production induced by poly(I · C) or Sendai virus. RNA binding of MERS-CoV 4a protein was required for IFN antagonism, a property shared by 4a protein of bat coronavirus HKU5 but not by the counterpart in bat coronavirus HKU4. MERS-CoV 4a protein interacted with PACT in an RNA-dependent manner but not with RIG-I or MDA5. It inhibited PACT-induced activation of RIG-I and MDA5 but did not affect the activity of downstream effectors such as RIG-I, MDA5, MAVS, TBK1, and IRF3. Taken together, our findings suggest a new mechanism through which MERS-CoV employs a viral double-stranded RNA-binding protein to circumvent the innate antiviral response by perturbing the function of cellular double-stranded RNA-binding protein PACT. PACT targeting might be a common strategy used by different viruses, including Ebola virus and herpes simplex virus 1, to counteract innate immunity.
DOI: 10.1128/JVI.03649-13
PubMed: 24522921
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pubmed:24522921Le document en format XML
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Woo</name></author><author><name sortKey="Yuen, Kwok Yung" sort="Yuen, Kwok Yung" uniqKey="Yuen K" first="Kwok-Yung" last="Yuen">Kwok-Yung Yuen</name></author><author><name sortKey="Jin, Dong Yan" sort="Jin, Dong Yan" uniqKey="Jin D" first="Dong-Yan" last="Jin">Dong-Yan Jin</name></author></analytic><series><title level="j">Journal of virology</title><idno type="eISSN">1098-5514</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Cell Line</term><term>Coronavirus (immunology)</term><term>DEAD Box Protein 58</term><term>DEAD-box RNA Helicases (antagonists & inhibitors)</term><term>Host-Pathogen Interactions</term><term>Humans</term><term>Immune Evasion</term><term>Interferon-Induced Helicase, IFIH1</term><term>Interferons (antagonists & inhibitors)</term><term>Protein Binding</term><term>Protein Interaction Mapping</term><term>RNA-Binding Proteins (metabolism)</term><term>Viral Proteins (metabolism)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Cartographie d'interactions entre protéines</term><term>Coronavirus (immunologie)</term><term>DEAD-box RNA helicases (antagonistes et inhibiteurs)</term><term>Humains</term><term>Hélicase IFIH1 inductrice de l'interféron</term><term>Interactions hôte-pathogène</term><term>Interférons (antagonistes et inhibiteurs)</term><term>Liaison aux protéines</term><term>Lignée cellulaire</term><term>Protéine-58 à domaine DEAD</term><term>Protéines de liaison à l'ARN (métabolisme)</term><term>Protéines virales (métabolisme)</term><term>Échappement immunitaire</term></keywords><keywords scheme="MESH" type="chemical" qualifier="antagonists & inhibitors" xml:lang="en"><term>DEAD-box RNA Helicases</term><term>Interferons</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>RNA-Binding Proteins</term><term>Viral Proteins</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>DEAD Box Protein 58</term><term>Interferon-Induced Helicase, IFIH1</term></keywords><keywords scheme="MESH" qualifier="antagonistes et inhibiteurs" xml:lang="fr"><term>DEAD-box RNA helicases</term><term>Interférons</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Coronavirus</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Coronavirus</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Protéines de liaison à l'ARN</term><term>Protéines virales</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Cell Line</term><term>Host-Pathogen Interactions</term><term>Humans</term><term>Immune Evasion</term><term>Protein Binding</term><term>Protein Interaction Mapping</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Cartographie d'interactions entre protéines</term><term>Humains</term><term>Hélicase IFIH1 inductrice de l'interféron</term><term>Interactions hôte-pathogène</term><term>Liaison aux protéines</term><term>Lignée