[A Novel Method for Detecting p53 Autoantibodies in Sera of Patients with NSCLC.].
Identifieur interne : 000769 ( Ncbi/Merge ); précédent : 000768; suivant : 000770[A Novel Method for Detecting p53 Autoantibodies in Sera of Patients with NSCLC.].
Auteurs : Kai Tang [République populaire de Chine] ; Wentao Yue ; Yue Wang ; Lina Zhang ; Shaofa XuSource :
- Zhongguo fei ai za zhi = Chinese journal of lung cancer [ 1999-6187 ] ; 2009.
Abstract
Serum autoantibody detection is useful means for the early diagnosis and prognosis of cancer. So our objective was to synthesize peptide array to analyse p53 autoantibodies in the sera of patients with non small cell lung cancer (NSCLC).
DOI: 10.3779/j.issn.1009-3419.2009.09.006
PubMed: 20719194
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">[A Novel Method for Detecting p53 Autoantibodies in Sera of Patients with NSCLC.].</title><author><name sortKey="Tang, Kai" sort="Tang, Kai" uniqKey="Tang K" first="Kai" last="Tang">Kai Tang</name><affiliation wicri:level="1"><nlm:affiliation>Department of Cellular and Molecular Biology, Beijing TB and Thoracic Tumor Research Institute, Beijing 101149, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Cellular and Molecular Biology, Beijing TB and Thoracic Tumor Research Institute, Beijing 101149</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Yue, Wentao" sort="Yue, Wentao" uniqKey="Yue W" first="Wentao" last="Yue">Wentao Yue</name></author><author><name sortKey="Wang, Yue" sort="Wang, Yue" uniqKey="Wang Y" first="Yue" last="Wang">Yue Wang</name></author><author><name sortKey="Zhang, Lina" sort="Zhang, Lina" uniqKey="Zhang L" first="Lina" last="Zhang">Lina Zhang</name></author><author><name sortKey="Xu, Shaofa" sort="Xu, Shaofa" uniqKey="Xu S" first="Shaofa" last="Xu">Shaofa Xu</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2009">2009</date><idno type="RBID">pubmed:20719194</idno><idno type="pmid">20719194</idno><idno type="doi">10.3779/j.issn.1009-3419.2009.09.006</idno><idno type="wicri:Area/PubMed/Corpus">001F41</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001F41</idno><idno type="wicri:Area/PubMed/Curation">001F41</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001F41</idno><idno type="wicri:Area/PubMed/Checkpoint">001E71</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001E71</idno><idno type="wicri:Area/Ncbi/Merge">000769</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">[A Novel Method for Detecting p53 Autoantibodies in Sera of Patients with NSCLC.].</title><author><name sortKey="Tang, Kai" sort="Tang, Kai" uniqKey="Tang K" first="Kai" last="Tang">Kai Tang</name><affiliation wicri:level="1"><nlm:affiliation>Department of Cellular and Molecular Biology, Beijing TB and Thoracic Tumor Research Institute, Beijing 101149, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Cellular and Molecular Biology, Beijing TB and Thoracic Tumor Research Institute, Beijing 101149</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Yue, Wentao" sort="Yue, Wentao" uniqKey="Yue W" first="Wentao" last="Yue">Wentao Yue</name></author><author><name sortKey="Wang, Yue" sort="Wang, Yue" uniqKey="Wang Y" first="Yue" last="Wang">Yue Wang</name></author><author><name sortKey="Zhang, Lina" sort="Zhang, Lina" uniqKey="Zhang L" first="Lina" last="Zhang">Lina Zhang</name></author><author><name sortKey="Xu, Shaofa" sort="Xu, Shaofa" uniqKey="Xu S" first="Shaofa" last="Xu">Shaofa Xu</name></author></analytic><series><title level="j">Zhongguo fei ai za zhi = Chinese journal of lung cancer</title><idno type="eISSN">1999-6187</idno><imprint><date when="2009" type="published">2009</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Serum autoantibody detection is useful means for the early diagnosis and prognosis of cancer. So our objective was to synthesize peptide array to analyse p53 autoantibodies in the sera of patients with non small cell lung cancer (NSCLC).