The Genomics of Streptococcus pneumoniae Carriage Isolates from UK Children and Their Household Contacts, Pre-PCV7 to Post-PCV13
Identifieur interne : 002335 ( Ncbi/Curation ); précédent : 002334; suivant : 002336The Genomics of Streptococcus pneumoniae Carriage Isolates from UK Children and Their Household Contacts, Pre-PCV7 to Post-PCV13
Auteurs : Carmen L. Sheppard [Royaume-Uni] ; Natalie Groves [Royaume-Uni] ; Nicholas Andrews [Royaume-Uni] ; David J. Litt [Royaume-Uni] ; Norman K. Fry [Royaume-Uni] ; Jo Southern [Royaume-Uni] ; Elizabeth Miller [Royaume-Uni]Source :
- Genes [ 2073-4425 ] ; 2019.
Descripteurs français
- KwdFr :
- Adolescent, Adulte, Caractéristiques familiales, Enfant, Enfant d'âge préscolaire, Génome bactérien, Humains, Infections à pneumocoques (), Infections à pneumocoques (microbiologie), Infections à pneumocoques (transmission), Infections à pneumocoques (épidémiologie), Phylogénie, Porteur sain (microbiologie), Porteur sain (épidémiologie), Programmes de vaccination (), Royaume-Uni, Streptococcus pneumoniae (génétique), Streptococcus pneumoniae (immunologie), Streptococcus pneumoniae (isolement et purification), Sérogroupe, Vaccin antipneumococcique conjugué heptavalent (usage thérapeutique), Vaccins antipneumococciques (usage thérapeutique).
- MESH :
- génétique : Streptococcus pneumoniae.
- immunologie : Streptococcus pneumoniae.
- isolement et purification : Streptococcus pneumoniae.
- microbiologie : Infections à pneumocoques, Porteur sain.
- usage thérapeutique : Infections à pneumocoques, Vaccin antipneumococcique conjugué heptavalent, Vaccins antipneumococciques.
- épidémiologie : Infections à pneumocoques, Porteur sain.
- Adolescent, Adulte, Caractéristiques familiales, Enfant, Enfant d'âge préscolaire, Génome bactérien, Humains, Infections à pneumocoques, Phylogénie, Programmes de vaccination, Royaume-Uni, Sérogroupe.
- Wicri :
- geographic : Royaume-Uni.
English descriptors
- KwdEn :
- Adolescent, Adult, Carrier State (epidemiology), Carrier State (microbiology), Child, Child, Preschool, Family Characteristics, Genome, Bacterial, Heptavalent Pneumococcal Conjugate Vaccine (therapeutic use), Humans, Immunization Programs (statistics & numerical data), Phylogeny, Pneumococcal Infections (epidemiology), Pneumococcal Infections (microbiology), Pneumococcal Infections (prevention & control), Pneumococcal Infections (transmission), Pneumococcal Vaccines (therapeutic use), Serogroup, Streptococcus pneumoniae (genetics), Streptococcus pneumoniae (immunology), Streptococcus pneumoniae (isolation & purification), United Kingdom.
- MESH :
- chemical , therapeutic use : Heptavalent Pneumococcal Conjugate Vaccine, Pneumococcal Vaccines.
- geographic : United Kingdom.
- epidemiology : Carrier State, Pneumococcal Infections.
- genetics : Streptococcus pneumoniae.
- immunology : Streptococcus pneumoniae.
- isolation & purification : Streptococcus pneumoniae.
- microbiology : Carrier State, Pneumococcal Infections.
- prevention & control : Pneumococcal Infections.
- statistics & numerical data : Immunization Programs.
- transmission : Pneumococcal Infections.
- Adolescent, Adult, Child, Child, Preschool, Family Characteristics, Genome, Bacterial, Humans, Phylogeny, Serogroup.
Abstract
We used whole genome sequencing (WGS) analysis to investigate the population structure of 877
Url:
DOI: 10.3390/genes10090687
PubMed: 31500179
PubMed Central: 6771020
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: Pour aller vers cette notice dans l'étape Curation :000C96
- to stream Pmc, to step Curation: Pour aller vers cette notice dans l'étape Curation :000C96
- to stream Pmc, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :000158
- to stream PubMed, to step Corpus: Pour aller vers cette notice dans l'étape Curation :000426
- to stream PubMed, to step Curation: Pour aller vers cette notice dans l'étape Curation :000426
- to stream PubMed, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :000356
- to stream Ncbi, to step Merge: Pour aller vers cette notice dans l'étape Curation :002335
Links to Exploration step
PMC:6771020Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">The Genomics of <italic>Streptococcus pneumoniae</italic>
Carriage Isolates from UK Children and Their Household Contacts, Pre-PCV7 to Post-PCV13</title>
<author><name sortKey="Sheppard, Carmen L" sort="Sheppard, Carmen L" uniqKey="Sheppard C" first="Carmen L." last="Sheppard">Carmen L. Sheppard</name>
<affiliation wicri:level="1"><nlm:aff id="af1-genes-10-00687">Vaccine Preventable Bacteria Section, Public Health England—National Infection Service, 61 Colindale Avenue, London NW9 5EQ, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Vaccine Preventable Bacteria Section, Public Health England—National Infection Service, 61 Colindale Avenue, London NW9 5EQ</wicri:regionArea>
<wicri:noRegion>London NW9 5EQ</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Groves, Natalie" sort="Groves, Natalie" uniqKey="Groves N" first="Natalie" last="Groves">Natalie Groves</name>
