MersV1, Ncbi, Merge, bibRecord, 000315

Exploring the characteristics of sequence elements in proximal promoters of human genes.

Identifieur interne : 000315 ( Ncbi/Merge ); précédent : 000314; suivant : 000316

Exploring the characteristics of sequence elements in proximal promoters of human genes.

Auteurs : Minou Bina [États-Unis] ; Phillip Wyss ; Wenhui Ren ; Wojciech Szpankowski ; Elizabeth Thomas ; Ranjit Randhawa ; Sreedeepti Reddy ; Priya M. John ; Elsie I. Pares-Matos ; Arnold Stein ; Hao Xu ; Sheryl A. Lazarus

Source :

Genomics [ 0888-7543 ] ; 2004.

RBID : pubmed:15533710

Descripteurs français

English descriptors

KwdEn :
- 5' Untranslated Regions (genetics), Base Sequence, Binding Sites, Computational Biology, Databases, Genetic, Gene Expression Regulation, Humans, Molecular Sequence Data, Promoter Regions, Genetic (genetics), Protein Binding, Response Elements (genetics), Transcription Factors (metabolism), Transcription Initiation Site, Transcription, Genetic (genetics).
MESH :
- chemical , genetics : 5' Untranslated Regions.
- genetics : Promoter Regions, Genetic, Response Elements, Transcription, Genetic.
- chemical , metabolism : Transcription Factors.
- Base Sequence, Binding Sites, Computational Biology, Databases, Genetic, Gene Expression Regulation, Humans, Molecular Sequence Data, Protein Binding, Transcription Initiation Site.

Abstract

Central to reconstruction of cis-regulatory networks is identification and classification of naturally occurring transcription factor-binding sites according to the genes that they control. We have examined salient characteristics of 9-mers that occur in various orders and combinations in the proximal promoters of human genes. In evaluations of a dataset derived with respect to experimentally defined transcription initiation sites, in some cases we observed a clear correspondence of highly ranked 9-mers with protein-binding sites in genomic DNA. Evaluations of the larger dataset, derived with respect to the 5' end of human ESTs, revealed that a subset of the highly ranked 9-mers corresponded to sites for several known transcription factor families (including CREB, ETS, EGR-1, SP1, KLF, MAZ, HIF-1, and STATs) that play important roles in the regulation of vertebrate genes. We identified several highly ranked CpG-containing 9-mers, defining sites for interactions with the CREB and ETS families of proteins, and identified potential target genes for these proteins. The results of the studies imply that the CpG-containing transcription factor-binding sites regulate the expression of genes with important roles in pathways leading to cell-type-specific gene expression and pathways controlled by the complex networks of signaling systems.

DOI: 10.1016/j.ygeno.2004.08.013
PubMed: 15533710

Links toward previous steps (curation, corpus...)

to stream PubMed, to step Corpus: 002361
to stream PubMed, to step Curation: 002361
to stream PubMed, to step Checkpoint: 002266

