Cyclic Peptide-Based Sirtuin Substrates
Identifieur interne : 002091 ( Ncbi/Curation ); précédent : 002090; suivant : 002092Cyclic Peptide-Based Sirtuin Substrates
Auteurs : Di Chen ; Lingling Yan ; Weiping ZhengSource :
- Molecules [ 1420-3049 ] ; 2019.
Descripteurs français
- KwdFr :
- MESH :
- analogues et dérivés : Lysine.
- métabolisme : Pronase.
- Acylation, Catalyse, Cinétique, Humains, Lysine, Oxydoréduction, Peptides cycliques, Relation structure-activité, Sirtuines, Structure moléculaire, Thermodynamique.
English descriptors
- KwdEn :
- MESH :
- chemical , analogs & derivatives : Lysine.
- chemical , chemistry : Lysine, Peptides, Cyclic, Sirtuins.
- chemical , metabolism : Pronase.
- Acylation, Catalysis, Humans, Kinetics, Molecular Structure, Oxidation-Reduction, Structure-Activity Relationship, Thermodynamics.
Abstract
In the current study, four side chain-to-side chain cyclic peptides (three 5-mers and one 4-mer) harboring Nε-acetyl-lysine or Nε-myristoyl-lysine were found to be in vitro substrates of the human SIRT1/2/3-catalyzed deacylation with good substrate activities, as judged by the
Url:
DOI: 10.3390/molecules24030424
PubMed: 30682801
PubMed Central: 6384901
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PMC:6384901Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Cyclic Peptide-Based Sirtuin Substrates</title><author><name sortKey="Chen, Di" sort="Chen, Di" uniqKey="Chen D" first="Di" last="Chen">Di Chen</name></author><author><name sortKey="Yan, Lingling" sort="Yan, Lingling" uniqKey="Yan L" first="Lingling" last="Yan">Lingling Yan</name></author><author><name sortKey="Zheng, Weiping" sort="Zheng, Weiping" uniqKey="Zheng W" first="Weiping" last="Zheng">Weiping Zheng</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">30682801</idno><idno type="pmc">6384901</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6384901</idno><idno type="RBID">PMC:6384901</idno><idno type="doi">10.3390/molecules24030424</idno><date when="2019">2019</date><idno type="wicri:Area/Pmc/Corpus">000F29</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000F29</idno><idno 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Sirtuin Substrates</title><author><name sortKey="Chen, Di" sort="Chen, Di" uniqKey="Chen D" first="Di" last="Chen">Di Chen</name></author><author><name sortKey="Yan, Lingling" sort="Yan, Lingling" uniqKey="Yan L" first="Lingling" last="Yan">Lingling Yan</name></author><author><name sortKey="Zheng, Weiping" sort="Zheng, Weiping" uniqKey="Zheng W" first="Weiping" last="Zheng">Weiping Zheng</name></author></analytic><series><title level="j">Molecules</title><idno type="eISSN">1420-3049</idno><imprint><date when="2019">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Acylation</term><term>Catalysis</term><term>Humans</term><term>Kinetics</term><term>Lysine (analogs & derivatives)</term><term>Lysine (chemistry)</term><term>Molecular Structure</term><term>Oxidation-Reduction</term><term>Peptides, Cyclic (chemistry)</term><term>Pronase (metabolism)</term><term>Sirtuins (chemistry)</term><term>Structure-Activity Relationship</term><term>Thermodynamics</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Acylation</term><term>Catalyse</term><term>Cinétique</term><term>Humains</term><term>Lysine ()</term><term>Lysine (analogues et dérivés)</term><term>Oxydoréduction</term><term>Peptides cycliques ()</term><term>Pronase (métabolisme)</term><term>Relation structure-activité</term><term>Sirtuines ()</term><term>Structure moléculaire</term><term>Thermodynamique</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analogs & derivatives" xml:lang="en"><term>Lysine</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Lysine</term><term>Peptides, Cyclic</term><term>Sirtuins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Pronase</term></keywords><keywords scheme="MESH" qualifier="analogues et dérivés" xml:lang="fr"><term>Lysine</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Pronase</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Acylation</term><term>Catalysis</term><term>Humans</term><term>Kinetics</term><term>Molecular Structure</term><term>Oxidation-Reduction</term><term>Structure-Activity Relationship</term><term>Thermodynamics</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Acylation</term><term>Catalyse</term><term>Cinétique</term><term>Humains</term><term>Lysine</term><term>Oxydoréduction</term><term>Peptides cycliques</term><term>Relation structure-activité</term><term>Sirtuines</term><term>Structure moléculaire</term><term>Thermodynamique</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>In the current study, four side chain-to-side chain cyclic peptides (three 5-mers and one 4-mer) harboring N<sup>ε</sup>-acetyl-lysine or N<sup>ε</sup>-myristoyl-lysine were found to be in vitro substrates of the human SIRT1/2/3-catalyzed deacylation with good substrate activities, as judged by the <italic>k</italic><sub>cat</sub>/<italic>K</italic><sub>M</sub> ratios.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Greiss, S" uniqKey="Greiss S">S. 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Zheng</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hirsch, B M" uniqKey="Hirsch B">B.M. Hirsch</name></author><author><name sortKey="Hao, Y" uniqKey="Hao Y">Y. Hao</name></author><author><name sortKey="Li, X" uniqKey="Li X">X. Li</name></author><author><name sortKey="Wesdemiotis, C" uniqKey="Wesdemiotis C">C. Wesdemiotis</name></author><author><name sortKey="Wang, Z" uniqKey="Wang Z">Z. Wang</name></author><author><name sortKey="Zheng, W" uniqKey="Zheng W">W. Zheng</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Hirsch, B M" uniqKey="Hirsch B">B.M. Hirsch</name></author><author><name sortKey="Gallo, C A" uniqKey="Gallo C">C.A. Gallo</name></author><author><name sortKey="Du, Z" uniqKey="Du Z">Z. Du</name></author><author><name sortKey="Wang, Z" uniqKey="Wang Z">Z. Wang</name></author><author><name sortKey="Zheng, W" uniqKey="Zheng W">W. 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