<affiliation wicri:level="1"><nlm:aff id="af1-genes-10-00687">Vaccine Preventable Bacteria Section, Public Health England—National Infection Service, 61 Colindale Avenue, London NW9 5EQ, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Vaccine Preventable Bacteria Section, Public Health England—National Infection Service, 61 Colindale Avenue, London NW9 5EQ</wicri:regionArea>
<wicri:noRegion>London NW9 5EQ</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Andrews, Nicholas" sort="Andrews, Nicholas" uniqKey="Andrews N" first="Nicholas" last="Andrews">Nicholas Andrews</name>
<affiliation wicri:level="1"><nlm:aff id="af2-genes-10-00687">Statistics, Modelling and Economics, Public Health England—National Infection Service, 61 Colindale Avenue, London NW9 5EQ, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Statistics, Modelling and Economics, Public Health England—National Infection Service, 61 Colindale Avenue, London NW9 5EQ</wicri:regionArea>
<wicri:noRegion>London NW9 5EQ</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Litt, David J" sort="Litt, David J" uniqKey="Litt D" first="David J." last="Litt">David J. Litt</name>
<affiliation wicri:level="1"><nlm:aff id="af1-genes-10-00687">Vaccine Preventable Bacteria Section, Public Health England—National Infection Service, 61 Colindale Avenue, London NW9 5EQ, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Vaccine Preventable Bacteria Section, Public Health England—National Infection Service, 61 Colindale Avenue, London NW9 5EQ</wicri:regionArea>
<wicri:noRegion>London NW9 5EQ</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Fry, Norman K" sort="Fry, Norman K" uniqKey="Fry N" first="Norman K." last="Fry">Norman K. Fry</name>
<affiliation wicri:level="1"><nlm:aff id="af1-genes-10-00687">Vaccine Preventable Bacteria Section, Public Health England—National Infection Service, 61 Colindale Avenue, London NW9 5EQ, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Vaccine Preventable Bacteria Section, Public Health England—National Infection Service, 61 Colindale Avenue, London NW9 5EQ</wicri:regionArea>
<wicri:noRegion>London NW9 5EQ</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af3-genes-10-00687">Immunisation and Countermeasures, Public Health England—National Infection Service, 61 Colindale Avenue, London NW9 5EQ, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Immunisation and Countermeasures, Public Health England—National Infection Service, 61 Colindale Avenue, London NW9 5EQ</wicri:regionArea>
<wicri:noRegion>London NW9 5EQ</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Southern, Jo" sort="Southern, Jo" uniqKey="Southern J" first="Jo" last="Southern">Jo Southern</name>
<affiliation wicri:level="1"><nlm:aff id="af3-genes-10-00687">Immunisation and Countermeasures, Public Health England—National Infection Service, 61 Colindale Avenue, London NW9 5EQ, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Immunisation and Countermeasures, Public Health England—National Infection Service, 61 Colindale Avenue, London NW9 5EQ</wicri:regionArea>
<wicri:noRegion>London NW9 5EQ</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Miller, Elizabeth" sort="Miller, Elizabeth" uniqKey="Miller E" first="Elizabeth" last="Miller">Elizabeth Miller</name>
<affiliation wicri:level="1"><nlm:aff id="af3-genes-10-00687">Immunisation and Countermeasures, Public Health England—National Infection Service, 61 Colindale Avenue, London NW9 5EQ, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Immunisation and Countermeasures, Public Health England—National Infection Service, 61 Colindale Avenue, London NW9 5EQ</wicri:regionArea>
<wicri:noRegion>London NW9 5EQ</wicri:noRegion>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">31500179</idno>
<idno type="pmc">6771020</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6771020</idno>
<idno type="RBID">PMC:6771020</idno>
<idno type="doi">10.3390/genes10090687</idno>
<date when="2019">2019</date>
<idno type="wicri:Area/Pmc/Corpus">000C96</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000C96</idno>
<idno type="wicri:Area/Pmc/Curation">000C96</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000C96</idno>
<idno type="wicri:Area/Pmc/Checkpoint">000158</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000158</idno>
<idno type="wicri:source">PubMed</idno>
<idno type="RBID">pubmed:31500179</idno>
<idno type="wicri:Area/PubMed/Corpus">000426</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000426</idno>
<idno type="wicri:Area/PubMed/Curation">000426</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000426</idno>
<idno type="wicri:Area/PubMed/Checkpoint">000356</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000356</idno>
<idno type="wicri:Area/Ncbi/Merge">002335</idno>
<idno type="wicri:Area/Ncbi/Curation">002335</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">The Genomics of <italic>Streptococcus pneumoniae</italic>
Carriage Isolates from UK Children and Their Household Contacts, Pre-PCV7 to Post-PCV13</title>
<author><name sortKey="Sheppard, Carmen L" sort="Sheppard, Carmen L" uniqKey="Sheppard C" first="Carmen L." last="Sheppard">Carmen L. Sheppard</name>
