Content and functional activity of von Willebrand factor in apheresis plasma.
Identifieur interne : 000291 ( Ncbi/Merge ); précédent : 000290; suivant : 000292Content and functional activity of von Willebrand factor in apheresis plasma.
Auteurs : T. Burnouf [France] ; C. Caron ; T. Burkhardt ; J. GoudemandSource :
- Vox sanguinis [ 0042-9007 ] ; 2004.
Descripteurs français
- KwdFr :
- Adulte, Adulte d'âge moyen, Antigènes (), Antigènes (pharmacologie), Antigènes (sang), Aphérèse (), Aphérèse (instrumentation), Biopolymères, Calibrage, Collagène (métabolisme), Endopeptidases (sang), Facteur de von Willebrand (), Facteur de von Willebrand (analyse), Facteur de von Willebrand (pharmacologie), Femelle, Humains, Masse moléculaire, Mâle, Plasma sanguin (métabolisme), Système ABO de groupes sanguins (analyse).
- MESH :
- analyse : Facteur de von Willebrand, Système ABO de groupes sanguins.
- métabolisme : Aphérèse, Collagène, Plasma sanguin.
- pharmacologie : Antigènes, Facteur de von Willebrand.
- sang : Antigènes, Endopeptidases.
- Adulte, Adulte d'âge moyen, Antigènes, Aphérèse, Biopolymères, Calibrage, Facteur de von Willebrand, Femelle, Humains, Masse moléculaire, Mâle.
English descriptors
- KwdEn :
- ABO Blood-Group System (analysis), Adult, Antigens (blood), Antigens (chemistry), Antigens (pharmacology), Biopolymers, Blood Component Removal (instrumentation), Blood Component Removal (methods), Calibration, Collagen (metabolism), Endopeptidases (blood), Female, Humans, Male, Middle Aged, Molecular Weight, Plasma (metabolism), von Willebrand Factor (analysis), von Willebrand Factor (chemistry), von Willebrand Factor (pharmacology).
- MESH :
- chemical , analysis : ABO Blood-Group System, von Willebrand Factor.
- chemical , blood : Antigens, Endopeptidases.
- chemical , chemistry : Antigens, von Willebrand Factor.
- chemical , metabolism : Collagen.
- chemical , pharmacology : Antigens, von Willebrand Factor.
- instrumentation : Blood Component Removal.
- metabolism : Plasma.
- methods : Blood Component Removal.
- Adult, Biopolymers, Calibration, Female, Humans, Male, Middle Aged, Molecular Weight.
Abstract
Von Willebrand Factor (VWF) is a complex high-molecular-weight (HMW) plasma glycoprotein playing a critical role in primary and secondary haemostasis. Owing to its multimeric structure and sensitivity to proteolysis, VWF can be used as a marker of the impact of collection procedures on the characteristics of plasma for transfusion and for fractionation. We studied VWF content, functional activity and HMW multimers in plasmas collected by five different automated apheresis collection procedures.
DOI: 10.1111/j.1423-0410.2004.00535.x
PubMed: 15260819
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pubmed:15260819Le document en format XML
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Burkhardt</name></author><author><name sortKey="Goudemand, J" sort="Goudemand, J" uniqKey="Goudemand J" first="J" last="Goudemand">J. 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Burnouf</name><affiliation wicri:level="3"><nlm:affiliation>Human Plasma Product Services, Lille, France. tburnou@attglobal.net</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Human Plasma Product Services, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Caron, C" sort="Caron, C" uniqKey="Caron C" first="C" last="Caron">C. Caron</name></author><author><name sortKey="Burkhardt, T" sort="Burkhardt, T" uniqKey="Burkhardt T" first="T" last="Burkhardt">T. Burkhardt</name></author><author><name sortKey="Goudemand, J" sort="Goudemand, J" uniqKey="Goudemand J" first="J" last="Goudemand">J. Goudemand</name></author></analytic><series><title level="j">Vox sanguinis</title><idno type="ISSN">0042-9007</idno><imprint><date when="2004" type="published">2004</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>ABO Blood-Group System (analysis)</term><term>Adult</term><term>Antigens (blood)</term><term>Antigens (chemistry)</term><term>Antigens (pharmacology)</term><term>Biopolymers</term><term>Blood Component Removal (instrumentation)</term><term>Blood Component Removal (methods)</term><term>Calibration</term><term>Collagen (metabolism)</term><term>Endopeptidases (blood)</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Molecular Weight</term><term>Plasma (metabolism)</term><term>von Willebrand Factor (analysis)</term><term>von Willebrand Factor (chemistry)</term><term>von Willebrand Factor (pharmacology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Antigènes ()</term><term>Antigènes (pharmacologie)</term><term>Antigènes (sang)</term><term>Aphérèse ()</term><term>Aphérèse (instrumentation)</term><term>Biopolymères</term><term>Calibrage</term><term>Collagène (métabolisme)</term><term>Endopeptidases (sang)</term><term>Facteur de von Willebrand ()</term><term>Facteur de von Willebrand (analyse)</term><term>Facteur de von