MersV1, Ncbi, Curation, bibRecord, 002675

Molecular Pathogenesis of Middle East Respiratory Syndrome (MERS) Coronavirus

Identifieur interne : 002675 ( Ncbi/Curation ); précédent : 002674; suivant : 002676

Molecular Pathogenesis of Middle East Respiratory Syndrome (MERS) Coronavirus

Auteurs : Arinjay Banerjee ; Kaushal Baid ; Karen Mossman

Source :

Current Clinical Microbiology Reports [ 2196-5471 ] ; 2019.

RBID : PMC:7100557

Abstract

Purpose of Review

Middle East respiratory syndrome coronavirus (MERS-CoV) emerged in 2012 and is listed in the World Health Organization’s blueprint of priority diseases that need immediate research. Camels are reservoirs of this virus, and the virus spills over into humans through direct contact with camels. Human-to-human transmission and travel-associated cases have been identified as well. Limited studies have characterized the molecular pathogenesis of MERS-CoV. Most studies have used ectopic expression of viral proteins to characterize MERS-CoV and its ability to modulate antiviral responses in human cells. Studies with live virus are limited, largely due to the requirement of high containment laboratories. In this review, we have summarized current studies on MERS-CoV molecular pathogenesis and have mentioned some recent strategies that are being developed to control MERS-CoV infection.

Recent Findings

Multiple antiviral molecules with the potential to inhibit MERS-CoV infection by disrupting virus-receptor interactions are being developed and tested. Although human vaccine candidates are still being developed, a candidate camel vaccine is being tested for efficacy. Combination of supportive treatment with interferon and antivirals is also being explored.

Summary

New antiviral molecules that inhibit MERS-CoV and host cell receptor interaction may become available in the future. Additional studies are required to identify and characterize the pathogenesis of MERS-CoV EMC/2012 and other circulating strains. An effective MERS-CoV vaccine, for humans and/or camels, along with an efficient combination antiviral therapy may help us prevent future MERS cases.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7100557

DOI: 10.1007/s40588-019-00122-7
PubMed: 32226718
PubMed Central: 7100557

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Arinjay Banerjee

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<institution>Department of Pathology and Molecular Medicine, McMaster Immunology Research Center, Michael DeGroote Institute for Infectious Disease Research,</institution>
<institution>McMaster University,</institution>
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Kaushal Baid

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Karen Mossman

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Karen Mossman

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<front><div type="abstract" xml:lang="en"><sec><title>Purpose of Review</title>
<p id="Par1">Middle East respiratory syndrome coronavirus (MERS-CoV) emerged in 2012 and is listed in the World Health Organization’s blueprint of priority diseases that need immediate research. Camels are reservoirs of this virus, and the virus spills over into humans through direct contact with camels. Human-to-human transmission and travel-associated cases have been identified as well. Limited studies have characterized the molecular pathogenesis of MERS-CoV. Most studies have used ectopic expression of viral proteins to characterize MERS-CoV and its ability to modulate antiviral responses in human cells. Studies with live virus are limited, largely due to the requirement of high containment laboratories. In this review, we have summarized current studies on MERS-CoV molecular pathogenesis and have mentioned some recent strategies that are being developed to control MERS-CoV infection.</p>
</sec>
<sec><title>Recent Findings</title>
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</sec>
<sec><title>Summary</title>
<p id="Par3">New antiviral molecules that inhibit MERS-CoV and host cell receptor interaction may become available in the future. Additional studies are required to identify and characterize the pathogenesis of MERS-CoV EMC/2012 and other circulating strains. An effective MERS-CoV vaccine, for humans and/or camels, along with an efficient combination antiviral therapy may help us prevent future MERS cases.</p>
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Molecular Pathogenesis of Middle East Respiratory Syndrome (MERS) Coronavirus

Molecular Pathogenesis of Middle East Respiratory Syndrome (MERS) Coronavirus

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Abstract

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