<affiliation wicri:level="1"><nlm:aff id="af1-genes-10-00687">Vaccine Preventable Bacteria Section, Public Health England—National Infection Service, 61 Colindale Avenue, London NW9 5EQ, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Vaccine Preventable Bacteria Section, Public Health England—National Infection Service, 61 Colindale Avenue, London NW9 5EQ</wicri:regionArea>
<wicri:noRegion>London NW9 5EQ</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Groves, Natalie" sort="Groves, Natalie" uniqKey="Groves N" first="Natalie" last="Groves">Natalie Groves</name>
<affiliation wicri:level="1"><nlm:aff id="af1-genes-10-00687">Vaccine Preventable Bacteria Section, Public Health England—National Infection Service, 61 Colindale Avenue, London NW9 5EQ, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Vaccine Preventable Bacteria Section, Public Health England—National Infection Service, 61 Colindale Avenue, London NW9 5EQ</wicri:regionArea>
<wicri:noRegion>London NW9 5EQ</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Andrews, Nicholas" sort="Andrews, Nicholas" uniqKey="Andrews N" first="Nicholas" last="Andrews">Nicholas Andrews</name>
<affiliation wicri:level="1"><nlm:aff id="af2-genes-10-00687">Statistics, Modelling and Economics, Public Health England—National Infection Service, 61 Colindale Avenue, London NW9 5EQ, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Statistics, Modelling and Economics, Public Health England—National Infection Service, 61 Colindale Avenue, London NW9 5EQ</wicri:regionArea>
<wicri:noRegion>London NW9 5EQ</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Litt, David J" sort="Litt, David J" uniqKey="Litt D" first="David J." last="Litt">David J. Litt</name>
<affiliation wicri:level="1"><nlm:aff id="af1-genes-10-00687">Vaccine Preventable Bacteria Section, Public Health England—National Infection Service, 61 Colindale Avenue, London NW9 5EQ, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Vaccine Preventable Bacteria Section, Public Health England—National Infection Service, 61 Colindale Avenue, London NW9 5EQ</wicri:regionArea>
<wicri:noRegion>London NW9 5EQ</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Fry, Norman K" sort="Fry, Norman K" uniqKey="Fry N" first="Norman K." last="Fry">Norman K. Fry</name>
<affiliation wicri:level="1"><nlm:aff id="af1-genes-10-00687">Vaccine Preventable Bacteria Section, Public Health England—National Infection Service, 61 Colindale Avenue, London NW9 5EQ, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Vaccine Preventable Bacteria Section, Public Health England—National Infection Service, 61 Colindale Avenue, London NW9 5EQ</wicri:regionArea>
<wicri:noRegion>London NW9 5EQ</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af3-genes-10-00687">Immunisation and Countermeasures, Public Health England—National Infection Service, 61 Colindale Avenue, London NW9 5EQ, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Immunisation and Countermeasures, Public Health England—National Infection Service, 61 Colindale Avenue, London NW9 5EQ</wicri:regionArea>
<wicri:noRegion>London NW9 5EQ</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Southern, Jo" sort="Southern, Jo" uniqKey="Southern J" first="Jo" last="Southern">Jo Southern</name>
<affiliation wicri:level="1"><nlm:aff id="af3-genes-10-00687">Immunisation and Countermeasures, Public Health England—National Infection Service, 61 Colindale Avenue, London NW9 5EQ, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Immunisation and Countermeasures, Public Health England—National Infection Service, 61 Colindale Avenue, London NW9 5EQ</wicri:regionArea>
<wicri:noRegion>London NW9 5EQ</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Miller, Elizabeth" sort="Miller, Elizabeth" uniqKey="Miller E" first="Elizabeth" last="Miller">Elizabeth Miller</name>
<affiliation wicri:level="1"><nlm:aff id="af3-genes-10-00687">Immunisation and Countermeasures, Public Health England—National Infection Service, 61 Colindale Avenue, London NW9 5EQ, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Immunisation and Countermeasures, Public Health England—National Infection Service, 61 Colindale Avenue, London NW9 5EQ</wicri:regionArea>
<wicri:noRegion>London NW9 5EQ</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j">Genes</title>
<idno type="eISSN">2073-4425</idno>
<imprint><date when="2019">2019</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term>
<term>Adult</term>
<term>Carrier State (epidemiology)</term>
<term>Carrier State (microbiology)</term>
<term>Child</term>
<term>Child, Preschool</term>
<term>Family Characteristics</term>
<term>Genome, Bacterial</term>
<term>Heptavalent Pneumococcal Conjugate Vaccine (therapeutic use)</term>
<term>Humans</term>
<term>Immunization Programs (statistics & numerical data)</term>
<term>Phylogeny</term>
<term>Pneumococcal Infections (epidemiology)</term>
<term>Pneumococcal Infections (microbiology)</term>
<term>Pneumococcal Infections (prevention & control)</term>
<term>Pneumococcal Infections (transmission)</term>
<term>Pneumococcal Vaccines (therapeutic use)</term>
<term>Serogroup</term>
<term>Streptococcus pneumoniae (genetics)</term>