cellulaire</term><term>Protéine-58 à domaine DEAD</term><term>Échappement immunitaire</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Middle East respiratory syndrome coronavirus (MERS-CoV) is an emerging pathogen that causes severe disease in human. MERS-CoV is closely related to bat coronaviruses HKU4 and HKU5. Evasion of the innate antiviral response might contribute significantly to MERS-CoV pathogenesis, but the mechanism is poorly understood. In this study, we characterized MERS-CoV 4a protein as a novel immunosuppressive factor that antagonizes type I interferon production. MERS-CoV 4a protein contains a double-stranded RNA-binding domain capable of interacting with poly(I · C). Expression of MERS-CoV 4a protein suppressed the interferon production induced by poly(I · C) or Sendai virus. RNA binding of MERS-CoV 4a protein was required for IFN antagonism, a property shared by 4a protein of bat coronavirus HKU5 but not by the counterpart in bat coronavirus HKU4. MERS-CoV 4a protein interacted with PACT in an RNA-dependent manner but not with RIG-I or MDA5. It inhibited PACT-induced activation of RIG-I and MDA5 but did not affect the activity of downstream effectors such as RIG-I, MDA5, MAVS, TBK1, and IRF3. Taken together, our findings suggest a new mechanism through which MERS-CoV employs a viral double-stranded RNA-binding protein to circumvent the innate antiviral response by perturbing the function of cellular double-stranded RNA-binding protein PACT. PACT targeting might be a common strategy used by different viruses, including Ebola virus and herpes simplex virus 1, to counteract innate immunity.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">24522921</PMID><DateCompleted><Year>2014</Year><Month>06</Month><Day>03</Day></DateCompleted><DateRevised><Year>2018</Year><Month>11</Month><Day>13</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1098-5514</ISSN><JournalIssue CitedMedium="Internet"><Volume>88</Volume><Issue>9</Issue><PubDate><Year>2014</Year><Month>May</Month></PubDate></JournalIssue><Title>Journal of virology</Title><ISOAbbreviation>J. Virol.</ISOAbbreviation></Journal><ArticleTitle>Middle east respiratory syndrome coronavirus 4a protein is a double-stranded RNA-binding protein that suppresses PACT-induced activation of RIG-I and MDA5 in the innate antiviral response.</ArticleTitle><Pagination><MedlinePgn>4866-76</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1128/JVI.03649-13</ELocationID><Abstract><AbstractText Label="UNLABELLED">Middle East respiratory syndrome coronavirus (MERS-CoV) is an emerging pathogen that causes severe disease in human. MERS-CoV is closely related to bat coronaviruses HKU4 and HKU5. Evasion of the innate antiviral response might contribute significantly to MERS-CoV pathogenesis, but the mechanism is poorly understood. In this study, we characterized MERS-CoV 4a protein as a novel immunosuppressive factor that antagonizes type I interferon production. MERS-CoV 4a protein contains a double-stranded RNA-binding domain capable of interacting with poly(I · C). Expression of MERS-CoV 4a protein suppressed the interferon production induced by poly(I · C) or Sendai virus. RNA binding of MERS-CoV 4a protein was required for IFN antagonism, a property shared by 4a protein of bat coronavirus HKU5 but not by the counterpart in bat coronavirus HKU4. MERS-CoV 4a protein interacted with PACT in an RNA-dependent manner but not with RIG-I or MDA5. It inhibited PACT-induced activation of RIG-I and MDA5 but did not affect the activity of downstream effectors such as RIG-I, MDA5, MAVS, TBK1, and IRF3. Taken together, our findings suggest a new mechanism through which MERS-CoV employs a viral double-stranded RNA-binding protein to circumvent the innate antiviral response by perturbing the function of cellular double-stranded RNA-binding protein PACT. PACT targeting might be a common strategy used by different viruses, including Ebola virus and herpes simplex virus 1, to counteract innate immunity.