Liquid crystal self-assembly of random-sequence DNA oligomers.
Identifieur interne : 000919 ( Ncbi/Merge ); précédent : 000918; suivant : 000920Liquid crystal self-assembly of random-sequence DNA oligomers.
Auteurs : Tommaso Bellini [Italie] ; Giuliano Zanchetta ; Tommaso P. Fraccia ; Roberto Cerbino ; Ethan Tsai ; Gregory P. Smith ; Mark J. Moran ; David M. Walba ; Noel A. ClarkSource :
- Proceedings of the National Academy of Sciences of the United States of America [ 1091-6490 ] ; 2012.
Descripteurs français
- KwdFr :
- MESH :
English descriptors
- KwdEn :
- MESH :
- chemical , chemistry : DNA.
- chemistry : Liquid Crystals.
- chemical , genetics : Oligonucleotides.
- Base Sequence, Kinetics, Molecular Sequence Data, Nucleic Acid Conformation.
Abstract
In biological systems and nanoscale assemblies, the self-association of DNA is typically studied and applied in the context of the evolved or directed design of base sequences that give complementary pairing, duplex formation, and specific structural motifs. Here we consider the collective behavior of DNA solutions in the distinctly different regime where DNA base sequences are chosen at random or with varying degrees of randomness. We show that in solutions of completely random sequences, corresponding to a remarkably large number of different molecules, e.g., approximately 10(12) for random 20-mers, complementary still emerges and, for a narrow range of oligomer lengths, produces a subtle hierarchical sequence of structured self-assembly and organization into liquid crystal (LC) phases. This ordering follows from the kinetic arrest of oligomer association into long-lived partially paired double helices, followed by reversible association of these pairs into linear aggregates that in turn condense into LC domains.
DOI: 10.1073/pnas.1117463109
PubMed: 22233803
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pubmed:22233803Le document en format XML
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Fraccia</name></author><author><name sortKey="Cerbino, Roberto" sort="Cerbino, Roberto" uniqKey="Cerbino R" first="Roberto" last="Cerbino">Roberto Cerbino</name></author><author><name sortKey="Tsai, Ethan" sort="Tsai, Ethan" uniqKey="Tsai E" first="Ethan" last="Tsai">Ethan Tsai</name></author><author><name sortKey="Smith, Gregory P" sort="Smith, Gregory P" uniqKey="Smith G" first="Gregory P" last="Smith">Gregory P. Smith</name></author><author><name sortKey="Moran, Mark J" sort="Moran, Mark J" uniqKey="Moran M" first="Mark J" last="Moran">Mark J. Moran</name></author><author><name sortKey="Walba, David M" sort="Walba, David M" uniqKey="Walba D" first="David M" last="Walba">David M. Walba</name></author><author><name sortKey="Clark, Noel A" sort="Clark, Noel A" uniqKey="Clark N" first="Noel A" last="Clark">Noel A. Clark</name></author></analytic><series><title level="j">Proceedings of the National Academy of Sciences of the United States of America</title><idno type="eISSN">1091-6490</idno><imprint><date when="2012" type="published">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Base Sequence</term><term>DNA (chemistry)</term><term>Kinetics</term><term>Liquid Crystals (chemistry)</term><term>Molecular Sequence Data</term><term>Nucleic Acid Conformation</term><term>Oligonucleotides (genetics)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>ADN ()</term><term>Cinétique</term><term>Conformation d'acide nucléique</term><term>Cristaux liquides ()</term><term>Données de séquences moléculaires</term><term>Oligonucléotides (génétique)</term><term>Séquence nucléotidique</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>DNA</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Liquid Crystals</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Oligonucleotides</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Oligonucléotides</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Base Sequence</term><term>Kinetics</term><term>Molecular Sequence Data</term><term>Nucleic Acid Conformation</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>ADN</term><term>Cinétique</term><term>Conformation d'acide nucléique</term><term>Cristaux liquides</term><term>Données de séquences moléculaires</term><term>Séquence nucléotidique</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">In biological systems and nanoscale assemblies, the self-association of DNA is typically studied and applied in the context of the evolved or directed design of base sequences that give complementary pairing, duplex formation, and specific structural motifs. Here we consider the collective behavior of DNA solutions in the distinctly different regime where DNA base sequences are chosen at random or with varying degrees of randomness. We show that in solutions of completely random sequences, corresponding to a remarkably large number of different molecules, e.g., approximately 10(12) for random 20-mers, complementary still emerges and, for a narrow range of oligomer lengths, produces a subtle hierarchical sequence of structured self-assembly and organization into liquid crystal (LC) phases. This ordering follows from the kinetic arrest of oligomer association into long-lived partially paired double helices, followed by reversible association of these pairs into linear aggregates that in turn condense into LC domains.