<term>Streptococcus pneumoniae (immunology)</term>
<term>Streptococcus pneumoniae (isolation & purification)</term>
<term>United Kingdom</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Adolescent</term>
<term>Adulte</term>
<term>Caractéristiques familiales</term>
<term>Enfant</term>
<term>Enfant d'âge préscolaire</term>
<term>Génome bactérien</term>
<term>Humains</term>
<term>Infections à pneumocoques ()</term>
<term>Infections à pneumocoques (microbiologie)</term>
<term>Infections à pneumocoques (transmission)</term>
<term>Infections à pneumocoques (épidémiologie)</term>
<term>Phylogénie</term>
<term>Porteur sain (microbiologie)</term>
<term>Porteur sain (épidémiologie)</term>
<term>Programmes de vaccination ()</term>
<term>Royaume-Uni</term>
<term>Streptococcus pneumoniae (génétique)</term>
<term>Streptococcus pneumoniae (immunologie)</term>
<term>Streptococcus pneumoniae (isolement et purification)</term>
<term>Sérogroupe</term>
<term>Vaccin antipneumococcique conjugué heptavalent (usage thérapeutique)</term>
<term>Vaccins antipneumococciques (usage thérapeutique)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Heptavalent Pneumococcal Conjugate Vaccine</term>
<term>Pneumococcal Vaccines</term>
</keywords>
<keywords scheme="MESH" type="geographic" xml:lang="en"><term>United Kingdom</term>
</keywords>
<keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Carrier State</term>
<term>Pneumococcal Infections</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Streptococcus pneumoniae</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Streptococcus pneumoniae</term>
</keywords>
<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Streptococcus pneumoniae</term>
</keywords>
<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Streptococcus pneumoniae</term>
</keywords>
<keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>Streptococcus pneumoniae</term>
</keywords>
<keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Streptococcus pneumoniae</term>
</keywords>
<keywords scheme="MESH" qualifier="microbiologie" xml:lang="fr"><term>Infections à pneumocoques</term>
<term>Porteur sain</term>
</keywords>
<keywords scheme="MESH" qualifier="microbiology" xml:lang="en"><term>Carrier State</term>
<term>Pneumococcal Infections</term>
</keywords>
<keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Pneumococcal Infections</term>
</keywords>
<keywords scheme="MESH" qualifier="statistics & numerical data" xml:lang="en"><term>Immunization Programs</term>
</keywords>
<keywords scheme="MESH" qualifier="transmission" xml:lang="en"><term>Pneumococcal Infections</term>
</keywords>
<keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Infections à pneumocoques</term>
<term>Vaccin antipneumococcique conjugué heptavalent</term>
<term>Vaccins antipneumococciques</term>
</keywords>
<keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Infections à pneumocoques</term>
<term>Porteur sain</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adolescent</term>
<term>Adult</term>
<term>Child</term>
<term>Child, Preschool</term>
<term>Family Characteristics</term>
<term>Genome, Bacterial</term>
<term>Humans</term>
<term>Phylogeny</term>
<term>Serogroup</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term>
<term>Adulte</term>
<term>Caractéristiques familiales</term>
<term>Enfant</term>
<term>Enfant d'âge préscolaire</term>
<term>Génome bactérien</term>
<term>Humains</term>
<term>Infections à pneumocoques</term>
<term>Phylogénie</term>
<term>Programmes de vaccination</term>
<term>Royaume-Uni</term>
<term>Sérogroupe</term>
</keywords>
<keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Royaume-Uni</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p>We used whole genome sequencing (WGS) analysis to investigate the population structure of 877 <italic>Streptococcus pneumoniae</italic>
isolates from five carriage studies from 2002 (<italic>N</italic>
= 346), 2010 (<italic>N</italic>
= 127), 2013 (<italic>N</italic>
= 153), 2016 (<italic>N</italic>
= 187) and 2018 (<italic>N</italic>
= 64) in UK households which covers the period pre-PCV7 to post-PCV13 implementation. The genomic lineages seen in the population were determined using multi-locus sequence typing (MLST) and PopPUNK (Population Partitioning Using Nucleotide K-mers) which was used for local and global comparisons. A Roary core genome alignment of all the carriage genomes was used to investigate phylogenetic relationships between the lineages. The results showed an influx of previously undetected sequence types after vaccination associated with non-vaccine serotypes. A small number of lineages persisted throughout, associated with both non-vaccine and vaccine types (such as ST199), or that could be an example of serotype switching from vaccine to non-vaccine types (ST177). Serotype 3 persisted throughout the study years, represented by ST180 and Global Pneumococcal Sequencing Cluster (GPSC) 12; the local PopPUNK analysis and core genome maximum likelihood phylogeny separated them into two clades, one of which is only seen in later study years. The genomic data showed that serotype replacement in the carriage studies was mostly due to a change in genotype as well as serotype, but that some important genetic lineages, previously associated with vaccine types, persisted.</p>