</AbstractText><AbstractText Label="IMPORTANCE" NlmCategory="OBJECTIVE">Middle East respiratory syndrome coronavirus (MERS-CoV) is an emerging and highly lethal human pathogen. Why MERS-CoV causes severe disease in human is unclear, and one possibility is that MERS-CoV is particularly efficient in counteracting host immunity, including the sensing of virus invasion. It will therefore be critical to clarify how MERS-CoV cripples the host proteins that sense viruses and to compare MERS-CoV with its ancestral viruses in bats in the counteraction of virus sensing. This work not only provides a new understanding of the abilities of MERS-CoV and closely related bat viruses to subvert virus sensing but also might prove useful in revealing new strategies for the development of vaccines and antivirals.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Siu</LastName><ForeName>Kam-Leung</ForeName><Initials>KL</Initials><AffiliationInfo><Affiliation>Department of Biochemistry, University of Hong Kong, Pokfulam, Hong Kong.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yeung</LastName><ForeName>Man Lung</ForeName><Initials>ML</Initials></Author><Author ValidYN="Y"><LastName>Kok</LastName><ForeName>Kin-Hang</ForeName><Initials>KH</Initials></Author><Author ValidYN="Y"><LastName>Yuen</LastName><ForeName>Kit-San</ForeName><Initials>KS</Initials></Author><Author ValidYN="Y"><LastName>Kew</LastName><ForeName>Chun</ForeName><Initials>C</Initials></Author><Author ValidYN="Y"><LastName>Lui</LastName><ForeName>Pak-Yin</ForeName><Initials>PY</Initials></Author><Author ValidYN="Y"><LastName>Chan</LastName><ForeName>Chi-Ping</ForeName><Initials>CP</Initials></Author><Author ValidYN="Y"><LastName>Tse</LastName><ForeName>Herman</ForeName><Initials>H</Initials></Author><Author ValidYN="Y"><LastName>Woo</LastName><ForeName>Patrick C Y</ForeName><Initials>PC</Initials></Author><Author ValidYN="Y"><LastName>Yuen</LastName><ForeName>Kwok-Yung</ForeName><Initials>KY</Initials></Author><Author ValidYN="Y"><LastName>Jin</LastName><ForeName>Dong-Yan</ForeName><Initials>DY</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2014</Year><Month>02</Month><Day>12</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>J Virol</MedlineTA><NlmUniqueID>0113724</NlmUniqueID><ISSNLinking>0022-538X</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C104647">PRKRA protein, human</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D016601">RNA-Binding Proteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D014764">Viral Proteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>9008-11-1</RegistryNumber><NameOfSubstance UI="D007372">Interferons</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 3.6.1.-</RegistryNumber><NameOfSubstance UI="C452820">DDX58 protein, human</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 3.6.1.-</RegistryNumber><NameOfSubstance UI="C452815">IFIH1 protein, human</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 3.6.4.13</RegistryNumber><NameOfSubstance UI="D000071457">DEAD Box Protein 58</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 3.6.4.13</RegistryNumber><NameOfSubstance UI="D053487">DEAD-box RNA Helicases</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 3.6.4.13</RegistryNumber><NameOfSubstance UI="D000072640">Interferon-Induced Helicase, IFIH1</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D002460" MajorTopicYN="N">Cell Line</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D017934" MajorTopicYN="N">Coronavirus</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000071457" MajorTopicYN="N">DEAD Box Protein 