MersV1, Ncbi, Merge, bibRecord, 000374

IgE and IgG4 epitope mapping by microarray immunoassay reveals the diversity of immune response to the peanut allergen, Ara h 2.

Identifieur interne : 000374 ( Ncbi/Merge ); précédent : 000373; suivant : 000375

IgE and IgG4 epitope mapping by microarray immunoassay reveals the diversity of immune response to the peanut allergen, Ara h 2.

Auteurs : Wayne G. Shreffler [États-Unis] ; Doerthe A. Lencer ; Ludmilla Bardina ; Hugh A. Sampson

Source :

The Journal of allergy and clinical immunology [ 0091-6749 ] ; 2005.

RBID : pubmed:16210066

Descripteurs français

English descriptors

KwdEn :
- 2S Albumins, Plant, Allergens (genetics), Allergens (immunology), Amino Acid Sequence, Antibody Specificity, Antigen-Antibody Reactions, Antigens, Plant, Arachis (genetics), Arachis (immunology), Case-Control Studies, Cluster Analysis, Epitope Mapping (methods), Epitope Mapping (statistics & numerical data), Glycoproteins (genetics), Glycoproteins (immunology), Humans, Immunoglobulin E (metabolism), Immunoglobulin G (metabolism), In Vitro Techniques, Molecular Sequence Data, Peanut Hypersensitivity (genetics), Peanut Hypersensitivity (immunology), Plant Proteins (genetics), Plant Proteins (immunology), Protein Array Analysis.
MESH :
- chemical , genetics : Allergens, Glycoproteins, Plant Proteins.
- chemical , immunology : Allergens, Glycoproteins, Plant Proteins.
- chemical , metabolism : Immunoglobulin E, Immunoglobulin G.
- chemical : 2S Albumins, Plant, Antigens, Plant.
- genetics : Arachis, Peanut Hypersensitivity.
- immunology : Arachis, Peanut Hypersensitivity.
- methods : Epitope Mapping.
- statistics & numerical data : Epitope Mapping.
- Amino Acid Sequence, Antibody Specificity, Antigen-Antibody Reactions, Case-Control Studies, Cluster Analysis, Humans, In Vitro Techniques, Molecular Sequence Data, Protein Array Analysis.

Abstract

Detailed assessment of antibody responses to allergens reveals clinically relevant information about both host response and antigen structure. Microarray technology offers advantages of scale and parallel design over previous methods of epitope mapping.

DOI: 10.1016/j.jaci.2005.06.033
PubMed: 16210066

Links toward previous steps (curation, corpus...)

to stream PubMed, to step Corpus: 002306
to stream PubMed, to step Curation: 002306
to stream PubMed, to step Checkpoint: 002200