</div>
</front>
<back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Miller, E" uniqKey="Miller E">E. Miller</name>
</author>
<author><name sortKey="Andrews, N J" uniqKey="Andrews N">N.J. Andrews</name>
</author>
<author><name sortKey="Waight, P A" uniqKey="Waight P">P.A. Waight</name>
</author>
<author><name sortKey="Slack, M P" uniqKey="Slack M">M.P. Slack</name>
</author>
<author><name sortKey="George, R C" uniqKey="George R">R.C. George</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hussain, M" uniqKey="Hussain M">M. Hussain</name>
</author>
<author><name sortKey="Melegaro, A" uniqKey="Melegaro A">A. Melegaro</name>
</author>
<author><name sortKey="Pebody, R G" uniqKey="Pebody R">R.G. Pebody</name>
</author>
<author><name sortKey="George, R" uniqKey="George R">R. George</name>
</author>
<author><name sortKey="Edmunds, W J" uniqKey="Edmunds W">W.J. Edmunds</name>
</author>
<author><name sortKey="Talukdar, R" uniqKey="Talukdar R">R. Talukdar</name>
</author>
<author><name sortKey="Martin, S A" uniqKey="Martin S">S.A. Martin</name>
</author>
<author><name sortKey="Efstratiou, A" uniqKey="Efstratiou A">A. Efstratiou</name>
</author>
<author><name sortKey="Miller, E" uniqKey="Miller E">E. Miller</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Flasche, S" uniqKey="Flasche S">S. Flasche</name>
</author>
<author><name sortKey="Van Hoek, A J" uniqKey="Van Hoek A">A.J. van Hoek</name>
</author>
<author><name sortKey="Sheasby, E" uniqKey="Sheasby E">E. Sheasby</name>
</author>
<author><name sortKey="Waight, P" uniqKey="Waight P">P. Waight</name>
</author>
<author><name sortKey="Andrews, N" uniqKey="Andrews N">N. Andrews</name>
</author>
<author><name sortKey="Sheppard, C" uniqKey="Sheppard C">C. Sheppard</name>
</author>
<author><name sortKey="George, R" uniqKey="George R">R. George</name>
</author>
<author><name sortKey="Miller, E" uniqKey="Miller E">E. Miller</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Van Hoek, A J" uniqKey="Van Hoek A">A.J. van Hoek</name>
</author>
<author><name sortKey="Sheppard, C L" uniqKey="Sheppard C">C.L. Sheppard</name>
</author>
<author><name sortKey="Andrews, N J" uniqKey="Andrews N">N.J. Andrews</name>
</author>
<author><name sortKey="Waight, P A" uniqKey="Waight P">P.A. Waight</name>
</author>
<author><name sortKey="Slack, M P E" uniqKey="Slack M">M.P.E. Slack</name>
</author>
<author><name sortKey="Harrison, T G" uniqKey="Harrison T">T.G. Harrison</name>
</author>
<author><name sortKey="Ladhani, S N" uniqKey="Ladhani S">S.N. Ladhani</name>
</author>
<author><name sortKey="Miller, E" uniqKey="Miller E">E. Miller</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Southern, J" uniqKey="Southern J">J. Southern</name>
</author>
<author><name sortKey="Andrews, N" uniqKey="Andrews N">N. Andrews</name>
</author>
<author><name sortKey="Sandu, P" uniqKey="Sandu P">P. Sandu</name>
</author>
<author><name sortKey="Sheppard, C L" uniqKey="Sheppard C">C.L. Sheppard</name>
</author>
<author><name sortKey="Waight, P A" uniqKey="Waight P">P.A. Waight</name>
</author>
<author><name sortKey="Fry, N K" uniqKey="Fry N">N.K. Fry</name>
</author>
<author><name sortKey="Van Hoek, A J" uniqKey="Van Hoek A">A.J. Van Hoek</name>
</author>
<author><name sortKey="Miller, E" uniqKey="Miller E">E. Miller</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Waight, P A" uniqKey="Waight P">P.A. Waight</name>
</author>
<author><name sortKey="Andrews, N J" uniqKey="Andrews N">N.J. Andrews</name>
</author>
<author><name sortKey="Ladhani, S N" uniqKey="Ladhani S">S.N. Ladhani</name>
</author>
<author><name sortKey="Sheppard, C L" uniqKey="Sheppard C">C.L. Sheppard</name>
</author>
<author><name sortKey="Slack, M P E" uniqKey="Slack M">M.P.E. Slack</name>
</author>
<author><name sortKey="Miller, E" uniqKey="Miller E">E. Miller</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ladhani, S N" uniqKey="Ladhani S">S.N. Ladhani</name>
</author>
<author><name sortKey="Collins, S" uniqKey="Collins S">S. Collins</name>
</author>
<author><name sortKey="Djennad, A" uniqKey="Djennad A">A. Djennad</name>
</author>
<author><name sortKey="Sheppard, C L" uniqKey="Sheppard C">C.L. Sheppard</name>
</author>
<author><name sortKey="Borrow, R" uniqKey="Borrow R">R. Borrow</name>
</author>
<author><name sortKey="Fry, N K" uniqKey="Fry N">N.K. Fry</name>
</author>
<author><name sortKey="Andrews, N J" uniqKey="Andrews N">N.J. Andrews</name>
</author>
<author><name sortKey="Miller, E" uniqKey="Miller E">E. Miller</name>
</author>
<author><name sortKey="Ramsay, M E" uniqKey="Ramsay M">M.E. Ramsay</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chewapreecha, C" uniqKey="Chewapreecha C">C. Chewapreecha</name>
</author>
<author><name sortKey="Harris, S R" uniqKey="Harris S">S.R. Harris</name>
</author>
<author><name sortKey="Croucher, N J" uniqKey="Croucher N">N.J. Croucher</name>
</author>
<author><name sortKey="Turner, C" uniqKey="Turner C">C. Turner</name>
</author>