Willebrand (pharmacologie)</term><term>Femelle</term><term>Humains</term><term>Masse moléculaire</term><term>Mâle</term><term>Plasma sanguin (métabolisme)</term><term>Système ABO de groupes sanguins (analyse)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>ABO Blood-Group System</term><term>von Willebrand Factor</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Antigens</term><term>Endopeptidases</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Antigens</term><term>von Willebrand Factor</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Collagen</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Antigens</term><term>von Willebrand Factor</term></keywords><keywords scheme="MESH" qualifier="analyse" xml:lang="fr"><term>Facteur de von Willebrand</term><term>Système ABO de groupes sanguins</term></keywords><keywords scheme="MESH" qualifier="instrumentation" xml:lang="en"><term>Blood Component Removal</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Plasma</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Blood Component Removal</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Aphérèse</term><term>Collagène</term><term>Plasma sanguin</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Antigènes</term><term>Facteur de von Willebrand</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Antigènes</term><term>Endopeptidases</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Biopolymers</term><term>Calibration</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Molecular Weight</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Antigènes</term><term>Aphérèse</term><term>Biopolymères</term><term>Calibrage</term><term>Facteur de von Willebrand</term><term>Femelle</term><term>Humains</term><term>Masse moléculaire</term><term>Mâle</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Von Willebrand Factor (VWF) is a complex high-molecular-weight (HMW) plasma glycoprotein playing a critical role in primary and secondary haemostasis. Owing to its multimeric structure and sensitivity to proteolysis, VWF can be used as a marker of the impact of collection procedures on the characteristics of plasma for transfusion and for fractionation. We studied VWF content, functional activity and HMW multimers in plasmas collected by five different automated apheresis collection procedures.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">15260819</PMID><DateCompleted><Year>2004</Year><Month>10</Month><Day>13</Day></DateCompleted><DateRevised><Year>2006</Year><Month>11</Month><Day>15</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0042-9007</ISSN><JournalIssue CitedMedium="Print"><Volume>87</Volume><Issue>1</Issue><PubDate><Year>2004</Year><Month>Jul</Month></PubDate></JournalIssue><Title>Vox sanguinis</Title><ISOAbbreviation>Vox Sang.</ISOAbbreviation></Journal><ArticleTitle>Content and functional activity of von Willebrand factor in apheresis plasma.</ArticleTitle><Pagination><MedlinePgn>27-33</MedlinePgn></Pagination><Abstract><AbstractText Label="BACKGROUND AND OBJECTIVES" NlmCategory="OBJECTIVE">Von Willebrand Factor (VWF) is a complex high-molecular-weight (HMW) plasma glycoprotein playing a critical role in primary and secondary haemostasis. Owing to its multimeric structure and sensitivity to proteolysis, VWF can be used as a marker of the impact of collection procedures on the characteristics of plasma for transfusion and for fractionation. We studied VWF content, functional activity and HMW multimers in plasmas collected by five different automated apheresis collection procedures.</AbstractText><AbstractText Label="MATERIALS AND METHODS" NlmCategory="METHODS">Five series of 30 plasma units were obtained from volunteer donors at two collection sites using Haemonetics PCS2 machines with Revision (Rev) F, Rev G, high-separation core (HSC), or filter core (FC) procedures, or Baxter-Fenwall Autopheresis-C (Auto-C). VWF antigen (VWF:Ag), ristocetin cofactor (VWF:RCo) activity and HMW multimers were first determined in 10 randomly selected plasma donations collected with Rev G, HSC, FC and Auto-C procedures. Then, the same analyses and the collagen binding (VWF:CB) activity were determined in the pools of 30 donations from each of the five procedures and compared with two normal plasma pools (NPP1 and NPP2). A reference plasma (RP) was used to calibrate each assay.