MersV1, Ncbi, Merge, bibRecord, 000903

Inactivated RNA polymerase II open complexes can be reactivated with TFIIE.

Identifieur interne : 000903 ( Ncbi/Merge ); précédent : 000902; suivant : 000904

Inactivated RNA polymerase II open complexes can be reactivated with TFIIE.

Auteurs : Pavel Abart [États-Unis] ; Donal S. Luse

Source :

The Journal of biological chemistry [ 1083-351X ] ; 2012.

RBID : pubmed:22119917

Descripteurs français

KwdFr :
- Adénosine triphosphate (), Adénosine triphosphate (génétique), Adénosine triphosphate (métabolisme), Cellules HeLa, Facteur de transcription TFIIH (), Facteur de transcription TFIIH (génétique), Facteur de transcription TFIIH (métabolisme), Facteurs de transcription TFII (), Facteurs de transcription TFII (génétique), Facteurs de transcription TFII (métabolisme), Humains, RNA polymerase II (), RNA polymerase II (génétique), RNA polymerase II (métabolisme), Transcription génétique (physiologie).
MESH :
- génétique : Adénosine triphosphate, Facteur de transcription TFIIH, Facteurs de transcription TFII, RNA polymerase II.
- métabolisme : Adénosine triphosphate, Facteur de transcription TFIIH, Facteurs de transcription TFII, RNA polymerase II.
- physiologie : Transcription génétique.
- Adénosine triphosphate, Cellules HeLa, Facteur de transcription TFIIH, Facteurs de transcription TFII, Humains, RNA polymerase II.

English descriptors

KwdEn :
- Adenosine Triphosphate (chemistry), Adenosine Triphosphate (genetics), Adenosine Triphosphate (metabolism), HeLa Cells, Humans, RNA Polymerase II (chemistry), RNA Polymerase II (genetics), RNA Polymerase II (metabolism), Transcription Factor TFIIH (chemistry), Transcription Factor TFIIH (genetics), Transcription Factor TFIIH (metabolism), Transcription Factors, TFII (chemistry), Transcription Factors, TFII (genetics), Transcription Factors, TFII (metabolism), Transcription, Genetic (physiology).
MESH :
- chemical , chemistry : Adenosine Triphosphate, RNA Polymerase II, Transcription Factor TFIIH, Transcription Factors, TFII.
- chemical , genetics : Adenosine Triphosphate, RNA Polymerase II, Transcription Factor TFIIH, Transcription Factors, TFII.
- chemical , metabolism : Adenosine Triphosphate, RNA Polymerase II, Transcription Factor TFIIH, Transcription Factors, TFII.
- physiology : Transcription, Genetic.
- HeLa Cells, Humans.

Abstract

Transcript initiation by RNA polymerase II (pol II) requires a helicase within TFIIH to generate the unpaired template strand. However, pol II preinitiation complexes (PICs) lose the ability to synthesize RNA very rapidly upon exposure to ATP alone in the absence of other NTPs. This inactivation is not caused by the TFIIH kinase activity, the loss of transcription factors or pol II from the PIC, or the collapse of the initially formed transcription bubble. TFIIE is necessary for PIC formation, but TFIIE is not retained as a stable component in PICs prepared by our protocol. Nevertheless, activity can be at least partially restored to ATP-treated PICs by the readdition of TFIIE. PICs formed on premelted (bubble) templates require TFIIH for effective transcript elongation to +20. Incubation of bubble template PICs with ATP caused reduced yields of 20-mers, but this effect was partially reversed by the addition of TFIIE. Our results suggest that once the open complex is formed, TFIIH decays into an inactive configuration in the absence of nucleotides for transcription. Although TFIIE does not play a role in transcript initiation itself, inactivation resulting from ATP preincubation can be reversed by a remodeling process mediated by TFIIE. Finally, we have also uncovered a major role for TFIIF in the earliest stages of transcript elongation that is unique to bubble templates.

DOI: 10.1074/jbc.M111.297572
PubMed: 22119917

Links toward previous steps (curation, corpus...)

to stream PubMed, to step Corpus: 001E33
to stream PubMed, to step Curation: 001E33
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pubmed:22119917

Le document en format XML

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<term>Cellules HeLa</term>
<term>Facteur de transcription TFIIH</term>
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<term>Humains</term>
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<front><div type="abstract" xml:lang="en">Transcript initiation by RNA polymerase II (pol II) requires a helicase within TFIIH to generate the unpaired template strand. However, pol II preinitiation complexes (PICs) lose the ability to synthesize RNA very rapidly upon exposure to ATP alone in the absence of other NTPs. This inactivation is not caused by the TFIIH kinase activity, the loss of transcription factors or pol II from the PIC, or the collapse of the initially formed transcription bubble. TFIIE is necessary for PIC formation, but TFIIE is not retained as a stable component in PICs prepared by our protocol. Nevertheless, activity can be at least partially restored to ATP-treated PICs by the readdition of TFIIE. PICs formed on premelted (bubble) templates require TFIIH for effective transcript elongation to +20. Incubation of bubble template PICs with ATP caused reduced yields of 20-mers, but this effect was partially reversed by the addition of TFIIE. Our results suggest that once the open complex is formed, TFIIH decays into an inactive configuration in the absence of nucleotides for transcription. Although TFIIE does not play a role in transcript initiation itself, inactivation resulting from ATP preincubation can be reversed by a remodeling process mediated by TFIIE. Finally, we have also uncovered a major role for TFIIF in the earliest stages of transcript elongation that is unique to bubble templates.</div>
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<ArticleIdList><ArticleId IdType="pubmed">21566144</ArticleId>
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<Reference><Citation>Mol Cell. 2011 Jul 22;43(2):263-74</Citation>
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<Reference><Citation>EMBO J. 1999 Mar 1;18(5):1357-66</Citation>
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<country name="États-Unis"><noRegion><name sortKey=" Abart, Pavel" sort=" Abart, Pavel" uniqKey=" Abart P" first="Pavel" last=" Abart">Pavel  Abart</name>
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{{Explor lien
   |wiki=    Sante
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   |clé=     pubmed:22119917
   |texte=   Inactivated RNA polymerase II open complexes can be reactivated with TFIIE.
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Inactivated RNA polymerase II open complexes can be reactivated with TFIIE.

Inactivated RNA polymerase II open complexes can be reactivated with TFIIE.

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