<author><name sortKey="Marttinen, P" uniqKey="Marttinen P">P. Marttinen</name>
</author>
<author><name sortKey="Cheng, L" uniqKey="Cheng L">L. Cheng</name>
</author>
<author><name sortKey="Pessia, A" uniqKey="Pessia A">A. Pessia</name>
</author>
<author><name sortKey="Aanensen, D M" uniqKey="Aanensen D">D.M. Aanensen</name>
</author>
<author><name sortKey="Mather, A E" uniqKey="Mather A">A.E. Mather</name>
</author>
<author><name sortKey="Page, A J" uniqKey="Page A">A.J. Page</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Turner, P" uniqKey="Turner P">P. Turner</name>
</author>
<author><name sortKey="Turner, C" uniqKey="Turner C">C. Turner</name>
</author>
<author><name sortKey="Jankhot, A" uniqKey="Jankhot A">A. Jankhot</name>
</author>
<author><name sortKey="Helen, N" uniqKey="Helen N">N. Helen</name>
</author>
<author><name sortKey="Lee, S J" uniqKey="Lee S">S.J. Lee</name>
</author>
<author><name sortKey="Day, N P" uniqKey="Day N">N.P. Day</name>
</author>
<author><name sortKey="White, N J" uniqKey="White N">N.J. White</name>
</author>
<author><name sortKey="Nosten, F" uniqKey="Nosten F">F. Nosten</name>
</author>
<author><name sortKey="Goldblatt, D" uniqKey="Goldblatt D">D. Goldblatt</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lees, J A" uniqKey="Lees J">J.A. Lees</name>
</author>
<author><name sortKey="Croucher, N J" uniqKey="Croucher N">N.J. Croucher</name>
</author>
<author><name sortKey="Goldblatt, D" uniqKey="Goldblatt D">D. Goldblatt</name>
</author>
<author><name sortKey="Nosten, F" uniqKey="Nosten F">F. Nosten</name>
</author>
<author><name sortKey="Parkhill, J" uniqKey="Parkhill J">J. Parkhill</name>
</author>
<author><name sortKey="Turner, C" uniqKey="Turner C">C. Turner</name>
</author>
<author><name sortKey="Turner, P" uniqKey="Turner P">P. Turner</name>
</author>
<author><name sortKey="Bentley, S D" uniqKey="Bentley S">S.D. Bentley</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Corander, J" uniqKey="Corander J">J. Corander</name>
</author>
<author><name sortKey="Fraser, C" uniqKey="Fraser C">C. Fraser</name>
</author>
<author><name sortKey="Gutmann, M U" uniqKey="Gutmann M">M.U. Gutmann</name>
</author>
<author><name sortKey="Arnold, B" uniqKey="Arnold B">B. Arnold</name>
</author>
<author><name sortKey="Hanage, W P" uniqKey="Hanage W">W.P. Hanage</name>
</author>
<author><name sortKey="Bentley, S D" uniqKey="Bentley S">S.D. Bentley</name>
</author>
<author><name sortKey="Lipsitch, M" uniqKey="Lipsitch M">M. Lipsitch</name>
</author>
<author><name sortKey="Croucher, N J" uniqKey="Croucher N">N.J. Croucher</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gladstone, R A" uniqKey="Gladstone R">R.A. Gladstone</name>
</author>
<author><name sortKey="Jefferies, J M" uniqKey="Jefferies J">J.M. Jefferies</name>
</author>
<author><name sortKey="Tocheva, A S" uniqKey="Tocheva A">A.S. Tocheva</name>
</author>
<author><name sortKey="Beard, K R" uniqKey="Beard K">K.R. Beard</name>
</author>
<author><name sortKey="Garley, D" uniqKey="Garley D">D. Garley</name>
</author>
<author><name sortKey="Chong, W W" uniqKey="Chong W">W.W. Chong</name>
</author>
<author><name sortKey="Bentley, S D" uniqKey="Bentley S">S.D. Bentley</name>
</author>
<author><name sortKey="Faust, S N" uniqKey="Faust S">S.N. Faust</name>
</author>
<author><name sortKey="Clarke, S C" uniqKey="Clarke S">S.C. Clarke</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Tewolde, R" uniqKey="Tewolde R">R. Tewolde</name>
</author>
<author><name sortKey="Dallman, T" uniqKey="Dallman T">T. Dallman</name>
</author>
<author><name sortKey="Schaefer, U" uniqKey="Schaefer U">U. Schaefer</name>
</author>
<author><name sortKey="Sheppard, C L" uniqKey="Sheppard C">C.L. Sheppard</name>
</author>
<author><name sortKey="Ashton, P" uniqKey="Ashton P">P. Ashton</name>
</author>
<author><name sortKey="Pichon, B" uniqKey="Pichon B">B. Pichon</name>
</author>
<author><name sortKey="Ellington, M" uniqKey="Ellington M">M. Ellington</name>
</author>
<author><name sortKey="Swift, C" uniqKey="Swift C">C. Swift</name>
</author>
<author><name sortKey="Green, J" uniqKey="Green J">J. Green</name>
</author>
<author><name sortKey="Underwood, A" uniqKey="Underwood A">A. Underwood</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kapatai, G" uniqKey="Kapatai G">G. Kapatai</name>
</author>
<author><name sortKey="Sheppard, C L" uniqKey="Sheppard C">C.L. Sheppard</name>
</author>
<author><name sortKey="Al Shahib, A" uniqKey="Al Shahib A">A. Al-Shahib</name>
</author>
<author><name sortKey="Litt, D J" uniqKey="Litt D">D.J. Litt</name>
</author>
<author><name sortKey="Underwood, A P" uniqKey="Underwood A">A.P. Underwood</name>
</author>
<author><name sortKey="Harrison, T G" uniqKey="Harrison T">T.G. Harrison</name>
</author>
<author><name sortKey="Fry, N K" uniqKey="Fry N">N.K. Fry</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Nascimento, M" uniqKey="Nascimento M">M. Nascimento</name>
</author>
<author><name sortKey="Sousa, A" uniqKey="Sousa A">A. Sousa</name>
</author>
<author><name sortKey="Ramirez, M" uniqKey="Ramirez M">M. Ramirez</name>
</author>
<author><name sortKey="Francisco, A P" uniqKey="Francisco A">A.P. Francisco</name>
