Short, terminally modified 2'-OMe RNAs as inhibitors of microRNA.
Identifieur interne : 000A85 ( Ncbi/Merge ); précédent : 000A84; suivant : 000A86Short, terminally modified 2'-OMe RNAs as inhibitors of microRNA.
Auteurs : Jenny Blechinger [Allemagne] ; Hanna Pieper ; Paul Marzenell ; Larisa Kovbasyuk ; Andrius Serva ; Vytaute Starkuviene ; Holger Erfle ; Andriy MokhirSource :
- Chemical communications (Cambridge, England) [ 1364-548X ] ; 2013.
Descripteurs français
- KwdFr :
- MESH :
- antagonistes et inhibiteurs : microARN.
- pharmacologie : Oligonucléotides, Stilbènes.
- Cellules HeLa, Humains, Oligonucléotides, Régulation négative, Stilbènes, Séquence nucléotidique, microARN.
English descriptors
- KwdEn :
- MESH :
- chemical , antagonists & inhibitors : MicroRNAs.
- chemical , chemistry : MicroRNAs, Oligonucleotides, Stilbenes.
- drug effects : Down-Regulation.
- chemical , pharmacology : Oligonucleotides, Stilbenes.
- Base Sequence, HeLa Cells, Humans.
Abstract
We applied 14-mer 2'-OMe RNAs as inhibitors of selected micro RNAs. To improve their properties, we introduced a trimethoxystilbene residue at the 5'-terminus and three 2'-fluoro-2'-deoxynucleotides at the 3'-terminus to obtain potent inhibitors, whose mismatch discrimination is substantially better than that of typically applied >18-mers.
DOI: 10.1039/c3cc43174f
PubMed: 23863995
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last="Mokhir">Andriy Mokhir</name><name sortKey="Pieper, Hanna" sort="Pieper, Hanna" uniqKey="Pieper H" first="Hanna" last="Pieper">Hanna Pieper</name><name sortKey="Serva, Andrius" sort="Serva, Andrius" uniqKey="Serva A" first="Andrius" last="Serva">Andrius Serva</name><name sortKey="Starkuviene, Vytaute" sort="Starkuviene, Vytaute" uniqKey="Starkuviene V" first="Vytaute" last="Starkuviene">Vytaute Starkuviene</name></noCountry><country name="Allemagne"><region name="Bavière"><name sortKey="Blechinger, Jenny" sort="Blechinger, Jenny" uniqKey="Blechinger J" first="Jenny" last="Blechinger">Jenny Blechinger</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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