58</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D053487" MajorTopicYN="N">DEAD-box RNA Helicases</DescriptorName><QualifierName UI="Q000037" MajorTopicYN="Y">antagonists & inhibitors</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D054884" MajorTopicYN="Y">Host-Pathogen Interactions</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D057131" MajorTopicYN="N">Immune Evasion</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000072640" MajorTopicYN="N">Interferon-Induced Helicase, IFIH1</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007372" MajorTopicYN="N">Interferons</DescriptorName><QualifierName UI="Q000037" MajorTopicYN="Y">antagonists & inhibitors</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011485" MajorTopicYN="N">Protein Binding</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D025941" MajorTopicYN="N">Protein Interaction Mapping</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016601" MajorTopicYN="N">RNA-Binding Proteins</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014764" MajorTopicYN="N">Viral Proteins</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2014</Year><Month>2</Month><Day>14</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2014</Year><Month>2</Month><Day>14</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2014</Year><Month>6</Month><Day>4</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">24522921</ArticleId><ArticleId IdType="pii">JVI.03649-13</ArticleId><ArticleId IdType="doi">10.1128/JVI.03649-13</ArticleId><ArticleId IdType="pmc">PMC3993821</ArticleId></ArticleIdList><ReferenceList><Reference><Citation>J Formos Med Assoc. 2013 Jul;112(7):372-81</Citation><ArticleIdList><ArticleId IdType="pubmed">23883791</ArticleId></ArticleIdList></Reference><Reference><Citation>Emerg Infect Dis. 2013 Nov;19(11):1819-23</Citation><ArticleIdList><ArticleId IdType="pubmed">24206838</ArticleId></ArticleIdList></Reference><Reference><Citation>Cell Host Microbe. 2011 Apr 21;9(4):299-309</Citation><ArticleIdList><ArticleId IdType="pubmed">21501829</ArticleId></ArticleIdList></Reference><Reference><Citation>J Virol. 2013 Aug;87(15):8638-50</Citation><ArticleIdList><ArticleId IdType="pubmed">23720729</ArticleId></ArticleIdList></Reference><Reference><Citation>Immunity. 2013 May 23;38(5):855-69</Citation><ArticleIdList><ArticleId IdType="pubmed">23706667</ArticleId></ArticleIdList></Reference><Reference><Citation>MBio. 2013;4(1):e00611-12</Citation><ArticleIdList><ArticleId IdType="pubmed">23422412</ArticleId></ArticleIdList></Reference><Reference><Citation>Cell Host Microbe. 2013 Jul 17;14(1):5-6</Citation><ArticleIdList><ArticleId IdType="pubmed">23870307</ArticleId></ArticleIdList></Reference><Reference><Citation>J Biochem. 1996 Jul;120(1):160-9</Citation><ArticleIdList><ArticleId IdType="pubmed">8864859</ArticleId></ArticleIdList></Reference><Reference><Citation>Cell Biosci. 2014 Jan 13;4(1):3</Citation><ArticleIdList><ArticleId IdType="pubmed">24410900</ArticleId></ArticleIdList></Reference><Reference><Citation>J Biol Chem. 2009 Jun 12;284(24):16202-9</Citation><ArticleIdList><ArticleId IdType="pubmed">19380580</ArticleId></ArticleIdList></Reference><Reference><Citation>J Infect Dis. 2014 May 1;209(9):1331-42</Citation><ArticleIdList><ArticleId IdType="pubmed">24065148</ArticleId></ArticleIdList></Reference><Reference><Citation>J Infect Dis. 2013 Jun 1;207(11):1743-52</Citation><ArticleIdList><ArticleId IdType="pubmed">23532101</ArticleId></ArticleIdList></Reference><Reference><Citation>Lancet. 