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">22233803</PMID><DateCompleted><Year>2012</Year><Month>03</Month><Day>28</Day></DateCompleted><DateRevised><Year>2018</Year><Month>11</Month><Day>13</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1091-6490</ISSN><JournalIssue CitedMedium="Internet"><Volume>109</Volume><Issue>4</Issue><PubDate><Year>2012</Year><Month>Jan</Month><Day>24</Day></PubDate></JournalIssue><Title>Proceedings of the National Academy of Sciences of the United States of America</Title><ISOAbbreviation>Proc. Natl. Acad. Sci. U.S.A.</ISOAbbreviation></Journal><ArticleTitle>Liquid crystal self-assembly of random-sequence DNA oligomers.</ArticleTitle><Pagination><MedlinePgn>1110-5</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1073/pnas.1117463109</ELocationID><Abstract><AbstractText>In biological systems and nanoscale assemblies, the self-association of DNA is typically studied and applied in the context of the evolved or directed design of base sequences that give complementary pairing, duplex formation, and specific structural motifs. Here we consider the collective behavior of DNA solutions in the distinctly different regime where DNA base sequences are chosen at random or with varying degrees of randomness. We show that in solutions of completely random sequences, corresponding to a remarkably large number of different molecules, e.g., approximately 10(12) for random 20-mers, complementary still emerges and, for a narrow range of oligomer lengths, produces a subtle hierarchical sequence of structured self-assembly and organization into liquid crystal (LC) phases. This ordering follows from the kinetic arrest of oligomer association into long-lived partially paired double helices, followed by reversible association of these pairs into linear aggregates that in turn condense into LC domains.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Bellini</LastName><ForeName>Tommaso</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Dipartimento di Chimica, Biochimica e Biotecnologie per la Medicina, Università degli Studi di Milano, Via F.lli Cervi 93, I-20090 Segrate, Italy. tommaso.bellini@unimi.it</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zanchetta</LastName><ForeName>Giuliano</ForeName><Initials>G</Initials></Author><Author ValidYN="Y"><LastName>Fraccia</LastName><ForeName>Tommaso P</ForeName><Initials>TP</Initials></Author><Author ValidYN="Y"><LastName>Cerbino</LastName><ForeName>Roberto</ForeName><Initials>R</Initials></Author><Author ValidYN="Y"><LastName>Tsai</LastName><ForeName>Ethan</ForeName><Initials>E</Initials></Author><Author ValidYN="Y"><LastName>Smith</LastName><ForeName>Gregory P</ForeName><Initials>GP</Initials></Author><Author ValidYN="Y"><LastName>Moran</LastName><ForeName>Mark J</ForeName><Initials>MJ</Initials></Author><Author ValidYN="Y"><LastName>Walba</LastName><ForeName>David M</ForeName><Initials>DM</Initials></Author><Author ValidYN="Y"><LastName>Clark</LastName><ForeName>Noel A</ForeName><Initials>NA</Initials></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>T32 GM065103</GrantID><Acronym>GM</Acronym><Agency>NIGMS NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D052061">Research Support, N.I.H., Extramural</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType><PublicationType 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Clark</name><name sortKey="Fraccia, Tommaso P" sort="Fraccia, Tommaso P" uniqKey="Fraccia T" first="Tommaso P" last="Fraccia">Tommaso P. Fraccia</name><name sortKey="Moran, Mark J" sort="Moran, Mark J" uniqKey="Moran M" first="Mark J" last="Moran">Mark J. Moran</name><name sortKey="Smith, Gregory P" sort="Smith, Gregory P" uniqKey="Smith G" first="Gregory P" last="Smith">Gregory P. Smith</name><name sortKey="Tsai, Ethan" sort="Tsai, Ethan" uniqKey="Tsai E" first="Ethan" last="Tsai">Ethan Tsai</name><name sortKey="Walba, David M" sort="Walba, David M" uniqKey="Walba D" first="David M" last="Walba">David M. Walba</name><name sortKey="Zanchetta, Giuliano" sort="Zanchetta, Giuliano" uniqKey="Zanchetta G" first="Giuliano" last="Zanchetta">Giuliano Zanchetta</name></noCountry><country name="Italie"><noRegion><name sortKey="Bellini, Tommaso" sort="Bellini, Tommaso" uniqKey="Bellini T" first="Tommaso" last="Bellini">Tommaso Bellini</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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