</author>
<author><name sortKey="Carrico, J A" uniqKey="Carrico J">J.A. Carriço</name>
</author>
<author><name sortKey="Vaz, C" uniqKey="Vaz C">C. Vaz</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wick, R R" uniqKey="Wick R">R.R. Wick</name>
</author>
<author><name sortKey="Judd, L M" uniqKey="Judd L">L.M. Judd</name>
</author>
<author><name sortKey="Gorrie, C L" uniqKey="Gorrie C">C.L. Gorrie</name>
</author>
<author><name sortKey="Holt, K E" uniqKey="Holt K">K.E. Holt</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lees, J A" uniqKey="Lees J">J.A. Lees</name>
</author>
<author><name sortKey="Harris, S R" uniqKey="Harris S">S.R. Harris</name>
</author>
<author><name sortKey="Tonkin Hill, G" uniqKey="Tonkin Hill G">G. Tonkin-Hill</name>
</author>
<author><name sortKey="Gladstone, R A" uniqKey="Gladstone R">R.A. Gladstone</name>
</author>
<author><name sortKey="Lo, S W" uniqKey="Lo S">S.W. Lo</name>
</author>
<author><name sortKey="Weiser, J N" uniqKey="Weiser J">J.N. Weiser</name>
</author>
<author><name sortKey="Corander, J" uniqKey="Corander J">J. Corander</name>
</author>
<author><name sortKey="Bentley, S D" uniqKey="Bentley S">S.D. Bentley</name>
</author>
<author><name sortKey="Croucher, N J" uniqKey="Croucher N">N.J. Croucher</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Seemann, T" uniqKey="Seemann T">T. Seemann</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Zankari, E" uniqKey="Zankari E">E. Zankari</name>
</author>
<author><name sortKey="Hasman, H" uniqKey="Hasman H">H. Hasman</name>
</author>
<author><name sortKey="Cosentino, S" uniqKey="Cosentino S">S. Cosentino</name>
</author>
<author><name sortKey="Vestergaard, M" uniqKey="Vestergaard M">M. Vestergaard</name>
</author>
<author><name sortKey="Rasmussen, S" uniqKey="Rasmussen S">S. Rasmussen</name>
</author>
<author><name sortKey="Lund, O" uniqKey="Lund O">O. Lund</name>
</author>
<author><name sortKey="Aarestrup, F M" uniqKey="Aarestrup F">F.M. Aarestrup</name>
</author>
<author><name sortKey="Larsen, M V" uniqKey="Larsen M">M.V. Larsen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Page, A J" uniqKey="Page A">A.J. Page</name>
</author>
<author><name sortKey="Cummins, C A" uniqKey="Cummins C">C.A. Cummins</name>
</author>
<author><name sortKey="Hunt, M" uniqKey="Hunt M">M. Hunt</name>
</author>
<author><name sortKey="Wong, V K" uniqKey="Wong V">V.K. Wong</name>
</author>
<author><name sortKey="Reuter, S" uniqKey="Reuter S">S. Reuter</name>
</author>
<author><name sortKey="Holden, M T G" uniqKey="Holden M">M.T.G. Holden</name>
</author>
<author><name sortKey="Fookes, M" uniqKey="Fookes M">M. Fookes</name>
</author>
<author><name sortKey="Falush, D" uniqKey="Falush D">D. Falush</name>
</author>
<author><name sortKey="Keane, J A" uniqKey="Keane J">J.A. Keane</name>
</author>
<author><name sortKey="Parkhill, J" uniqKey="Parkhill J">J. Parkhill</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Stamatakis, A" uniqKey="Stamatakis A">A. Stamatakis</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Yu, G" uniqKey="Yu G">G. Yu</name>
</author>
<author><name sortKey="Smith, D K" uniqKey="Smith D">D.K. Smith</name>
</author>
<author><name sortKey="Zhu, H" uniqKey="Zhu H">H. Zhu</name>
</author>
<author><name sortKey="Guan, Y" uniqKey="Guan Y">Y. Guan</name>
</author>
<author><name sortKey="Lam, T T Y" uniqKey="Lam T">T.T.-Y. Lam</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gladstone, R A" uniqKey="Gladstone R">R.A. Gladstone</name>
</author>
<author><name sortKey="Lo, S W" uniqKey="Lo S">S.W. Lo</name>
</author>
<author><name sortKey="Lees, J A" uniqKey="Lees J">J.A. Lees</name>
</author>
<author><name sortKey="Croucher, N J" uniqKey="Croucher N">N.J. Croucher</name>
</author>
<author><name sortKey="Van Tonder, A J" uniqKey="Van Tonder A">A.J. van Tonder</name>
</author>
<author><name sortKey="Corander, J" uniqKey="Corander J">J. Corander</name>
</author>
<author><name sortKey="Page, A J" uniqKey="Page A">A.J. Page</name>
</author>
<author><name sortKey="Marttinen, P" uniqKey="Marttinen P">P. Marttinen</name>
</author>
<author><name sortKey="Bentley, L J" uniqKey="Bentley L">L.J. Bentley</name>
</author>
<author><name sortKey="Ochoa, T J" uniqKey="Ochoa T">T.J. Ochoa</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kamada, T" uniqKey="Kamada T">T. Kamada</name>
</author>
<author><name sortKey="Kawai, S" uniqKey="Kawai S">S. Kawai</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Shannon, P" uniqKey="Shannon P">P. Shannon</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Makwana, A" uniqKey="Makwana A">A. Makwana</name>
</author>
<author><name sortKey="Ladhani, S N" uniqKey="Ladhani S">S.N. Ladhani</name>
</author>
<author><name sortKey="Kapatai, G" uniqKey="Kapatai G">G. Kapatai</name>
</author>
<author><name sortKey="Campion, E" uniqKey="Campion E">E. Campion</name>
</author>
<author><name sortKey="Fry, N K" uniqKey="Fry N">N.K. Fry</name>
</author>
<author><name sortKey="Sheppard, C" uniqKey="Sheppard C">C. Sheppard</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lo, S W" uniqKey="Lo S">S.W. Lo</name>