Links to Exploration step

pubmed:16210066

Le document en format XML

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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>2S Albumins, Plant</term>
<term>Allergens (genetics)</term>
<term>Allergens (immunology)</term>
<term>Amino Acid Sequence</term>
<term>Antibody Specificity</term>
<term>Antigen-Antibody Reactions</term>
<term>Antigens, Plant</term>
<term>Arachis (genetics)</term>
<term>Arachis (immunology)</term>
<term>Case-Control Studies</term>
<term>Cluster Analysis</term>
<term>Epitope Mapping (methods)</term>
<term>Epitope Mapping (statistics & numerical data)</term>
<term>Glycoproteins (genetics)</term>
<term>Glycoproteins (immunology)</term>
<term>Humans</term>
<term>Immunoglobulin E (metabolism)</term>
<term>Immunoglobulin G (metabolism)</term>
<term>In Vitro Techniques</term>
<term>Molecular Sequence Data</term>
<term>Peanut Hypersensitivity (genetics)</term>
<term>Peanut Hypersensitivity (immunology)</term>
<term>Plant Proteins (genetics)</term>
<term>Plant Proteins (immunology)</term>
<term>Protein Array Analysis</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Albumines 2S de plante</term>
<term>Allergènes (génétique)</term>
<term>Allergènes (immunologie)</term>
<term>Analyse de regroupements</term>
<term>Analyse par réseau de protéines</term>
<term>Antigènes végétaux</term>
<term>Arachis (génétique)</term>
<term>Arachis (immunologie)</term>
<term>Cartographie épitopique ()</term>
<term>Données de séquences moléculaires</term>
<term>Glycoprotéines (génétique)</term>
<term>Glycoprotéines (immunologie)</term>
<term>Humains</term>
<term>Hypersensibilité à l'arachide (génétique)</term>
<term>Hypersensibilité à l'arachide (immunologie)</term>
<term>Immunoglobuline E (métabolisme)</term>
<term>Immunoglobuline G (métabolisme)</term>
<term>Protéines végétales (génétique)</term>
<term>Protéines végétales (immunologie)</term>
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<term>Spécificité des anticorps</term>
<term>Séquence d'acides aminés</term>
<term>Techniques in vitro</term>
<term>Études cas-témoins</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Allergens</term>
<term>Glycoproteins</term>
<term>Plant Proteins</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Allergens</term>
<term>Glycoproteins</term>
<term>Plant Proteins</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Immunoglobulin E</term>
<term>Immunoglobulin G</term>
</keywords>
<keywords scheme="MESH" type="chemical" xml:lang="en"><term>2S Albumins, Plant</term>
<term>Antigens, Plant</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Arachis</term>
<term>Peanut Hypersensitivity</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Allergènes</term>
<term>Arachis</term>
<term>Glycoprotéines</term>
<term>Hypersensibilité à l'arachide</term>
<term>Protéines végétales</term>
</keywords>
<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Allergènes</term>
<term>Arachis</term>
<term>Glycoprotéines</term>
<term>Hypersensibilité à l'arachide</term>
<term>Protéines végétales</term>
</keywords>
<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Arachis</term>
<term>Peanut Hypersensitivity</term>
</keywords>
<keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Epitope Mapping</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Immunoglobuline E</term>
<term>Immunoglobuline G</term>
</keywords>
<keywords scheme="MESH" qualifier="statistics & numerical data" xml:lang="en"><term>Epitope Mapping</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Amino Acid Sequence</term>
<term>Antibody Specificity</term>
<term>Antigen-Antibody Reactions</term>
<term>Case-Control Studies</term>
<term>Cluster Analysis</term>
<term>Humans</term>
<term>In Vitro Techniques</term>
<term>Molecular Sequence Data</term>
<term>Protein Array Analysis</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Albumines 2S de plante</term>
<term>Analyse de regroupements</term>
<term>Analyse par réseau de protéines</term>
<term>Antigènes végétaux</term>
<term>Cartographie épitopique</term>
<term>Données de séquences moléculaires</term>
<term>Humains</term>
<term>Réaction antigène-anticorps</term>
<term>Spécificité des anticorps</term>
<term>Séquence d'acides aminés</term>
<term>Techniques in vitro</term>
<term>Études cas-témoins</term>
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<front><div type="abstract" xml:lang="en">Detailed assessment of antibody responses to allergens reveals clinically relevant information about both host response and antigen structure. Microarray technology offers advantages of scale and parallel design over previous methods of epitope mapping.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">16210066</PMID>
<DateCompleted><Year>2005</Year>
<Month>11</Month>
<Day>21</Day>
</DateCompleted>
<DateRevised><Year>2015</Year>
<Month>11</Month>
<Day>19</Day>
</DateRevised>
<Article PubModel="Print"><Journal><ISSN IssnType="Print">0091-6749</ISSN>
<JournalIssue CitedMedium="Print"><Volume>116</Volume>
<Issue>4</Issue>
<PubDate><Year>2005</Year>
<Month>Oct</Month>
</PubDate>
</JournalIssue>
<Title>The Journal of allergy and clinical immunology</Title>
<ISOAbbreviation>J. Allergy Clin. Immunol.</ISOAbbreviation>
</Journal>
<ArticleTitle>IgE and IgG4 epitope mapping by microarray immunoassay reveals the diversity of immune response to the peanut allergen, Ara h 2.</ArticleTitle>
<Pagination><MedlinePgn>893-9</MedlinePgn>
</Pagination>
<Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Detailed assessment of antibody responses to allergens reveals clinically relevant information about both host response and antigen structure. Microarray technology offers advantages of scale and parallel design over previous methods of epitope mapping.</AbstractText>
<AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">We designed a redundant peptide microarray for IgE and IgG4 epitope mapping of the previously characterized peanut allergen, Ara h 2.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">Six complete sets of overlapping peptides were commercially synthesized and site-specifically bound to epoxy-derivatized glass slides in triplicate. Peptides were 10, 15, or 20 amino acids in length with an offset of either 2 or 3 amino acids. A total of 10 control and 45 peanut-allergic sera were assayed. Specific IgE and IgG4 were detected by using fluorochrome-labeled monoclonal secondary antibodies.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">By using 15-mer and 20-mer peptides, we could define 11 antigenic regions, whereas only 5 were identifiable using 10-mers. Controls and patients produced IgG4 recognizing a comparable number of Ara h 2 peptides, although the dominant epitopes were distinct. As expected, patient IgE bound a larger number of Ara h 2 peptides (9.4% vs 0.9%). IgE and IgG4 epitopes recognized by patients were largely the same, and there was a positive association between IgE and IgG(4) signal, suggesting coordinate regulation. Cluster analysis of peptide binding patterns confirmed the specificity of antibody-peptide interactions and was used to define 9 core epitopes ranging from 6 to 16 residues in length-7 of which (78%) agreed with previous mapping.</AbstractText>
<AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">Epitope mapping by microarray peptide immunoassay and cluster analysis reveals interpatient heterogeneity and a more detailed map.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Shreffler</LastName>
<ForeName>Wayne G</ForeName>
<Initials>WG</Initials>
<AffiliationInfo><Affiliation>Jaffe Food Allergy Institute, Department of Pediatrics, Division of Allergy and Immunology, Mount Sinai School of Medicine, New York, NY 10029, USA. wayne.shreffler@mssm.edu</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Lencer</LastName>
<ForeName>Doerthe A</ForeName>
<Initials>DA</Initials>
</Author>
<Author ValidYN="Y"><LastName>Bardina</LastName>
<ForeName>Ludmilla</ForeName>
<Initials>L</Initials>
</Author>
<Author ValidYN="Y"><LastName>Sampson</LastName>
<ForeName>Hugh A</ForeName>
<Initials>HA</Initials>
</Author>
</AuthorList>
<Language>eng</Language>
<GrantList CompleteYN="Y"><Grant><GrantID>M01-RR-00071</GrantID>
<Acronym>RR</Acronym>
<Agency>NCRR NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>P01-AI44236-01</GrantID>
<Acronym>AI</Acronym>
<Agency>NIAID NIH HHS</Agency>
<Country>United States</Country>
</Grant>
</GrantList>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D052061">Research Support, N.I.H., Extramural</PublicationType>
<PublicationType UI="D013487">Research Support, U.S. Gov't, P.H.S.</PublicationType>
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</Article>
<MedlineJournalInfo><Country>United States</Country>
<MedlineTA>J Allergy Clin Immunol</MedlineTA>
<NlmUniqueID>1275002</NlmUniqueID>
<ISSNLinking>0091-6749</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D055516">2S Albumins, Plant</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D000485">Allergens</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D052179">Antigens, Plant</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="C500890">Ara h 2 allergen, Arachis hypogaea</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D006023">Glycoproteins</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D007074">Immunoglobulin G</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D010940">Plant Proteins</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>37341-29-0</RegistryNumber>
<NameOfSubstance UI="D007073">Immunoglobulin E</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>AIM</CitationSubset>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D055516" MajorTopicYN="N">2S Albumins, Plant</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000485" MajorTopicYN="N">Allergens</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName>
<QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000595" MajorTopicYN="N">Amino Acid Sequence</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000918" MajorTopicYN="N">Antibody Specificity</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000937" MajorTopicYN="N">Antigen-Antibody Reactions</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D052179" MajorTopicYN="N">Antigens, Plant</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D010367" MajorTopicYN="N">Arachis</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName>
<QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D016022" MajorTopicYN="N">Case-Control Studies</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D016000" MajorTopicYN="N">Cluster Analysis</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D018604" MajorTopicYN="N">Epitope Mapping</DescriptorName>
<QualifierName UI="Q000379" MajorTopicYN="Y">methods</QualifierName>
<QualifierName UI="Q000706" MajorTopicYN="N">statistics & numerical data</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006023" MajorTopicYN="N">Glycoproteins</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName>
<QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D007073" MajorTopicYN="N">Immunoglobulin E</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D007074" MajorTopicYN="N">Immunoglobulin G</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D066298" MajorTopicYN="N">In Vitro Techniques</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008969" MajorTopicYN="N">Molecular Sequence Data</DescriptorName>
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<MeshHeading><DescriptorName UI="D021183" MajorTopicYN="N">Peanut Hypersensitivity</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName>
<QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D010940" MajorTopicYN="N">Plant Proteins</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName>
<QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D040081" MajorTopicYN="N">Protein Array Analysis</DescriptorName>
</MeshHeading>
</MeshHeadingList>
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IgE and IgG4 epitope mapping by microarray immunoassay reveals the diversity of immune response to the peanut allergen, Ara h 2.

IgE and IgG4 epitope mapping by microarray immunoassay reveals the diversity of immune response to the peanut allergen, Ara h 2.

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Abstract

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