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">There were a greater number of group O individuals in the Rev F, Rev G and FC donors than in the HSC and Auto-C donors. The mean VWF:Ag level was > 100 IU/dl, VWF:RCo activity was > 90 U/dl, the VWF:RCo/Ag ratio was close to 1, and the percentage of 11-15 mers was above 100% of RP in the 10 individual plasma units from Rev G, HSC, FC, and Auto-C and in their respective pools. The mean percentage of multimers > 15 mers, relative to RP, was significantly less in Rev G plasmas (48 +/- 17%; range 32-91%), compared with Auto-C, HSC and FC plasmas (P = 0.0211; 0.0257; and 0.0376, respectively). The VWF:CB activity of the 30-donation pools was 61 and 60 U/dl in Auto C and HSC, 50 U/dl in Rev F and FC, and 43 U/dl in the Rev G pool. The VWF:CB/Ag ratio was 0.54 (Auto-C), 0.49 (HSC), 0.46 (Rev F), 0.45 (FC) and 0.37 (Rev G), compared with 0.81and 0.92 in NPPs. The percentage of VWF multimers of 11-15 mers in apheresis plasma and NPP was normal. VWF multimers > 15 mers ranged from 38 to 64% of that of RP plasma, and was 111 and 112% in NPPs.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">The VWF:Ag, VWF:RCo activity and 11-15 mer VWF multimers were well preserved in all plasma units from each of the five apheresis procedures. The VWF:CB activity and the percentage of multimers > 15 mers in apheresis plasma was less than in normal plasma pools and differed slightly among procedures.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Burnouf</LastName><ForeName>T</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Human Plasma Product Services, Lille, France. tburnou@attglobal.net</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Caron</LastName><ForeName>C</ForeName><Initials>C</Initials></Author><Author ValidYN="Y"><LastName>Burkhardt</LastName><ForeName>T</ForeName><Initials>T</Initials></Author><Author ValidYN="Y"><LastName>Goudemand</LastName><ForeName>J</ForeName><Initials>J</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D003160">Comparative Study</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Vox Sang</MedlineTA><NlmUniqueID>0413606</NlmUniqueID><ISSNLinking>0042-9007</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000017">ABO Blood-Group System</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000941">Antigens</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D001704">Biopolymers</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C029417">Von Willebrand antigen</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D014841">von Willebrand Factor</NameOfSubstance></Chemical><Chemical><RegistryNumber>9007-34-5</RegistryNumber><NameOfSubstance UI="D003094">Collagen</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 3.4.-</RegistryNumber><NameOfSubstance UI="D010450">Endopeptidases</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000017" MajorTopicYN="N">ABO Blood-Group System</DescriptorName><QualifierName UI="Q000032" MajorTopicYN="N">analysis</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000941" MajorTopicYN="N">Antigens</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="Y">blood</QualifierName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D001704" MajorTopicYN="N">Biopolymers</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001781" MajorTopicYN="Y">Blood Component Removal</DescriptorName><QualifierName UI="Q000295" MajorTopicYN="N">instrumentation</QualifierName><QualifierName UI="Q000379" MajorTopicYN="N">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002138" MajorTopicYN="N">Calibration</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D003094" MajorTopicYN="N">Collagen</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010450" MajorTopicYN="N">Endopeptidases</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008970" MajorTopicYN="N">Molecular Weight</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010949" MajorTopicYN="N">Plasma</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014841" MajorTopicYN="N">von Willebrand Factor</DescriptorName><QualifierName UI="Q000032" MajorTopicYN="Y">analysis</QualifierName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2004</Year><Month>7</Month><Day>21</Day><Hour>5</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2004</Year><Month>10</Month><Day>14</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2004</Year><Month>7</Month><Day>21</Day><Hour>5</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">15260819</ArticleId><ArticleId IdType="doi">10.1111/j.1423-0410.2004.00535.x</ArticleId><ArticleId IdType="pii">VOX535</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>France</li></country><region><li>Hauts-de-France</li><li>Nord-Pas-de-Calais</li></region><settlement><li>Lille</li></settlement></list><tree><noCountry><name sortKey="Burkhardt, T" sort="Burkhardt, T" uniqKey="Burkhardt T" first="T" last="Burkhardt">T. Burkhardt</name><name sortKey="Caron, C" sort="Caron, C" uniqKey="Caron C" first="C" last="Caron">C. Caron</name><name sortKey="Goudemand, J" sort="Goudemand, J" uniqKey="Goudemand J" first="J" last="Goudemand">J. Goudemand</name></noCountry><country name="France"><region name="Hauts-de-France"><name sortKey="Burnouf, T" sort="Burnouf, T" uniqKey="Burnouf T" first="T" last="Burnouf">T. Burnouf</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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