</author>
<author><name sortKey="Gladstone, R A" uniqKey="Gladstone R">R.A. Gladstone</name>
</author>
<author><name sortKey="Van Tonder, A J" uniqKey="Van Tonder A">A.J. van Tonder</name>
</author>
<author><name sortKey="Lees, J A" uniqKey="Lees J">J.A. Lees</name>
</author>
<author><name sortKey="Du Plessis, M" uniqKey="Du Plessis M">M. du Plessis</name>
</author>
<author><name sortKey="Benisty, R" uniqKey="Benisty R">R. Benisty</name>
</author>
<author><name sortKey="Givon Lavi, N" uniqKey="Givon Lavi N">N. Givon-Lavi</name>
</author>
<author><name sortKey="Hawkins, P A" uniqKey="Hawkins P">P.A. Hawkins</name>
</author>
<author><name sortKey="Cornick, J E" uniqKey="Cornick J">J.E. Cornick</name>
</author>
<author><name sortKey="Kwambana Adams, B" uniqKey="Kwambana Adams B">B. Kwambana-Adams</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Andrews, N" uniqKey="Andrews N">N. Andrews</name>
</author>
<author><name sortKey="Kent, A" uniqKey="Kent A">A. Kent</name>
</author>
<author><name sortKey="Amin Chowdhury, Z" uniqKey="Amin Chowdhury Z">Z. Amin-Chowdhury</name>
</author>
<author><name sortKey="Sheppard, C" uniqKey="Sheppard C">C. Sheppard</name>
</author>
<author><name sortKey="Fry, N" uniqKey="Fry N">N. Fry</name>
</author>
<author><name sortKey="Ramsay, M" uniqKey="Ramsay M">M. Ramsay</name>
</author>
<author><name sortKey="Ladhani, S N" uniqKey="Ladhani S">S.N. Ladhani</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kapatai, G" uniqKey="Kapatai G">G. Kapatai</name>
</author>
<author><name sortKey="Sheppard, C L" uniqKey="Sheppard C">C.L. Sheppard</name>
</author>
<author><name sortKey="Troxler, L J" uniqKey="Troxler L">L.J. Troxler</name>
</author>
<author><name sortKey="Litt, D J" uniqKey="Litt D">D.J. Litt</name>
</author>
<author><name sortKey="Furrer, J" uniqKey="Furrer J">J. Furrer</name>
</author>
<author><name sortKey="Hilty, M" uniqKey="Hilty M">M. Hilty</name>
</author>
<author><name sortKey="Fry, N K" uniqKey="Fry N">N.K. Fry</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Azarian, T" uniqKey="Azarian T">T. Azarian</name>
</author>
<author><name sortKey="Mitchell, P K" uniqKey="Mitchell P">P.K. Mitchell</name>
</author>
<author><name sortKey="Georgieva, M" uniqKey="Georgieva M">M. Georgieva</name>
</author>
<author><name sortKey="Thompson, C M" uniqKey="Thompson C">C.M. Thompson</name>
</author>
<author><name sortKey="Ghouila, A" uniqKey="Ghouila A">A. Ghouila</name>
</author>
<author><name sortKey="Pollard, A J" uniqKey="Pollard A">A.J. Pollard</name>
</author>
<author><name sortKey="Von Gottberg, A" uniqKey="Von Gottberg A">A. von Gottberg</name>
</author>
<author><name sortKey="Du Plessis, M" uniqKey="Du Plessis M">M. du Plessis</name>
</author>
<author><name sortKey="Antonio, M" uniqKey="Antonio M">M. Antonio</name>
</author>
<author><name sortKey="Kwambana Adams, B A" uniqKey="Kwambana Adams B">B.A. Kwambana-Adams</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mitchell, P K" uniqKey="Mitchell P">P.K. Mitchell</name>
</author>
<author><name sortKey="Azarian, T" uniqKey="Azarian T">T. Azarian</name>
</author>
<author><name sortKey="Croucher, N J" uniqKey="Croucher N">N.J. Croucher</name>
</author>
<author><name sortKey="Callendrello, A" uniqKey="Callendrello A">A. Callendrello</name>
</author>
<author><name sortKey="Thompson, C M" uniqKey="Thompson C">C.M. Thompson</name>
</author>
<author><name sortKey="Pelton, S I" uniqKey="Pelton S">S.I. Pelton</name>
</author>
<author><name sortKey="Lipsitch, M" uniqKey="Lipsitch M">M. Lipsitch</name>
</author>
<author><name sortKey="Hanage, W P" uniqKey="Hanage W">W.P. Hanage</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Jansen, K U" uniqKey="Jansen K">K.U. Jansen</name>
</author>
<author><name sortKey="Anderson, A S" uniqKey="Anderson A">A.S. Anderson</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Obolski, U" uniqKey="Obolski U">U. Obolski</name>
</author>
<author><name sortKey="Lourenco, J" uniqKey="Lourenco J">J. Lourenço</name>
</author>
<author><name sortKey="Thompson, C" uniqKey="Thompson C">C. Thompson</name>
</author>
<author><name sortKey="Thompson, R" uniqKey="Thompson R">R. Thompson</name>
</author>
<author><name sortKey="Gori, A" uniqKey="Gori A">A. Gori</name>
</author>
<author><name sortKey="Gupta, S" uniqKey="Gupta S">S. Gupta</name>
</author>
</analytic>
</biblStruct>
</listBibl>
</div1>
</back>
</TEI>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/MersV1/Data/Ncbi/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002335 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Ncbi/Curation/biblio.hfd -nk 002335 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Sante |area= MersV1 |flux= Ncbi |étape= Curation |type= RBID |clé= PMC:6771020 |texte= The Genomics of Streptococcus pneumoniae Carriage Isolates from UK Children and Their Household Contacts, Pre-PCV7 to Post-PCV13 }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Ncbi/Curation/RBID.i -Sk "pubmed:31500179" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Ncbi/Curation/biblio.hfd \ | NlmPubMed2Wicri -a MersV1
![]() | This area was generated with Dilib version V0.6.33. | ![]() |