2013 Jun 29;381(9885):2265-72</Citation><ArticleIdList><ArticleId IdType="pubmed">23727167</ArticleId></ArticleIdList></Reference><Reference><Citation>Emerg Infect Dis. 2013 Oct;19(10):1697-9</Citation><ArticleIdList><ArticleId IdType="pubmed">24050621</ArticleId></ArticleIdList></Reference><Reference><Citation>N Engl J Med. 2012 Nov 8;367(19):1814-20</Citation><ArticleIdList><ArticleId IdType="pubmed">23075143</ArticleId></ArticleIdList></Reference><Reference><Citation>N Engl J Med. 2013 Jun 27;368(26):2487-94</Citation><ArticleIdList><ArticleId IdType="pubmed">23718156</ArticleId></ArticleIdList></Reference><Reference><Citation>MBio. 2012;3(6). pii: e00473-12. doi: 10.1128/mBio.00473-12</Citation><ArticleIdList><ArticleId IdType="pubmed">23170002</ArticleId></ArticleIdList></Reference><Reference><Citation>Cell Mol Immunol. 2014 Mar;11(2):141-9</Citation><ArticleIdList><ArticleId IdType="pubmed">24509444</ArticleId></ArticleIdList></Reference><Reference><Citation>J Gen Virol. 2009 Sep;90(Pt 9):2107-13</Citation><ArticleIdList><ArticleId IdType="pubmed">19423547</ArticleId></ArticleIdList></Reference><Reference><Citation>Viruses. 2013 Nov;5(11):2679-89</Citation><ArticleIdList><ArticleId IdType="pubmed">24184965</ArticleId></ArticleIdList></Reference><Reference><Citation>Retrovirology. 2013;10:40</Citation><ArticleIdList><ArticleId IdType="pubmed">23577667</ArticleId></ArticleIdList></Reference><Reference><Citation>Nat Immunol. 2004 Jul;5(7):730-7</Citation><ArticleIdList><ArticleId IdType="pubmed">15208624</ArticleId></ArticleIdList></Reference><Reference><Citation>MBio. 2013;4(5):e00650-13</Citation><ArticleIdList><ArticleId IdType="pubmed">24023385</ArticleId></ArticleIdList></Reference><Reference><Citation>Clin Microbiol Rev. 2007 Oct;20(4):660-94</Citation><ArticleIdList><ArticleId IdType="pubmed">17934078</ArticleId></ArticleIdList></Reference><Reference><Citation>Virus Res. 2009 Mar;140(1-2):8-14</Citation><ArticleIdList><ArticleId IdType="pubmed">19041915</ArticleId></ArticleIdList></Reference><Reference><Citation>Trends Microbiol. 2013 Oct;21(10):544-55</Citation><ArticleIdList><ArticleId IdType="pubmed">23770275</ArticleId></ArticleIdList></Reference><Reference><Citation>J Gen Virol. 2013 Dec;94(Pt 12):2679-90</Citation><ArticleIdList><ArticleId IdType="pubmed">24077366</ArticleId></ArticleIdList></Reference><Reference><Citation>Lancet. 2013 Aug 24;382(9893):694-9</Citation><ArticleIdList><ArticleId IdType="pubmed">23831141</ArticleId></ArticleIdList></Reference><Reference><Citation>Proc Natl Acad Sci U S A. 2013 Oct 1;110(40):16157-62</Citation><ArticleIdList><ArticleId IdType="pubmed">24043791</ArticleId></ArticleIdList></Reference><Reference><Citation>Cell Host Microbe. 2013 Jul 17;14(1):74-84</Citation><ArticleIdList><ArticleId IdType="pubmed">23870315</ArticleId></ArticleIdList></Reference><Reference><Citation>Curr Opin Virol. 2012 Jun;2(3):264-75</Citation><ArticleIdList><ArticleId IdType="pubmed">22572391</ArticleId></ArticleIdList></Reference><Reference><Citation>J Virol. 2013 Nov;87(22):12489-95</Citation><ArticleIdList><ArticleId IdType="pubmed">24027320</ArticleId></ArticleIdList></Reference><Reference><Citation>J Virol. 2010 Jul;84(13):6472-82</Citation><ArticleIdList><ArticleId IdType="pubmed">20427526</ArticleId></ArticleIdList></Reference><Reference><Citation>J Virol. 2005 Dec;79(23):14909-22</Citation><ArticleIdList><ArticleId IdType="pubmed">16282490</ArticleId></ArticleIdList></Reference><Reference><Citation>J Virol. 2013 Jul;87(14):7790-2</Citation><ArticleIdList><ArticleId IdType="pubmed">23678167</ArticleId></ArticleIdList></Reference><Reference><Citation>Euro Surveill. 2013;18(36):pii=20574</Citation><ArticleIdList><ArticleId IdType="pubmed">24079378</ArticleId></ArticleIdList></Reference><Reference><Citation>N Engl J Med. 2013 Aug 1;369(5):407-16</Citation><ArticleIdList><ArticleId IdType="pubmed">23782161</ArticleId></ArticleIdList></Reference><Reference><Citation>Zoonoses Public Health. 