</div></front></TEI><pubmed><MedlineCitation Status="PubMed-not-MEDLINE" Owner="NLM"><PMID Version="1">20719194</PMID><DateCompleted><Year>2012</Year><Month>10</Month><Day>02</Day></DateCompleted><DateRevised><Year>2010</Year><Month>08</Month><Day>19</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1999-6187</ISSN><JournalIssue CitedMedium="Internet"><Volume>12</Volume><Issue>9</Issue><PubDate><Year>2009</Year><Month>Sep</Month><Day>20</Day></PubDate></JournalIssue><Title>Zhongguo fei ai za zhi = Chinese journal of lung cancer</Title><ISOAbbreviation>Zhongguo Fei Ai Za Zhi</ISOAbbreviation></Journal><ArticleTitle>[A Novel Method for Detecting p53 Autoantibodies in Sera of Patients with NSCLC.].</ArticleTitle><Pagination><MedlinePgn>969-74</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.3779/j.issn.1009-3419.2009.09.006</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Serum autoantibody detection is useful means for the early diagnosis and prognosis of cancer. So our objective was to synthesize peptide array to analyse p53 autoantibodies in the sera of patients with non small cell lung cancer (NSCLC).</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">Cellulose-bound overlapping peptides (12 mers) derived from p53 wild type protein were synthesized using SOPTs synthesis technique by an AutoSpot robot -ASP SL (Intavis, Germany). The membrane was incubated with 1/400 dilutions of p53 monoclonal antibody (Sc-53394) to establish a new approach to detect p53 antibody, and the epitopes of the p53 monoclonal antibody is already known. We analysed the p53 autoantibodies from the sera of NSCLC and controls by peptide array and ELISA.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">We synthesized on cellulose membranes twelve-amino-acid overlapping peptides which included all of the sequences of the polypeptide chain of p53. The p53 autoantibody was positive in seven cases of thirty patients sera with NSCLC and was negative in sera of the controls, with the same result of ELISA CONCLUSIONS: The peptide array could be applied not only to detect the autoantibodies in the sera of patients with lung cancer, but also to map the epitopes of the autoantibodies which might be useful for the early diagnosis and prognosis of cancer.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Tang</LastName><ForeName>Kai</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Department of Cellular and Molecular Biology, Beijing TB and Thoracic Tumor Research Institute, Beijing 101149, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yue</LastName><ForeName>Wentao</ForeName><Initials>W</Initials></Author><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>Yue</ForeName><Initials>Y</Initials></Author><Author ValidYN="Y"><LastName>Zhang</LastName><ForeName>Lina</ForeName><Initials>L</Initials></Author><Author ValidYN="Y"><LastName>Xu</LastName><ForeName>Shaofa</ForeName><Initials>S</Initials></Author></AuthorList><Language>chi</Language><PublicationTypeList><PublicationType UI="D004740">English Abstract</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>China</Country><MedlineTA>Zhongguo Fei Ai Za Zhi</MedlineTA><NlmUniqueID>101126433</NlmUniqueID><ISSNLinking>1009-3419</ISSNLinking></MedlineJournalInfo></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2010</Year><Month>8</Month><Day>20</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2010</Year><Month>8</Month><Day>20</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2010</Year><Month>8</Month><Day>20</Day><Hour>6</Hour><Minute>1</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">20719194</ArticleId><ArticleId IdType="doi">10.3779/j.issn.1009-3419.2009.09.006</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>République populaire de Chine</li></country><settlement><li>Pékin</li></settlement></list><tree><noCountry><name sortKey="Wang, Yue" sort="Wang, Yue" uniqKey="Wang Y" first="Yue" last="Wang">Yue Wang</name><name sortKey="Xu, Shaofa" sort="Xu, Shaofa" uniqKey="Xu S" first="Shaofa" last="Xu">Shaofa Xu</name><name sortKey="Yue, Wentao" sort="Yue, Wentao" uniqKey="Yue W" first="Wentao" last="Yue">Wentao Yue</name><name sortKey="Zhang, Lina" sort="Zhang, Lina" uniqKey="Zhang L" first="Lina" last="Zhang">Lina Zhang</name></noCountry><country name="République populaire de Chine"><noRegion><name sortKey="Tang, Kai" sort="Tang, Kai" uniqKey="Tang K" first="Kai" last="Tang">Kai Tang</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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