Links to Exploration step

pubmed:15533710

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Exploring the characteristics of sequence elements in proximal promoters of human genes.</title>
<author><name sortKey="Bina, Minou" sort="Bina, Minou" uniqKey="Bina M" first="Minou" last="Bina">Minou Bina</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Chemistry, Purdue University, West Lafayette, IN 47907, USA. Bina@Purdue.edu</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Chemistry, Purdue University, West Lafayette, IN 47907</wicri:regionArea>
<placeName><region type="state">Indiana</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Wyss, Phillip" sort="Wyss, Phillip" uniqKey="Wyss P" first="Phillip" last="Wyss">Phillip Wyss</name>
</author>
<author><name sortKey="Ren, Wenhui" sort="Ren, Wenhui" uniqKey="Ren W" first="Wenhui" last="Ren">Wenhui Ren</name>
</author>
<author><name sortKey="Szpankowski, Wojciech" sort="Szpankowski, Wojciech" uniqKey="Szpankowski W" first="Wojciech" last="Szpankowski">Wojciech Szpankowski</name>
</author>
<author><name sortKey="Thomas, Elizabeth" sort="Thomas, Elizabeth" uniqKey="Thomas E" first="Elizabeth" last="Thomas">Elizabeth Thomas</name>
</author>
<author><name sortKey="Randhawa, Ranjit" sort="Randhawa, Ranjit" uniqKey="Randhawa R" first="Ranjit" last="Randhawa">Ranjit Randhawa</name>
</author>
<author><name sortKey="Reddy, Sreedeepti" sort="Reddy, Sreedeepti" uniqKey="Reddy S" first="Sreedeepti" last="Reddy">Sreedeepti Reddy</name>
</author>
<author><name sortKey="John, Priya M" sort="John, Priya M" uniqKey="John P" first="Priya M" last="John">Priya M. John</name>
</author>
<author><name sortKey="Pares Matos, Elsie I" sort="Pares Matos, Elsie I" uniqKey="Pares Matos E" first="Elsie I" last="Pares-Matos">Elsie I. Pares-Matos</name>
</author>
<author><name sortKey="Stein, Arnold" sort="Stein, Arnold" uniqKey="Stein A" first="Arnold" last="Stein">Arnold Stein</name>
</author>
<author><name sortKey="Xu, Hao" sort="Xu, Hao" uniqKey="Xu H" first="Hao" last="Xu">Hao Xu</name>
</author>
<author><name sortKey="Lazarus, Sheryl A" sort="Lazarus, Sheryl A" uniqKey="Lazarus S" first="Sheryl A" last="Lazarus">Sheryl A. Lazarus</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2004">2004</date>
<idno type="RBID">pubmed:15533710</idno>
<idno type="pmid">15533710</idno>
<idno type="doi">10.1016/j.ygeno.2004.08.013</idno>
<idno type="wicri:Area/PubMed/Corpus">002361</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002361</idno>
<idno type="wicri:Area/PubMed/Curation">002361</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">002361</idno>
<idno type="wicri:Area/PubMed/Checkpoint">002266</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">002266</idno>
<idno type="wicri:Area/Ncbi/Merge">000315</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Exploring the characteristics of sequence elements in proximal promoters of human genes.</title>
<author><name sortKey="Bina, Minou" sort="Bina, Minou" uniqKey="Bina M" first="Minou" last="Bina">Minou Bina</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Chemistry, Purdue University, West Lafayette, IN 47907, USA. Bina@Purdue.edu</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Chemistry, Purdue University, West Lafayette, IN 47907</wicri:regionArea>
<placeName><region type="state">Indiana</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Wyss, Phillip" sort="Wyss, Phillip" uniqKey="Wyss P" first="Phillip" last="Wyss">Phillip Wyss</name>
</author>
<author><name sortKey="Ren, Wenhui" sort="Ren, Wenhui" uniqKey="Ren W" first="Wenhui" last="Ren">Wenhui Ren</name>
</author>
<author><name sortKey="Szpankowski, Wojciech" sort="Szpankowski, Wojciech" uniqKey="Szpankowski W" first="Wojciech" last="Szpankowski">Wojciech Szpankowski</name>
</author>
<author><name sortKey="Thomas, Elizabeth" sort="Thomas, Elizabeth" uniqKey="Thomas E" first="Elizabeth" last="Thomas">Elizabeth Thomas</name>
</author>
<author><name sortKey="Randhawa, Ranjit" sort="Randhawa, Ranjit" uniqKey="Randhawa R" first="Ranjit" last="Randhawa">Ranjit Randhawa</name>
</author>
<author><name sortKey="Reddy, Sreedeepti" sort="Reddy, Sreedeepti" uniqKey="Reddy S" first="Sreedeepti" last="Reddy">Sreedeepti Reddy</name>
</author>
<author><name sortKey="John, Priya M" sort="John, Priya M" uniqKey="John P" first="Priya M" last="John">Priya M. John</name>
</author>
<author><name sortKey="Pares Matos, Elsie I" sort="Pares Matos, Elsie I" uniqKey="Pares Matos E" first="Elsie I" last="Pares-Matos">Elsie I. Pares-Matos</name>
</author>
