Prophylactic and therapeutic remdesivir (GS-5734) treatment in the rhesus macaque model of MERS-CoV infection
Identifieur interne : 002532 ( Ncbi/Curation ); précédent : 002531; suivant : 002533Prophylactic and therapeutic remdesivir (GS-5734) treatment in the rhesus macaque model of MERS-CoV infection
Auteurs : Emmie De Wit ; Friederike Feldmann ; Jacqueline Cronin ; Robert Jordan ; Atsushi Okumura ; Tina Thomas ; Dana Scott ; Tomas Cihlar ; Heinz FeldmannSource :
- Proceedings of the National Academy of Sciences of the United States of America [ 0027-8424 ] ; 2020.
Descripteurs français
- KwdFr :
- AMP (analogues et dérivés), AMP (pharmacologie), Alanine (analogues et dérivés), Alanine (pharmacologie), Animaux, Antiviraux (pharmacologie), Charge virale, Coronavirus du syndrome respiratoire du Moyen-Orient (), Coronavirus du syndrome respiratoire du Moyen-Orient (physiologie), Infections à coronavirus (), Infections à coronavirus (traitement médicamenteux), Macaca mulatta, Modèles animaux de maladie humaine, Mâle, Pandémies, Pneumopathie virale, Poumon (anatomopathologie), Poumon (virologie), Prophylaxie après exposition, Réplication virale ().
- MESH :
- analogues et dérivés : AMP, Alanine.
- anatomopathologie : Poumon.
- pharmacologie : AMP, Alanine, Antiviraux.
- physiologie : Coronavirus du syndrome respiratoire du Moyen-Orient.
- traitement médicamenteux : Infections à coronavirus.
- virologie : Poumon.
- Animaux, Charge virale, Coronavirus du syndrome respiratoire du Moyen-Orient, Infections à coronavirus, Macaca mulatta, Modèles animaux de maladie humaine, Mâle, Pandémies, Pneumopathie virale, Prophylaxie après exposition, Réplication virale.
English descriptors
- KwdEn :
- Adenosine Monophosphate (analogs & derivatives), Adenosine Monophosphate (pharmacology), Alanine (analogs & derivatives), Alanine (pharmacology), Animals, Antiviral Agents (pharmacology), Betacoronavirus, Coronavirus Infections (drug therapy), Coronavirus Infections (prevention & control), Disease Models, Animal, Lung (pathology), Lung (virology), Macaca mulatta, Male, Middle East Respiratory Syndrome Coronavirus (drug effects), Middle East Respiratory Syndrome Coronavirus (physiology), Pandemics, Pneumonia, Viral, Post-Exposure Prophylaxis, Viral Load, Virus Replication (drug effects).
- MESH :
- chemical , analogs & derivatives : Adenosine Monophosphate, Alanine.
- chemical , pharmacology : Adenosine Monophosphate, Alanine, Antiviral Agents.
- drug effects : Middle East Respiratory Syndrome Coronavirus, Virus Replication.
- drug therapy : Coronavirus Infections.
- pathology : Lung.
- physiology : Middle East Respiratory Syndrome Coronavirus.
- prevention & control : Coronavirus Infections.
- virology : Lung.
- Animals, Betacoronavirus, Disease Models, Animal, Macaca mulatta, Male, Pandemics, Pneumonia, Viral, Post-Exposure Prophylaxis, Viral Load.
Abstract
Middle East Respiratory Syndrome, caused by the MERS coronavirus (MERS-CoV), continues to cause severe respiratory disease with a high case fatality rate. To date, potential antiviral treatments for MERS-CoV have shown limited efficacy in animal studies. Here, we tested the efficacy of the broad-acting antiviral remdesivir in the rhesus macaque model of MERS-CoV infection. Remdesivir reduced the severity of disease, virus replication, and damage to the lungs when administered either before or after animals were infected with MERS-CoV. Our data show that remdesivir is a promising antiviral treatment against MERS that could be considered for implementation in clinical trials. It may also have utility for related coronaviruses such as the novel coronavirus 2019-nCoV emerging from Wuhan, China.
Url:
DOI: 10.1073/pnas.1922083117
PubMed: 32054787
PubMed Central: 7104368
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PMC:7104368Le document en format XML
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59840;</nlm:aff>
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<front><div type="abstract" xml:lang="en"><title>Significance</title>
<p>Middle East Respiratory Syndrome, caused by the MERS coronavirus (MERS-CoV), continues to cause severe respiratory disease with a high case fatality rate. To date, potential antiviral treatments for MERS-CoV have shown limited efficacy in animal studies. Here, we tested the efficacy of the broad-acting antiviral remdesivir in the rhesus macaque model of MERS-CoV infection. Remdesivir reduced the severity of disease, virus replication, and damage to the lungs when administered either before or after animals were infected with MERS-CoV. Our data show that remdesivir is a promising antiviral treatment against MERS that could be considered for implementation in clinical trials. It may also have utility for related coronaviruses such as the novel coronavirus 2019-nCoV emerging from Wuhan, China.</p>
</div>
</front>
<back><div1 type="bibliography"><listBibl><biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Modjarrad, K" uniqKey="Modjarrad K">K. Modjarrad</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Brende, B" uniqKey="Brende B">B. Brende</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lo, M K" uniqKey="Lo M">M. K. Lo</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Warren, T K" uniqKey="Warren T">T. K. Warren</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lo, M K" uniqKey="Lo M">M. K. Lo</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Sheahan, T P" uniqKey="Sheahan T">T. P. Sheahan</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Sheahan, T P" uniqKey="Sheahan T">T. P. Sheahan</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Agostini, M L" uniqKey="Agostini M">M. L. Agostini</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="De Wit, E" uniqKey="De Wit E">E. de Wit</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hui, D S" uniqKey="Hui D">D. S. Hui</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Assiri, A" uniqKey="Assiri A">A. Assiri</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chan, J F" uniqKey="Chan J">J. F. Chan</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chen, Z" uniqKey="Chen Z">Z. Chen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="De Wit, E" uniqKey="De Wit E">E. de Wit</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Falzarano, D" uniqKey="Falzarano D">D. Falzarano</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Van Doremalen, N" uniqKey="Van Doremalen N">N. van Doremalen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Al Abdely, H M" uniqKey="Al Abdely H">H. M. Al-Abdely</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bin, S Y" uniqKey="Bin S">S. Y. Bin</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Prescott, J" uniqKey="Prescott J">J. Prescott</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Dornemann, J" uniqKey="Dornemann J">J. Dörnemann</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Jacobs, M" uniqKey="Jacobs M">M. Jacobs</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mulangu, S" uniqKey="Mulangu S">S. Mulangu</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Falzarano, D" uniqKey="Falzarano D">D. Falzarano</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Brining, D L" uniqKey="Brining D">D. L. Brining</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Corman, V M" uniqKey="Corman V">V. M. Corman</name>
</author>
</analytic>
</biblStruct>
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