2013 Feb;60(1):104-16</Citation><ArticleIdList><ArticleId IdType="pubmed">23302292</ArticleId></ArticleIdList></Reference><Reference><Citation>Lancet Infect Dis. 2013 Oct;13(10):859-66</Citation><ArticleIdList><ArticleId IdType="pubmed">23933067</ArticleId></ArticleIdList></Reference><Reference><Citation>Curr Biol. 2011 Jul 12;21(13):R488-93</Citation><ArticleIdList><ArticleId IdType="pubmed">21741580</ArticleId></ArticleIdList></Reference><Reference><Citation>Retrovirology. 2013;10:47</Citation><ArticleIdList><ArticleId IdType="pubmed">23622267</ArticleId></ArticleIdList></Reference><Reference><Citation>J Biol Chem. 2007 Jun 15;282(24):17649-57</Citation><ArticleIdList><ArticleId IdType="pubmed">17452327</ArticleId></ArticleIdList></Reference><Reference><Citation>Virology. 2006 Jul 20;351(1):180-7</Citation><ArticleIdList><ArticleId IdType="pubmed">16647731</ArticleId></ArticleIdList></Reference><Reference><Citation>Protein Cell. 2013 Dec;4(12):951-61</Citation><ArticleIdList><ArticleId IdType="pubmed">24318862</ArticleId></ArticleIdList></Reference><Reference><Citation>J Virol. 2013 Jun;87(12):6604-14</Citation><ArticleIdList><ArticleId IdType="pubmed">23552422</ArticleId></ArticleIdList></Reference><Reference><Citation>J Virol. 2007 Feb;81(4):1574-85</Citation><ArticleIdList><ArticleId IdType="pubmed">17121802</ArticleId></ArticleIdList></Reference><Reference><Citation>Gene. 1989 Apr 15;77(1):51-9</Citation><ArticleIdList><ArticleId IdType="pubmed">2744487</ArticleId></ArticleIdList></Reference><Reference><Citation>J Immunol. 2011 Dec 15;187(12):6473-82</Citation><ArticleIdList><ArticleId IdType="pubmed">22079989</ArticleId></ArticleIdList></Reference><Reference><Citation>J Virol. 2013 May;87(9):5300-4</Citation><ArticleIdList><ArticleId IdType="pubmed">23449793</ArticleId></ArticleIdList></Reference><Reference><Citation>J Gen Virol. 2013 Aug;94(Pt 8):1749-60</Citation><ArticleIdList><ArticleId IdType="pubmed">23620378</ArticleId></ArticleIdList></Reference><Reference><Citation>Nat Med. 2013 Oct;19(10):1313-7</Citation><ArticleIdList><ArticleId IdType="pubmed">24013700</ArticleId></ArticleIdList></Reference><Reference><Citation>J Gen Virol. 2006 Sep;87(Pt 9):2639-44</Citation><ArticleIdList><ArticleId IdType="pubmed">16894203</ArticleId></ArticleIdList></Reference><Reference><Citation>J Virol. 2013 Dec;87(24):13141-9</Citation><ArticleIdList><ArticleId IdType="pubmed">24067967</ArticleId></ArticleIdList></Reference></ReferenceList></PubmedData></pubmed><affiliations><list><country><li>Hong Kong</li></country></list><tree><noCountry><name sortKey="Chan, Chi Ping" sort="Chan, Chi Ping" uniqKey="Chan C" first="Chi-Ping" last="Chan">Chi-Ping Chan</name><name sortKey="Jin, Dong Yan" sort="Jin, Dong Yan" uniqKey="Jin D" first="Dong-Yan" last="Jin">Dong-Yan Jin</name><name sortKey="Kew, Chun" sort="Kew, Chun" uniqKey="Kew C" first="Chun" last="Kew">Chun Kew</name><name sortKey="Kok, Kin Hang" sort="Kok, Kin Hang" uniqKey="Kok K" first="Kin-Hang" last="Kok">Kin-Hang Kok</name><name sortKey="Lui, Pak Yin" sort="Lui, Pak Yin" uniqKey="Lui P" first="Pak-Yin" last="Lui">Pak-Yin Lui</name><name sortKey="Tse, Herman" sort="Tse, Herman" uniqKey="Tse H" first="Herman" last="Tse">Herman Tse</name><name sortKey="Woo, Patrick C Y" sort="Woo, Patrick C Y" uniqKey="Woo P" first="Patrick C Y" last="Woo">Patrick C Y. Woo</name><name sortKey="Yeung, Man Lung" sort="Yeung, Man Lung" uniqKey="Yeung M" first="Man Lung" last="Yeung">Man Lung Yeung</name><name sortKey="Yuen, Kit San" sort="Yuen, Kit San" uniqKey="Yuen K" first="Kit-San" last="Yuen">Kit-San Yuen</name><name sortKey="Yuen, Kwok Yung" sort="Yuen, Kwok Yung" uniqKey="Yuen K" first="Kwok-Yung" last="Yuen">Kwok-Yung Yuen</name></noCountry><country name="Hong Kong"><noRegion><name sortKey="Siu, Kam Leung" sort="Siu, Kam Leung" uniqKey="Siu K" first="Kam-Leung" last="Siu">Kam-Leung Siu</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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