<author><name sortKey="Stein, Arnold" sort="Stein, Arnold" uniqKey="Stein A" first="Arnold" last="Stein">Arnold Stein</name>
</author>
<author><name sortKey="Xu, Hao" sort="Xu, Hao" uniqKey="Xu H" first="Hao" last="Xu">Hao Xu</name>
</author>
<author><name sortKey="Lazarus, Sheryl A" sort="Lazarus, Sheryl A" uniqKey="Lazarus S" first="Sheryl A" last="Lazarus">Sheryl A. Lazarus</name>
</author>
</analytic>
<series><title level="j">Genomics</title>
<idno type="ISSN">0888-7543</idno>
<imprint><date when="2004" type="published">2004</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>5' Untranslated Regions (genetics)</term>
<term>Base Sequence</term>
<term>Binding Sites</term>
<term>Computational Biology</term>
<term>Databases, Genetic</term>
<term>Gene Expression Regulation</term>
<term>Humans</term>
<term>Molecular Sequence Data</term>
<term>Promoter Regions, Genetic (genetics)</term>
<term>Protein Binding</term>
<term>Response Elements (genetics)</term>
<term>Transcription Factors (metabolism)</term>
<term>Transcription Initiation Site</term>
<term>Transcription, Genetic (genetics)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Bases de données génétiques</term>
<term>Biologie informatique</term>
<term>Données de séquences moléculaires</term>
<term>Facteurs de transcription (métabolisme)</term>
<term>Humains</term>
<term>Liaison aux protéines</term>
<term>Régions 5' non traduites (génétique)</term>
<term>Régions promotrices (génétique) (génétique)</term>
<term>Régulation de l'expression des gènes</term>
<term>Site d'initiation de la transcription</term>
<term>Sites de fixation</term>
<term>Séquence nucléotidique</term>
<term>Transcription génétique (génétique)</term>
<term>Éléments de réponse (génétique)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>5' Untranslated Regions</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Promoter Regions, Genetic</term>
<term>Response Elements</term>
<term>Transcription, Genetic</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Régions 5' non traduites</term>
<term>Régions promotrices (génétique)</term>
<term>Transcription génétique</term>
<term>Éléments de réponse</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Transcription Factors</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Facteurs de transcription</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Base Sequence</term>
<term>Binding Sites</term>
<term>Computational Biology</term>
<term>Databases, Genetic</term>
<term>Gene Expression Regulation</term>
<term>Humans</term>
<term>Molecular Sequence Data</term>
<term>Protein Binding</term>
<term>Transcription Initiation Site</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Bases de données génétiques</term>
<term>Biologie informatique</term>
<term>Données de séquences moléculaires</term>
<term>Humains</term>
<term>Liaison aux protéines</term>
<term>Régulation de l'expression des gènes</term>
<term>Site d'initiation de la transcription</term>
<term>Sites de fixation</term>
<term>Séquence nucléotidique</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Central to reconstruction of cis-regulatory networks is identification and classification of naturally occurring transcription factor-binding sites according to the genes that they control. We have examined salient characteristics of 9-mers that occur in various orders and combinations in the proximal promoters of human genes. In evaluations of a dataset derived with respect to experimentally defined transcription initiation sites, in some cases we observed a clear correspondence of highly ranked 9-mers with protein-binding sites in genomic DNA. Evaluations of the larger dataset, derived with respect to the 5' end of human ESTs, revealed that a subset of the highly ranked 9-mers corresponded to sites for several known transcription factor families (including CREB, ETS, EGR-1, SP1, KLF, MAZ, HIF-1, and STATs) that play important roles in the regulation of vertebrate genes. We identified several highly ranked CpG-containing 9-mers, defining sites for interactions with the CREB and ETS families of proteins, and identified potential target genes for these proteins. The results of the studies imply that the CpG-containing transcription factor-binding sites regulate the expression of genes with important roles in pathways leading to cell-type-specific gene expression and pathways controlled by the complex networks of signaling systems.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">15533710</PMID>
<DateCompleted><Year>2005</Year>
<Month>03</Month>
<Day>24</Day>
</DateCompleted>
<DateRevised><Year>2008</Year>
<Month>11</Month>
<Day>21</Day>
</DateRevised>
<Article PubModel="Print"><Journal><ISSN IssnType="Print">0888-7543</ISSN>
<JournalIssue CitedMedium="Print"><Volume>84</Volume>
<Issue>6</Issue>
<PubDate><Year>2004</Year>
<Month>Dec</Month>
</PubDate>
</JournalIssue>
<Title>Genomics</Title>
<ISOAbbreviation>Genomics</ISOAbbreviation>
</Journal>
<ArticleTitle>Exploring the characteristics of sequence elements in proximal promoters of human genes.</ArticleTitle>
<Pagination><MedlinePgn>929-40</MedlinePgn>
</Pagination>
<Abstract><AbstractText>Central to reconstruction of cis-regulatory networks is identification and classification of naturally occurring transcription factor-binding sites according to the genes that they control. We have examined salient characteristics of 9-mers that occur in various orders and combinations in the proximal promoters of human genes. In evaluations of a dataset derived with respect to experimentally defined transcription initiation sites, in some cases we observed a clear correspondence of highly ranked 9-mers with protein-binding sites in genomic DNA. Evaluations of the larger dataset, derived with respect to the 5' end of human ESTs, revealed that a subset of the highly ranked 9-mers corresponded to sites for several known transcription factor families (including CREB, ETS, EGR-1, SP1, KLF, MAZ, HIF-1, and STATs) that play important roles in the regulation of vertebrate genes. We identified several highly ranked CpG-containing 9-mers, defining sites for interactions with the CREB and ETS families of proteins, and identified potential target genes for these proteins. The results of the studies imply that the CpG-containing transcription factor-binding sites regulate the expression of genes with important roles in pathways leading to cell-type-specific gene expression and pathways controlled by the complex networks of signaling systems.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Bina</LastName>
<ForeName>Minou</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Department of Chemistry, Purdue University, West Lafayette, IN 47907, USA. Bina@Purdue.edu</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Wyss</LastName>
<ForeName>Phillip</ForeName>
<Initials>P</Initials>
</Author>
<Author ValidYN="Y"><LastName>Ren</LastName>
<ForeName>Wenhui</ForeName>
<Initials>W</Initials>
</Author>
<Author ValidYN="Y"><LastName>Szpankowski</LastName>
<ForeName>Wojciech</ForeName>
<Initials>W</Initials>
</Author>
<Author ValidYN="Y"><LastName>Thomas</LastName>
<ForeName>Elizabeth</ForeName>
<Initials>E</Initials>
</Author>
<Author ValidYN="Y"><LastName>Randhawa</LastName>
<ForeName>Ranjit</ForeName>
<Initials>R</Initials>
</Author>
<Author ValidYN="Y"><LastName>Reddy</LastName>
<ForeName>Sreedeepti</ForeName>
<Initials>S</Initials>
</Author>
<Author ValidYN="Y"><LastName>John</LastName>
<ForeName>Priya M</ForeName>
<Initials>PM</Initials>
</Author>
<Author ValidYN="Y"><LastName>Pares-Matos</LastName>
<ForeName>Elsie I</ForeName>
<Initials>EI</Initials>
</Author>
<Author ValidYN="Y"><LastName>Stein</LastName>
<ForeName>Arnold</ForeName>
<Initials>A</Initials>
</Author>
<Author ValidYN="Y"><LastName>Xu</LastName>
<ForeName>Hao</ForeName>
<Initials>H</Initials>
</Author>
<Author ValidYN="Y"><LastName>Lazarus</LastName>
<ForeName>Sheryl A</ForeName>
<Initials>SA</Initials>
</Author>
</AuthorList>
<Language>eng</Language>
<GrantList CompleteYN="Y"><Grant><GrantID>R01 GM068959-01</GrantID>
<Acronym>GM</Acronym>
<Agency>NIGMS NIH HHS</Agency>
<Country>United States</Country>
</Grant>
</GrantList>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D013486">Research Support, U.S. Gov't, Non-P.H.S.</PublicationType>
<PublicationType UI="D013487">Research Support, U.S. Gov't, P.H.S.</PublicationType>
</PublicationTypeList>
</Article>
<MedlineJournalInfo><Country>United States</Country>
<MedlineTA>Genomics</MedlineTA>
<NlmUniqueID>8800135</NlmUniqueID>
<ISSNLinking>0888-7543</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D020121">5' Untranslated Regions</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D014157">Transcription Factors</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D020121" MajorTopicYN="N">5' Untranslated Regions</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D001483" MajorTopicYN="N">Base Sequence</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D001665" MajorTopicYN="N">Binding Sites</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D019295" MajorTopicYN="Y">Computational Biology</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D030541" MajorTopicYN="N">Databases, Genetic</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005786" MajorTopicYN="Y">Gene Expression Regulation</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008969" MajorTopicYN="N">Molecular Sequence Data</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D011401" MajorTopicYN="N">Promoter Regions, Genetic</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D011485" MajorTopicYN="N">Protein Binding</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D020218" MajorTopicYN="N">Response Elements</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D014157" MajorTopicYN="N">Transcription Factors</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D024363" MajorTopicYN="Y">Transcription Initiation Site</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D014158" MajorTopicYN="N">Transcription, Genetic</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName>
</MeshHeading>
</MeshHeadingList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="received"><Year>2004</Year>
<Month>06</Month>
<Day>28</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="accepted"><Year>2004</Year>
<Month>08</Month>
<Day>16</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="pubmed"><Year>2004</Year>
<Month>11</Month>
<Day>10</Day>
<Hour>9</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2005</Year>
<Month>3</Month>
<Day>25</Day>
<Hour>9</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="entrez"><Year>2004</Year>
<Month>11</Month>
<Day>10</Day>
<Hour>9</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">15533710</ArticleId>
<ArticleId IdType="pii">S0888-7543(04)00243-5</ArticleId>
<ArticleId IdType="doi">10.1016/j.ygeno.2004.08.013</ArticleId>
</ArticleIdList>
</PubmedData>
</pubmed>
<affiliations><list><country><li>États-Unis</li>
</country>
<region><li>Indiana</li>
</region>
</list>
<tree><noCountry><name sortKey="John, Priya M" sort="John, Priya M" uniqKey="John P" first="Priya M" last="John">Priya M. John</name>
<name sortKey="Lazarus, Sheryl A" sort="Lazarus, Sheryl A" uniqKey="Lazarus S" first="Sheryl A" last="Lazarus">Sheryl A. Lazarus</name>
<name sortKey="Pares Matos, Elsie I" sort="Pares Matos, Elsie I" uniqKey="Pares Matos E" first="Elsie I" last="Pares-Matos">Elsie I. Pares-Matos</name>
<name sortKey="Randhawa, Ranjit" sort="Randhawa, Ranjit" uniqKey="Randhawa R" first="Ranjit" last="Randhawa">Ranjit Randhawa</name>
<name sortKey="Reddy, Sreedeepti" sort="Reddy, Sreedeepti" uniqKey="Reddy S" first="Sreedeepti" last="Reddy">Sreedeepti Reddy</name>
<name sortKey="Ren, Wenhui" sort="Ren, Wenhui" uniqKey="Ren W" first="Wenhui" last="Ren">Wenhui Ren</name>
<name sortKey="Stein, Arnold" sort="Stein, Arnold" uniqKey="Stein A" first="Arnold" last="Stein">Arnold Stein</name>
<name sortKey="Szpankowski, Wojciech" sort="Szpankowski, Wojciech" uniqKey="Szpankowski W" first="Wojciech" last="Szpankowski">Wojciech Szpankowski</name>
<name sortKey="Thomas, Elizabeth" sort="Thomas, Elizabeth" uniqKey="Thomas E" first="Elizabeth" last="Thomas">Elizabeth Thomas</name>
<name sortKey="Wyss, Phillip" sort="Wyss, Phillip" uniqKey="Wyss P" first="Phillip" last="Wyss">Phillip Wyss</name>
<name sortKey="Xu, Hao" sort="Xu, Hao" uniqKey="Xu H" first="Hao" last="Xu">Hao Xu</name>
</noCountry>
<country name="États-Unis"><region name="Indiana"><name sortKey="Bina, Minou" sort="Bina, Minou" uniqKey="Bina M" first="Minou" last="Bina">Minou Bina</name>
</region>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Sante/explor/MersV1/Data/Ncbi/Merge

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000315 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Ncbi/Merge/biblio.hfd -nk 000315 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Sante
   |area=    MersV1
   |flux=    Ncbi
   |étape=   Merge
   |type=    RBID
   |clé=     pubmed:15533710
   |texte=   Exploring the characteristics of sequence elements in proximal promoters of human genes.
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/Ncbi/Merge/RBID.i   -Sk "pubmed:15533710" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Ncbi/Merge/biblio.hfd   \
       | NlmPubMed2Wicri -a MersV1

This area was generated with Dilib version V0.6.33.
Data generation: Mon Apr 20 23:26:43 2020. Site generation: Sat Mar 27 09:06:09 2021

	Serveur d'exploration MERS
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Serveur d'exploration MERS

Exploring the characteristics of sequence elements in proximal promoters of human genes.

Exploring the characteristics of sequence elements in proximal promoters of human genes.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki